Page last updated: 2024-10-31

mitotane and Pregnancy

mitotane has been researched along with Pregnancy in 14 studies

Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
" A 33-year-old woman who underwent surgery for adrenocortical carcinoma and treated with mitotane was referred for infertility."8.12Live birth after in-vitro maturation of oocytes in a patient with specific ovarian insufficiency caused by long-term mitotane treatment for adrenocortical carcinoma. ( Belin, F; Bry-Gauillard, H; Grynberg, M; Massin, N; Renoult-Pierre, P; Sifer, C; Vinolas, C; Young, J, 2022)
"We present the case of a female patient with virilising adrenocortical carcinoma treated surgically who conceived during adjuvant treatment with mitotane."7.77Pregnancy in a patient with adrenocortical carcinoma during treatment with Mitotane - a case report. ( Baszko-Błaszyk, D; Ochmańska, K; Sowiński, J; Waśko, R, 2011)
"Mitotane was stopped at gestation week 6."6.49Pregnancy in a patient with adrenal carcinoma treated with mitotane: a case report and review of literature. ( Blumenfeld, Z; Bronshtein, M; Jaffe, A; Salmon, A; Tripto-Shkolnik, L, 2013)
"The pregnancy was complicated by fetal exposure to mitotane and dexamethasone."5.37Normal adrenal function in an infant following a pregnancy complicated by maternal adrenal cortical carcinoma and mitotane exposure. ( Burym, C; Cronin, CM; Kojori, F; Salamon, E; Sellers, EA, 2011)
"Mitotane proved to be an efficacious drug which in exceptional cases can be used without significant side effects in low dosage for the long-term treatment of hypothalamic-pituitary Cushing disease."5.30[The long-term therapy of hypothalamic-hypophyseal Cushing's syndrome with mitotane (o,p'-DDD)]. ( Gerl, H; Knappe, G; Rohde, W; Ventz, M, 1997)
" A 33-year-old woman who underwent surgery for adrenocortical carcinoma and treated with mitotane was referred for infertility."4.12Live birth after in-vitro maturation of oocytes in a patient with specific ovarian insufficiency caused by long-term mitotane treatment for adrenocortical carcinoma. ( Belin, F; Bry-Gauillard, H; Grynberg, M; Massin, N; Renoult-Pierre, P; Sifer, C; Vinolas, C; Young, J, 2022)
"We present the case of a female patient with virilising adrenocortical carcinoma treated surgically who conceived during adjuvant treatment with mitotane."3.77Pregnancy in a patient with adrenocortical carcinoma during treatment with Mitotane - a case report. ( Baszko-Błaszyk, D; Ochmańska, K; Sowiński, J; Waśko, R, 2011)
"Although adrenocortical carcinoma (ACC) during pregnancy is rare, a retrospective review of a case series at our hospital revealed that almost one third of our patients were women in childbearing age."3.01Pregnancy in patients with adrenocortical carcinoma: a case-based discussion. ( Basile, V; Puglisi, S; Sperone, P; Terzolo, M, 2023)
"Mitotane was stopped at gestation week 6."2.49Pregnancy in a patient with adrenal carcinoma treated with mitotane: a case report and review of literature. ( Blumenfeld, Z; Bronshtein, M; Jaffe, A; Salmon, A; Tripto-Shkolnik, L, 2013)
"Virilizing adrenal carcinoma is a rare disease, especially in women of reproductive age."2.39Virilizing adrenal carcinoma in a woman of reproductive age: a case presentation and literature review. ( Coonrod, DV; Rizkallah, TH, 1995)
"The pregnancy was complicated by fetal exposure to mitotane and dexamethasone."1.37Normal adrenal function in an infant following a pregnancy complicated by maternal adrenal cortical carcinoma and mitotane exposure. ( Burym, C; Cronin, CM; Kojori, F; Salamon, E; Sellers, EA, 2011)
"Mitotane proved to be an efficacious drug which in exceptional cases can be used without significant side effects in low dosage for the long-term treatment of hypothalamic-pituitary Cushing disease."1.30[The long-term therapy of hypothalamic-hypophyseal Cushing's syndrome with mitotane (o,p'-DDD)]. ( Gerl, H; Knappe, G; Rohde, W; Ventz, M, 1997)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19904 (28.57)18.7374
1990's2 (14.29)18.2507
2000's1 (7.14)29.6817
2010's4 (28.57)24.3611
2020's3 (21.43)2.80

