mitotane has been researched along with Li-Fraumeni Syndrome in 2 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Li-Fraumeni Syndrome: Rare autosomal dominant syndrome characterized by mesenchymal and epithelial neoplasms at multiple sites. MUTATION of the p53 tumor suppressor gene, a component of the DNA DAMAGE response pathway, apparently predisposes family members who inherit it to develop certain cancers. The spectrum of cancers in the syndrome was shown to include, in addition to BREAST CANCER and soft tissue sarcomas (SARCOMA); BRAIN TUMORS; OSTEOSARCOMA; LEUKEMIA; and ADRENOCORTICAL CARCINOMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Adrenocortical carcinomas are rare in children and sometimes occur in patients with predisposing syndrome like Li-Fraumeni or Beckwith-Wiedemann syndromes." | 2.47 | [Management of adrenocortical carcinomas in children]. ( Aubert, S; Delebarre, M; Leblond, P, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ilanchezhian, M | 3 |
| Varghese, DG | 3 |
| Glod, JW | 3 |
| Reilly, KM | 3 |
| Widemann, BC | 3 |
| Pommier, Y | 3 |
| Kaplan, RN | 3 |
| Del Rivero, J | 3 |
| Leblond, P | 1 |
| Delebarre, M | 1 |
| Aubert, S | 1 |
2 reviews available for mitotane and Li-Fraumeni Syndrome
| Article | Year |
|---|---|
Pediatric adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Child; Humans; Li-Fraumeni Syndrome; Mito | 2022 |
Pediatric adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Child; Humans; Li-Fraumeni Syndrome; Mito | 2022 |
Pediatric adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Child; Humans; Li-Fraumeni Syndrome; Mito | 2022 |
Pediatric adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Child; Humans; Li-Fraumeni Syndrome; Mito | 2022 |
Pediatric adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Child; Humans; Li-Fraumeni Syndrome; Mito | 2022 |
Pediatric adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Child; Humans; Li-Fraumeni Syndrome; Mito | 2022 |
Pediatric adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Child; Humans; Li-Fraumeni Syndrome; Mito | 2022 |
Pediatric adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Child; Humans; Li-Fraumeni Syndrome; Mito | 2022 |
Pediatric adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Child; Humans; Li-Fraumeni Syndrome; Mito | 2022 |
[Management of adrenocortical carcinomas in children].
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; Beckwith-Wiedem | 2011 |