mitotane has been researched along with Neoplasm Metastasis in 48 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mitotane has been used for more than 5 decades as therapy for adrenocortical carcinoma (ACC)." | 7.83 | Rapid and Complete Remission of Metastatic Adrenocortical Carcinoma Persisting 10 Years After Treatment With Mitotane Monotherapy: Case Report and Review of the Literature. ( Bourdeau, I; Cohade, C; El Ghorayeb, N; Lacroix, A; Latour, M; Mazzuco, TL; Olney, H; Perrotte, P; Rondeau, G; Sabourin, A, 2016) |
| "Two patients with metastatic adrenal cortical carcinoma were treated with cisplatin and etoposide." | 7.67 | Treatment of metastatic adrenal cortical carcinoma with cisplatin and etoposide (VP-16). ( Greco, FA; Johnson, DH, 1986) |
| "Treatment with mitotane was started shortly after surgical removal of the tumor (three patients) or the tumor and multiple lung metastasis (one patient)." | 5.30 | Is there a role for low doses of mitotane (o,p'-DDD) as adjuvant therapy in adrenocortical carcinoma? ( Arad, E; Best, LA; Dickstein, G; Nativ, O; Shechner, C, 1998) |
| "Mitotane has been used for 50 years as the first-line drug in the treatment of disseminated adrenocortical carcinoma." | 4.86 | [Mitotane in the treatment of adrenal carcinoma]. ( Sane, T, 2010) |
| "Mitotane has been used for more than 5 decades as therapy for adrenocortical carcinoma (ACC)." | 3.83 | Rapid and Complete Remission of Metastatic Adrenocortical Carcinoma Persisting 10 Years After Treatment With Mitotane Monotherapy: Case Report and Review of the Literature. ( Bourdeau, I; Cohade, C; El Ghorayeb, N; Lacroix, A; Latour, M; Mazzuco, TL; Olney, H; Perrotte, P; Rondeau, G; Sabourin, A, 2016) |
| "Two patients with metastatic adrenal cortical carcinoma were treated with cisplatin and etoposide." | 3.67 | Treatment of metastatic adrenal cortical carcinoma with cisplatin and etoposide (VP-16). ( Greco, FA; Johnson, DH, 1986) |
| "In 1966, we published the case report of a patient with adrenal carcinoma and wide spread metatasis who, after treatment with mitotane (o,p-DDD) and fluorouracil, developed Addison disease accompanied by a clinical remission." | 3.65 | Metastatic adrenal cortical carcinoma. Documented cure with combined chemotherapy. ( Ostuni, JA; Roginsky, MS, 1975) |
| "Mitotane was increased to 2." | 1.31 | Long-term (15 years) outcome in an infant with metastatic adrenocortical carcinoma. ( De León, DD; Lange, BJ; Moshang, T; Walterhouse, D, 2002) |
| "Treatment with mitotane was started shortly after surgical removal of the tumor (three patients) or the tumor and multiple lung metastasis (one patient)." | 1.30 | Is there a role for low doses of mitotane (o,p'-DDD) as adjuvant therapy in adrenocortical carcinoma? ( Arad, E; Best, LA; Dickstein, G; Nativ, O; Shechner, C, 1998) |
| "Mitotane therapy was ineffective at controlling tumor growth." | 1.28 | Recurrent or metastatic disease in select patients with adrenocortical carcinoma. Aggressive resection vs chemotherapy. ( Jensen, JC; Norton, JA; Pass, HI; Sindelar, WF, 1991) |
| "Age over 40 years and the presence of metastases at the time of diagnosis were the only factors recognized as indicating a poor prognosis." | 1.28 | Clinical features of adrenocortical carcinoma, prognostic factors, and the effect of mitotane therapy. ( Bertagna, X; Billaud, L; Blondeau, P; Cerdas, S; Chapuis, Y; Guilhaume, B; Laudat, MH; Louvel, A; Luton, JP; Thomas, G, 1990) |
