Page last updated: 2024-10-31

mitotane and Hypertension

mitotane has been researched along with Hypertension in 9 studies

Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.

Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Research Excerpts

ExcerptRelevanceReference
" The patient described in this report had widely metastatic Leydig cell carcinoma associated with hypertension, hypokalemic alkalosis, and an elevated serum concentration of desoxycorticosterone."3.66Malignant Leydig cell tumor: objective tumor response to o,p'-DDD. ( Azer, PC; Braunstein, GD, 1981)
"In untreated hyperadrenocorticism, clinical problems may result from metastasis of an adrenocortical carcinoma, growth of a pituitary tumor, or complications associated with sustained hypercortisolemia itself, such as hypertension, cardiovascular disease, thromboembolism, glucose intolerance, and increased susceptibility to infection."2.40Complications and concurrent disease associated with canine hyperadrenocorticism. ( Nichols, R, 1997)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19903 (33.33)18.7374
1990's2 (22.22)18.2507
2000's4 (44.44)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Goy-Thollot, I1
Péchereau, D1
Kéroack, S1
Dezempte, JC1
Bonnet, JM1
Shibata, H1
Carmona-Bayonas, A1
Soler, IO1
Gómez, FI1
Billalabeitia, EG1
Saura, HP1
Tafalla, MS1
Díaz, MP1
Perigli, G1
Borrelli, D1
Salvatore, S1
Cicchi, P1
Burci, P1
Azer, PC1
Braunstein, GD1
Nichols, R2
Yamanaka, K1
Iitaka, M1
Inaba, M1
Morita, T1
Sasano, H1
Katayama, S1
Aida, M1
Miura, K1

Reviews

4 reviews available for mitotane and Hypertension

ArticleYear
[Deoxycorticosterone-producing adrenal tumor].
    Nihon rinsho. Japanese journal of clinical medicine, 2006, May-28, Volume: Suppl 1

    Topics: Adrenal Gland Neoplasms; Adrenalectomy; Antineoplastic Agents, Hormonal; Desoxycorticosterone; Diagn

2006
Concurrent illness and complications associated with canine hyperadrenocorticism.
    Seminars in veterinary medicine and surgery (small animal), 1994, Volume: 9, Issue:3

    Topics: Acute Disease; Animals; Cushing Syndrome; Diabetes Complications; Diabetes Mellitus; Dog Diseases; D

1994
Complications and concurrent disease associated with canine hyperadrenocorticism.
    The Veterinary clinics of North America. Small animal practice, 1997, Volume: 27, Issue:2

    Topics: Adrenal Cortex Diseases; Adrenocortical Hyperfunction; Animals; Antineoplastic Agents; Diabetes Comp

1997
[Agents inhibiting steroid biosynthesis--aminoglutethimide and o,p'-DDD].
    Nihon rinsho. Japanese journal of clinical medicine, 1974, Nov-10, Volume: 32, Issue:11

    Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aminogl

1974

Other Studies

5 other studies available for mitotane and Hypertension

ArticleYear
Investigation of the role of aldosterone in hypertension associated with spontaneous pituitary-dependent hyperadrenocorticism in dogs.
    The Journal of small animal practice, 2002, Volume: 43, Issue:11

    Topics: Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Aldosterone; Animals; Antineoplastic Agen

2002
Tailored hormonal therapy in secretory adrenocortical cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2007, Volume: 18, Issue:7

    Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Aged; Aldosterone; Alkalosis; Ang

2007
[Associated role of surgery and antimitotic o, p'-DDD treatment in hyperfunctioning adrenal cancers with diffuse metastases].
    Chirurgia italiana, 1981, Volume: 33, Issue:1

    Topics: Adolescent; Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Hyperfunction; Cushing Syndrome;

1981
Malignant Leydig cell tumor: objective tumor response to o,p'-DDD.
    Cancer, 1981, Mar-15, Volume: 47, Issue:6

    Topics: Desoxycorticosterone; Humans; Hypertension; Hypokalemia; Leydig Cell Tumor; Lung Neoplasms; Male; Mi

1981
A case of renin-producing adrenocortical cancer.
    Endocrine journal, 2000, Volume: 47, Issue:2

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; 3-Hydroxysteroid Dehydrogenases; Adrenal Cortex Neoplasm

2000