mitotane has been researched along with Leukocytopenia in 2 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The use of either mitotane or chemotherapy in the treatment of advanced adrenocortical carcinoma (ACC) has led to scanty and controversial results." | 9.08 | Mitotane associated with etoposide, doxorubicin, and cisplatin in the treatment of advanced adrenocortical carcinoma. Italian Group for the Study of Adrenal Cancer. ( Angeli, A; Berruti, A; Dogliotti, L; Pia, A; Terzolo, M, 1998) |
| "The use of either mitotane or chemotherapy in the treatment of advanced adrenocortical carcinoma (ACC) has led to scanty and controversial results." | 5.08 | Mitotane associated with etoposide, doxorubicin, and cisplatin in the treatment of advanced adrenocortical carcinoma. Italian Group for the Study of Adrenal Cancer. ( Angeli, A; Berruti, A; Dogliotti, L; Pia, A; Terzolo, M, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berruti, A | 1 |
| Terzolo, M | 1 |
| Pia, A | 1 |
| Angeli, A | 1 |
| Dogliotti, L | 1 |
| Lubitz, JA | 1 |
| Freeman, L | 1 |
| Okun, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mitotane With or Without Cisplatin and Etoposide After Surgery in Treating Participants With Stage I-III Adrenocortical Cancer With High Risk of Recurrence[NCT03723941] | Phase 3 | 240 participants (Anticipated) | Interventional | 2018-07-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for mitotane and Leukocytopenia
| Article | Year |
|---|---|
Mitotane associated with etoposide, doxorubicin, and cisplatin in the treatment of advanced adrenocortical carcinoma. Italian Group for the Study of Adrenal Cancer.
Topics: Administration, Oral; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Antineoplasti | 1998 |
1 other study available for mitotane and Leukocytopenia
| Article | Year |
|---|---|
Mitotane use in inoperable adrenal cortical carcinoma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Diabetic Retinopathy; Female; Follow-Up Studies; Gastroi | 1973 |