| "Twenty-eight patients presented with metastases at entry, and spillage of tumour cells occurred at surgery in 6 other patients." | 1.27 | The treatment of adrenocortical carcinoma with o,p'-DDD: prognostic implications of serum level monitoring. ( Moolenaar, AJ; Smeenk, D; van Seters, AP; van Slooten, H, 1984) |
| "There months following surgery, liver metastases were documented associated with elevated levels of serum androgens." | 1.26 | Virilizing adrenal tumor in a child suppressed with dexamethasone for three years. Effect of o,p'-DDD on serum and urinary androgens. ( Korth-Schutz, S; Levine, LS; New, MI; Roth, JA; Saenger, P, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (47.92) | 18.7374 |
| 1990's | 9 (18.75) | 18.2507 |
| 2000's | 7 (14.58) | 29.6817 |
| 2010's | 9 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Taza, F | 1 |
| Chovanec, M | 1 |
| Hahn, N | 1 |
| Albany, C | 1 |
| Vezzosi, D | 1 |
| Do Cao, C | 1 |
| Hescot, S | 1 |
| Bertherat, J | 1 |
| Haissaguerre, M | 1 |
| Bongard, V | 1 |
| Drui, D | 1 |
| De La Fouchardière, C | 1 |
| Illouz, F | 1 |
| Borson-Chazot, F | 1 |
| Djobo, B | 1 |
| Berdelou, A | 1 |
| Tabarin, A | 1 |
| Schlumberger, M | 2 |
| Briet, C | 1 |
| Caron, P | 1 |
| Leboulleux, S | 1 |
| Libe, R | 1 |
| Baudin, E | 3 |
| Chortis, V | 1 |
| Johal, NJ | 1 |
| Bancos, I | 1 |
| Evans, M | 1 |
| Skordilis, K | 1 |
| Guest, P | 1 |
| Cullen, MH | 1 |
| Porfiri, E | 1 |
| Arlt, W | 1 |
| Fassnacht, M | 1 |
| Dekkers, OM | 1 |
| Else, T | 1 |
| Berruti, A | 1 |
| de Krijger, R | 1 |
| Haak, HR | 2 |
| Mihai, R | 1 |
| Assie, G | 1 |
| Terzolo, M | 1 |
| Freire, DS | 1 |
| Siqueira, SA | 1 |
| Zerbini, MC | 1 |
| Wajchenberg, BL | 1 |
| Corrêa-Giannella, ML | 1 |
| Lucon, AM | 1 |
| Pereira, MA | 1 |
| Kerkhofs, TM | 1 |
| Ettaieb, MH | 1 |
| Hermsen, IG | 1 |
| Guelho, D | 1 |
| Paiva, I | 1 |
| Vieira, A | 1 |
| Carrilho, F | 1 |
| El Ghorayeb, N | 1 |
| Rondeau, G | 1 |
| Latour, M | 1 |
| Cohade, C | 1 |
| Olney, H | 1 |
| Lacroix, A | 1 |
| Perrotte, P | 1 |
| Sabourin, A | 1 |
| Mazzuco, TL | 1 |
| Bourdeau, I | 1 |
| Huang, H | 1 |
| Fojo, T | 2 |
| Strosberg, JR | 1 |
| Hammer, GD | 1 |
| Doherty, GM | 1 |
| Sane, T | 1 |
| De León, DD | 1 |
| Lange, BJ | 1 |
| Walterhouse, D | 1 |
| Moshang, T | 1 |
| MONTGOMERY, DA | 1 |
| WELBOURN, RB | 1 |
| Perigli, G | 1 |
| Borrelli, D | 1 |
| Salvatore, S | 1 |
| Cicchi, P | 1 |
| Burci, P | 1 |
| van Slooten, H | 1 |
| Moolenaar, AJ | 1 |
| van Seters, AP | 1 |
| Smeenk, D | 1 |
| Tattersall, MH | 1 |
| Lander, H | 1 |
| Bain, B | 1 |
| Stocks, AE | 1 |
| Woods, RL | 1 |
| Fox, RM | 1 |
| Byrne, E | 1 |
| Trotten, JR | 1 |
| Roos, I | 1 |
| Jarabak, J | 1 |
| Rice, K | 1 |
| Charbonnel, B | 1 |
| Guillon, J | 1 |
| Chupin, M | 1 |
| Gutierrez, ML | 1 |
| Crooke, ST | 1 |
| Lee, JE | 1 |
| Berger, DH | 1 |
| el-Naggar, AK | 1 |
| Hickey, RC | 3 |
| Vassilopoulou-Sellin, R | 1 |
| Gagel, RF | 1 |
| Burgess, MA | 1 |
| Evans, DB | 1 |
| Freeman, DA | 1 |
| Ahlman, H | 1 |
| Jansson, S | 1 |
| Wängberg, B | 1 |
| Tisell, LE | 1 |
| Scherstén, T | 1 |
| Hansson, G | 1 |
