mitoxantrone has been researched along with Experimental Leukemia in 20 studies
Mitoxantrone: An anthracenedione-derived antineoplastic agent.
mitoxantrone : A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In addition, ICRF-187 allowed for 50% greater cumulative dosing in normal mice that, nonetheless, showed extensive histological heart damage 7 wk after dosing." | 1.29 | Characterization of experimental mitoxantrone cardiotoxicity and its partial inhibition by ICRF-187 in cultured neonatal rat heart cells. ( Alberts, DS; Dawson, BV; Dorr, RT; Hendrix, M; Shipp, NG, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (75.00) | 18.7374 |
| 1990's | 5 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zee-Cheng, RK | 2 |
| Podrebarac, EG | 1 |
| Menon, CS | 1 |
| Cheng, CC | 2 |
| Murdock, KC | 1 |
| Child, RG | 1 |
| Fabio, PF | 1 |
| Angier, RB | 1 |
| Wallace, RE | 1 |
| Durr, FE | 1 |
| Citarella, RV | 1 |
| Stefanska, B | 1 |
| Dzieduszycka, M | 1 |
| Martelli, S | 1 |
| Borowski, E | 1 |
| Showalter, HD | 1 |
| Johnson, JL | 1 |
| Hoftiezer, JM | 1 |
| Turner, WR | 1 |
| Werbel, LM | 1 |
| Leopold, WR | 1 |
| Shillis, JL | 1 |
| Jackson, RC | 1 |
| Elslager, EF | 1 |
| Schabel, FM | 1 |
| Corbett, TH | 1 |
| Griswold, DP | 1 |
| Laster, WR | 1 |
| Trader, MW | 1 |
| Inaba, M | 1 |
| Nagashima, K | 1 |
| Sakurai, Y | 1 |
| Evenson, DP | 1 |
| Traganos, F | 2 |
| Darzynkiewicz, Z | 2 |
| Staiano-Coico, L | 1 |
| Melamed, MR | 2 |
| Kapuscinski, J | 1 |
| Shipp, NG | 1 |
| Dorr, RT | 1 |
| Alberts, DS | 1 |
| Dawson, BV | 1 |
| Hendrix, M | 1 |
| Abubakar, AA | 1 |
| Riches, AC | 1 |
| Kamath, NS | 2 |
| Chitnis, MP | 2 |
| Denny, WA | 1 |
| Wakelin, LP | 1 |
| Parekh, H | 1 |
| Chitnis, M | 1 |
| Matuszyk, J | 2 |
| Kuśnierczyk, H | 2 |
| Radzikowski, C | 2 |
| Ganapathi, R | 1 |
| Grabowski, D | 1 |
| Schmidt, H | 1 |
| Seshadri, R | 1 |
| Israel, M | 1 |
| Osswald, H | 1 |
| Youssef, M | 1 |
| Islam, SA | 1 |
| Neidle, S | 1 |
| Gandecha, BM | 1 |
| Partridge, M | 1 |
| Patterson, LH | 1 |
| Brown, JR | 1 |
1 review available for mitoxantrone and Experimental Leukemia
| Article | Year |
|---|---|
Therapeutic activity of mitoxantrone and ametantrone against murine tumors.
Topics: Animals; Anthraquinones; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug | 1983 |
19 other studies available for mitoxantrone and Experimental Leukemia
| Article | Year |
|---|---|
Structural modification study of bis(substituted aminoalkylamino)anthraquinones. An evaluation of the relationship of the [2-[(2-hydroxyethyl)amino]ethyl]amino side chain with antineoplastic activity.
Topics: Animals; Anthraquinones; Antineoplastic Agents; Colonic Neoplasms; Leukemia L1210; Leukemia, Experim | 1979 |
Antitumor agents. 1. 1,4-Bis[(aminoalkyl)amino]-9,10-anthracenediones.
Topics: Animals; Anthracenes; Antineoplastic Agents; Leukemia, Experimental; Mice; Neoplasms, Experimental; | 1979 |
Antineoplastic agents. Structure-activity relationship study of bis(substituted aminoalkylamino)anthraquinones.
Topics: Animals; Anthraquinones; Antineoplastic Agents; Leukemia, Experimental; Melanoma; Mice; Neoplasms, E | 1978 |
Synthesis of unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones as potential antileukemic agents.
