mitotane has been researched along with Cushing Syndrome in 172 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Cushing Syndrome: A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our objective was to assess the efficacy and safety of combination therapy with mitotane, metyrapone, and ketoconazole in severe ACTH-dependent Cushing's syndrome." | 7.77 | Mitotane, metyrapone, and ketoconazole combination therapy as an alternative to rescue adrenalectomy for severe ACTH-dependent Cushing's syndrome. ( Baudin, E; Blanchard, A; Brailly-Tabard, S; Chanson, P; Droumaguet, C; Gautier, JF; Jublanc, C; Kamenický, P; Leboulleux, S; Salenave, S; Schlumberger, M; Young, J, 2011) |
| "Mitotane proved to be an efficacious drug which in exceptional cases can be used without significant side effects in low dosage for the long-term treatment of hypothalamic-pituitary Cushing disease." | 5.30 | [The long-term therapy of hypothalamic-hypophyseal Cushing's syndrome with mitotane (o,p'-DDD)]. ( Gerl, H; Knappe, G; Rohde, W; Ventz, M, 1997) |
| "By treatment with Mitotane in a dose aiming at completely destroying the adrenal cortex, a complete disappearance of the tumor as well as a dramatic reduction of the size of the metastases could be achieved." | 5.30 | [Mitotane treatment in a dog with a recurring adrenocortical carcinoma--a case report]. ( Flückiger, M; Gardelle, O; Keiser, M; Reusch, C, 1999) |
| "Inhibitors of steroid synthesis such as o,p'-DDD, aminoglutethimide, metyrapone, trilostane and ketoconazole are usually used for treatment of Cushing's syndrome in order to reduce the steroid production in the patients showing several complications, including severe hypertension and diabetes mellitus, and also an incomplete remission after the surgical treatment." | 4.79 | [Clinical usefulness of pharmacological treatment of Cushing's syndrome]. ( Nishikawa, T; Saito, J, 1994) |
| "Our objective was to assess the efficacy and safety of combination therapy with mitotane, metyrapone, and ketoconazole in severe ACTH-dependent Cushing's syndrome." | 3.77 | Mitotane, metyrapone, and ketoconazole combination therapy as an alternative to rescue adrenalectomy for severe ACTH-dependent Cushing's syndrome. ( Baudin, E; Blanchard, A; Brailly-Tabard, S; Chanson, P; Droumaguet, C; Gautier, JF; Jublanc, C; Kamenický, P; Leboulleux, S; Salenave, S; Schlumberger, M; Young, J, 2011) |
| "Surgery with immediate adjuvant long term mitotane administration was the most effective form of therapy for patients with adrenocortical carcinoma." | 3.69 | Adrenocortical carcinoma. A clinical study and treatment results of 52 patients. ( Kasperlik-Załuska, AA; Makowska, AM; Migdalska, BM; Zgliczyński, S, 1995) |
| "Ortho,para,dichlorodiphenyl dichloroethane (o,p'DDD, Mitotane (Roussell)) is used as an adrenolytic drug to reduce adrenocortical mass and circulating cortisol levels in Cushing's syndrome but has the unwanted side-effect of inducing hypercholesterolaemia." | 3.68 | Possible mechanism and treatment of o,p'DDD-induced hypercholesterolaemia. ( Anderson, JV; Besser, GM; Maher, VM; Scoppola, A; Thompson, GR; Trainer, PJ, 1992) |
| "Mitotane (o,p'-DDD) can be used for the treatment of various adrenocortical diseases such as Cushing's syndrome, but the usual doses of 6-8 g per day are often associated with severe adverse effects." | 3.68 | Plasma level monitoring of mitotane (o,p'-DDD) and its metabolite (o,p'-DDE) during long-term treatment of Cushing's disease with low doses. ( Benecke, R; de Zeeuw, RA; Keller, E; Vetter, B, 1991) |
| "In the present study, the effects of o,p'-DDD on plasma levels of pregnenolone, 17 alpha-hydroxypregnenolone, progesterone, 17 alpha-hydroxyprogesterone, 11-deoxycorticosterone, deoxycortisol, corticosterone, cortisol, androstenedione and testosterone were studied in 6 patients with adrenal carcinoma (3 with Cushing's syndrome, 2 with adrenogenital syndrome, one without clinical manifestation) and 6 with Cushing's disease." | 3.67 | [The effects of o,p'-DDD on human adrenal steroid synthesis]. ( Fukuchi, S; Ojima, M; Saito, M, 1984) |
| "Serum from a patient with Cushing's syndrome who was being treated with mitotane contained components that interfered with determination of cholesterol in the Du Pont aca." | 3.67 | Inhibition of cholesterol oxidase in a patient with Cushing's syndrome. ( Alber, DB; Davey, DD; Hostetler, ML; Jones, JM; Moorehead, WR; Oei, TO; Ryder, KW, 1984) |
| "However, hypercortisolism may persist or recur postoperatively; in other cases, the underlying tumor may not be resectable or its location may not be known." | 2.72 | Adrenally Directed Medical Therapies for Cushing Syndrome. ( Tritos, NA, 2021) |
| "Severe hypercortisolism is characterized as a life-threatening endocrine condition in patients with Cushing syndrome, usually related to the concomitant onset of one or more comorbidities, requiring rapid normalization of cortisol concentrations and aggressive treatment of associated complications." | 2.72 | Medical therapy in severe hypercortisolism. ( Boguszewski, CL; Marques, JVO, 2021) |
| "Medical therapy to control hypercortisolism in adrenal Cushing's syndrome is currently not the first-line therapy." | 2.66 | What is the role of medical therapy in adrenal-dependent Cushing's syndrome? ( Braun, LT; Reincke, M, 2020) |
| "Cushing's syndrome is associated with serious morbidity and increased mortality." | 2.46 | Medical treatment of Cushing's syndrome: adrenal-blocking drugs and ketaconazole. ( de Herder, WW; Feelders, RA; Hofland, LJ, 2010) |
| "Cushing's syndrome is a rare but frequently considered disease." | 2.44 | [Management of hypercortisolism]. ( Bertagna, X; Fierrard, H; Raffin-Sanson, ML; Rosales, C, 2008) |
| "ACTH-dependent Cushing's syndrome is a heterogeneous disorder requiring a multidisciplinary and individualized approach to patient management." | 2.44 | Treatment of adrenocorticotropin-dependent Cushing's syndrome: a consensus statement. ( Bertagna, X; Bertherat, J; Biller, BM; Boscaro, M; Buchfelder, M; Colao, A; Grossman, AB; Hermus, AR; Hofland, LJ; Klibanski, A; Lacroix, A; Lindsay, JR; Melmed, S; Newell-Price, J; Nieman, LK; Petersenn, S; Sonino, N; Stalla, GK; Stewart, PM; Swearingen, B; Vance, ML; Wass, JA, 2008) |
| "Adrenal cortical carcinoma is a rare endocrine tumor, and complete surgical resection is the only potentially curative treatment." | 2.41 | Adrenal cortical carcinoma. ( Boushey, RP; Dackiw, AP, 2001) |