| Bengtsson, BA | 1 |
| Ernest, I | 1 |
| Jakobsson, CE | 1 |
| Lindstedt, S | 1 |
| Roelofs, EJ | 1 |
| de Mulder, PH | 1 |
| Hermus, AR | 1 |
| Dickstein, G | 1 |
| Shechner, C | 1 |
| Arad, E | 1 |
| Best, LA | 1 |
| Nativ, O | 1 |
| Yamanaka, K | 1 |
| Iitaka, M | 1 |
| Inaba, M | 1 |
| Morita, T | 1 |
| Sasano, H | 1 |
| Katayama, S | 1 |
| Godil, MA | 1 |
| Atlas, MP | 1 |
| Parker, RI | 1 |
| Priebe, CJ | 1 |
| Zerah, MM | 1 |
| Kane, P | 1 |
| Tsung, J | 1 |
| Wilson, TA | 1 |
| Pellegriti, G | 1 |
| Bonnay, M | 1 |
| Penfornis, A | 1 |
| Laplanche, A | 1 |
| Vassal, G | 1 |
| Abraham, J | 1 |
| Bakke, S | 1 |
| Rutt, A | 1 |
| Meadows, B | 1 |
| Merino, M | 1 |
| Alexander, R | 1 |
| Schrump, D | 1 |
| Bartlett, D | 1 |
| Choyke, P | 1 |
| Robey, R | 1 |
| Hung, E | 1 |
| Steinberg, SM | 1 |
| Bates, S | 1 |
| Korth-Schutz, S | 1 |
| Levine, LS | 1 |
| Roth, JA | 1 |
| Saenger, P | 1 |
| New, MI | 1 |
| Hajjar, RA | 1 |
| Samaan, NA | 2 |
| Rappaport, R | 1 |
| Schweisguth, O | 1 |
| Cachin, O | 1 |
| Pellerin, D | 1 |
| McKiernan, P | 1 |
| Doyle, DA | 1 |
| Duffy, GJ | 1 |
| Towers, RP | 1 |
| Duff, FA | 1 |
| O'Donovan, DK | 1 |
| Bulger, AR | 1 |
| Correa, RJ | 1 |
| Ostuni, JA | 1 |
| Roginsky, MS | 1 |
| Giraldi, T | 1 |
| Perissin, L | 1 |
| Zorzet, S | 1 |
| Rapozzi, V | 1 |
| Jensen, JC | 1 |
| Pass, HI | 1 |
| Sindelar, WF | 1 |
| Norton, JA | 1 |
| Hamborg, B | 1 |
| Frey, H | 1 |
| Bøhmer, T | 1 |
| Norman, N | 1 |
| Luton, JP | 1 |
| Cerdas, S | 1 |
| Billaud, L | 1 |
| Thomas, G | 1 |
| Guilhaume, B | 1 |
| Bertagna, X | 1 |
| Laudat, MH | 1 |
| Louvel, A | 1 |
| Chapuis, Y | 1 |
| Blondeau, P | 1 |
| Johnson, DH | 1 |
| Greco, FA | 1 |
| Carey, RM | 1 |
| Orth, DN | 1 |
| Hartmann, WH | 1 |
| Judy, JC | 1 |
| Scardino, PL | 1 |
| Hellman, L | 1 |
| Bradlow, HL | 1 |
| Zumoff, B | 1 |
| Schein, PS | 1 |
| Newmark, SR | 1 |
| Dluhy, RG | 1 |
| Bennett, AH | 1 |
| Downing, V | 1 |
| Eule, J | 1 |
| Huseby, RA | 1 |
| Lubitz, JA | 1 |
| Freeman, L | 1 |
| Okun, R | 1 |
| Schick, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Metabolic, Pressor and Neuropsychological Effects of Metyrapone Treatment in Patients With Hypercortisolism[NCT05255900] | 20 participants (Anticipated) | Observational | 2022-04-28 | Recruiting | |||
| The Impact of Mitotane Therapy on Serum Free Proteins in Patients With Adrenocortical Carcinoma[NCT05344027] | 35 participants (Actual) | Observational | 2022-04-11 | Completed | |||
| Activity of Abiraterone Acetate in the Management of Cushing's Syndrome in Patients With Adrenocortical Carcinoma[NCT03145285] | Phase 2 | 10 participants (Anticipated) | Interventional | 2017-04-18 | Active, not recruiting | ||
| Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-Pathway in Metastatic, Recurrent or Primary Unresectable Adrenocortical Cancer[NCT01255137] | Phase 2 | 13 participants (Actual) | Interventional | 2010-09-30 | Completed | ||
| A Study of Combination Chemotherapy and Surgical Resection in the Treatment of Adrenocortical Carcinoma: Continuous Infusion Doxorubicin, Vincristine and Etoposide With Daily Mitotane Before and After Surgical Resection[NCT00001339] | Phase 2 | 42 participants | Interventional | 1993-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Here is the number of participants with adverse events. For a detailed list of adverse events, see the adverse events module. (NCT01255137)
