mitotane has been researched along with Nervous System Disorders in 3 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Low-dose mitotane has been widely used for many decades in patients with advanced adrenocortical carcinoma (ACC), which exhibited good safety profiles compared with the high-dose regimen." | 3.96 | A case report of neurological adverse events caused by short-term and low-dose treatment of mitotane: The role of therapeutic drug monitoring. ( Deng, JH; Fu, Q; Liu, X; Mei, D; Tang, Y; Zhang, B, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, X | 1 |
| Fu, Q | 1 |
| Tang, Y | 1 |
| Deng, JH | 1 |
| Mei, D | 1 |
| Zhang, B | 1 |
| Théon, AP | 1 |
| Feldman, EC | 1 |
| du Rostu, H | 1 |
| Krempf, M | 1 |
| Mussini, JM | 1 |
| Murat, A | 1 |
| Guillon, J | 1 |
| Charbonnel, B | 1 |
1 trial available for mitotane and Nervous System Disorders
| Article | Year |
|---|---|
Megavoltage irradiation of pituitary macrotumors in dogs with neurologic signs.
Topics: Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Animals; Antineoplastic Agents, Hormonal; | 1998 |
2 other studies available for mitotane and Nervous System Disorders
| Article | Year |
|---|---|
A case report of neurological adverse events caused by short-term and low-dose treatment of mitotane: The role of therapeutic drug monitoring.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; Asian People; D | 2020 |
[Neurotoxicity of mitotane therapy of adrenocortical carcinoma (5 cases) and Cushing's syndrome (7 cases)].
Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Cushing Syndrome; Female; Humans; Male; Middle Aged; Mi | 1987 |