| "Treatment with metyrapone or o,p'-DDD can always induce a clinical remission but not a cure, and neurotransmitter therapy may be effective in a minority of cases." | 2.37 | Cushing's syndrome. ( Besser, GM; Howlett, TA; Rees, LH, 1985) |
| "Two patients experienced a recurrence of hypercortisolism, and one was treated with mitotane, whereas the other underwent a second adrenal surgery 9 years after initial UA." | 1.42 | Unilateral Adrenalectomy as a First-Line Treatment of Cushing's Syndrome in Patients With Primary Bilateral Macronodular Adrenal Hyperplasia. ( Benoit, M; Caron, P; Chabre, O; Chaffanjon, P; Debillon, E; Lambert, B; Massoutier, M; Salenave, S; Tabarin, A; Velayoudom-Cephise, FL; Wagner, T; Young, J, 2015) |
| "Overt hypercortisolism was observed in 197 patients (37." | 1.40 | Prognostic role of overt hypercortisolism in completely operated patients with adrenocortical cancer. ( Allolio, B; Ardito, A; Baudin, E; Berruti, A; Deutschbein, T; Else, T; Fassnacht, M; Feelders, R; Gelderblom, H; Grisanti, S; Haak, H; Hammer, GD; Kerkhofs, T; Kroiss, M; Leboulleux, S; Papotti, M; Porpiglia, F; Ronchi, C; Sperone, P; Terzolo, M; Volante, M; Williams, AR, 2014) |
| "We report the first case of adrenocortical carcinoma secreting cortisol (Cushing's syndrome) and aldosterone (Conn's syndrome) with extensive distant metastasis at the time of diagnosis." | 1.37 | Metastatic adrenocortical carcinoma presenting simultaneously with Cushing's and Conn's syndromes: a case report. ( Bang, SM; Beom, SH; Choi, Y; Chung, JH; Kim, JH; Kim, YJ; Lee, JS; Lee, KW; Song, KH; Yang, Y, 2011) |
| "Cushing syndrome was diagnosed on the basis of a markedly elevated 24-hour urine free cortisol level and classic cushingoid features." | 1.35 | A patient with ectopic cortisol production derived from malignant testicular masses. ( Dluhy, RG; Jain, SH; Nosé, V; Sadow, PM, 2008) |
| "Mitotane proved to be an efficacious drug which in exceptional cases can be used without significant side effects in low dosage for the long-term treatment of hypothalamic-pituitary Cushing disease." | 1.30 | [The long-term therapy of hypothalamic-hypophyseal Cushing's syndrome with mitotane (o,p'-DDD)]. ( Gerl, H; Knappe, G; Rohde, W; Ventz, M, 1997) |
| "Cushing's syndrome was diagnosed and treatment with Lysodren was started." | 1.30 | [Case presentation in small animal medicine]. ( Gfeller, G; Reusch, C, 1998) |
| "By treatment with Mitotane in a dose aiming at completely destroying the adrenal cortex, a complete disappearance of the tumor as well as a dramatic reduction of the size of the metastases could be achieved." | 1.30 | [Mitotane treatment in a dog with a recurring adrenocortical carcinoma--a case report]. ( Flückiger, M; Gardelle, O; Keiser, M; Reusch, C, 1999) |
| "Six to 10 months after hypercorticism was cured with ketoconazole and bilateral adrenalectomy, a thymic mass 2 to 5 cm in length was detected by computerized tomography or magnetic resonance imaging in all 3 patients." | 1.29 | [Paraneoplastic Cushing's syndrome. Pseudotumors of the thymus occurring after correction of hypercorticism. 3 cases]. ( Caillé, JM; Catargi, B; Drouillard, J; Greselle, JF; Laurent, F; Martigne, C; Roger, P; Tabarin, A, 1993) |
| "61 Lysodren -treated dogs with hyperadrenocorticism are compared with 36 untreated dogs with the same disease." | 1.28 | [Formal pathogenesis, average age and breed distribution in the comparison of 61 Lysodren-treated and 36 untreated cases of canine hyperadrenocorticism which were dissected in the years 1975 to 1991 at the Institute for Veterinary Pathology of the Free Un ( Nothelfer, HB; Weinhold, K, 1992) |
| "Mitotane therapy was ineffective at controlling tumor growth." | 1.28 | Recurrent or metastatic disease in select patients with adrenocortical carcinoma. Aggressive resection vs chemotherapy. ( Jensen, JC; Norton, JA; Pass, HI; Sindelar, WF, 1991) |
| "However, in adrenal cancer, urinary 17OHCS did not correlate with either plasma cortisol or urinary free cortisol, while the latter two parameters did." | 1.27 | Effect of o,p'-DDD on cortisol metabolism in Cushing's syndrome of various etiology. ( Inoue, S; Kawai, K; Koide, Y; Murayama, H; Yamashita, K, 1985) |
| " By lowering the dosage of o,p'-DDD and supplementing with glucocorticoids during the o,p'-DDD loading period, serious hypoglycemia was avoided." | 1.26 | Diagnosis and management of concurrent diabetes mellitus and hyperadrenocorticism in thirty dogs. ( Nesbitt, GH; Peterson, ME; Schaer, M, 1981) |
| "Virilism is the major manifestation in children (83 percent of the cases), either isolated or associated with hypercortisolism and/or feminization." | 1.25 | [Corticosuprarenaloma in children]. ( Benaily, M; Job, JC; Schweisguth, O, 1975) |
| "Amelioration of the hypercortisolism occurred after removal of the bronchial adenoma." | 1.25 | Cushing's syndrome associated with a bronchial adenoma. Possible periodic hormonogenesis. ( Bruderman, I; Griffel, WB; Gutman, A; Myers, B; Shapiro, MS, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 109 (63.37) | 18.7374 |
| 1990's | 30 (17.44) | 18.2507 |
| 2000's | 14 (8.14) | 29.6817 |
| 2010's | 13 (7.56) | 24.3611 |
| 2020's | 6 (3.49) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, X | 1 |
| Zhang, S | 1 |
| Guo, Y | 1 |
| Gang, X | 1 |
| Wang, G | 1 |
| Golinelli, S | 1 |
| Fracassi, F | 1 |
| Bianchi, E | 1 |
| Pöppl, ÁG | 1 |
| Miceli, DD | 1 |
| Benedicenti, L | 1 |
| De Marco, V | 1 |
| Cook, AK | 1 |
| Espada Castro, L | 1 |
| Ramsey, I | 1 |
| Seo, KW | 1 |
| Cantile, C | 1 |
| Gandini, G | 1 |
| Hulsebosch, SE | 1 |
| Feldman, EC | 1 |
| Braun, LT | 1 |
| Reincke, M | 1 |
| Salle, L | 1 |
| Mas, R | 1 |
| Teissier-Clément, MP | 1 |
| Tritos, NA | 2 |
| Marques, JVO | 1 |
| Boguszewski, CL | 1 |
| Claps, M | 1 |
| Cerri, S | 1 |
| Grisanti, S | 2 |
| Lazzari, B | 1 |
| Ferrari, V | 1 |
| Roca, E | 1 |
| Perotti, P | 1 |
| Terzolo, M | 2 |
| Sigala, S | 1 |
| Berruti, A | 2 |
| Broersen, LHA | 1 |
| Jha, M | 1 |
| Biermasz, NR | 1 |
| Pereira, AM | 2 |
| Dekkers, OM | 1 |
| Fassnacht, M | 1 |
| Haak, H | 1 |
| Else, T | 1 |
| Baudin, E | 2 |
| Sperone, P | 1 |
| Kroiss, M | 1 |
| Kerkhofs, T | 1 |
| Williams, AR | 1 |
| Ardito, A | 1 |
| Leboulleux, S | 2 |
| Volante, M | 1 |
| Deutschbein, T | 1 |
| Feelders, R | 1 |
| Ronchi, C | 1 |
| Gelderblom, H | 1 |
| Porpiglia, F | 1 |
| Papotti, M | 1 |
| Hammer, GD | 2 |
| Allolio, B | 1 |
| Daniel, E | 1 |
| Newell-Price, JD | 1 |
| Debillon, E | 1 |
| Velayoudom-Cephise, FL | 1 |
| Salenave, S | 2 |
| Caron, P | 1 |
| Chaffanjon, P | 1 |
