mitotane has been researched along with Lung Neoplasms in 33 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fourteen patients with progressive metastatic adrenal cortical carcinoma were treated with a combination of 5-fluorouracil (5-FU), doxorubicin, and cisplatin (FAP)." | 7.68 | 5-Fluorouracil, doxorubicin, and cisplatin as treatment for adrenal cortical carcinoma. ( Brugieres, L; Droz, JP; Gicquel, C; Parmentier, C; Schlumberger, M; Travagli, JP, 1991) |
| "Under the diagnosis of stage IV adrenocortical carcinoma, mitotane therapy was started in May 2013." | 5.51 | [A CASE REPORT: A PATIENT WITH METASTATIC ADRENOCORTICAL CARCINOMA EXCLUSIVELY TREATED WITH MITOTANE WITH LONG-TERM FOLLOW-UP]. ( Hanai, T; Nakayama, T; Onuki, T; Suzuki, K; Yamashita, D, 2019) |
| "Treatment with mitotane was started shortly after surgical removal of the tumor (three patients) or the tumor and multiple lung metastasis (one patient)." | 5.30 | Is there a role for low doses of mitotane (o,p'-DDD) as adjuvant therapy in adrenocortical carcinoma? ( Arad, E; Best, LA; Dickstein, G; Nativ, O; Shechner, C, 1998) |
| "Adrenal cortical carcinoma is a rare tumour with a poor prognosis." | 5.28 | Treatment of adrenal cortical carcinoma with mitotane: outcome and complications. ( Cheah, JS; Chong, PY; Lim, MC; Tan, YO, 1990) |
| "Fourteen patients with progressive metastatic adrenal cortical carcinoma were treated with a combination of 5-fluorouracil (5-FU), doxorubicin, and cisplatin (FAP)." | 3.68 | 5-Fluorouracil, doxorubicin, and cisplatin as treatment for adrenal cortical carcinoma. ( Brugieres, L; Droz, JP; Gicquel, C; Parmentier, C; Schlumberger, M; Travagli, JP, 1991) |
| "Two cases are described in which metastatic adrenocortical carcinoma associated with Cushing's syndrome was treated with mitotane (o,p'DDD)." | 3.67 | Hepatic microsomal enzyme induction and adrenal crisis due to o,p'DDD therapy for metastatic adrenocortical carcinoma. ( Cullen, DR; Hague, RV; May, W, 1989) |
| " The patient described in this report had widely metastatic Leydig cell carcinoma associated with hypertension, hypokalemic alkalosis, and an elevated serum concentration of desoxycorticosterone." | 3.66 | Malignant Leydig cell tumor: objective tumor response to o,p'-DDD. ( Azer, PC; Braunstein, GD, 1981) |
| "Adrenal Cancer is an infrequent and very aggressive tumor." | 2.48 | Giant adrenal carcinoma associated with renal vein and inferior vena cava thrombus. Case report and literature review. ( Fernández Arjona, M; Garrido Abad, P; Gómez de Vicente, JM; Herranz Fernández, LM; Jiménez Gálvez, M; Santos Arrontes, D; Suárez Fonseca, C, 2012) |
| "Under the diagnosis of stage IV adrenocortical carcinoma, mitotane therapy was started in May 2013." | 1.51 | [A CASE REPORT: A PATIENT WITH METASTATIC ADRENOCORTICAL CARCINOMA EXCLUSIVELY TREATED WITH MITOTANE WITH LONG-TERM FOLLOW-UP]. ( Hanai, T; Nakayama, T; Onuki, T; Suzuki, K; Yamashita, D, 2019) |
