mitoxantrone has been researched along with Kidney Neoplasms in 8 studies
Mitoxantrone: An anthracenedione-derived antineoplastic agent.
mitoxantrone : A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.
Kidney Neoplasms: Tumors or cancers of the KIDNEY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mitoxantrone is an anthracenedione, showing structural similarities to doxorubicin." | 5.27 | An EORTC phase II study of mitoxantrone in solid tumors and lymphomas. ( Armand, JP; Bastit, P; Cappelaere, P; De Jager, R; Earl, H; Fargeot, P; Keiling, R; Renard, J; Rubens, R; van Glabbeke, M, 1984) |
| "Verapamil was more effective in potentiation of doxorubicin and this action increased in proportion to the concentration of verapamil added." | 1.28 | The effect of verapamil on the anti-tumour action of mitozantrone and doxorubicin against renal carcinoma cells in vitro. ( Lai, T; Morgan, AP; Smith, PJ; Symes, MO, 1990) |
| "Mitoxantrone is an anthracenedione, showing structural similarities to doxorubicin." | 1.27 | An EORTC phase II study of mitoxantrone in solid tumors and lymphomas. ( Armand, JP; Bastit, P; Cappelaere, P; De Jager, R; Earl, H; Fargeot, P; Keiling, R; Renard, J; Rubens, R; van Glabbeke, M, 1984) |
| " Distribution and half-life data provide a pharmacological rationale for the use of mitoxantrone on an intermittent dosing schedule." | 1.27 | Pharmacology of mitoxantrone: mode of action and pharmacokinetics. ( Alberts, DS; Bowden, GT; Dalton, WS; Mackel, C; Peng, YM, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (75.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Toh, YM | 1 |
| Li, TK | 1 |
| van Oosterom, AT | 1 |
| Fosså, SD | 1 |
| Pizzocaro, G | 1 |
| Bergerat, JP | 1 |
| Bono, AV | 1 |
| De Pauw, M | 1 |
| Sylvester, R | 1 |
| De Jager, R | 1 |
| Cappelaere, P | 1 |
| Armand, JP | 1 |
| Keiling, R | 1 |
| Fargeot, P | 1 |
| Bastit, P | 1 |
| van Glabbeke, M | 1 |
| Renard, J | 1 |
| Earl, H | 1 |
| Rubens, R | 1 |
| Taylor, SA | 1 |
| Von Hoff, DD | 1 |
| Baker, LH | 1 |
| Balcerzak, SP | 1 |
| Lai, T | 1 |
| Morgan, AP | 1 |
| Smith, PJ | 1 |
| Symes, MO | 1 |
| Oliver, RT | 1 |
| Miller, RM | 1 |
| Mehta, A | 1 |
| Barnett, MJ | 1 |
| Gams, RA | 1 |
| Nelson, O | 1 |
| Birch, R | 1 |
| Alberts, DS | 1 |
| Peng, YM | 1 |
| Bowden, GT | 1 |
| Dalton, WS | 1 |
| Mackel, C | 1 |
2 trials available for mitoxantrone and Kidney Neoplasms
| Article | Year |
|---|---|
Phase II clinical trial of mitoxantrone in patients with advanced renal cell carcinoma: a Southwest Oncology Group study.
Topics: Adenocarcinoma; Adult; Aged; Anthraquinones; Antineoplastic Agents; Drug Evaluation; Humans; Kidney | 1984 |
Phase II evaluation of mitoxantrone in advanced renal cell carcinoma: a Southeastern Cancer Study Group Trial.
Topics: Adult; Anthraquinones; Antineoplastic Agents; Carcinoma, Renal Cell; Clinical Trials as Topic; Drug | 1986 |
6 other studies available for mitoxantrone and Kidney Neoplasms
| Article | Year |
|---|---|
Mitoxantrone inhibits HIF-1α expression in a topoisomerase II-independent pathway.
Topics: Antineoplastic Agents; Cell Line, Tumor; Colorectal Neoplasms; DNA Topoisomerases, Type II; Gene Kno | 2011 |
Mitoxantrone in advanced renal cancer: a phase II study in previously untreated patients from the EORTC Genito-Urinary Tract Cancer Cooperative Group.
Topics: Adult; Aged; Anthraquinones; Antineoplastic Agents; Carcinoma, Renal Cell; Drug Evaluation; Female; | 1984 |
An EORTC phase II study of mitoxantrone in solid tumors and lymphomas.
Topics: Adolescent; Adult; Aged; Alopecia; Anthraquinones; Antineoplastic Agents; Breast Neoplasms; Carcinom | 1984 |
The effect of verapamil on the anti-tumour action of mitozantrone and doxorubicin against renal carcinoma cells in vitro.
Topics: Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Humans; Ki | 1990 |
A phase 2 study of surveillance in patients with metastatic renal cell carcinoma and assessment of response of such patients to therapy on progression.
Topics: BCG Vaccine; Carcinoma, Renal Cell; Drug Evaluation; Follow-Up Studies; Humans; Interferon Type I; K | 1988 |
Pharmacology of mitoxantrone: mode of action and pharmacokinetics.
Topics: Animals; Anthraquinones; Antineoplastic Agents; Bone Marrow; Bone Neoplasms; Chromatography, High Pr | 1985 |