mitotempo and Ileitis

Although perturbations in mitochondrial function and structure have been described in the intestinal epithelium of Crohn's disease and ulcerative colitis patients, the role of epithelial mitochondrial stress in the pathophysiology of inflammatory bowel diseases (IBD) is not well elucidated. Prohibitin 1 (PHB1), a major component protein of the inner mitochondrial membrane crucial for optimal respiratory chain assembly and function, is decreased during IBD.. Male and female mice with inducible intestinal epithelial cell deletion of. Our results identify Paneth cells as highly susceptible to mitochondrial dysfunction and central to the pathogenesis of ileitis, with translational implications for the subset of Crohn's disease patients exhibiting Paneth cell defects.

Topics: Animals; Disease Models, Animal; Female; Humans; Ileitis; Male; Mice; Mitochondria; Organophosphorus Compounds; Paneth Cells; Piperidines; Prohibitins; Repressor Proteins