| Wagner, T | 1 |
| Massoutier, M | 1 |
| Lambert, B | 1 |
| Benoit, M | 1 |
| Young, J | 2 |
| Tabarin, A | 2 |
| Chabre, O | 1 |
| Sedhom, R | 1 |
| Hu, S | 1 |
| Ohri, A | 1 |
| Infantino, D | 1 |
| Lubitz, S | 1 |
| Jain, SH | 1 |
| Sadow, PM | 1 |
| Nosé, V | 1 |
| Dluhy, RG | 2 |
| Leal-Cerro, A | 1 |
| Soto Moreno, A | 1 |
| Mangas, MA | 1 |
| León Justel, A | 1 |
| Webb, S | 1 |
| Strosberg, JR | 1 |
| Doherty, GM | 1 |
| Donadille, B | 1 |
| Groussin, L | 1 |
| Waintrop, C | 1 |
| Abbas, H | 1 |
| Tenenbaum, F | 1 |
| Dugué, MA | 1 |
| Coste, J | 1 |
| Bertagna, X | 3 |
| Bertherat, J | 2 |
| Greenman, Y | 1 |
| Feelders, RA | 1 |
| Hofland, LJ | 2 |
| de Herder, WW | 1 |
| Kamenický, P | 1 |
| Droumaguet, C | 1 |
| Blanchard, A | 1 |
| Jublanc, C | 1 |
| Gautier, JF | 1 |
| Brailly-Tabard, S | 1 |
| Schlumberger, M | 1 |
| Chanson, P | 1 |
| Beom, SH | 1 |
| Lee, KW | 1 |
| Yang, Y | 1 |
| Choi, Y | 1 |
| Song, KH | 1 |
| Kim, YJ | 1 |
| Kim, JH | 1 |
| Bang, SM | 1 |
| Chung, JH | 1 |
| Lee, JS | 1 |
| Biller, BM | 2 |
| Hubertus, J | 1 |
| Boxberger, N | 1 |
| Redlich, A | 1 |
| von Schweinitz, D | 1 |
| Vorwerk, P | 1 |
| BLEDSOE, T | 1 |
| ISLAND, DP | 1 |
| NEY, RL | 1 |
| LIDDLE, GW | 1 |
| MONTGOMERY, DA | 1 |
| WELBOURN, RB | 2 |
| Ramé, A | 1 |
| Dang, CN | 1 |
| Trainer, P | 1 |
| Rosales, C | 1 |
| Fierrard, H | 1 |
| Raffin-Sanson, ML | 1 |
| Chamuleau, SA | 1 |
| Corssmit, EP | 1 |
| van de Berg, BT | 1 |
| Siegert, CE | 1 |
| Grossman, AB | 1 |
| Stewart, PM | 1 |
| Melmed, S | 1 |
| Buchfelder, M | 1 |
| Colao, A | 1 |
| Hermus, AR | 1 |
| Klibanski, A | 1 |
| Lacroix, A | 1 |
| Lindsay, JR | 1 |
| Newell-Price, J | 1 |
| Nieman, LK | 1 |
| Petersenn, S | 1 |
| Sonino, N | 1 |
| Stalla, GK | 1 |
| Swearingen, B | 1 |
| Vance, ML | 1 |
| Wass, JA | 1 |
| Boscaro, M | 2 |
| Peterson, ME | 5 |
| Ojima, M | 2 |
| Saito, M | 1 |
| Fukuchi, S | 2 |
| Slavnov, VN | 12 |
| Valueva, GV | 2 |
| Luchitskiĭ, EV | 9 |
| Jacobelli, A | 1 |
| Agostino, A | 1 |
| Altomonte, G | 1 |
| Komissarenko, IV | 11 |
| Markov, VV | 2 |
| Cheban, AK | 9 |
| Perigli, G | 1 |
| Borrelli, D | 1 |
| Salvatore, S | 1 |
| Cicchi, P | 1 |
| Burci, P | 1 |
| Dal Bo Zanon, R | 1 |
| Fornasiero, L | 1 |
| Ruffato, G | 1 |
| Luzzato, G | 1 |
| Fabris, F | 1 |
| Girolami, A | 1 |
| Schteingart, DE | 3 |
| Tsao, HS | 1 |
| Taylor, CI | 1 |
| McKenzie, A | 1 |
| Victoria, R | 1 |
| Therrien, BA | 1 |
| Takamatsu, J | 1 |
| Kitazawa, A | 1 |
| Nakata, K | 1 |
| Furukawa, K | 1 |
| Nakai, Y | 1 |
| Rybakov, SI | 3 |
| Pomerantsev, IuV | 1 |
| Slavnov, VI | 1 |
| Aron, DC | 1 |
| Findling, JW | 1 |
| Fitzgerald, PA | 1 |
| Forsham, PH | 1 |
| Wilson, CB | 1 |
| Tyrrell, JB | 1 |
| Bergstrand, CG | 1 |
| Nilsson, KO | 1 |
| Kaufman, J | 1 |
| Appelqvist, P | 1 |
| Kostianinen, S | 1 |
| Davey, DD | 1 |
| Alber, DB | 1 |
| Ryder, KW | 1 |
| Jones, JM | 1 |
| Hostetler, ML | 1 |
| Moorehead, WR | 1 |
| Oei, TO | 1 |
| Opitz, M | 2 |
| Lettow, E | 2 |
| Loppnow, H | 2 |
| Grevel, V | 2 |
| Eremenko, NI | 1 |
| Nesbitt, GH | 1 |
| Schaer, M | 1 |
| Iakovlev, AA | 1 |
| Krieger, DT | 1 |
| Willard, MD | 1 |
| Schall, WD | 1 |
| Nachreiner, RF | 2 |
| Shelton, DG | 1 |
| Gordienko, VM | 1 |
| Grid'ko, AN | 1 |
| Kinouchi, T | 1 |
| Shimizu, N | 1 |
| Ibayashi, H | 1 |
| Demura, H | 1 |
| Oshima, H | 1 |
| Mikhaĭlenko, TI | 1 |
| Kaneko, K | 1 |
| Saito, T | 1 |
| Fujioka, T | 1 |
| Sugita, Y | 1 |
| Takai, K | 1 |
| Kasperlik-Załuska, A | 2 |
| Migdalska, B | 2 |
| Tattersall, MH | 1 |
| Lander, H | 1 |
| Bain, B | 1 |
| Stocks, AE | 1 |
| Woods, RL | 1 |
| Fox, RM | 1 |
| Byrne, E | 1 |
| Trotten, JR | 1 |
| Roos, I | 1 |
| Tenschert, W | 1 |
| Vetter, H | 1 |
| Siegenthaler, W | 1 |
| Vetter, W | 1 |
| Bricaire, H | 7 |
| Luton, JP | 10 |
| Keller, E | 2 |
| Willgerodt, H | 1 |
| Teichmann, B | 1 |
| Hoepffner, W | 1 |
| Nakagawa, K | 1 |
| Ito, S | 1 |
| Ohara, T | 1 |
| Kubo, M | 1 |
| Horikawa, H | 1 |
| Moolenaar, AJ | 2 |
| van Slooten, H | 1 |
| van Seters, AP | 1 |
| Smeenk, D | 1 |
| Colliard, M | 1 |
| Duprey, J | 1 |
| Lepine, B | 1 |
| Tcherdakoff, P | 1 |
| Bennett, BD | 1 |
| McKenna, TJ | 1 |
| Hough, AJ | 1 |
| Dean, R | 1 |
| Page, DL | 1 |
| Charbonnel, B | 2 |
| Guillon, J | 2 |
| Chupin, M | 1 |
| Simonin, R | 1 |
| Heim, M | 1 |
| Grisoli, F | 1 |
| Brindisi, G | 1 |
| Favia, G | 1 |
| Lumachi, F | 1 |
| Carraro, P | 1 |
| D'Amico, DF | 1 |
| Miller, JW | 1 |
| Crapo, L | 1 |
| Freeman, DA | 2 |
| Solomon, CG | 1 |
| Kasperlik-Załuska, AA | 1 |
| Migdalska, BM | 1 |
| Zgliczyński, S | 1 |
| Makowska, AM | 1 |
| Kintzer, PP | 1 |
| Nichols, R | 2 |
| Myers, NC | 1 |
| Bruyette, DS | 1 |
| Engelhardt, D | 1 |
| Catargi, B | 1 |
| Laurent, F | 1 |
| Greselle, JF | 1 |
| Martigne, C | 1 |
| Caillé, JM | 1 |
| Drouillard, J | 1 |
| Roger, P | 1 |
| Saito, J | 1 |
| Nishikawa, T | 1 |
| Raux-Demay, MC | 1 |
| Girard, F | 1 |
| Gingerich, DA | 1 |
| Mathivon, L | 1 |
| Carel, JC | 1 |
| Coutant, R | 1 |
| Derome, P | 1 |
| Adamsbaum, C | 1 |
| Bougnères, P | 1 |
| Chaussain, JL | 1 |
| Knappe, G | 1 |
| Gerl, H | 1 |
| Ventz, M | 1 |
| Rohde, W | 1 |
| Gfeller, G | 1 |
| Reusch, C | 4 |
| den Hertog, E | 1 |
| Braakman, JC | 1 |
| Teske, E | 1 |
| Kooistra, HS | 1 |
| Rijnberk, A | 1 |
| Hörauf, A | 1 |
| Keiser, M | 1 |
| Flückiger, M | 1 |
| Gardelle, O | 1 |
| Kawai, S | 1 |
| Ichikawa, Y | 1 |
| Kaburaki, J | 1 |
| Yoshida, T | 1 |
| Trainer, PJ | 2 |
| Besser, M | 1 |
| Kasperlik-Zaluska, AA | 2 |
| Andrès, E | 1 |
| Vinzio, S | 1 |
| Goichot, B | 1 |
| Schlienger, JL | 1 |
| Magiakou, MA | 1 |
| Chrousos, GP | 1 |
| Boushey, RP | 1 |
| Dackiw, AP | 1 |
| Besser, GM | 3 |
| Jeffcoate, WJ | 1 |
| Reach, G | 1 |
| Elkik, F | 1 |
| Parry, C | 1 |
| Corvol, P | 1 |
| Milleiz, P | 1 |
| Benaily, M | 1 |
| Schweisguth, O | 1 |
| Job, JC | 2 |
| Kishi, DT | 1 |
| Ghnassia, JP | 1 |
| Thieblot, P | 2 |
| Valcke, JC | 1 |
| Mahoudeau, JA | 2 |
| Owens, JM | 1 |
| Drucker, WD | 1 |
| Bouchard, P | 1 |
| Hautecouverture, M | 1 |
| Simon, D | 1 |
| Laudat, MH | 1 |
| Touitou, Y | 3 |
| Kelly, WF | 1 |
| Barnes, AJ | 1 |
| Cassar, J | 1 |
| White, M | 1 |
| Mashiter, K | 1 |
| Loizou, S | 1 |
| Joplin, GF | 1 |
| Prinz, RA | 2 |
| Brooks, MH | 2 |
| Lawrence, AM | 2 |
| Paloyan, E | 2 |
| Dickerman, Z | 1 |
| Kaufman, H | 1 |
| Laron, Z | 1 |
| Cooper, PR | 1 |
| Shucart, WA | 1 |
| Vasiukova, EA | 3 |
| Granovskaia, AM | 2 |
| Pisarskaia, IV | 2 |
| Ryzhikov, VD | 2 |
| Ling, GV | 1 |
| Lowenstine, LJ | 1 |
| Pulley, LT | 1 |
| Kaneko, JJ | 1 |
