mitotane has been researched along with Emesis in 3 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Measurement of o,p'-DDD and its metabolites in plasma may prove clinically useful in developing effective but less toxic dosage schedules." | 1.26 | o,p'-DDD (mitotane) therapy of adrenal cortical carcinoma: observations on drug dosage, toxicity, and steroid replacement. ( Borden, EC; Citrin, DL; Davis, TE; Hogan, TF; Johnson, BM; Nakamura, S, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| den Hertog, E | 1 |
| Braakman, JC | 1 |
| Teske, E | 1 |
| Kooistra, HS | 1 |
| Rijnberk, A | 1 |
| Ling, GV | 1 |
| Lowenstine, LJ | 1 |
| Pulley, LT | 1 |
| Kaneko, JJ | 1 |
| Hogan, TF | 1 |
| Citrin, DL | 1 |
| Johnson, BM | 1 |
| Nakamura, S | 1 |
| Davis, TE | 1 |
| Borden, EC | 1 |
1 trial available for mitotane and Emesis
| Article | Year |
|---|---|
Results of non-selective adrenocorticolysis by o,p'-DDD in 129 dogs with pituitary-dependent hyperadrenocorticism.
Topics: Adrenal Glands; Animals; Anorexia; Antineoplastic Agents, Hormonal; Body Weight; Cushing Syndrome; D | 1999 |
2 other studies available for mitotane and Emesis
| Article | Year |
|---|---|
Diabetes mellitus in dogs: a review of initial evaluation, immediate and long-term management, and outcome.
Topics: Amylases; Animals; Anorexia; Bicarbonates; Blood Glucose; Blood Urea Nitrogen; Cushing Syndrome; Deh | 1977 |
o,p'-DDD (mitotane) therapy of adrenal cortical carcinoma: observations on drug dosage, toxicity, and steroid replacement.
Topics: Adrenal Cortex Neoplasms; Adult; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Male; M | 1978 |