mitotane has been researched along with Testicular Neoplasms in 9 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Testicular Neoplasms: Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The patient described in this report had widely metastatic Leydig cell carcinoma associated with hypertension, hypokalemic alkalosis, and an elevated serum concentration of desoxycorticosterone." | 3.66 | Malignant Leydig cell tumor: objective tumor response to o,p'-DDD. ( Azer, PC; Braunstein, GD, 1981) |
| "Malignant Leydig cell tumors (LCT) are rare." | 2.38 | Treatment of malignant Leydig cell tumor. ( Bertram, KA; Bratloff, B; Davidson, H; Hodges, GF, 1991) |
| "Cushing syndrome was diagnosed on the basis of a markedly elevated 24-hour urine free cortisol level and classic cushingoid features." | 1.35 | A patient with ectopic cortisol production derived from malignant testicular masses. ( Dluhy, RG; Jain, SH; Nosé, V; Sadow, PM, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Bachelot, A | 1 |
| Lapoirie, M | 1 |
| Dulon, J | 1 |
| Leban, M | 1 |
| Renard Penna, R | 1 |
| Touraine, P | 1 |
| Chortis, V | 1 |
| Johal, NJ | 1 |
| Bancos, I | 1 |
| Evans, M | 1 |
| Skordilis, K | 1 |
| Guest, P | 1 |
| Cullen, MH | 1 |
| Porfiri, E | 1 |
| Arlt, W | 1 |
| Bry-Gauillard, H | 1 |
| Cartes, A | 1 |
| Young, J | 1 |
| Jain, SH | 1 |
| Sadow, PM | 1 |
| Nosé, V | 1 |
| Dluhy, RG | 1 |
| Knyrim, K | 1 |
| Higi, M | 1 |
| Hossfeld, DK | 1 |
| Seeber, S | 1 |
| Schmidt, CG | 1 |
| Azer, PC | 1 |
| Braunstein, GD | 1 |
| van der Hem, KG | 1 |
| Boven, E | 1 |
| van Hennik, MB | 1 |
| Pinedo, HM | 1 |
| Bertram, KA | 1 |
| Bratloff, B | 1 |
| Hodges, GF | 1 |
| Davidson, H | 1 |
| Freeman, DA | 1 |
2 reviews available for mitotane and Testicular Neoplasms
| Article | Year |
|---|---|
Treatment of malignant Leydig cell tumor.
Topics: Doxorubicin; Humans; Leydig Cell Tumor; Male; Middle Aged; Mitotane; Retroperitoneal Neoplasms; Test | 1991 |
Steroid hormone-producing tumors in man.
Topics: 17-Ketosteroids; Adenoma; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Adult; Androgens; C | 1986 |
7 other studies available for mitotane and Testicular Neoplasms
| Article | Year |
|---|---|
Effects of mitotane on testicular adrenal rest tumors in congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a retrospective series of five patients.
Topics: Adrenal Hyperplasia, Congenital; Adrenal Rest Tumor; Adult; Antineoplastic Agents, Hormonal; Humans; | 2021 |
Mitotane treatment in patients with metastatic testicular Leydig cell tumor associated with severe androgen excess.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgens; Antineoplastic Agents, Hormonal; Gas Chromatograph | 2018 |
Mitotane for 21-hydroxylase deficiency in an infertile man.
Topics: Adrenal Hyperplasia, Congenital; Adrenal Rest Tumor; Adult; Antineoplastic Agents, Hormonal; Azoospe | 2014 |
A patient with ectopic cortisol production derived from malignant testicular masses.
Topics: Adrenal Rest Tumor; Adrenocortical Carcinoma; Adrenocorticotropic Hormone; Aged; Cushing Syndrome; H | 2008 |
Autonomous cortisol secretion by a metastatic Leydig cell carcinoma associated with Klinefelter's syndrome.
Topics: Adult; Aldosterone; Angiotensin II; Dexamethasone; Humans; Hydrocortisone; Klinefelter Syndrome; Ley | 1981 |
Malignant Leydig cell tumor: objective tumor response to o,p'-DDD.
Topics: Desoxycorticosterone; Humans; Hypertension; Hypokalemia; Leydig Cell Tumor; Lung Neoplasms; Male; Mi | 1981 |
Malignant Leydig cell tumor of the testis in complete remission on o,p'-dichlorodiphenyl-dichloroethane.
Topics: Humans; Leydig Cell Tumor; Male; Middle Aged; Mitotane; Remission Induction; Testicular Neoplasms | 1992 |