Page last updated: 2024-10-31

mitotane and Testicular Neoplasms

mitotane has been researched along with Testicular Neoplasms in 9 studies

Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.

Testicular Neoplasms: Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.

Research Excerpts

ExcerptRelevanceReference
" The patient described in this report had widely metastatic Leydig cell carcinoma associated with hypertension, hypokalemic alkalosis, and an elevated serum concentration of desoxycorticosterone."3.66Malignant Leydig cell tumor: objective tumor response to o,p'-DDD. ( Azer, PC; Braunstein, GD, 1981)
"Malignant Leydig cell tumors (LCT) are rare."2.38Treatment of malignant Leydig cell tumor. ( Bertram, KA; Bratloff, B; Davidson, H; Hodges, GF, 1991)
"Cushing syndrome was diagnosed on the basis of a markedly elevated 24-hour urine free cortisol level and classic cushingoid features."1.35A patient with ectopic cortisol production derived from malignant testicular masses. ( Dluhy, RG; Jain, SH; Nosé, V; Sadow, PM, 2008)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19903 (33.33)18.7374
1990's2 (22.22)18.2507
2000's1 (11.11)29.6817
2010's2 (22.22)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Bachelot, A1
Lapoirie, M1
Dulon, J1
Leban, M1
Renard Penna, R1
Touraine, P1
Chortis, V1
Johal, NJ1
Bancos, I1
Evans, M1
Skordilis, K1
Guest, P1
Cullen, MH1
Porfiri, E1
Arlt, W1
Bry-Gauillard, H1
Cartes, A1
Young, J1
Jain, SH1
Sadow, PM1
Nosé, V1
Dluhy, RG1
Knyrim, K1
Higi, M1
Hossfeld, DK1
Seeber, S1
Schmidt, CG1
Azer, PC1
Braunstein, GD1
van der Hem, KG1
Boven, E1
van Hennik, MB1
Pinedo, HM1
Bertram, KA1
Bratloff, B1
Hodges, GF1
Davidson, H1
Freeman, DA1

Reviews

2 reviews available for mitotane and Testicular Neoplasms

ArticleYear
Treatment of malignant Leydig cell tumor.
    Cancer, 1991, Nov-15, Volume: 68, Issue:10

    Topics: Doxorubicin; Humans; Leydig Cell Tumor; Male; Middle Aged; Mitotane; Retroperitoneal Neoplasms; Test

1991
Steroid hormone-producing tumors in man.
    Endocrine reviews, 1986, Volume: 7, Issue:2

    Topics: 17-Ketosteroids; Adenoma; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Adult; Androgens; C

1986

Other Studies

7 other studies available for mitotane and Testicular Neoplasms

ArticleYear
Effects of mitotane on testicular adrenal rest tumors in congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a retrospective series of five patients.
    European journal of endocrinology, 2021, Volume: 184, Issue:3

    Topics: Adrenal Hyperplasia, Congenital; Adrenal Rest Tumor; Adult; Antineoplastic Agents, Hormonal; Humans;

2021
Mitotane treatment in patients with metastatic testicular Leydig cell tumor associated with severe androgen excess.
    European journal of endocrinology, 2018, Volume: 178, Issue:3

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgens; Antineoplastic Agents, Hormonal; Gas Chromatograph

2018
Mitotane for 21-hydroxylase deficiency in an infertile man.
    The New England journal of medicine, 2014, Nov-20, Volume: 371, Issue:21

    Topics: Adrenal Hyperplasia, Congenital; Adrenal Rest Tumor; Adult; Antineoplastic Agents, Hormonal; Azoospe

2014
A patient with ectopic cortisol production derived from malignant testicular masses.
    Nature clinical practice. Endocrinology & metabolism, 2008, Volume: 4, Issue:12

    Topics: Adrenal Rest Tumor; Adrenocortical Carcinoma; Adrenocorticotropic Hormone; Aged; Cushing Syndrome; H

2008
Autonomous cortisol secretion by a metastatic Leydig cell carcinoma associated with Klinefelter's syndrome.
    Journal of cancer research and clinical oncology, 1981, Volume: 100, Issue:1

    Topics: Adult; Aldosterone; Angiotensin II; Dexamethasone; Humans; Hydrocortisone; Klinefelter Syndrome; Ley

1981
Malignant Leydig cell tumor: objective tumor response to o,p'-DDD.
    Cancer, 1981, Mar-15, Volume: 47, Issue:6

    Topics: Desoxycorticosterone; Humans; Hypertension; Hypokalemia; Leydig Cell Tumor; Lung Neoplasms; Male; Mi

1981
Malignant Leydig cell tumor of the testis in complete remission on o,p'-dichlorodiphenyl-dichloroethane.
    The Journal of urology, 1992, Volume: 148, Issue:4

    Topics: Humans; Leydig Cell Tumor; Male; Middle Aged; Mitotane; Remission Induction; Testicular Neoplasms

1992