Page last updated: 2024-10-31

mitotane and Heart Failure

mitotane has been researched along with Heart Failure in 3 studies

Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.

Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"In untreated hyperadrenocorticism, clinical problems may result from metastasis of an adrenocortical carcinoma, growth of a pituitary tumor, or complications associated with sustained hypercortisolemia itself, such as hypertension, cardiovascular disease, thromboembolism, glucose intolerance, and increased susceptibility to infection."2.40Complications and concurrent disease associated with canine hyperadrenocorticism. ( Nichols, R, 1997)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's2 (66.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mitchell, CW1
Carmona-Bayonas, A1
Soler, IO1
Gómez, FI1
Billalabeitia, EG1
Saura, HP1
Tafalla, MS1
Díaz, MP1
Nichols, R1

Reviews

1 review available for mitotane and Heart Failure

ArticleYear
Complications and concurrent disease associated with canine hyperadrenocorticism.
    The Veterinary clinics of North America. Small animal practice, 1997, Volume: 27, Issue:2

    Topics: Adrenal Cortex Diseases; Adrenocortical Hyperfunction; Animals; Antineoplastic Agents; Diabetes Comp

1997

Other Studies

2 other studies available for mitotane and Heart Failure

ArticleYear
The imaging diagnosis of pulmonary thromboembolism.
    The Canadian veterinary journal = La revue veterinaire canadienne, 2009, Volume: 50, Issue:2

    Topics: Animals; Diagnosis, Differential; Dog Diseases; Dogs; Echocardiography; Fatal Outcome; Heart Failure

2009
Tailored hormonal therapy in secretory adrenocortical cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2007, Volume: 18, Issue:7

    Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Aged; Aldosterone; Alkalosis; Ang

2007