mitotane has been researched along with Klinefelter Syndrome in 1 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Klinefelter Syndrome: A form of male HYPOGONADISM, characterized by the presence of an extra X CHROMOSOME, small TESTES, seminiferous tubule dysgenesis, elevated levels of GONADOTROPINS, low serum TESTOSTERONE, underdeveloped secondary sex characteristics, and male infertility (INFERTILITY, MALE). Patients tend to have long legs and a slim, tall stature. GYNECOMASTIA is present in many of the patients. The classic form has the karyotype 47,XXY. Several karyotype variants include 48,XXYY; 48,XXXY; 49,XXXXY, and mosaic patterns ( 46,XY/47,XXY; 47,XXY/48,XXXY, etc.).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Knyrim, K | 1 |
| Higi, M | 1 |
| Hossfeld, DK | 1 |
| Seeber, S | 1 |
| Schmidt, CG | 1 |
1 other study available for mitotane and Klinefelter Syndrome
| Article | Year |
|---|---|
Autonomous cortisol secretion by a metastatic Leydig cell carcinoma associated with Klinefelter's syndrome.
Topics: Adult; Aldosterone; Angiotensin II; Dexamethasone; Humans; Hydrocortisone; Klinefelter Syndrome; Ley | 1981 |