mitotane has been researched along with Multiple Endocrine Neoplasia Type 1 in 1 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Multiple Endocrine Neoplasia Type 1: A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Multiple endocrine neoplasia type 1 was diagnosed in a 12-year-old male crossbred dog." | 1.31 | Multiple endocrine neoplasia type 1 in a crossbred dog. ( Alley, MR; Burbidge, HM; Guildford, WG; Jones, BR; Walker, MC, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Walker, MC | 1 |
| Jones, BR | 1 |
| Guildford, WG | 1 |
| Burbidge, HM | 1 |
| Alley, MR | 1 |
1 other study available for mitotane and Multiple Endocrine Neoplasia Type 1
| Article | Year |
|---|---|
Multiple endocrine neoplasia type 1 in a crossbred dog.
Topics: Adenoma; Animals; Antineoplastic Agents, Hormonal; Diagnosis, Differential; Dog Diseases; Dogs; Male | 2000 |