| Lucickij, EV | 1 |
| Wortsman, J | 1 |
| Soler, NG | 1 |
| Senior, B | 1 |
| Bigler, U | 1 |
| Müller, J | 1 |
| deAsis, DN | 1 |
| Samaan, NA | 1 |
| Nash, AS | 1 |
| Bogan, JA | 1 |
| Kommisarenko, IV | 1 |
| Bogdan, A | 2 |
| Kelly, DF | 1 |
| Darke, PG | 1 |
| Leutenegger, M | 1 |
| Caron, J | 1 |
| Couchot, J | 1 |
| Gross, A | 1 |
| Maes, B | 1 |
| Enger, A | 1 |
| Millart, H | 1 |
| Lavelle, RB | 1 |
| Butez, J | 1 |
| Bonnin, A | 1 |
| Pallardy, G | 1 |
| Ledoux-Lebard, G | 1 |
| Schrub, JC | 1 |
| Courtois, H | 1 |
| Scott, RD | 1 |
| Shapiro, MS | 1 |
| Gutman, A | 1 |
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| Myers, B | 1 |
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| Gilboa, Y | 1 |
| Ametov, AS | 1 |
| Nothelfer, HB | 1 |
| Weinhold, K | 1 |
| Maher, VM | 1 |
| Scoppola, A | 1 |
| Anderson, JV | 1 |
| Thompson, GR | 1 |
| Hähnle, B | 1 |
| Bieluńska, S | 1 |
| Jensen, JC | 1 |
| Pass, HI | 1 |
| Sindelar, WF | 1 |
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| Benecke, R | 2 |
| Vetter, B | 2 |
| de Zeeuw, RA | 2 |
| Schwartz, RW | 1 |
| Sloan, DA | 1 |
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| De Coster, PM | 1 |
| De Plaen, JF | 1 |
| Ketelslegers, JM | 1 |
| Buysschaert, M | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Activity of Abiraterone Acetate in the Management of Cushing's Syndrome in Patients With Adrenocortical Carcinoma[NCT03145285] | Phase 2 | 10 participants (Anticipated) | Interventional | 2017-04-18 | Active, not recruiting | ||
| Metabolic, Pressor and Neuropsychological Effects of Metyrapone Treatment in Patients With Hypercortisolism[NCT05255900] | 20 participants (Anticipated) | Observational | 2022-04-28 | Recruiting | |||
| Treatment of Pituitary Cushing Disease With a Selective CDK Inhibitor, R-roscovitine[NCT02160730] | Phase 2 | 4 participants (Actual) | Interventional | 2014-05-31 | Terminated (stopped due to NIH grant ended.) | ||
| An Open-label Study of the Efficacy and Safety of CORLUX (Mifepristone) in the Treatment of the Signs and Symptoms of Endogenous Cushing's Syndrome[NCT00569582] | Phase 3 | 50 participants (Actual) | Interventional | 2007-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The number of participants that achieved a urinary free cortisol level above the upper limit of the normal range but reduced by ≥50% from baseline at week 4. (NCT02160730)
Timeframe: Baseline, Week 4
| Intervention | Participants (Count of Participants) |
|---|---|
| R-roscovitine | 2 |
A visible change in tumor size as determined by the investigator after reviewing MRI reports between baseline and 4 weeks of treatment. (NCT02160730)
Timeframe: Baseline, 4 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| R-roscovitine | 0 |
"To evaluate the efficacy of R-roscovitine 400 mg oral administration twice daily for 4 days every week for total of 4 weeks on normalizing 24 hour urinary free cortisol (24 h UFC) levels in CD patients. Normalizing is defined as having urine free cortisol levels within the normal range for that lab value." (NCT02160730)
Timeframe: Baseline, 4 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| R-roscovitine | 0 |
The number of participants that experience an adverse event between baseline and study end likely related to study drug as a measure of safety and tolerability. (NCT02160730)
Timeframe: Baseline, 4 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| R-roscovitine | 2 |
Change in typical Cushing's syndrome clinical signs and symptoms defined by mean weight at baseline and 4 weeks. (NCT02160730)
Timeframe: Baseline, 4 weeks
| Intervention | lbs (Mean) | |
|---|---|---|
| Baseline | 4 Weeks | |
| R-roscovitine | 217 | 217.4 |
Mean diastolic blood pressure between baseline and 4 weeks. (NCT02160730)
Timeframe: Baseline, 4 weeks
| Intervention | mmHg (Mean) | |
|---|---|---|
| Baseline | 4 Weeks | |
| R-roscovitine | 76.5 | 71 |
HbA1c levels are measured at baseline and at study end, these are averaged across all subjects. (NCT02160730)
Timeframe: Baseline, 4 Weeks
| Intervention | Percentage (Mean) | |
|---|---|---|
| Baseline | Study End-4 weeks | |
| R-roscovitine | 6.9 | 7 |
Mean change in systolic blood pressure between baseline and 4 weeks. (NCT02160730)
Timeframe: Baseline, 4 weeks
| Intervention | mmHg (Mean) | |
|---|---|---|
| Baseline | 4 weeks | |
| R-roscovitine | 150.3 | 128.3 |
Mean serum cortisol values at baseline and 4 weeks (NCT02160730)
Timeframe: Baseline, 4 weeks
| Intervention | mg/dL (Mean) | |
|---|---|---|
| Baseline | 4 Weeks | |
| R-roscovitine | 25.6 | 27.1 |
Mean change between baseline and week 4 of fasting blood glucose levels. (NCT02160730)
Timeframe: Baseline, 4 Weeks
| Intervention | g/dL (Mean) | |
|---|---|---|
| Baseline | 4 weeks | |
| R-roscovitine | 121.4 | 104.3 |
Mean change in Plasma ACTH between baseline and 4 weeks. (NCT02160730)
Timeframe: Baseline, 4 weeks
| Intervention | pg/mL (Mean) | |
|---|---|---|
| Baseline | 4 weeks | |
| R-roscovitine | 79.3 | 79.9 |
Responder is defined as subject with a decrease greater than or equal to 5mm Hg in diastolic blood pressure from baseline to week 24 or last visit. (NCT00569582)
Timeframe: Baseline to Week 24
| Intervention | participants (Number) |
|---|---|
| Mifepristone | 8 |
Responder is defined as subject with a decrease greater than or equal to 25% in area under the curve for glucose on 2-hour oral glucose test from baseline to week 24 or last visit, for Cushing's patients with type-2 diabetes mellitus/impaired glucose tolerance. (NCT00569582)
Timeframe: Baseline to Week 24
| Intervention | participants (Number) |
|---|---|
| Mifepristone | 15 |
37 reviews available for mitotane and Cushing Syndrome
| Article | Year |
|---|---|
Treatment of Primary Pigmented Nodular Adrenocortical Disease.
Topics: Adrenal Cortex Diseases; Adrenalectomy; Adrenocorticotropic Hormone; Child; Cushing Syndrome; Humans | 2022 |
What is the role of medical therapy in adrenal-dependent Cushing's syndrome?
Topics: Adrenal Gland Diseases; Cushing Syndrome; Humans; Ketoconazole; Metyrapone; Mitotane; Pituitary ACTH | 2020 |
Adrenally Directed Medical Therapies for Cushing Syndrome.
Topics: Adrenal Glands; Cushing Syndrome; Etomidate; Humans; Imidazoles; Ketoconazole; Metyrapone; Mitotane; | 2021 |
Medical therapy in severe hypercortisolism.
Topics: Cabergoline; Cushing Syndrome; Humans; Ketoconazole; Metyrapone; Mitotane | 2021 |
Effectiveness of medical treatment for Cushing's syndrome: a systematic review and meta-analysis.