Timeframe: 3/2/11 - 8/2/12
| Intervention | Participants (Number) |
|---|---|
| Adrenal Cortex Neoplasms | 13 |
Response was defined by the Response Evaluation Criteria in Solid Tumors (RECIST). Complete response (CR) is a disappearance of all target lesions. Any pathological lymph nodes (whether target or non-target) must have reduction in short axis to <10mm. Partial response (PR) is at least a 30% decrease in the sum of the diameters of target lesions, taking as reference the baseline sum diameter. Progressive disease (PD) is a 20% increase in the sum of the diameters of target lesions, taking as reference the smallest sum on study (this includes the baseline sum if that is the smallest on study). In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5mm (Note: the appearance of one or more new lesions is also considered progression). Stable disease (SD) is neither sufficient shrinkage to qualify for PR nor sufficient increase to qualify for PD, taking s reference the smallest sum diameters while on study. (NCT01255137)
Timeframe: 2 years
| Intervention | Participants (Number) | |||
|---|---|---|---|---|
| Complete Response | Partial Response | Progression | Stable Disease | |
| Adrenal Cortex Neoplasms | 0 | 0 | 13 | 0 |
5 reviews available for mitotane and Neoplasm Metastasis
| Article | Year |
|---|---|
Developing treatment for adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Antineoplastic Agents, Hormonal; Antineoplastic Combined Ch | 2015 |
[Mitotane in the treatment of adrenal carcinoma].
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; Humans; Mitotan | 2010 |
[Treatment of adrenal cortex carcinoma].
Topics: Adrenal Cortex Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; | 1993 |
Adrenal cortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Androgens; Antineoplastic Agents; Carcinoma; Estrogens; Fem | 1987 |
Chemotherapeutic management of the hormone-secreting endocrine malignancies.
Topics: Adenoma, Islet Cell; Adrenal Gland Neoplasms; Aminoglutethimide; Aniline Compounds; Antibiotics, Ant | 1972 |
43 other studies available for mitotane and Neoplasm Metastasis
| Article | Year |
|---|---|
Long-Term Survival in a Patient With Metastatic DDR2-Positive Adrenal Cortical Carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Carboplatin; Combined Modality Th | 2017 |
Time Until Partial Response in Metastatic Adrenocortical Carcinoma Long-Term Survivors.
Topics: Adrenocortical Carcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Moda | 2018 |
Mitotane treatment in patients with metastatic testicular Leydig cell tumor associated with severe androgen excess.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgens; Antineoplastic Agents, Hormonal; Gas Chromatograph | 2018 |
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; | 2018 |
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; | 2018 |
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; | 2018 |
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; | 2018 |
Development and internal validation of an adrenal cortical carcinoma prognostic score for predicting the risk of metastasis and local recurrence.