| "We report the first case of adrenocortical carcinoma secreting cortisol (Cushing's syndrome) and aldosterone (Conn's syndrome) with extensive distant metastasis at the time of diagnosis." | 1.37 | Metastatic adrenocortical carcinoma presenting simultaneously with Cushing's and Conn's syndromes: a case report. ( Bang, SM; Beom, SH; Choi, Y; Chung, JH; Kim, JH; Kim, YJ; Lee, JS; Lee, KW; Song, KH; Yang, Y, 2011) |
| "Mitotane was increased to 2." | 1.31 | Long-term (15 years) outcome in an infant with metastatic adrenocortical carcinoma. ( De León, DD; Lange, BJ; Moshang, T; Walterhouse, D, 2002) |
| "Treatment with mitotane was started shortly after surgical removal of the tumor (three patients) or the tumor and multiple lung metastasis (one patient)." | 1.30 | Is there a role for low doses of mitotane (o,p'-DDD) as adjuvant therapy in adrenocortical carcinoma? ( Arad, E; Best, LA; Dickstein, G; Nativ, O; Shechner, C, 1998) |
| "Six to 10 months after hypercorticism was cured with ketoconazole and bilateral adrenalectomy, a thymic mass 2 to 5 cm in length was detected by computerized tomography or magnetic resonance imaging in all 3 patients." | 1.29 | [Paraneoplastic Cushing's syndrome. Pseudotumors of the thymus occurring after correction of hypercorticism. 3 cases]. ( Caillé, JM; Catargi, B; Drouillard, J; Greselle, JF; Laurent, F; Martigne, C; Roger, P; Tabarin, A, 1993) |
| "Adrenal cortical carcinoma is a rare tumour with a poor prognosis." | 1.28 | Treatment of adrenal cortical carcinoma with mitotane: outcome and complications. ( Cheah, JS; Chong, PY; Lim, MC; Tan, YO, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (30.30) | 18.7374 |
| 1990's | 8 (24.24) | 18.2507 |
| 2000's | 7 (21.21) | 29.6817 |
| 2010's | 7 (21.21) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Yamashita, D | 1 |
| Hanai, T | 1 |
| Onuki, T | 1 |
| Suzuki, K | 1 |
| Nakayama, T | 1 |
| Salle, L | 1 |
| Mas, R | 1 |
| Teissier-Clément, MP | 1 |
| Pal, SK | 1 |
| Gartrell, B | 1 |
| Olsson, CA | 1 |
| Stein, CA | 1 |
| Ranvier, GG | 1 |
| Inabnet, WB | 1 |
| Zhuang, J | 1 |
| Wang, D | 1 |
| Wu, R | 1 |
| Tu, X | 1 |
| Chen, Y | 1 |
| Qiu, S | 1 |
| Arai, H | 1 |
| Rino, Y | 1 |
| Yamanaka, S | 2 |
| Yukawa, N | 1 |
| Wada, N | 1 |
| Kato, H | 1 |
| Yanagimachi, M | 1 |
| Goto, H | 1 |
| Oshiro, H | 1 |
| Inayama, Y | 1 |
| Lee, J | 1 |
| Masuda, M | 1 |
| Beom, SH | 1 |
| Lee, KW | 1 |
| Yang, Y | 1 |
| Choi, Y | 1 |
| Song, KH | 1 |
| Kim, YJ | 1 |
| Kim, JH | 1 |
| Bang, SM | 1 |
| Chung, JH | 1 |
| Lee, JS | 1 |
| Hubertus, J | 1 |
| Boxberger, N | 1 |
| Redlich, A | 1 |
| von Schweinitz, D | 1 |
| Vorwerk, P | 1 |
| Garrido Abad, P | 1 |
| Gómez de Vicente, JM | 1 |
| Herranz Fernández, LM | 1 |
| Jiménez Gálvez, M | 1 |
| Santos Arrontes, D | 1 |
| Suárez Fonseca, C | 1 |
| Fernández Arjona, M | 1 |
| De León, DD | 1 |
| Lange, BJ | 1 |
| Walterhouse, D | 1 |
| Moshang, T | 1 |
| MONTGOMERY, DA | 1 |
| WELBOURN, RB | 1 |
| Yoshimasu, T | 1 |
| Oura, S | 1 |
