Page last updated: 2024-10-31

mitotane and Hypokalemia

mitotane has been researched along with Hypokalemia in 5 studies

Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.

Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
" The patient described in this report had widely metastatic Leydig cell carcinoma associated with hypertension, hypokalemic alkalosis, and an elevated serum concentration of desoxycorticosterone."3.66Malignant Leydig cell tumor: objective tumor response to o,p'-DDD. ( Azer, PC; Braunstein, GD, 1981)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19903 (60.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Carmona-Bayonas, A1
Soler, IO1
Gómez, FI1
Billalabeitia, EG1
Saura, HP1
Tafalla, MS1
Díaz, MP1
Azer, PC1
Braunstein, GD1
Yamanaka, K1
Iitaka, M1
Inaba, M1
Morita, T1
Sasano, H1
Katayama, S1
Wortsman, J1
Soler, NG1
Müller, OA1

Other Studies

5 other studies available for mitotane and Hypokalemia

ArticleYear
Tailored hormonal therapy in secretory adrenocortical cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2007, Volume: 18, Issue:7

    Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Aged; Aldosterone; Alkalosis; Ang

2007
Malignant Leydig cell tumor: objective tumor response to o,p'-DDD.
    Cancer, 1981, Mar-15, Volume: 47, Issue:6

    Topics: Desoxycorticosterone; Humans; Hypertension; Hypokalemia; Leydig Cell Tumor; Lung Neoplasms; Male; Mi

1981
A case of renin-producing adrenocortical cancer.
    Endocrine journal, 2000, Volume: 47, Issue:2

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; 3-Hydroxysteroid Dehydrogenases; Adrenal Cortex Neoplasm

2000
Mitotane. Spironolactone antagonism in Cushing's syndrome.
    JAMA, 1977, Dec-05, Volume: 238, Issue:23

    Topics: Aged; Cushing Syndrome; Diarrhea; Female; Humans; Hypokalemia; Mitotane; Nausea; Spironolactone

1977
[Therapy of Cushing's syndrome].
    Deutsche medizinische Wochenschrift (1946), 1985, Dec-06, Volume: 110, Issue:49

    Topics: Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Cushing Syndrome; Humans; Hypokalemia; Mitota

1985