mitotane has been researched along with Interstitial Cell Tumor in 6 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The patient described in this report had widely metastatic Leydig cell carcinoma associated with hypertension, hypokalemic alkalosis, and an elevated serum concentration of desoxycorticosterone." | 3.66 | Malignant Leydig cell tumor: objective tumor response to o,p'-DDD. ( Azer, PC; Braunstein, GD, 1981) |
| "Malignant Leydig cell tumors (LCT) are rare." | 2.38 | Treatment of malignant Leydig cell tumor. ( Bertram, KA; Bratloff, B; Davidson, H; Hodges, GF, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chortis, V | 1 |
| Johal, NJ | 1 |
| Bancos, I | 1 |
| Evans, M | 1 |
| Skordilis, K | 1 |
| Guest, P | 1 |
| Cullen, MH | 1 |
| Porfiri, E | 1 |
| Arlt, W | 1 |
| Knyrim, K | 1 |
| Higi, M | 1 |
| Hossfeld, DK | 1 |
| Seeber, S | 1 |
| Schmidt, CG | 1 |
| Azer, PC | 1 |
| Braunstein, GD | 1 |
| van der Hem, KG | 1 |
| Boven, E | 1 |
| van Hennik, MB | 1 |
| Pinedo, HM | 1 |
| Bertram, KA | 1 |
| Bratloff, B | 1 |
| Hodges, GF | 1 |
| Davidson, H | 1 |
| Freeman, DA | 1 |
2 reviews available for mitotane and Interstitial Cell Tumor
| Article | Year |
|---|---|
Treatment of malignant Leydig cell tumor.
Topics: Doxorubicin; Humans; Leydig Cell Tumor; Male; Middle Aged; Mitotane; Retroperitoneal Neoplasms; Test | 1991 |
Steroid hormone-producing tumors in man.
Topics: 17-Ketosteroids; Adenoma; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Adult; Androgens; C | 1986 |
4 other studies available for mitotane and Interstitial Cell Tumor
| Article | Year |
|---|---|
Mitotane treatment in patients with metastatic testicular Leydig cell tumor associated with severe androgen excess.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgens; Antineoplastic Agents, Hormonal; Gas Chromatograph | 2018 |
Autonomous cortisol secretion by a metastatic Leydig cell carcinoma associated with Klinefelter's syndrome.
Topics: Adult; Aldosterone; Angiotensin II; Dexamethasone; Humans; Hydrocortisone; Klinefelter Syndrome; Ley | 1981 |
Malignant Leydig cell tumor: objective tumor response to o,p'-DDD.
Topics: Desoxycorticosterone; Humans; Hypertension; Hypokalemia; Leydig Cell Tumor; Lung Neoplasms; Male; Mi | 1981 |
Malignant Leydig cell tumor of the testis in complete remission on o,p'-dichlorodiphenyl-dichloroethane.
Topics: Humans; Leydig Cell Tumor; Male; Middle Aged; Mitotane; Remission Induction; Testicular Neoplasms | 1992 |