Topics: Adolescent; Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Antineo | 2013 |
Adrenocortical carcinoma: Retrospective analysis of the last 22 years.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Adult; Aged; Chemothe | 2016 |
Rapid and Complete Remission of Metastatic Adrenocortical Carcinoma Persisting 10 Years After Treatment With Mitotane Monotherapy: Case Report and Review of the Literature.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; beta Catenin; C | 2016 |
Adjuvant mitotane for adrenocortical cancer--a recurring controversy.
Topics: Adrenal Cortex Neoplasms; Antineoplastic Agents, Hormonal; Carcinoma; Chemotherapy, Adjuvant; Dose-R | 2008 |
Management of adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; Catecholamines; | 2009 |
Long-term (15 years) outcome in an infant with metastatic adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Antineoplastic Agents, Hormonal; Carcinoma; Cortodoxone; Growth Disorders; | 2002 |
ADRENOCORTICAL CARCINOMA TREATED WITH O,P' -DDD.
Topics: Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents; Child; Cushing Syndrome; D | 1965 |
[Associated role of surgery and antimitotic o, p'-DDD treatment in hyperfunctioning adrenal cancers with diffuse metastases].
Topics: Adolescent; Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Hyperfunction; Cushing Syndrome; | 1981 |
The treatment of adrenocortical carcinoma with o,p'-DDD: prognostic implications of serum level monitoring.
Topics: Adrenal Cortex Neoplasms; Adult; Aged; Female; Humans; Male; Middle Aged; Mitotane; Neoplasm Metasta | 1984 |
Cis-platinum treatment of metastatic adrenal carcinoma.
Topics: Abdominal Neoplasms; Adrenal Cortex Neoplasms; Adult; Carcinoma; Cisplatin; Cushing Syndrome; Female | 1980 |
Metastatic adrenal cortical carcinoma. Prolonged regression with mitotane therapy.
Topics: Adrenal Cortex Neoplasms; Breast Neoplasms; Carcinoma; Female; Humans; Middle Aged; Mitotane; Neopla | 1981 |
[Regression under the influence of OP'DDD of a malignant cortico-adrenaloma and of its metastases (author's transl)].
Topics: Adrenal Cortex Neoplasms; Carcinoma; Cushing Syndrome; Female; Humans; Liver Neoplasms; Middle Aged; | 1980 |
Mitotane (o,p'-DDD).
Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Animals; Carcinoma; Dogs; Drug Administration Schedule; Dr | 1980 |
Surgical management, DNA content, and patient survival in adrenal cortical carcinoma.
Topics: Adenoma; Adolescent; Adrenal Cortex Neoplasms; Adult; Aged; Aneuploidy; Carcinoma; Combined Modality | 1995 |
Adrenal carcinoma.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Aminoglutethimide; Carcinoma; Cushing Syndrome; Dia | 1994 |
Adrenocortical carcinoma--diagnostic and therapeutical implications.
Topics: Adrenal Gland Neoplasms; Adrenal Rest Tumor; Adult; Aged; Carcinoma; Chemotherapy, Adjuvant; Female; | 1993 |
Is there a role for low doses of mitotane (o,p'-DDD) as adjuvant therapy in adrenocortical carcinoma?
Topics: Adrenal Cortex Neoplasms; Adult; Aged; Antineoplastic Agents, Hormonal; Carcinoma; Chemotherapy, Adj | 1998 |
A case of renin-producing adrenocortical cancer.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; 3-Hydroxysteroid Dehydrogenases; Adrenal Cortex Neoplasm | 2000 |
Metastatic congenital adrenocortical carcinoma: a case report with tumor remission at 3 1/2 years.
Topics: Adrenal Cortex Neoplasms; Antineoplastic Agents, Hormonal; Combined Modality Therapy; Follow-Up Stud | 2000 |
Impact of monitoring plasma 1,1-dichlorodiphenildichloroethane (o,p'DDD) levels on the treatment of patients with adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adult; Aged; Chemotherapy, Adjuvant; Chromatography, High Pressure Liquid; | 2001 |
A phase II trial of combination chemotherapy and surgical resection for the treatment of metastatic adrenocortical carcinoma: continuous infusion doxorubicin, vincristine, and etoposide with daily mitotane as a P-glycoprotein antagonist.
