mitotane has been researched along with Hypertension in 9 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The patient described in this report had widely metastatic Leydig cell carcinoma associated with hypertension, hypokalemic alkalosis, and an elevated serum concentration of desoxycorticosterone." | 3.66 | Malignant Leydig cell tumor: objective tumor response to o,p'-DDD. ( Azer, PC; Braunstein, GD, 1981) |
| "In untreated hyperadrenocorticism, clinical problems may result from metastasis of an adrenocortical carcinoma, growth of a pituitary tumor, or complications associated with sustained hypercortisolemia itself, such as hypertension, cardiovascular disease, thromboembolism, glucose intolerance, and increased susceptibility to infection." | 2.40 | Complications and concurrent disease associated with canine hyperadrenocorticism. ( Nichols, R, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goy-Thollot, I | 1 |
| Péchereau, D | 1 |
| Kéroack, S | 1 |
| Dezempte, JC | 1 |
| Bonnet, JM | 1 |
| Shibata, H | 1 |
| Carmona-Bayonas, A | 1 |
| Soler, IO | 1 |
| Gómez, FI | 1 |
| Billalabeitia, EG | 1 |
| Saura, HP | 1 |
| Tafalla, MS | 1 |
| Díaz, MP | 1 |
| Perigli, G | 1 |
| Borrelli, D | 1 |
| Salvatore, S | 1 |
| Cicchi, P | 1 |
| Burci, P | 1 |
| Azer, PC | 1 |
| Braunstein, GD | 1 |
| Nichols, R | 2 |
| Yamanaka, K | 1 |
| Iitaka, M | 1 |
| Inaba, M | 1 |
| Morita, T | 1 |
| Sasano, H | 1 |
| Katayama, S | 1 |
| Aida, M | 1 |
| Miura, K | 1 |
4 reviews available for mitotane and Hypertension
| Article | Year |
|---|---|
[Deoxycorticosterone-producing adrenal tumor].
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Antineoplastic Agents, Hormonal; Desoxycorticosterone; Diagn | 2006 |
Concurrent illness and complications associated with canine hyperadrenocorticism.
Topics: Acute Disease; Animals; Cushing Syndrome; Diabetes Complications; Diabetes Mellitus; Dog Diseases; D | 1994 |
Complications and concurrent disease associated with canine hyperadrenocorticism.
Topics: Adrenal Cortex Diseases; Adrenocortical Hyperfunction; Animals; Antineoplastic Agents; Diabetes Comp | 1997 |
[Agents inhibiting steroid biosynthesis--aminoglutethimide and o,p'-DDD].
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aminogl | 1974 |
5 other studies available for mitotane and Hypertension
| Article | Year |
|---|---|
Investigation of the role of aldosterone in hypertension associated with spontaneous pituitary-dependent hyperadrenocorticism in dogs.
Topics: Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Aldosterone; Animals; Antineoplastic Agen | 2002 |
Tailored hormonal therapy in secretory adrenocortical cancer.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Aged; Aldosterone; Alkalosis; Ang | 2007 |
[Associated role of surgery and antimitotic o, p'-DDD treatment in hyperfunctioning adrenal cancers with diffuse metastases].
Topics: Adolescent; Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Hyperfunction; Cushing Syndrome; | 1981 |
Malignant Leydig cell tumor: objective tumor response to o,p'-DDD.
Topics: Desoxycorticosterone; Humans; Hypertension; Hypokalemia; Leydig Cell Tumor; Lung Neoplasms; Male; Mi | 1981 |
A case of renin-producing adrenocortical cancer.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; 3-Hydroxysteroid Dehydrogenases; Adrenal Cortex Neoplasm | 2000 |