mitoxantrone has been researched along with Gastrointestinal Stromal Tumors in 2 studies
Mitoxantrone: An anthracenedione-derived antineoplastic agent.
mitoxantrone : A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.
Gastrointestinal Stromal Tumors: All tumors in the GASTROINTESTINAL TRACT arising from mesenchymal cells (MESODERM) except those of smooth muscle cells (LEIOMYOMA) or Schwann cells (SCHWANNOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Most gastrointestinal stromal tumors (GIST) are caused by oncogenic KIT or platelet-derived growth factor receptor activation, and the small molecule kinase inhibitor imatinib mesylate is an effective first-line therapy for metastatic or unresectable GIST." | 1.40 | Unbiased compound screening identifies unexpected drug sensitivities and novel treatment options for gastrointestinal stromal tumors. ( Boichuk, S; Brown, MF; Cuevas, R; Debiec-Rychter, M; Duensing, A; Korzeniewski, N; Kuan, SF; Lee, DJ; Makielski, KR; Mehalek, KR; Parry, JA; Schöffski, P; Seneviratne, DS; Taguchi, T; Wozniak, A; Zewe, J, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boichuk, S | 1 |
| Lee, DJ | 1 |
| Mehalek, KR | 1 |
| Makielski, KR | 1 |
| Wozniak, A | 1 |
| Seneviratne, DS | 1 |
| Korzeniewski, N | 1 |
| Cuevas, R | 1 |
| Parry, JA | 1 |
| Brown, MF | 1 |
| Zewe, J | 1 |
| Taguchi, T | 1 |
| Kuan, SF | 1 |
| Schöffski, P | 1 |
| Debiec-Rychter, M | 1 |
| Duensing, A | 1 |
| Thorne, J | 1 |
2 other studies available for mitoxantrone and Gastrointestinal Stromal Tumors
| Article | Year |
|---|---|
Unbiased compound screening identifies unexpected drug sensitivities and novel treatment options for gastrointestinal stromal tumors.
Topics: Animals; Antineoplastic Agents; Apoptosis; Drug Screening Assays, Antitumor; Female; Gastrointestina | 2014 |
Drug repurposing identifies therapeutic agents for gastrointestinal stromal tumors.
Topics: Antineoplastic Agents; Drug Discovery; Drug Repositioning; Gastrointestinal Neoplasms; Gastrointesti | 2014 |