mitotane has been researched along with Encephalopathy, Toxic in 2 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mitotane is the only approved drug for treatment of adrenocortical carcinoma." | 9.17 | Comparison of two mitotane starting dose regimens in patients with advanced adrenocortical carcinoma. ( Allolio, B; Baudin, E; Chadarevian, R; Fassnacht, M; Haak, HR; Kerkhofs, TM; Leboulleux, S; Mantero, F; Mueller, HH; Skogseid, B; Terzolo, M, 2013) |
| "Mitotane is the only approved drug for treatment of adrenocortical carcinoma." | 5.17 | Comparison of two mitotane starting dose regimens in patients with advanced adrenocortical carcinoma. ( Allolio, B; Baudin, E; Chadarevian, R; Fassnacht, M; Haak, HR; Kerkhofs, TM; Leboulleux, S; Mantero, F; Mueller, HH; Skogseid, B; Terzolo, M, 2013) |
| "Low-dose mitotane has been widely used for many decades in patients with advanced adrenocortical carcinoma (ACC), which exhibited good safety profiles compared with the high-dose regimen." | 3.96 | A case report of neurological adverse events caused by short-term and low-dose treatment of mitotane: The role of therapeutic drug monitoring. ( Deng, JH; Fu, Q; Liu, X; Mei, D; Tang, Y; Zhang, B, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, X | 1 |
| Fu, Q | 1 |
| Tang, Y | 1 |
| Deng, JH | 1 |
| Mei, D | 1 |
| Zhang, B | 1 |
| Kerkhofs, TM | 1 |
| Baudin, E | 1 |
| Terzolo, M | 1 |
| Allolio, B | 1 |
| Chadarevian, R | 1 |
| Mueller, HH | 1 |
| Skogseid, B | 1 |
| Leboulleux, S | 1 |
| Mantero, F | 1 |
| Haak, HR | 1 |
| Fassnacht, M | 1 |
1 trial available for mitotane and Encephalopathy, Toxic
| Article | Year |
|---|---|
Comparison of two mitotane starting dose regimens in patients with advanced adrenocortical carcinoma.
Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Antineoplastic Agents, Ho | 2013 |
1 other study available for mitotane and Encephalopathy, Toxic
| Article | Year |
|---|---|
A case report of neurological adverse events caused by short-term and low-dose treatment of mitotane: The role of therapeutic drug monitoring.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; Asian People; D | 2020 |