mitoxantrone has been researched along with Carcinoma, Small Cell in 19 studies
Mitoxantrone: An anthracenedione-derived antineoplastic agent.
mitoxantrone : A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.
Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mitoxantrone treated NCI-H69 cells were found to accumulate DNA-protein crosslinks during a 4 hr post-treatment incubation period whereas variant cells maintained depressed levels of crosslinking." | 1.28 | Mitoxantrone-DNA binding and the induction of topoisomerase II associated DNA damage in multi-drug resistant small cell lung cancer cells. ( Fox, ME; Morgan, SA; Smith, PJ; Watson, JV, 1990) |
| "Mitoxantrone is a new effective antineoplastic agent with activity against a wide range of tumors." | 1.28 | Accidental overdose of mitoxantrone in three patients. ( Büchner, T; Essink, M; Hiddemann, W; Huhn, D; Jung, M; Koppensteiner, R; Marosi, L; Martin, T; Minar, E; Siegert, W, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (52.63) | 18.7374 |
| 1990's | 6 (31.58) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, CC | 1 |
| Dong, Q | 1 |
| Liu, DF | 1 |
| Luo, YL | 1 |
| Liu, LF | 1 |
| Chen, AY | 1 |
| Yu, C | 1 |
| Savaraj, N | 1 |
| Chou, TC | 1 |
| Boonstra, R | 1 |
| Timmer-Bosscha, H | 3 |
| van Echten-Arends, J | 1 |
| van der Kolk, DM | 1 |
| van den Berg, A | 1 |
| de Jong, B | 1 |
| Tew, KD | 1 |
| Poppema, S | 1 |
| de Vries, EG | 4 |
| Nakamura, Y | 1 |
| Oka, M | 1 |
| Soda, H | 1 |
| Shiozawa, K | 1 |
| Yoshikawa, M | 1 |
| Itoh, A | 1 |
| Ikegami, Y | 1 |
| Tsurutani, J | 1 |
| Nakatomi, K | 1 |
| Kitazaki, T | 1 |
| Doi, S | 1 |
| Yoshida, H | 1 |
| Kohno, S | 1 |
| Von Hoff, DD | 1 |
| Chen, T | 1 |
| Clark, GM | 1 |
| Callahan, SK | 1 |
| Livingston, R | 1 |
| Valdivieso, M | 1 |
| Umsawasdi, T | 1 |
| Spitzer, G | 1 |
| Chiuten, DF | 1 |
| Booser, DJ | 1 |
| Dhingra, HM | 1 |
| Bodey, GP | 1 |
| van der Graaf, WT | 2 |
| Meersma, GJ | 1 |
| Mesander, G | 1 |
| Vellenga, E | 1 |
| Mulder, NH | 3 |
| De Isabella, P | 1 |
| Capranico, G | 1 |
| Palumbo, M | 1 |
| Sissi, C | 1 |
| Krapcho, AP | 1 |
| Zunino, F | 1 |
| Withoff, S | 1 |
| Keith, WN | 1 |
| Nienhuis, EF | 1 |
| Uges, DR | 1 |
| Hosomi, Y | 1 |
| Shibuya, M | 1 |
| Kober, F | 1 |
| Heiss, A | 1 |
| Keminger, K | 1 |
| Depisch, D | 1 |
| Smith, PJ | 1 |
| Morgan, SA | 1 |
| Fox, ME | 1 |
| Watson, JV | 1 |
| Mirski, SE | 1 |
| Gerlach, JH | 1 |
| Cole, SP | 1 |
| Siegert, W | 1 |
| Hiddemann, W | 1 |
| Koppensteiner, R | 2 |
| Büchner, T | 1 |
| Essink, M | 1 |
| Huhn, D | 1 |
| Jung, M | 1 |
| Marosi, L | 2 |
| Martin, T | 1 |
| Minar, E | 2 |
| Jensen, PB | 1 |
| Vindeløv, L | 1 |
| Roed, H | 1 |
| Demant, EJ | 1 |
| Sehested, M | 1 |
| Skovsgaard, T | 1 |
| Hansen, HH | 1 |
| Malik, ST | 1 |
| Rayner, H | 1 |
| Fletcher, J | 1 |
| Slevin, ML | 1 |
| Ehringer, H | 1 |
| Miyamoto, H | 1 |
| Zijlstra, JG | 1 |
| Meijer, C | 1 |
| Le, TK | 1 |
| Lau, SS | 1 |
| McMahon, JB | 1 |
| McMenamin, MG | 1 |
| Schuller, HM | 1 |
| Boyd, MR | 1 |
1 review available for mitoxantrone and Carcinoma, Small Cell
| Article | Year |
|---|---|
[Combination chemotherapy with VP-16 in the treatment of lung cancer and malignant lymphoma].