Topics: Cabergoline; Cushing Syndrome; Dopamine Agonists; Humans; Hydrocortisone; Mitotane; Treatment Outcom | 2018 |
Therapy of endocrine disease: steroidogenesis enzyme inhibitors in Cushing's syndrome.
Topics: Cushing Syndrome; Etomidate; Humans; Imidazoles; Ketoconazole; Metyrapone; Mitotane; Pyridines; Ster | 2015 |
[The medical management of Cushing's syndrome].
Topics: Adrenal Cortex; Adrenalectomy; Adrenocorticotropic Hormone; Aminoglutethimide; Combined Modality The | 2009 |
Management of dyslipidemia in Cushing's syndrome.
Topics: Cushing Syndrome; Dyslipidemias; Enzyme Inhibitors; Humans; Ketoconazole; Mitotane | 2010 |
Medical treatment of Cushing's syndrome: adrenal-blocking drugs and ketaconazole.
Topics: Cushing Syndrome; Enzyme Inhibitors; Etomidate; Humans; Ketoconazole; Metyrapone; Mitotane | 2010 |
Advances in medical therapies for Cushing's syndrome.
Topics: Animals; Bexarotene; Cushing Syndrome; Etomidate; Humans; Ketoconazole; Lapatinib; Metyrapone; Mifep | 2012 |
[Management of hypercortisolism].
Topics: Antineoplastic Agents, Hormonal; Cushing Syndrome; Decision Trees; Enzyme Inhibitors; Humans; Hypoph | 2008 |
Treatment of adrenocorticotropin-dependent Cushing's syndrome: a consensus statement.
Topics: ACTH Syndrome, Ectopic; Adrenal Insufficiency; Adrenalectomy; Adrenocorticotropic Hormone; Cushing S | 2008 |
Hyperadrenocorticism.
Topics: Adrenal Cortex Function Tests; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Animals; Cushi | 1984 |
Cushing's syndrome: problems in management.
Topics: ACTH Syndrome, Ectopic; Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone | 1982 |
Treatment of Cushing's disease in children.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Aminoglutethimide; Bromocriptine; Child; Cushing Syndrom | 1982 |
Diseases of the adrenal cortex of dogs and cats.
Topics: Adrenocorticotropic Hormone; Animals; Cat Diseases; Cats; Cushing Syndrome; Dexamethasone; Disease S | 1984 |
Multiple thoracotomy combined with chemotherapy in metastatic adrenal cortical carcinoma: a case report and review of the literature.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Carcinoma; Cortisone; Cushing Syndrom | 1983 |
Pathophysiology and treatment of Cushing's disease.
Topics: Adrenal Glands; Adrenalectomy; Aminoglutethimide; Cushing Syndrome; Delayed-Action Preparations; Hum | 1982 |
Adrenocortical carcinoma. Our experience.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Aged; Antineoplastic Combined Chemothera | 1995 |
The medical treatment of Cushing's syndrome.
Topics: Adrenal Cortex Neoplasms; Adrenal Glands; Aminoglutethimide; Animals; Bromocriptine; Cushing Syndrom | 1993 |
Medical treatment of pituitary-dependent hyperadrenocorticism in dogs.
Topics: Animals; Bromocriptine; Cushing Syndrome; Cyproheptadine; Dog Diseases; Dogs; Drug Administration Sc | 1994 |
Concurrent illness and complications associated with canine hyperadrenocorticism.
Topics: Acute Disease; Animals; Cushing Syndrome; Diabetes Complications; Diabetes Mellitus; Dog Diseases; D | 1994 |
Feline adrenocortical diseases: Part I--Hyperadrenocorticism.
Topics: Adrenocorticotropic Hormone; Animals; Cat Diseases; Cats; Cushing Syndrome; Dexamethasone; Diagnosis | 1994 |
Steroid biosynthesis inhibitors in Cushing's syndrome.
Topics: Adrenal Cortex Hormones; Aminoglutethimide; Cushing Syndrome; Dihydrotestosterone; Etomidate; Humans | 1994 |
[Clinical usefulness of pharmacological treatment of Cushing's syndrome].
Topics: Administration, Oral; Aminoglutethimide; Cushing Syndrome; Dihydrotestosterone; Humans; Ketoconazole | 1994 |
[Cushing syndrome in children].
Topics: Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hor | 1993 |
Medical treatment of canine pituitary-dependent hyperadrenocorticism (Cushing's disease).
Topics: Animals; Antifungal Agents; Cushing Syndrome; Dog Diseases; Dogs; Dose-Response Relationship, Drug; | 2001 |
Cushing's syndrome in children and adolescents: current diagnostic and therapeutic strategies.
Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Antineopla | 2002 |
Adrenal cortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Algorithms; Antineoplastic Agents; Carcinoma; Chemot | 2001 |
Current therapeutic concepts--Cushing's syndrome.
Topics: Adenoma; Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Aminoglutethimide; Ci | 1975 |
Hyperadrenocorticism in the dog: canine Cushing's syndrome.
Topics: 17-Hydroxycorticosteroids; Adenoma; Adrenal Cortex Function Tests; Adrenal Gland Neoplasms; Adrenal | 1977 |
Cushing's syndrome in the dog.
Topics: 17-Hydroxycorticosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Animals; Calcinosis; Cu | 1976 |
Diagnosis and treatment of primary adrenal tumors.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Carcinoma; Cushing Syndrome; Diagnosis | 1991 |
Problems associated with medical therapy of canine hyperadrenocorticism.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Hyperfunction; Animals; Cushing Syndrome; Diabetes Mellitus | 1990 |
Cushing's syndrome.
Topics: Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Alcoho | 1985 |
Steroid hormone-producing tumors in man.
Topics: 17-Ketosteroids; Adenoma; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Adult; Androgens; C | 1986 |
[Agents inhibiting steroid biosynthesis--aminoglutethimide and o,p'-DDD].
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aminogl | 1974 |
1 trial available for mitotane and Cushing Syndrome
| Article | Year |
|---|---|
Results of non-selective adrenocorticolysis by o,p'-DDD in 129 dogs with pituitary-dependent hyperadrenocorticism.
Topics: Adrenal Glands; Animals; Anorexia; Antineoplastic Agents, Hormonal; Body Weight; Cushing Syndrome; D | 1999 |
134 other studies available for mitotane and Cushing Syndrome
| Article | Year |
|---|---|
Clinical features of muscle stiffness in 37 dogs with concurrent naturally occurring hypercortisolism.
Topics: Animals; Cushing Syndrome; Dog Diseases; Dogs; Mitotane; Muscles; Pituitary ACTH Hypersecretion | 2023 |
Ectopic adrenocortical carcinoma of the ovary: An unexpected outcome.
Topics: ACTH Syndrome, Ectopic; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Antineoplastic Ag | 2020 |
Adding metyrapone to chemotherapy plus mitotane for Cushing's syndrome due to advanced adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Antimetabolites, Antineoplastic; An | 2018 |
Prognostic role of overt hypercortisolism in completely operated patients with adrenocortical cancer.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Antineoplastic Agents, | 2014 |
Unilateral Adrenalectomy as a First-Line Treatment of Cushing's Syndrome in Patients With Primary Bilateral Macronodular Adrenal Hyperplasia.
Topics: Adrenal Hyperplasia, Congenital; Adrenal Insufficiency; Adrenalectomy; Adrenocorticotropic Hormone; | 2015 |
Symptomatic Cushing's syndrome and hyperandrogenemia in a steroid cell ovarian neoplasm: a case report.
Topics: Aged; Antineoplastic Agents, Hormonal; Cushing Syndrome; Disease Progression; Fatal Outcome; Female; | 2016 |
A patient with ectopic cortisol production derived from malignant testicular masses.
Topics: Adrenal Rest Tumor; Adrenocortical Carcinoma; Adrenocorticotropic Hormone; Aged; Cushing Syndrome; H | 2008 |
Management of adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; Catecholamines; | 2009 |
Management of Cushing's syndrome due to ectopic adrenocorticotropin secretion with 1,ortho-1, para'-dichloro-diphenyl-dichloro-ethane: findings in 23 patients from a single center.
Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Adult; Aged; Aged, 80 and over; Cushing Syndrom | 2010 |
Mitotane, metyrapone, and ketoconazole combination therapy as an alternative to rescue adrenalectomy for severe ACTH-dependent Cushing's syndrome.