Topics: Administration, Oral; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Antineoplasti | 2002 |
Virilizing adrenal tumor in a child suppressed with dexamethasone for three years. Effect of o,p'-DDD on serum and urinary androgens.
Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Androgens; Child, Preschool; | 1977 |
Adrenal cortical carcinoma. A study of 32 patients.
Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adult; Age Factors; Aged; Bone Neoplasms; Female; Hepa | 1975 |
[Malignant adrenal carcinoma with metastases: exeresis and treatment with op'DD followed by cure].
Topics: Adrenal Gland Neoplasms; Child; Female; Follow-Up Studies; Humans; Mitotane; Neoplasm Metastasis; Ne | 1978 |
o,p'--DDD and adrenal carcinoma.
Topics: Adrenal Cortex Neoplasms; Female; Humans; Iodine Radioisotopes; Liver; Liver Neoplasms; Middle Aged; | 1978 |
Experience with adrenal cortical carcinoma.
Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adult; Aged; Female; Humans; Male | 1977 |
Metastatic adrenal cortical carcinoma. Documented cure with combined chemotherapy.
Topics: Adolescent; Adrenal Gland Neoplasms; Carcinoma; Drug Therapy, Combination; Female; Fluorouracil; Hum | 1975 |
Metastasis and neuroendocrine system in stressed mice.
Topics: Animals; Bromocriptine; Carcinoma; Female; Guanethidine; Lung Neoplasms; Mice; Mitotane; Naltrexone; | 1992 |
Recurrent or metastatic disease in select patients with adrenocortical carcinoma. Aggressive resection vs chemotherapy.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; C | 1991 |
[Carcinoma of the adrenal cortex].
Topics: 17-Ketosteroids; Adrenal Cortex Neoplasms; Adult; Aged; Biomarkers, Tumor; Cortodoxone; Cushing Synd | 1990 |
Clinical features of adrenocortical carcinoma, prognostic factors, and the effect of mitotane therapy.
Topics: Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Combined Modality Therapy; Female; Follow-Up Stud | 1990 |
Clinical features of adrenocortical carcinoma, prognostic factors, and the effect of mitotane therapy.
Topics: Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Combined Modality Therapy; Female; Follow-Up Stud | 1990 |
Clinical features of adrenocortical carcinoma, prognostic factors, and the effect of mitotane therapy.
Topics: Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Combined Modality Therapy; Female; Follow-Up Stud | 1990 |
Clinical features of adrenocortical carcinoma, prognostic factors, and the effect of mitotane therapy.
Topics: Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Combined Modality Therapy; Female; Follow-Up Stud | 1990 |
Treatment of metastatic adrenal cortical carcinoma with cisplatin and etoposide (VP-16).
Topics: Adrenal Cortex Neoplasms; Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplati | 1986 |
Malignant melanoma with ectopic production of adrenocorticotropic hormone. Palliative treatment with inhibitors of adrenal steroid biosynthesis.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocortical Hyperfunction; Adrenocorticotropic Hormon | 1973 |
Adrenal cortical carcinoma: a case report.
Topics: Adrenal Gland Neoplasms; Carcinoma; Female; Humans; Middle Aged; Mitotane; Neoplasm Metastasis; Pall | 1973 |
Decreased conversion of androgens to normal 17-ketosteroid metabolites as a result of treatment with o,p'-DDD.
Topics: Adrenal Gland Neoplasms; Androsterone; Anemia, Pernicious; Carbon Isotopes; Dehydroepiandrosterone; | 1973 |
Ectopic adrenocorticotropin syndrome with prostatic carcinoma.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adrenocorticotropic Hormone; Blood Gluco | 1973 |
Regression of an adrenal cortical carcinoma and its neovascular bed following mitotane therapy: a case report.
Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Aortography; Blood Pressure; Catheterization; Fem | 1974 |
Mitotane use in inoperable adrenal cortical carcinoma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Diabetic Retinopathy; Female; Follow-Up Studies; Gastroi | 1973 |
Survival with adrenal carcinoma.
Topics: Adrenal Gland Neoplasms; Female; Fluorouracil; Humans; Mitotane; Neoplasm Metastasis | 1973 |