Authors

AuthorsStudies
Bry-Gauillard, H1
Belin, F1
Vinolas, C1
Renoult-Pierre, P1
Massin, N1
Young, J2
Sifer, C1
Grynberg, M1
Puglisi, S3
Basile, V3
Sperone, P3
Terzolo, M3
Salle, L1
Mas, R1
Teissier-Clément, MP1
Magkou, D1
Do Cao, C1
Bouvattier, C1
Douillard, C1
de Marcellus, C1
Cazabat, L1
Gérard, M1
Raffin-Sanson, ML1
Baszko-Błaszyk, D1
Ochmańska, K1
Waśko, R1
Sowiński, J1
Kojori, F1
Cronin, CM1
Salamon, E1
Burym, C1
Sellers, EA1
Tripto-Shkolnik, L1
Blumenfeld, Z1
Bronshtein, M1
Salmon, A1
Jaffe, A1
Wassermann, M1
Bercovici, B1
Cucos, S1
Wassermann, D1
Ron, M1
Coonrod, DV1
Rizkallah, TH1
Knappe, G1
Gerl, H1
Ventz, M1
Rohde, W1
Foster, W1
Chan, S1
Platt, L1
Hughes, C1
Leiba, S1
Weinstein, R1
Shindel, B1
Lapidot, M1
Stern, E1
Levavi, H1
Rusecki, Y1
Abramovici, A1
Freeman, DA1
Yamada, S1

Reviews

4 reviews available for mitotane and Pregnancy

ArticleYear
Pregnancy in patients with adrenocortical carcinoma: a case-based discussion.
    Reviews in endocrine & metabolic disorders, 2023, Volume: 24, Issue:1

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Female; Humans; Male; Mitotane; Pregnancy; Retro

2023
Pregnancy in patients with adrenocortical carcinoma: a case-based discussion.
    Reviews in endocrine & metabolic disorders, 2023, Volume: 24, Issue:1

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Female; Humans; Male; Mitotane; Pregnancy; Retro

2023
Pregnancy in patients with adrenocortical carcinoma: a case-based discussion.
    Reviews in endocrine & metabolic disorders, 2023, Volume: 24, Issue:1

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Female; Humans; Male; Mitotane; Pregnancy; Retro

2023
Pregnancy in patients with adrenocortical carcinoma: a case-based discussion.
    Reviews in endocrine & metabolic disorders, 2023, Volume: 24, Issue:1

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Female; Humans; Male; Mitotane; Pregnancy; Retro

2023
Pregnancy in patients with adrenocortical carcinoma: a case-based discussion.
    Reviews in endocrine & metabolic disorders, 2023, Volume: 24, Issue:1

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Female; Humans; Male; Mitotane; Pregnancy; Retro

2023
Pregnancy in patients with adrenocortical carcinoma: a case-based discussion.
    Reviews in endocrine & metabolic disorders, 2023, Volume: 24, Issue:1

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Female; Humans; Male; Mitotane; Pregnancy; Retro

2023
Pregnancy in patients with adrenocortical carcinoma: a case-based discussion.
    Reviews in endocrine & metabolic disorders, 2023, Volume: 24, Issue:1

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Female; Humans; Male; Mitotane; Pregnancy; Retro

2023
Pregnancy in patients with adrenocortical carcinoma: a case-based discussion.
    Reviews in endocrine & metabolic disorders, 2023, Volume: 24, Issue:1

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Female; Humans; Male; Mitotane; Pregnancy; Retro

2023
Pregnancy in patients with adrenocortical carcinoma: a case-based discussion.
    Reviews in endocrine & metabolic disorders, 2023, Volume: 24, Issue:1