Topics: Adolescent; Adult; Aged; Antimetabolites; Antineoplastic Agents; Cushing Syndrome; Drug Therapy, Com | 2011 |
Metastatic adrenocortical carcinoma presenting simultaneously with Cushing's and Conn's syndromes: a case report.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Aged; Antineoplastic Combined Chemotherapy Proto | 2011 |
Surgical aspects in the treatment of adrenocortical carcinomas in children: data of the GPOH-MET 97 trial.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adrenalectomy; Antineoplastic Agents, Hormonal; Chemotherapy, | 2012 |
AN EFFECT OF O,P'-DDD ON THE EXTRA-ADRENAL METABOLISM OF CORTISOL IN MAN.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adrenal Insufficiency; Adrenalectomy; A | 1964 |
ADRENOCORTICAL CARCINOMA TREATED WITH O,P' -DDD.
Topics: Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents; Child; Cushing Syndrome; D | 1965 |
[Cushing syndrome].
Topics: Adrenalectomy; Causality; Cushing Syndrome; Humans; Hydrocortisone; Ketoconazole; Magnetic Resonance | 2007 |
Pharmacological management of Cushing's syndrome: an update.
Topics: Cushing Syndrome; Dopamine Antagonists; Hormone Antagonists; Humans; Hypothalamo-Hypophyseal System; | 2007 |
A young woman with a severe bilateral pneumonia as the presenting sign of an adrenal carcinoma.
Topics: Adrenal Gland Neoplasms; Adult; Antineoplastic Agents, Hormonal; Carcinoma; Cushing Syndrome; Female | 2008 |
[The effects of o,p'-DDD on human adrenal steroid synthesis].
Topics: 17-alpha-Hydroxypregnenolone; Adolescent; Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Adrenoc | 1984 |
[Dynamics of beta-lipotropin and beta-endorphin levels in Itsenko-Cushing disease patients being treated with the antiserotonin preparation cyproheptadine (peritol) and chloditan].
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; beta-Endorphin; beta-Lipotropin; Cushing Syndrome; C | 1984 |
[Treatment of glycoactive hypercorticism].
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; A | 1984 |
[Hypothalamo-pituitary-adrenal cortex system and the glucocorticoid kinetics in Cushing's syndrome treated with chlodithane and large doses of reserpine].
Topics: Adolescent; Adrenal Cortex; Adrenergic beta-Antagonists; Adrenocorticotropic Hormone; Adult; Cushing | 1980 |
[Associated role of surgery and antimitotic o, p'-DDD treatment in hyperfunctioning adrenal cancers with diffuse metastases].
Topics: Adolescent; Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Hyperfunction; Cushing Syndrome; | 1981 |
Clotting changes in Cushing's syndrome: elevated factor VIII activity.
Topics: Adrenalectomy; Blood Coagulation; Blood Coagulation Tests; Cushing Syndrome; Factor VIII; Female; Hu | 1983 |
Sustained remission of Cushing's disease with mitotane and pituitary irradiation.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Cobalt Radioisotopes; Cushing Syndrome; Dehydroepiandro | 1980 |
Does mitotane reduce endogenous ACTH secretion?
Topics: Adrenocorticotropic Hormone; Aged; Cushing Syndrome; Female; Humans; Mitotane | 1981 |
[Use of cyproheptadine (Peritol) as a drug blocking corticotropin secretion in the treatment of Cushing's syndrome].
Topics: Adrenocorticotropic Hormone; Cushing Syndrome; Cyproheptadine; Depression, Chemical; Drug Therapy, C | 1981 |
o,p'-DDD (mitotane) treatment of canine pituitary-dependent hyperadrenocorticism.
Topics: Adrenocorticotropic Hormone; Animals; Cortisone; Cushing Syndrome; Diabetes Complications; Diabetes | 1983 |
[Function of the hypophysis in patients with Itsenko-Cushing disease treated with peritol and chloditan].
Topics: Adolescent; Adult; Cushing Syndrome; Cyproheptadine; Female; Humans; Male; Middle Aged; Mitotane; Pi | 1983 |
Inhibition of cholesterol oxidase in a patient with Cushing's syndrome.
Topics: 3-Hydroxysteroid Dehydrogenases; Adult; Cholesterol; Cholesterol Oxidase; Cushing Syndrome; Female; | 1984 |
[Experiences with Lysodren therapy of Cushing's syndrome in the dog (1)].
Topics: Animals; Cushing Syndrome; Dog Diseases; Dogs; Female; Male; Mitotane | 1983 |
[Effect of different methods of treatment on glucagon secretion in patients with Cushing's syndrome].
Topics: Cushing Syndrome; Drug Therapy, Combination; Glucagon; Humans; Mitotane; Serotonin Antagonists | 1983 |
[Experiences with Lysodren treatment of Cushing's syndrome in dogs].
Topics: Adrenal Insufficiency; Animals; Central Nervous System Diseases; Cushing Syndrome; Dog Diseases; Dog | 1983 |
Diagnosis and management of concurrent diabetes mellitus and hyperadrenocorticism in thirty dogs.
Topics: Animals; Cushing Syndrome; Diabetes Mellitus; Dog Diseases; Dogs; Female; Insulin; Male; Mitotane | 1981 |
[Renin-angiotensin-aldosterone system in patients with Itsenko-Cushing syndrome treated with chloditane and large doses of reserpine].
Topics: Adolescent; Adult; Aldosterone; Angiotensin II; Cushing Syndrome; Humans; Middle Aged; Mitotane; Ren | 1980 |
[Pancreatic alpha cell function in Itsenko-Cushing disease].
Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Blood Glucose; Cushing Syndrome; Glucagon; Humans; Hypo | 1982 |
Hypoadrenocorticism following therapy with o,p-DDD for hyperadrenocorticism in four dogs.
Topics: Addison Disease; Animals; Cushing Syndrome; Dog Diseases; Dogs; Female; Male; Mitotane | 1982 |
[Structural changes in the adrenal cortex in those suffering from Itsenko-Cushing's disease treated with chloditan].
Topics: Adolescent; Adrenal Cortex; Adrenalectomy; Adult; Child; Cushing Syndrome; Female; Humans; Male; Mid | 1982 |
[Treatment of Cushing's syndrome and adrenal cancer with O,p-DDD].
Topics: Adrenal Gland Neoplasms; Adult; Aged; Cushing Syndrome; Drug Evaluation; Female; Humans; Male; Middl | 1982 |
[State of the skin in Itsenko-Cushing disease and hormonally active tumors of the adrenal cortex before and after treatment with chloditan].
Topics: Adrenal Cortex Neoplasms; Cushing Syndrome; Female; Humans; Male; Mitotane; Skin | 1982 |
[A case of Cushing's disease treated with o,p'-DDD].
Topics: Cushing Syndrome; Humans; Male; Middle Aged; Mitotane | 1982 |
[Use of mitotane (o,p'-DDD) in adrenal cortex hyperfunction].
Topics: Adrenal Cortex; Adrenal Cortex Function Tests; Adrenal Cortex Neoplasms; Adult; Cushing Syndrome; Fe | 1982 |
Cis-platinum treatment of metastatic adrenal carcinoma.
Topics: Abdominal Neoplasms; Adrenal Cortex Neoplasms; Adult; Carcinoma; Cisplatin; Cushing Syndrome; Female | 1980 |
[Diagnosis and therapy of hormonally active cancer of the adrenal cortex. Study of 5 cases].
Topics: Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Adrenalectomy; Aged; Aldosterone; Cushing Syndrom | 1981 |
[Cushing's syndrome. Medical treatment of adrenal hypercorticism].
Topics: Adrenal Gland Neoplasms; Aminoglutethimide; Androstanols; Bromocriptine; Cushing Syndrome; Cyprohept | 1980 |
[O.p. DDD (lysodren) in treatment of adrenal cortex hyperfunction in childhood].
Topics: Adrenocortical Hyperfunction; Adult; Cushing Syndrome; Female; Humans; Microsomes, Liver; Mitotane | 1981 |
[Treatment of Cushing's disease with o, p'-DDD (author's transl)].
Topics: Adult; Cushing Syndrome; Female; Humans; Middle Aged; Mitotane | 1981 |
Blood levels of o,p'-DDD following administration in various vehicles after a single dose and during long-term treatment.
Topics: Administration, Oral; Adrenal Cortex Neoplasms; Antineoplastic Agents; Cushing Syndrome; Emulsions; | 1981 |
[Visual acuity disorders caused by op'DDD?].
Topics: Cushing Syndrome; Female; Humans; Middle Aged; Mitotane; Visual Acuity | 1980 |
Adrenal myelolipoma associated with Cushing's disease.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Gland Neoplasms; Cushing Syndrome; Humans; Male; Mito | 1980 |
[Regression under the influence of OP'DDD of a malignant cortico-adrenaloma and of its metastases (author's transl)].
