mitotane has been researched along with Liver Neoplasms in 21 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 42-year-old woman with liver metastasis from adrenal cortical carcinoma was treated with mitotane (o,p'DDD) for 11 months with a minimal response." | 7.69 | Treatment of metastatic adrenal cortical carcinoma with etoposide (VP-16) and cisplatin after failure with o,p'DDD. Clinical case reports. ( Robinson, E; Shpendler, M; Zidan, J, 1996) |
| "Fourteen patients with progressive metastatic adrenal cortical carcinoma were treated with a combination of 5-fluorouracil (5-FU), doxorubicin, and cisplatin (FAP)." | 7.68 | 5-Fluorouracil, doxorubicin, and cisplatin as treatment for adrenal cortical carcinoma. ( Brugieres, L; Droz, JP; Gicquel, C; Parmentier, C; Schlumberger, M; Travagli, JP, 1991) |
| "By treatment with Mitotane in a dose aiming at completely destroying the adrenal cortex, a complete disappearance of the tumor as well as a dramatic reduction of the size of the metastases could be achieved." | 5.30 | [Mitotane treatment in a dog with a recurring adrenocortical carcinoma--a case report]. ( Flückiger, M; Gardelle, O; Keiser, M; Reusch, C, 1999) |
| "A 42-year-old woman with liver metastasis from adrenal cortical carcinoma was treated with mitotane (o,p'DDD) for 11 months with a minimal response." | 3.69 | Treatment of metastatic adrenal cortical carcinoma with etoposide (VP-16) and cisplatin after failure with o,p'DDD. Clinical case reports. ( Robinson, E; Shpendler, M; Zidan, J, 1996) |
| "Fourteen patients with progressive metastatic adrenal cortical carcinoma were treated with a combination of 5-fluorouracil (5-FU), doxorubicin, and cisplatin (FAP)." | 3.68 | 5-Fluorouracil, doxorubicin, and cisplatin as treatment for adrenal cortical carcinoma. ( Brugieres, L; Droz, JP; Gicquel, C; Parmentier, C; Schlumberger, M; Travagli, JP, 1991) |
| " Treatment resulted in an improvement of performance status and a reduction of the daily dosage of mitotane in all patients." | 1.35 | Percutaneous laser ablation of unresectable primary and metastatic adrenocortical carcinoma. ( Bizzarri, G; Graziano, FM; Guglielmi, R; Pacella, CM; Pacella, S; Papini, E; Stasi, R, 2008) |
| "By treatment with Mitotane in a dose aiming at completely destroying the adrenal cortex, a complete disappearance of the tumor as well as a dramatic reduction of the size of the metastases could be achieved." | 1.30 | [Mitotane treatment in a dog with a recurring adrenocortical carcinoma--a case report]. ( Flückiger, M; Gardelle, O; Keiser, M; Reusch, C, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (23.81) | 18.7374 |
| 1990's | 8 (38.10) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 3 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pal, SK | 1 |
| Gartrell, B | 1 |
| Olsson, CA | 1 |
| Stein, CA | 1 |
| Ranvier, GG | 1 |
| Inabnet, WB | 1 |
| Wahab, NA | 1 |
| Zainudin, S | 1 |
| AbAziz, A | 1 |
| Mustafa, N | 1 |
| Sukor, N | 1 |
| Kamaruddin, NA | 1 |
| MONTGOMERY, DA | 1 |
| WELBOURN, RB | 1 |
| Tanaka, K | 1 |
| Kumano, Y | 1 |
| Kanomata, N | 1 |
| Takeda, M | 1 |
| Hara, I | 1 |
| Fujisawa, M | 1 |
| Kawabata, G | 1 |
| Kamidono, S | 1 |
| Valo, I | 1 |
| Verrièle, V | 1 |
| Giraud, P | 1 |
| Lorimier, G | 1 |
| Guyétant, S | 1 |
| Sommelet, D | 1 |
| Bednarek-Tupikowska, G | 1 |
| Florczak, A | 1 |
| Witkiewicz, W | 1 |
| Tupikowski, W | 1 |
| Cisarz, E | 1 |
| Abiven, G | 1 |
| Coste, J | 1 |
| Groussin, L | 1 |
| Anract, P | 1 |
| Tissier, F | 1 |
| Legmann, P | 1 |
| Dousset, B | 1 |
| Bertagna, X | 1 |
| Bertherat, J | 1 |
| Pacella, CM | 1 |
| Stasi, R | 1 |
| Bizzarri, G | 1 |
| Pacella, S | 1 |
| Graziano, FM | 1 |
| Guglielmi, R | 1 |
| Papini, E | 1 |
| Schteingart, DE | 1 |
| Motazedi, A | 1 |
| Noonan, RA | 1 |
| Thompson, NW | 1 |
| Charbonnel, B | 2 |
| Guillon, J | 1 |
| Chupin, M | 1 |
| Kornely, E | 1 |
| Schlaghecke, R | 1 |
| Zidan, J | 1 |
| Shpendler, M | 1 |
| Robinson, E | 1 |
| Bennett, PF | 1 |
| Norman, EJ | 1 |
| Keiser, M | 1 |
| Flückiger, M | 1 |
| Gardelle, O | 1 |
| Reusch, C | 1 |
| Hajjar, RA | 1 |
| Hickey, RC | 1 |
| Samaan, NA | 1 |
| McKiernan, P | 1 |
| Doyle, DA | 1 |
| Duffy, GJ | 1 |
| Towers, RP | 1 |
| Duff, FA | 1 |
| O'Donovan, DK | 1 |
| Remond, S | 1 |
| Bardet, S | 1 |
| Buchholz, NP | 1 |
| Süberli, H | 1 |
| Ausfeld, R | 1 |
| Schlumberger, M | 1 |
| Brugieres, L | 1 |
| Gicquel, C | 1 |
| Travagli, JP | 1 |
| Droz, JP | 1 |
| Parmentier, C | 1 |
| Nakamura, S | 1 |
| Kuzuya, N | 1 |
| Koide, Y | 1 |
| Matsumara, M | 1 |
| Watanabe, Y | 1 |
| Tomizawa, H | 1 |
| Murayama, Y | 1 |
| Okuda, Y | 1 |
| Takuwa, Y | 1 |
| Itakura, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Activity of Abiraterone Acetate in the Management of Cushing's Syndrome in Patients With Adrenocortical Carcinoma[NCT03145285] | Phase 2 | 10 participants (Anticipated) | Interventional | 2017-04-18 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for mitotane and Liver Neoplasms
| Article | Year |
|---|---|
Surgical management of adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; | 2015 |
Oncocytic adrenocortical carcinoma.
