mitotane has been researched along with Long QT Syndrome in 2 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We designed a single-center retrospective study to assess the QT interval duration and to describe cardio vascular events among patients treated with mitotane for a adrenocortical carcinoma (ACC)." | 9.16 | No evidence for relevant QT interval prolongation in mitotane-treated patients with adrenocortical carcinoma. ( Abbas, H; Bertagna, X; Chaderevian, R; Cohen, A; Dufaitre, G; Ederhy, S; Libé, R, 2012) |
| "We designed a single-center retrospective study to assess the QT interval duration and to describe cardio vascular events among patients treated with mitotane for a adrenocortical carcinoma (ACC)." | 5.16 | No evidence for relevant QT interval prolongation in mitotane-treated patients with adrenocortical carcinoma. ( Abbas, H; Bertagna, X; Chaderevian, R; Cohen, A; Dufaitre, G; Ederhy, S; Libé, R, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ederhy, S | 1 |
| Cohen, A | 1 |
| Dufaitre, G | 1 |
| Chaderevian, R | 1 |
| Abbas, H | 1 |
| Bertagna, X | 1 |
| Libé, R | 1 |
| Pliquett, RU | 1 |
| Eichfeld, U | 1 |
| Stumvoll, M | 1 |
| Koch, CA | 1 |
1 trial available for mitotane and Long QT Syndrome
| Article | Year |
|---|---|
No evidence for relevant QT interval prolongation in mitotane-treated patients with adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Antineoplastic Agents, Hormonal; El | 2012 |
1 other study available for mitotane and Long QT Syndrome
| Article | Year |
|---|---|
Long QT syndrome under mitotane therapy.
Topics: Antineoplastic Agents, Hormonal; Female; Humans; Long QT Syndrome; Middle Aged; Mitotane | 2007 |