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Female; Humans; Male; Mitotane; Pregnancy; Retro

2023
Pregnancy in a patient with adrenal carcinoma treated with mitotane: a case report and review of literature.
    The Journal of clinical endocrinology and metabolism, 2013, Volume: 98, Issue:2

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Antineoplastic Agents, Hormonal; Fatal Ou

2013
Virilizing adrenal carcinoma in a woman of reproductive age: a case presentation and literature review.
    American journal of obstetrics and gynecology, 1995, Volume: 172, Issue:6

    Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Carcinoma; Female; Hirsutism; Humans; Infertility, F

1995
Steroid hormone-producing tumors in man.
    Endocrine reviews, 1986, Volume: 7, Issue:2

    Topics: 17-Ketosteroids; Adenoma; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Adult; Androgens; C

1986

Other Studies

10 other studies available for mitotane and Pregnancy

ArticleYear
Live birth after in-vitro maturation of oocytes in a patient with specific ovarian insufficiency caused by long-term mitotane treatment for adrenocortical carcinoma.
    Reproductive biomedicine online, 2022, Volume: 44, Issue:2

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Female; Humans; In Vitro Oocyte Maturation Techn

2022
Ectopic adrenocortical carcinoma of the ovary: An unexpected outcome.
    Annales d'endocrinologie, 2020, Volume: 81, Issue:5

    Topics: ACTH Syndrome, Ectopic; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Antineoplastic Ag

2020
Foetal exposure to mitotane/Op'DDD: Post-natal study of four children.
    Clinical endocrinology, 2018, Volume: 89, Issue:6

    Topics: Adult; Child, Preschool; Dichlorodiphenyldichloroethane; Female; Fetus; Humans; Infant; Infant, Newb

2018
Pregnancy in a patient with adrenocortical carcinoma during treatment with Mitotane - a case report.
    Endokrynologia Polska, 2011, Volume: 62, Issue:2

    Topics: Abortion, Induced; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Antineoplastic Agents,

2011
Normal adrenal function in an infant following a pregnancy complicated by maternal adrenal cortical carcinoma and mitotane exposure.
    Journal of pediatric endocrinology & metabolism : JPEM, 2011, Volume: 24, Issue:3-4

    Topics: Adrenal Cortex Neoplasms; Adrenal Glands; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal;

2011
Storage of some organochlorine compounds in toxemia of pregnancy.
    Environmental research, 1980, Volume: 22, Issue:2

    Topics: Adult; Chromatography; Chromatography, Gas; DDT; Dichlorodiphenyl Dichloroethylene; Female; Humans;

1980
[The long-term therapy of hypothalamic-hypophyseal Cushing's syndrome with mitotane (o,p'-DDD)].
    Deutsche medizinische Wochenschrift (1946), 1997, Jul-11, Volume: 122, Issue:28-29

    Topics: Adult; Chronic Disease; Combined Modality Therapy; Cushing Syndrome; Drug Evaluation; Female; Humans

1997
Detection of endocrine disrupting chemicals in samples of second trimester human amniotic fluid.
    The Journal of clinical endocrinology and metabolism, 2000, Volume: 85, Issue:8

    Topics: Adult; Amniotic Fluid; Dichlorodiphenyl Dichloroethylene; Female; Gas Chromatography-Mass Spectromet

2000
The protracted effect of o,p'-DDD in Cushing's disease and its impact on adrenal morphogenesis of young human embryo.
    Annales d'endocrinologie, 1989, Volume: 50, Issue:1

    Topics: Abortion, Therapeutic; Adrenal Glands; Adult; Cushing Syndrome; Female; Fetus; Humans; Middle Aged;

1989
[Urinary 6beta-hydroxycortisol. II. Urinary 6beta-hydroxycortisol in different diseases and after administration of drugs].
    Nihon Naibunpi Gakkai zasshi, 1973, Jun-20, Volume: 49, Issue:6

    Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Carcinoma; Cushing Syndrome; F

1973