| Hirai, I | 1 |
| Kokawa, Y | 1 |
| Nishida, M | 1 |
| Sasaki, R | 1 |
| Tanino, H | 1 |
| Sakurai, T | 1 |
| Okamura, Y | 1 |
| Inagaki, T | 1 |
| Kodama, Y | 1 |
| Shinke, T | 1 |
| Tanaka, K | 1 |
| Kumano, Y | 1 |
| Kanomata, N | 1 |
| Takeda, M | 1 |
| Hara, I | 1 |
| Fujisawa, M | 1 |
| Kawabata, G | 1 |
| Kamidono, S | 1 |
| Valo, I | 1 |
| Verrièle, V | 1 |
| Giraud, P | 1 |
| Lorimier, G | 1 |
| Guyétant, S | 1 |
| Sommelet, D | 1 |
| Abiven, G | 1 |
| Coste, J | 1 |
| Groussin, L | 1 |
| Anract, P | 1 |
| Tissier, F | 1 |
| Legmann, P | 1 |
| Dousset, B | 1 |
| Bertagna, X | 1 |
| Bertherat, J | 1 |
| Sperone, P | 1 |
| Berruti, A | 1 |
| Gorzegno, G | 1 |
| Paccotti, P | 1 |
| Terzolo, M | 1 |
| Porpiglia, F | 1 |
| Angeli, A | 1 |
| Dogliotti, L | 1 |
| Appelqvist, P | 1 |
| Kostianinen, S | 1 |
| Schteingart, DE | 1 |
| Motazedi, A | 1 |
| Noonan, RA | 1 |
| Thompson, NW | 1 |
| Tattersall, MH | 1 |
| Lander, H | 1 |
| Bain, B | 1 |
| Stocks, AE | 1 |
| Woods, RL | 1 |
| Fox, RM | 1 |
| Byrne, E | 1 |
| Trotten, JR | 1 |
| Roos, I | 1 |
| Azer, PC | 1 |
| Braunstein, GD | 1 |
| Tabarin, A | 1 |
| Catargi, B | 1 |
| Laurent, F | 1 |
| Greselle, JF | 1 |
| Martigne, C | 1 |
| Caillé, JM | 1 |
| Drouillard, J | 1 |
| Roger, P | 1 |
| Dickstein, G | 1 |
| Shechner, C | 1 |
| Arad, E | 1 |
| Best, LA | 1 |
| Nativ, O | 1 |
| Hajjar, RA | 1 |
| Hickey, RC | 1 |
| Samaan, NA | 1 |
| van Aalderen, W | 1 |
| van Seters, AP | 1 |
| Backer, ET | 1 |
| Chang, PC | 1 |
| van Krieken, JH | 1 |
| Moolenaar, AJ | 1 |
| Remond, S | 1 |
| Bardet, S | 1 |
| Charbonnel, B | 1 |
| Giraldi, T | 1 |
| Perissin, L | 1 |
| Zorzet, S | 1 |
| Rapozzi, V | 1 |
| Schlumberger, M | 1 |
| Brugieres, L | 1 |
| Gicquel, C | 1 |
| Travagli, JP | 1 |
| Droz, JP | 1 |
| Parmentier, C | 1 |
| Nakamura, S | 1 |
| Kuzuya, N | 1 |
| Koide, Y | 1 |
| Matsumara, M | 1 |
| Watanabe, Y | 1 |
| Tomizawa, H | 1 |
| Murayama, Y | 1 |
| Okuda, Y | 1 |
| Takuwa, Y | 1 |
| Itakura, M | 1 |
| Lim, MC | 1 |
| Tan, YO | 1 |
| Chong, PY | 1 |
| Cheah, JS | 1 |
| Hague, RV | 1 |
| May, W | 1 |
| Cullen, DR | 1 |
| Katsumi, T | 1 |
| Murayama, K | 1 |
| Krzisnik, C | 1 |
| Petric, G | 1 |
| Jereb, B | 1 |
| Downing, V | 1 |
| Eule, J | 1 |
| Huseby, RA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Activity of Abiraterone Acetate in the Management of Cushing's Syndrome in Patients With Adrenocortical Carcinoma[NCT03145285] | Phase 2 | 10 participants (Anticipated) | Interventional | 2017-04-18 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for mitotane and Lung Neoplasms
| Article | Year |
|---|---|
Surgical management of adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; | 2015 |
Giant adrenal carcinoma associated with renal vein and inferior vena cava thrombus. Case report and literature review.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Aged; Antineoplastic Agents; Carcinoma; Contraindications; F | 2012 |
Oncocytic adrenocortical carcinoma.
