Page last updated: 2024-10-31

mitotane and Diarrhea

mitotane has been researched along with Diarrhea in 3 studies

Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.

Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.

Research Excerpts

ExcerptRelevanceReference
" On the other hand, Mitometh resisted side-chain oxidative metabolism and was less toxic than Lysodren."1.27Toxicity, ultrastructural effects, and metabolic studies with 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane(o,p'-DDD) and its methyl analog in the guinea pig and rat. ( Briggs, DG; Caldwell, MW; French, LG; Jensen, BL, 1987)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19902 (66.67)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Carmona-Bayonas, A1
Soler, IO1
Gómez, FI1
Billalabeitia, EG1
Saura, HP1
Tafalla, MS1
Díaz, MP1
Wortsman, J1
Soler, NG1
Jensen, BL1
Caldwell, MW1
French, LG1
Briggs, DG1

Other Studies

3 other studies available for mitotane and Diarrhea

ArticleYear
Tailored hormonal therapy in secretory adrenocortical cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2007, Volume: 18, Issue:7

    Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Aged; Aldosterone; Alkalosis; Ang

2007
Mitotane. Spironolactone antagonism in Cushing's syndrome.
    JAMA, 1977, Dec-05, Volume: 238, Issue:23

    Topics: Aged; Cushing Syndrome; Diarrhea; Female; Humans; Hypokalemia; Mitotane; Nausea; Spironolactone

1977
Toxicity, ultrastructural effects, and metabolic studies with 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane(o,p'-DDD) and its methyl analog in the guinea pig and rat.
    Toxicology and applied pharmacology, 1987, Volume: 87, Issue:1

    Topics: Adrenal Cortex; Alopecia; Animals; Diarrhea; Guinea Pigs; Male; Mitochondria; Mitotane; Rats; Rats,

1987