mitotane has been researched along with Porphyria, Acute Intermittent in 1 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Porphyria, Acute Intermittent: An autosomal dominant porphyria that is due to a deficiency of HYDROXYMETHYLBILANE SYNTHASE in the LIVER, the third enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features are recurrent and life-threatening neurologic disturbances, ABDOMINAL PAIN, and elevated level of AMINOLEVULINIC ACID and PORPHOBILINOGEN in the urine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mitotane therapy was discontinued but the attack of porphyria persisted for more than four months and included episodes with severe metabolic and neurologic toxicities." | 1.37 | [Mitotane as possible cause of acute intermittent porphyria]. ( von Eyben, FE, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| von Eyben, FE | 1 |
1 other study available for mitotane and Porphyria, Acute Intermittent
| Article | Year |
|---|---|
[Mitotane as possible cause of acute intermittent porphyria].
Topics: Adrenal Cortex Neoplasms; Antineoplastic Agents, Hormonal; Female; Humans; Middle Aged; Mitotane; Po | 2011 |