Topics: Adrenal Cortex Neoplasms; Carcinoma; Cushing Syndrome; Female; Humans; Liver Neoplasms; Middle Aged; | 1980 |
[Disclosure of a pituitary microadenoma during treatment of Cushing's disease].
Topics: Adenoma; Adult; Cushing Syndrome; Female; Humans; Mitotane; Pituitary Neoplasms | 1981 |
Adrenal carcinoma.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Aminoglutethimide; Carcinoma; Cushing Syndrome; Dia | 1994 |
Paraneoplastic endocrine syndromes.
Topics: Acromegaly; Adrenocorticotropic Hormone; Aminoglutethimide; Bromocriptine; Calcitonin; Cushing Syndr | 1994 |
Adrenocortical carcinoma. A clinical study and treatment results of 52 patients.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex Neoplasms; Adrenocortical Car | 1995 |
[Paraneoplastic Cushing's syndrome. Pseudotumors of the thymus occurring after correction of hypercorticism. 3 cases].
Topics: Adrenalectomy; Adrenocortical Hyperfunction; Adult; Carcinoid Tumor; Cushing Syndrome; Drug Therapy, | 1993 |
Increased approvals--myth or reality.
Topics: Animals; Animals, Domestic; Cushing Syndrome; Dog Diseases; Dogs; Drug Approval; Drug Labeling; Legi | 1993 |
[Cushing disease in children and in adolescents. Therapeutic results].
Topics: Adenoma, Basophil; Adolescent; Antineoplastic Agents, Hormonal; Child; Cushing Syndrome; Female; Hum | 1997 |
[The long-term therapy of hypothalamic-hypophyseal Cushing's syndrome with mitotane (o,p'-DDD)].
Topics: Adult; Chronic Disease; Combined Modality Therapy; Cushing Syndrome; Drug Evaluation; Female; Humans | 1997 |
[Case presentation in small animal medicine].
Topics: Animals; Antineoplastic Agents, Hormonal; Cushing Syndrome; Diabetes Complications; Diabetes Mellitu | 1998 |
[Effects of mitotane therapy in dogs with pituitary dependent Cushing syndrome on the adrenal gland size--an ultrasonographic study].
Topics: Adrenal Glands; Animals; Antineoplastic Agents, Hormonal; Cushing Syndrome; Dog Diseases; Dogs; Fema | 1999 |
[Mitotane treatment in a dog with a recurring adrenocortical carcinoma--a case report].
Topics: Adrenal Cortex Neoplasms; Animals; Antineoplastic Agents, Hormonal; Carcinoma; Cushing Syndrome; Dog | 1999 |
18 years mitotane therapy for intractable Cushing's disease.
Topics: Adult; Antineoplastic Agents, Hormonal; Cushing Syndrome; Female; Follow-Up Studies; Humans; Long-Te | 1999 |
Cushing's disease.
Topics: Antineoplastic Agents, Hormonal; Cushing Syndrome; Humans; Hypercholesterolemia; Mitotane | 2000 |
Clinical results of the use of mitotane for adrenocortical carcinoma.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Aged; Antineoplastic Agents, Hormonal; Carcinoma; Cushi | 2000 |
Mitotane-induced febrile pancytopenia: a first case report in paraneoplastic Cushing's syndrome.
Topics: Cushing Syndrome; Female; Fever; Humans; Middle Aged; Mitotane; Pancytopenia; Paraneoplastic Syndrom | 2001 |
Endocrine and metabolic diseases. Adrenal diseases.
Topics: Adenoma; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Insuffici | 1976 |
Increased urate excretion after o,p'-DDD.
Topics: Adult; Cushing Syndrome; Female; Humans; Mitotane; Uric Acid | 1978 |
[Corticosuprarenaloma in children].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adolescent; Adrenal Cortex Neoplasms; Adrenal G | 1975 |
[Medical treatment and Cushing's disease].
Topics: Aminoglutethimide; Bromocriptine; Cushing Syndrome; Cyproheptadine; Humans; Mitotane | 1977 |
Reversible gonadotropin deficiency in male Cushing's disease.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Chorionic Gonadotropin; Cushing Syndrome; Follicle S | 1977 |
[Corticotropic function of the pituitary gland in Cushing's syndrome treated with chloditane].
Topics: Adolescent; Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Humans; Middle Age | 1978 |
Treatment of Cushing's disease by O,p'DDD. Survey of 62 cases.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; | 1979 |
Cushing's syndrome due to adrenocortical carcinoma - a comphrensive clinical and biochemical study of patients treated by surgery and chemotherapy.
Topics: 17-Ketosteroids; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Aldosterone; Carcinoma; Cort | 1979 |
The continued importance of adrenalectomy in the treatment of Cushing's disease.
Topics: Adolescent; Adrenalectomy; Adult; Cushing Syndrome; Cyproheptadine; Female; Humans; Hypophysectomy; | 1979 |
[Glucocorticoid function of the adrenals in patients with Itsenko-Cushing disease treated with chloditane].
Topics: Adolescent; Adrenal Glands; Adult; Cushing Syndrome; Humans; Hydrocortisone; Middle Aged; Mitotane | 1979 |
Successful treatment of Cushing's disease with o,p'-DDD followed by pituitary irradiation in a 19-year-old male patient.
Topics: Adult; Cushing Syndrome; Humans; Male; Mitotane; Pituitary Irradiation | 1979 |
Treatment of Cushing's disease with o,p'-DDD.
Topics: Adenoma; Aged; Cushing Syndrome; Humans; Mitotane; Pituitary Neoplasms | 1979 |
Cushing's disease: the role of adrenalectomy and autotransplantation.
Topics: Adolescent; Adosterol; Adrenal Glands; Adrenalectomy; Cushing Syndrome; Cyproheptadine; Female; Huma | 1979 |
[Treatment of Itsenko-Cushing disease with chlodithane].
Topics: Adult; Cushing Syndrome; Humans; Mitotane | 1979 |
Diabetes mellitus in dogs: a review of initial evaluation, immediate and long-term management, and outcome.
Topics: Amylases; Animals; Anorexia; Bicarbonates; Blood Glucose; Blood Urea Nitrogen; Cushing Syndrome; Deh | 1977 |
[Nuclear medical and radioimmunological examinations of the adrenal cortical function (author's transl)].
Topics: Adolescent; Adult; Aldosterone; Circadian Rhythm; Cushing Syndrome; Female; Humans; Hydrocortisone; | 1978 |
Mitotane. Spironolactone antagonism in Cushing's syndrome.
Topics: Aged; Cushing Syndrome; Diarrhea; Female; Humans; Hypokalemia; Mitotane; Nausea; Spironolactone | 1977 |
Cessation of growth.
Topics: Adolescent; Cushing Syndrome; Diagnosis, Differential; Growth Disorders; Humans; Mitotane; Turner Sy | 1978 |
[Multiple recurrence of Cushing's syndrome after bilateral adrenalectomy and pituitary gland surgery. Cure with o,p'-DDD].
Topics: Adolescent; Adrenalectomy; Adult; Cushing Syndrome; Female; Humans; Mitotane; Obesity; Pigmentation | 1978 |
Feminizing adrenocortical carcinoma with Cushing's syndrome and pseudohyperparathyroidism.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adult | 1978 |
o,p-DDD in the treatment of Cushing's disease.
Topics: Animals; Cushing Syndrome; Dog Diseases; Dogs; Mitotane | 1978 |
[The medical treatment of Cushing's syndrome: conclusions drawn from 220 cases].
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Cushing Syndrome; Humans; Mitotane | 1978 |
[Hypothalamo-hypophyseal-thyroid relationship in patients with Itsenko-Cushing disease treated with chloditan].
Topics: Adolescent; Adult; Cushing Syndrome; Female; Humans; Hypothalamo-Hypophyseal System; Male; Middle Ag | 1978 |
Changes in corticosteroid synthesis of the human adrenal cortex in vitro, induced by treatment with o,p'-DDD for Cushing's syndrome: evidence for the sites of action of the drug.
Topics: Adolescent; Adrenal Cortex; Adrenal Cortex Hormones; Adult; Cushing Syndrome; Female; Humans; Male; | 1978 |
[Plasma determination of O,P-DDD. Clinical value].
Topics: Chromatography, Gas; Cushing Syndrome; Humans; Mitotane | 1977 |
[Therapeutic effect of adrenocortical inhibitor-chloditan in Itsenko-Cushing disease].
Topics: Adolescent; Adult; Cushing Syndrome; Female; Humans; Male; Middle Aged; Mitotane | 1977 |
The treatment of Cushing's disease in the dog.
Topics: Animals; Cushing Syndrome; Dog Diseases; Dogs; Mitotane | 1976 |
[Treatment of Cushing's syndrome with chloditane].
