mitotane has been researched along with Pituitary Neoplasms in 18 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypercortisolism induced by Cushing disease causes high morbidity and mortality." | 2.48 | New prospects for drug treatment in Cushing disease. ( Barahona Constanzo, MJ; del Pozo Picó, C, 2012) |
| "Multiple endocrine neoplasia type 1 was diagnosed in a 12-year-old male crossbred dog." | 1.31 | Multiple endocrine neoplasia type 1 in a crossbred dog. ( Alley, MR; Burbidge, HM; Guildford, WG; Jones, BR; Walker, MC, 2000) |
| "However, in adrenal cancer, urinary 17OHCS did not correlate with either plasma cortisol or urinary free cortisol, while the latter two parameters did." | 1.27 | Effect of o,p'-DDD on cortisol metabolism in Cushing's syndrome of various etiology. ( Inoue, S; Kawai, K; Koide, Y; Murayama, H; Yamashita, K, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (44.44) | 18.7374 |
| 1990's | 6 (33.33) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Murao, K | 1 |
| Imachi, H | 1 |
| Ishida, T | 1 |
| Hosomi, N | 1 |
| Masugata, H | 1 |
| Barahona Constanzo, MJ | 1 |
| del Pozo Picó, C | 1 |
| Aron, DC | 1 |
| Findling, JW | 1 |
| Fitzgerald, PA | 1 |
| Forsham, PH | 1 |
| Wilson, CB | 1 |
| Tyrrell, JB | 1 |
| Simonin, R | 1 |
| Heim, M | 1 |
| Grisoli, F | 1 |
| Brindisi, G | 1 |
| Nichols, R | 1 |
| Bertoy, EH | 1 |
| Feldman, EC | 3 |
| Nelson, RW | 2 |
| Dublin, AB | 1 |
| Reid, MH | 1 |
| Feldman, MS | 1 |
| Ihle, SL | 2 |
| Mathivon, L | 1 |
| Carel, JC | 1 |
| Coutant, R | 1 |
| Derome, P | 1 |
| Adamsbaum, C | 1 |
| Bougnères, P | 1 |
| Chaussain, JL | 1 |
| Théon, AP | 1 |
| Behrend, EN | 1 |
| Kemppainen, RJ | 1 |
| Clark, TP | 1 |
| Salman, MD | 1 |
| Peterson, ME | 1 |
| Walker, MC | 1 |
| Jones, BR | 1 |
| Guildford, WG | 1 |
| Burbidge, HM | 1 |
| Alley, MR | 1 |
| Magiakou, MA | 1 |
| Chrousos, GP | 1 |
| Cooper, PR | 1 |
| Shucart, WA | 1 |
| Kelly, DF | 1 |
| Darke, PG | 1 |
| Kuhn, JM | 1 |
| Proeschel, MF | 1 |
| Seurin, DJ | 1 |
| Bertagna, XY | 1 |
| Luton, JP | 1 |
| Girard, FL | 1 |
| Koide, Y | 1 |
| Inoue, S | 1 |
| Murayama, H | 1 |
| Kawai, K | 1 |
| Yamashita, K | 1 |
| Chandler, WF | 1 |
| Schteingart, DE | 1 |
6 reviews available for mitotane and Pituitary Neoplasms
| Article | Year |
|---|---|
New prospects for drug treatment in Cushing disease.
Topics: Adenoma; Adrenocorticotropic Hormone; Animals; Cabergoline; Clinical Trials as Topic; Clinical Trial | 2012 |
Cushing's syndrome: problems in management.
Topics: ACTH Syndrome, Ectopic; Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone | 1982 |
Concurrent illness and complications associated with canine hyperadrenocorticism.
Topics: Acute Disease; Animals; Cushing Syndrome; Diabetes Complications; Diabetes Mellitus; Dog Diseases; D | 1994 |
Pituitary corticotroph macrotumors. Diagnosis and treatment.
Topics: Adenoma; Animals; Bromocriptine; Dog Diseases; Dogs; Dopamine Agonists; Mitotane; Monoamine Oxidase | 1997 |
Cushing's syndrome in children and adolescents: current diagnostic and therapeutic strategies.
Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Antineopla | 2002 |
Cushing's syndrome in the dog.
Topics: 17-Hydroxycorticosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Animals; Calcinosis; Cu | 1976 |
1 trial available for mitotane and Pituitary Neoplasms
| Article | Year |
|---|---|
Megavoltage irradiation of pituitary macrotumors in dogs with neurologic signs.
Topics: Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Animals; Antineoplastic Agents, Hormonal; | 1998 |
11 other studies available for mitotane and Pituitary Neoplasms
| Article | Year |
|---|---|
Successful therapy of Cushing's disease caused by an extrapituitary parasellar adenoma.
Topics: Adenoma; Aged; Female; Humans; Magnetic Resonance Imaging; Mitotane; Pituitary ACTH Hypersecretion; | 2010 |
[Disclosure of a pituitary microadenoma during treatment of Cushing's disease].
Topics: Adenoma; Adult; Cushing Syndrome; Female; Humans; Mitotane; Pituitary Neoplasms | 1981 |
One-year follow-up evaluation of magnetic resonance imaging of the brain in dogs with pituitary-dependent hyperadrenocorticism.
Topics: Adrenocortical Hyperfunction; Animals; Antineoplastic Agents, Hormonal; Dog Diseases; Dogs; Female; | 1996 |
[Cushing disease in children and in adolescents. Therapeutic results].
Topics: Adenoma, Basophil; Adolescent; Antineoplastic Agents, Hormonal; Child; Cushing Syndrome; Female; Hum | 1997 |
Treatment of hyperadrenocorticism in dogs: a survey of internists and dermatologists.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; | 1999 |
Multiple endocrine neoplasia type 1 in a crossbred dog.
Topics: Adenoma; Animals; Antineoplastic Agents, Hormonal; Diagnosis, Differential; Dog Diseases; Dogs; Male | 2000 |
Treatment of Cushing's disease with o,p'-DDD.
Topics: Adenoma; Aged; Cushing Syndrome; Humans; Mitotane; Pituitary Neoplasms | 1979 |
Comparative assessment of ACTH and lipotropin plasma levels in the diagnosis and follow-up of patients with Cushing's syndrome: a study of 210 cases.
Topics: ACTH Syndrome, Ectopic; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotr | 1989 |
Pituitary macroadenomas and macroadenocarcinomas in dogs treated with mitotane for pituitary-dependent hyperadrenocorticism: 13 cases (1981-1986).
Topics: Adenocarcinoma; Adenoma; Adrenocortical Hyperfunction; Animals; Dog Diseases; Dogs; Mitotane; Pituit | 1989 |
Effect of o,p'-DDD on cortisol metabolism in Cushing's syndrome of various etiology.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Ho | 1985 |
Controversies in the management of Cushing's disease.
Topics: Adrenocorticotropic Hormone; Combined Modality Therapy; Cushing Syndrome; Diagnosis, Differential; H | 1986 |