mitotane and Diarrhea
mitotane has been researched along with Diarrhea in 3 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " On the other hand, Mitometh resisted side-chain oxidative metabolism and was less toxic than Lysodren." | 1.27 | Toxicity, ultrastructural effects, and metabolic studies with 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane(o,p'-DDD) and its methyl analog in the guinea pig and rat. ( Briggs, DG; Caldwell, MW; French, LG; Jensen, BL, 1987) |
Research
Studies (3)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Carmona-Bayonas, A | 1 |
| Soler, IO | 1 |
| Gómez, FI | 1 |
| Billalabeitia, EG | 1 |
| Saura, HP | 1 |
| Tafalla, MS | 1 |
| Díaz, MP | 1 |
| Wortsman, J | 1 |
| Soler, NG | 1 |
| Jensen, BL | 1 |
| Caldwell, MW | 1 |
| French, LG | 1 |
| Briggs, DG | 1 |
Other Studies
3 other studies available for mitotane and Diarrhea
| Article | Year |
|---|---|
Tailored hormonal therapy in secretory adrenocortical cancer.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Aged; Aldosterone; Alkalosis; Ang | 2007 |
Mitotane. Spironolactone antagonism in Cushing's syndrome.
Topics: Aged; Cushing Syndrome; Diarrhea; Female; Humans; Hypokalemia; Mitotane; Nausea; Spironolactone | 1977 |
Toxicity, ultrastructural effects, and metabolic studies with 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane(o,p'-DDD) and its methyl analog in the guinea pig and rat.
Topics: Adrenal Cortex; Alopecia; Animals; Diarrhea; Guinea Pigs; Male; Mitochondria; Mitotane; Rats; Rats, | 1987 |