mitotempo and Magnesium-Deficiency

Background Dietary Mg intake is associated with a decreased risk of developing heart failure, whereas low circulating Mg level is associated with increased cardiovascular mortality. We investigated whether Mg deficiency alone could cause cardiomyopathy. Methods and Results C57BL/6J mice were fed with a low Mg (low-Mg, 15-30 mg/kg Mg) or a normal Mg (nl-Mg, 600 mg/kg Mg) diet for 6 weeks. To test reversibility, half of the low-Mg mice were fed then with nl-Mg diet for another 6 weeks. Low-Mg diet significantly decreased mouse serum Mg (0.38±0.03 versus 1.14±0.03 mmol/L for nl-Mg;

Topics: Adenosine Triphosphate; Animals; Antioxidants; Calcium Signaling; Cardiomyopathies; Carrier Proteins; Diastole; Disease Models, Animal; Magnesium Deficiency; Mice, Inbred C57BL; Mitochondria, Heart; Myocardial Contraction; Myocytes, Cardiac; Organophosphorus Compounds; Piperidines; Reactive Oxygen Species; Ventricular Function, Left