Topics: Adenocarcinoma; Adrenal Cortex Neoplasms; Adrenalectomy; Antineoplastic Combined Chemotherapy Protoc | 2004 |
Multiple thoracotomy combined with chemotherapy in metastatic adrenal cortical carcinoma: a case report and review of the literature.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Carcinoma; Cortisone; Cushing Syndrom | 1983 |
29 other studies available for mitotane and Lung Neoplasms
| Article | Year |
|---|---|
[A CASE REPORT: A PATIENT WITH METASTATIC ADRENOCORTICAL CARCINOMA EXCLUSIVELY TREATED WITH MITOTANE WITH LONG-TERM FOLLOW-UP].
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Aged; Antineoplastic Agents, Hormonal; Follow-Up | 2019 |
Ectopic adrenocortical carcinoma of the ovary: An unexpected outcome.
Topics: ACTH Syndrome, Ectopic; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Antineoplastic Ag | 2020 |
Metastatic adrenocortical carcinoma with a prolonged response to mitotane.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; | 2014 |
Sunitinib monotherapy instead of mitotane combination therapy for the treatment of refractory adrenocortical carcinoma.
Topics: Adrenocortical Carcinoma; Adult; Antineoplastic Agents; Chemotherapy, Adjuvant; Female; Humans; Indo | 2015 |
Successful treatment of adrenocortical carcinoma with pulmonary metastasis in a child: report of a case.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; Chemotherapy, A | 2008 |
Metastatic adrenocortical carcinoma presenting simultaneously with Cushing's and Conn's syndromes: a case report.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Aged; Antineoplastic Combined Chemotherapy Proto | 2011 |
Surgical aspects in the treatment of adrenocortical carcinomas in children: data of the GPOH-MET 97 trial.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adrenalectomy; Antineoplastic Agents, Hormonal; Chemotherapy, | 2012 |
Long-term (15 years) outcome in an infant with metastatic adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Antineoplastic Agents, Hormonal; Carcinoma; Cortodoxone; Growth Disorders; | 2002 |
ADRENOCORTICAL CARCINOMA TREATED WITH O,P' -DDD.
Topics: Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents; Child; Cushing Syndrome; D | 1965 |
[Histoculture drug response assay guided concurrent chemoradiotherapy for lung metastasis from adrenocortical carcinoma--a case report].
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Antineoplastic Combined Chemotherapy Protocols; | 2004 |
[Thyroid metastases of an adrenocortical carcinoma 41 years after the diagnosis of the primary tumor].
Topics: Adenocarcinoma, Clear Cell; Adrenal Cortex Neoplasms; Adrenalectomy; Antineoplastic Agents; Biomarke | 2004 |
Clinical and biological features in the prognosis of adrenocortical cancer: poor outcome of cortisol-secreting tumors in a series of 202 consecutive patients.
Topics: Adrenal Cortex Neoplasms; Adult; Analysis of Variance; Androgens; Antineoplastic Agents, Hormonal; B | 2006 |
Long-term disease free survival in a patient with metastatic adreno-cortical carcinoma after complete pathological response to chemotherapy plus mitotane.