Topics: Adenocarcinoma; Adrenal Cortex Neoplasms; Adrenalectomy; Antineoplastic Combined Chemotherapy Protoc | 2004 |
19 other studies available for mitotane and Liver Neoplasms
| Article | Year |
|---|---|
Metastatic adrenocortical carcinoma with a prolonged response to mitotane.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; | 2014 |
Multi-Target Approach to Metastatic Adrenal Cell Carcinoma.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Combin | 2016 |
ADRENOCORTICAL CARCINOMA TREATED WITH O,P' -DDD.
Topics: Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents; Child; Cushing Syndrome; D | 1965 |
[Thyroid metastases of an adrenocortical carcinoma 41 years after the diagnosis of the primary tumor].
Topics: Adenocarcinoma, Clear Cell; Adrenal Cortex Neoplasms; Adrenalectomy; Antineoplastic Agents; Biomarke | 2004 |
[A long term survival of the patient treated due to advanced adrenocortical carcinoma].
Topics: Adrenal Cortex Neoplasms; Antineoplastic Agents, Hormonal; Disease-Free Survival; Female; Humans; Li | 2005 |
Clinical and biological features in the prognosis of adrenocortical cancer: poor outcome of cortisol-secreting tumors in a series of 202 consecutive patients.
Topics: Adrenal Cortex Neoplasms; Adult; Analysis of Variance; Androgens; Antineoplastic Agents, Hormonal; B | 2006 |
Percutaneous laser ablation of unresectable primary and metastatic adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; Combined Modali | 2008 |
Treatment of adrenal carcinomas.
Topics: Adrenal Gland Neoplasms; Adult; Carcinoma; Female; Humans; Liver Neoplasms; Lung Neoplasms; Male; Mi | 1982 |
[Regression under the influence of OP'DDD of a malignant cortico-adrenaloma and of its metastases (author's transl)].
Topics: Adrenal Cortex Neoplasms; Carcinoma; Cushing Syndrome; Female; Humans; Liver Neoplasms; Middle Aged; | 1980 |
Complete remission of metastasized adrenocortical carcinoma under o,p'-DDD.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Female; Humans; Liver Neoplasms; Middle Aged; Mitotane; Rem | 1994 |
Treatment of metastatic adrenal cortical carcinoma with etoposide (VP-16) and cisplatin after failure with o,p'DDD. Clinical case reports.
Topics: Adrenal Cortex Neoplasms; Adult; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemothera | 1996 |
Mitotane (o,p'-DDD) resistance in a dog with pituitary-dependent hyperadrenocorticism and phaeochromocytoma.
Topics: Adrenal Cortex Function Tests; Adrenal Gland Neoplasms; Adrenal Medulla; Adrenocortical Hyperfunctio | 1998 |
[Mitotane treatment in a dog with a recurring adrenocortical carcinoma--a case report].
Topics: Adrenal Cortex Neoplasms; Animals; Antineoplastic Agents, Hormonal; Carcinoma; Cushing Syndrome; Dog | 1999 |
Adrenal cortical carcinoma. A study of 32 patients.
Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adult; Age Factors; Aged; Bone Neoplasms; Female; Hepa | 1975 |
o,p'--DDD and adrenal carcinoma.
Topics: Adrenal Cortex Neoplasms; Female; Humans; Iodine Radioisotopes; Liver; Liver Neoplasms; Middle Aged; | 1978 |
[Complete and lasting remission of a metastatic malignant adrenocortical carcinoma under treatment with OP'DDD alone].
Topics: Adrenal Cortex Neoplasms; Carcinoma; Female; Humans; Liver Neoplasms; Lung Neoplasms; Middle Aged; M | 1992 |
[Case report on metastasis surgery in adrenal cortex cancer].
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Androstenedione; Antineoplastic Combined Chemotherap | 1992 |
5-Fluorouracil, doxorubicin, and cisplatin as treatment for adrenal cortical carcinoma.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Antineoplastic Combined Chemotherapy Protocols; Carcino | 1991 |
Successful treatment of a metastatic hormone-producing adrenal cancer by a combination of mitotane, tegafur and surgical resection.
Topics: 17-alpha-Hydroxypregnenolone; Adrenal Gland Neoplasms; Adult; Aldosterone; Androstenedione; Antineop | 1990 |