Topics: Adolescent; Adult; Child; Cushing Syndrome; Drug Evaluation; Female; Humans; Male; Middle Aged; Mito | 1976 |
[Change in blood coagulation in Itsenko-Cushing's disease under the influence of chloditan treatment].
Topics: Adult; Blood Coagulation; Chronic Disease; Cushing Syndrome; Depression, Chemical; Female; Humans; M | 1976 |
[Value of retropneumoperitoneum in the exploration of Cushing's syndrome. 155 cases].
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortical Hyperfunction; Angiography; Cushing | 1975 |
[Letter: Idiopathic hemochromatosis and Cushing's disease].
Topics: Adrenocortical Hyperfunction; Adult; Cushing Syndrome; Female; Hemochromatosis; Humans; Mitotane; Sp | 1975 |
Treatment of an adrenal cortical carcinoma with a combination of o,p'-DDD and aminoglutethimide.
Topics: 11-Hydroxycorticosteroids; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenalectomy; Adult; | 1975 |
Cushing's syndrome associated with a bronchial adenoma. Possible periodic hormonogenesis.
Topics: Adenoma; Adrenalectomy; Adult; Aminoglutethimide; Bronchial Neoplasms; Cushing Syndrome; Dexamethaso | 1975 |
[Treatment of Cushing's disease with op' DDD].
Topics: Cushing Syndrome; Female; Humans; Middle Aged; Mitotane | 1975 |
[Treatment of Itsenko-Cushing syndrome with chlodithan].
Topics: Adult; Cushing Syndrome; Drug Evaluation; Female; Follow-Up Studies; Humans; Male; Middle Aged; Mito | 1975 |
[12 years of medical treatment of Cushing's disease. Long-term use of Op, DDD in 46 cases].
Topics: Adolescent; Adult; Child; Cushing Syndrome; Dose-Response Relationship, Drug; Drug Evaluation; Femal | 1976 |
[Formal pathogenesis, average age and breed distribution in the comparison of 61 Lysodren-treated and 36 untreated cases of canine hyperadrenocorticism which were dissected in the years 1975 to 1991 at the Institute for Veterinary Pathology of the Free Un
Topics: Adrenal Cortex Neoplasms; Adrenocortical Hyperfunction; Age Factors; Animals; Breeding; Cushing Synd | 1992 |
Possible mechanism and treatment of o,p'DDD-induced hypercholesterolaemia.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Cushing Syndrome; Cytochrome P-450 Enzyme System | 1992 |
[Laboratory parameters for the control of the course of therapy of canine Cushing's syndrome].
Topics: Adrenocorticotropic Hormone; Alkaline Phosphatase; Animals; Cholesterol; Cushing Syndrome; Dog Disea | 1991 |
Effect of mitotane on Alternaria alternata infection in Cushing's syndrome.
Topics: Adult; Alternaria; Cushing Syndrome; Dermatomycoses; Female; Humans; Mitotane | 1991 |
Recurrent or metastatic disease in select patients with adrenocortical carcinoma. Aggressive resection vs chemotherapy.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; C | 1991 |
Plasma level monitoring of mitotane (o,p'-DDD) and its metabolite (o,p'-DDE) during long-term treatment of Cushing's disease with low doses.
Topics: Adolescent; Adult; Cushing Syndrome; Female; Humans; Male; Mitotane; Time Factors | 1991 |
[Changes in the secretion of the hormones of the hypothalamo-hypophyseo-adrenal system in Itsenko-Cushing disease under the influence of insulin-induced hypoglycemia and thyroliberin].
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Cyproheptadine; Fasting; Humans; H | 1990 |
[Carcinoma of the adrenal cortex].
Topics: 17-Ketosteroids; Adrenal Cortex Neoplasms; Adult; Aged; Biomarkers, Tumor; Cortodoxone; Cushing Synd | 1990 |
Late recurrence of operated adrenocortical carcinoma: atrial natriuretic factor before and after treatment with mitotane.
Topics: Adrenal Gland Neoplasms; Atrial Natriuretic Factor; Carcinoma; Combined Modality Therapy; Cushing Sy | 1989 |
Comparative assessment of ACTH and lipotropin plasma levels in the diagnosis and follow-up of patients with Cushing's syndrome: a study of 210 cases.
Topics: ACTH Syndrome, Ectopic; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotr | 1989 |
The protracted effect of o,p'-DDD in Cushing's disease and its impact on adrenal morphogenesis of young human embryo.
Topics: Abortion, Therapeutic; Adrenal Glands; Adult; Cushing Syndrome; Female; Fetus; Humans; Middle Aged; | 1989 |
[Neurotoxicity of mitotane therapy of adrenocortical carcinoma (5 cases) and Cushing's syndrome (7 cases)].
Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Cushing Syndrome; Female; Humans; Male; Middle Aged; Mi | 1987 |
[Idiopathic intracranial hypertension during treatment of Cushing's disease with mitotane].
Topics: Adult; Cushing Syndrome; Female; Humans; Mitotane; Pseudotumor Cerebri | 1987 |
[Therapy of Cushing's syndrome].
Topics: Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Cushing Syndrome; Humans; Hypokalemia; Mitota | 1985 |
Effect of o,p'-DDD on cortisol metabolism in Cushing's syndrome of various etiology.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Ho | 1985 |
Adrenal and pituitary effects of mitotane in Cushing's syndrome.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Adult; Child; Cushing Syndrome; F | 1986 |
Controversies in the management of Cushing's disease.
Topics: Adrenocorticotropic Hormone; Combined Modality Therapy; Cushing Syndrome; Diagnosis, Differential; H | 1986 |
Cushing's syndrome after treatment: changes in cortisol and ACTH levels, and amelioration of the depressive syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Depression; Female; Humans; Hydrocortisone; Ma | 1986 |
[Effects of o,p'-DDD on pituitary-gonadal function in patients with Cushing's disease].
Topics: Adolescent; Adult; Androgens; Cushing Syndrome; Estrogens; Female; Follicle Stimulating Hormone; Hum | 1988 |
Hyperadrenocorticism in a cat.
Topics: Adrenal Cortex; Adrenal Cortex Function Tests; Animals; Cat Diseases; Cats; Cushing Syndrome; Diabet | 1987 |
Significant regression of the tumor combined with the high level of plasma cortisol by low-dose administration of O, p'-DDD in a case with Cushing's syndrome caused by adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Cushing Syndrome; Female; Hormones; Humans; Hydrocortisone; Middle Aged; M | 1986 |
[Information value of methods for determining glucocorticoids in patients with Itsenko-Cushing disease].
Topics: Adolescent; Adult; Cushing Syndrome; Female; Glucocorticoids; Humans; Male; Methods; Middle Aged; Mi | 1987 |
Rapid micromethod for the analysis of mitotane and its metabolite in plasma by gas chromatography with electron-capture detection.
Topics: Child; Chromatography, Gas; Cushing Syndrome; Dichlorodiphenyl Dichloroethylene; Dichlorodiphenyldic | 1987 |
o,p'-DDD (mitotane) treatment for Cushing's syndrome: adrenal drug concentration and inhibition in vitro of steroid synthesis.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Carcinoma; Child; Cort | 1985 |
Malignant melanoma with ectopic production of adrenocorticotropic hormone. Palliative treatment with inhibitors of adrenal steroid biosynthesis.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocortical Hyperfunction; Adrenocorticotropic Hormon | 1973 |
[Diagnosis and therapy of endogenic hypercortisolism (Cushing's syndrome)].
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Dexamethasone; Diagnosis, Diffe | 1972 |
[Medical therapy of hyperadrenalism].
Topics: Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Aminoglutethimide; Cushing Syndrome; Huma | 1973 |
[Urinary 6beta-hydroxycortisol. II. Urinary 6beta-hydroxycortisol in different diseases and after administration of drugs].
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Carcinoma; Cushing Syndrome; F | 1973 |
Proceedings: Tumors of the adrenal cortex.
Topics: Adenoma; Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortico | 1973 |
[Prolonged remission in Cushing's syndrome following treatment with ortho-para-dichlordiphenyldichlorethane].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Aldosterone; Cushing | 1974 |
[Letter to the editor].
Topics: Cushing Syndrome; Humans; Mitotane; Remission, Spontaneous | 1973 |
Cushing's syndrome due to bilateral adrenal cortical hyperplasia in a 13-year old girl: successful treatment with op'DDD'.
Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenal Gland Diseases; Body Height; Body Weig | 1974 |
[Trial treatment of Cushing's syndrome with OP'DDD in children].
Topics: Adrenalectomy; Child; Cushing Syndrome; Humans; Male; Mitotane | 1972 |