Topics: Adrenal Cortex Neoplasms; Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplati | 2006 |
Treatment of adrenal carcinomas.
Topics: Adrenal Gland Neoplasms; Adult; Carcinoma; Female; Humans; Liver Neoplasms; Lung Neoplasms; Male; Mi | 1982 |
Cis-platinum treatment of metastatic adrenal carcinoma.
Topics: Abdominal Neoplasms; Adrenal Cortex Neoplasms; Adult; Carcinoma; Cisplatin; Cushing Syndrome; Female | 1980 |
Malignant Leydig cell tumor: objective tumor response to o,p'-DDD.
Topics: Desoxycorticosterone; Humans; Hypertension; Hypokalemia; Leydig Cell Tumor; Lung Neoplasms; Male; Mi | 1981 |
[Paraneoplastic Cushing's syndrome. Pseudotumors of the thymus occurring after correction of hypercorticism. 3 cases].
Topics: Adrenalectomy; Adrenocortical Hyperfunction; Adult; Carcinoid Tumor; Cushing Syndrome; Drug Therapy, | 1993 |
Is there a role for low doses of mitotane (o,p'-DDD) as adjuvant therapy in adrenocortical carcinoma?
Topics: Adrenal Cortex Neoplasms; Adult; Aged; Antineoplastic Agents, Hormonal; Carcinoma; Chemotherapy, Adj | 1998 |
Adrenal cortical carcinoma. A study of 32 patients.
Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adult; Age Factors; Aged; Bone Neoplasms; Female; Hepa | 1975 |
A case of recurrent adrenocortical carcinoma, with observations on long-term o,p'-DDD therapy and complications.
Topics: Adrenal Gland Neoplasms; Carcinoma; Carcinosarcoma; Combined Modality Therapy; Female; Humans; Lung | 1992 |
[Complete and lasting remission of a metastatic malignant adrenocortical carcinoma under treatment with OP'DDD alone].
Topics: Adrenal Cortex Neoplasms; Carcinoma; Female; Humans; Liver Neoplasms; Lung Neoplasms; Middle Aged; M | 1992 |
Metastasis and neuroendocrine system in stressed mice.
Topics: Animals; Bromocriptine; Carcinoma; Female; Guanethidine; Lung Neoplasms; Mice; Mitotane; Naltrexone; | 1992 |
5-Fluorouracil, doxorubicin, and cisplatin as treatment for adrenal cortical carcinoma.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Antineoplastic Combined Chemotherapy Protocols; Carcino | 1991 |
Successful treatment of a metastatic hormone-producing adrenal cancer by a combination of mitotane, tegafur and surgical resection.
Topics: 17-alpha-Hydroxypregnenolone; Adrenal Gland Neoplasms; Adult; Aldosterone; Androstenedione; Antineop | 1990 |
Treatment of adrenal cortical carcinoma with mitotane: outcome and complications.
Topics: Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Carcinoma; Cortisone; Female; Humans; Hydroco | 1990 |
Hepatic microsomal enzyme induction and adrenal crisis due to o,p'DDD therapy for metastatic adrenocortical carcinoma.
Topics: Addison Disease; Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Alanine Transaminase; Aspartate Ami | 1989 |
[A case of non-functioning adrenal cortical carcinoma with pulmonary and bony metastases].
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Antineoplastic Agents; Bone Neoplasms; Combined Modality Th | 1989 |
Complete response of metastatic adrenal cortical carcinoma to o,p'-DDD in a child.
Topics: Adolescent; Adrenal Cortex Neoplasms; Carcinoma; Female; Humans; Lung Neoplasms; Mitotane; Tomograph | 1988 |
Regression of an adrenal cortical carcinoma and its neovascular bed following mitotane therapy: a case report.
Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Aortography; Blood Pressure; Catheterization; Fem | 1974 |