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carc | 2001 |
18 other studies available for mitoxantrone and Carcinoma, Small Cell
| Article | Year |
|---|---|
Design of antineoplastic agents on the basis of the "2-phenylnaphthalene-type" structural pattern. 2. Synthesis and biological activity studies of benzo]b]naphtho[2,3-d]furan-6,11-dione derivatives.
Topics: Antineoplastic Agents; Carcinoma, Small Cell; Cisplatin; DNA Topoisomerases, Type II; Furans; Humans | 1993 |
Mitoxantrone resistance in a small cell lung cancer cell line is associated with ABCA2 upregulation.
Topics: Antineoplastic Agents; ATP-Binding Cassette Transporters; Carcinoma, Small Cell; Drug Resistance, Ne | 2004 |
Gefitinib ("Iressa", ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, reverses breast cancer resistance protein/ABCG2-mediated drug resistance.
Topics: Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassett | 2005 |
Mitoxantrone for treatment of patients with refractory small cell carcinoma of the lung: a Southwest Oncology Group Study.
Topics: Adult; Aged; Anthraquinones; Antineoplastic Agents; Carcinoma, Small Cell; Drug Evaluation; Female; | 1983 |
Phase II clinical evaluation of dihydroxyanthracenedione in patients with advanced lung cancer.
Topics: Adenocarcinoma; Adult; Aged; Anthraquinones; Antineoplastic Agents; Carcinoma, Small Cell; Carcinoma | 1984 |
Effects of amiodarone, cyclosporin A, and PSC 833 on the cytotoxicity of mitoxantrone, doxorubicin, and vincristine in non-P-glycoprotein human small cell lung cancer cell lines.
Topics: Amiodarone; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cell; Cyclospo | 1994 |
Sequence selectivity of topoisomerase II DNA cleavage stimulated by mitoxantrone derivatives: relationships to drug DNA binding and cellular effects.
Topics: Animals; Carcinoma, Small Cell; DNA; DNA Damage; DNA Topoisomerases, Type II; DNA, Neoplasm; DNA, Vi | 1993 |
Differential expression of DNA topoisomerase II alpha and -beta in P-gp and MRP-negative VM26, mAMSA and mitoxantrone-resistant sublines of the human SCLC cell line GLC4.
Topics: Amsacrine; Antigens, Neoplasm; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding | 1996 |
[Chemotherapy of highly malignant thyroid tumors].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Carcinoma, Small Cell; Cisplatin; C | 1990 |
Mitoxantrone-DNA binding and the induction of topoisomerase II associated DNA damage in multi-drug resistant small cell lung cancer cells.
Topics: Aclarubicin; Carcinoma, Small Cell; Cell Survival; DNA Damage; DNA Topoisomerases, Type II; DNA, Neo | 1990 |
Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin.
Topics: Animals; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, | 1987 |
Accidental overdose of mitoxantrone in three patients.
Topics: Adult; Aged; Breast Neoplasms; Carcinoma, Small Cell; Cytarabine; Drug Overdose; Drug Tolerance; Fem | 1989 |
In vitro evaluation of the potential of aclarubicin in the treatment of small cell carcinoma of the lung (SCCL).
Topics: Aclarubicin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Proteins; Carcinoma, Sma | 1989 |
Phase II trial of mitoxantrone as first-line chemotherapy for extensive small cell lung cancer.
Topics: Aged; Carcinoma, Small Cell; Drug Evaluation; Humans; Lung Neoplasms; Middle Aged; Mitoxantrone | 1987 |
Survival following an extremely high-dose of mitoxantrone in a 73-year-old female with small cell bronchial carcinoma.
Topics: Aged; Bronchial Neoplasms; Carcinoma, Small Cell; Female; Humans; Mitoxantrone | 1988 |
In vitro chemosensitivity and radiosensitivity of an adriamycin-resistant subline of human small cell lung cancer cells.
Topics: Anthraquinones; Antineoplastic Agents; Carcinoma, Small Cell; Cell Line; Cell Survival; Cisplatin; D | 1986 |
Activity of (7) anthracycline related compounds in an doxorubicin sensitive human small cell lung cancer line and its doxorubicin resistant descendant. Activity of doxorubicin, daunorubicin, 4-deoxyrubicin, 4-demethoxydaunorubicin, detorubicin, 4'-epidoxo
Topics: Antibiotics, Antineoplastic; Carcinoma, Small Cell; Daunorubicin; Doxorubicin; Drug Resistance; Huma | 1987 |
Metabolism of arachidonic acid in human lung cancer cell lines.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Carci | 1987 |