Topics: Animals; Anthracenes; Antineoplastic Agents; Chemical Phenomena; Chemistry; Leukemia, Experimental; | 1989 |
Anthrapyrazole anticancer agents. Synthesis and structure-activity relationships against murine leukemias.
Topics: Animals; Anthracenes; Antineoplastic Agents; Drug Evaluation, Preclinical; Indicators and Reagents; | 1987 |
Cross-resistance of vincristine-resistant sublines of P388 leukemia to mitoxantrone with special emphasis on the relationship between in vitro and in vivo cross-resistance.
Topics: Animals; Anthraquinones; Antineoplastic Agents; Cell Line; Cells, Cultured; Drug Resistance; Female; | 1984 |
Effects of 9,10-anthracenedione, 1,4-bis[[2-[(2-hydroxyethyl)amino]-ethyl]amino]-, diacetate on cell morphology and nucleic acids of friend leukemia cells.
Topics: Animals; Anthraquinones; Antineoplastic Agents; Cell Cycle; Cell Survival; Cells, Cultured; Chromati | 1980 |
Interactions of a new antitumor agent, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]-ethyl]amino]-9,10-anthracenedione, with nucleic acids.
Topics: Animals; Anthracenes; Antineoplastic Agents; Binding Sites; Cell Nucleus; Cricetinae; Cytoplasm; DNA | 1981 |
Characterization of experimental mitoxantrone cardiotoxicity and its partial inhibition by ICRF-187 in cultured neonatal rat heart cells.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Heart Diseases; | 1993 |
A possible correlation between growth-factor sensitivity and response to mitoxantrone treatment in a murine myeloid leukaemia (SA7HD) cell line.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Cell Count; Cell Division; Culture Media, Conditioned; | 1997 |
In vivo response of mitoxantrone and doxorubicin with dipyrone in parental and doxorubicin-resistant P388 leukemia.
Topics: Aminopyrine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Membrane Permeability; Di | 1990 |
Kinetics of the binding of mitoxantrone, ametantrone and analogues to DNA: relationship with binding mode and anti-tumour activity.
Topics: Animals; Anthraquinones; Antineoplastic Agents; Binding Sites; DNA; Kinetics; Leukemia, Experimental | 1990 |
Evaluation of quinidine effect on the antitumor activity of adriamycin and mitoxantrone in adriamycin-sensitive and -resistant P388 leukemia cells.
Topics: Animals; Antineoplastic Agents; Cell Survival; DNA, Neoplasm; Doxorubicin; Drug Resistance; Female; | 1990 |
Biological evaluation of mitoxantrone dihydrochloride synthesized by a new method. I. Acute toxicity and antitumor activity in mouse transplantable tumor systems.
Topics: Animals; Antineoplastic Agents; Carcinoma; Dose-Response Relationship, Drug; Female; Lethal Dose 50; | 1989 |
Biological evaluation of mitoxantrone dihydrochloride synthesized by a new method. II. Comparison of Now 85/34 and Novantrone (Lederle) acute toxicity and antitumor activity.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Leukemia, Experimental; Male; Mela | 1989 |
Calmodulin inhibitor trifluoperazine selectively enhances cytotoxic effects of strong vs weak DNA binding antitumor drugs in doxorubicin-resistant P388 mouse leukemia cells.
Topics: Aminoacridines; Amsacrine; Animals; Anthraquinones; Antibiotics, Antineoplastic; Antineoplastic Agen | 1985 |
Overadditive synergism between the intercalators mitoxantrone and lucanthone in advanced L 12010 and P 388 leukemia.
Topics: Animals; Anthraquinones; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, | 1986 |
Restoration of doxorubicin responsiveness in doxorubicin-resistant P388 murine leukaemia cells by dipyrone.
Topics: Aminopyrine; Animals; Dipyrone; DNA; Doxorubicin; Drug Resistance; Drug Synergism; Leukemia P388; Le | 1987 |
Comparative computer graphics and solution studies of the DNA interaction of substituted anthraquinones based on doxorubicin and mitoxantrone.
Topics: Animals; Anthraquinones; Cell Line; Chemical Phenomena; Chemistry; Chemistry, Physical; Computers; D | 1985 |