mitotane has been researched along with Carcinoma, Anaplastic in 79 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
| Excerpt | Relevance | Reference |
|---|---|---|
| "From November 1979 to July 1986, 52 patients (27 women and 25 men; median age 52 years) with advanced adrenocortical carcinoma entered a prospective, nonrandomized study evaluating moderate-dose mitotane and doxorubicin hydrochloride (Adriamycin)." | 9.07 | Eastern Cooperative Oncology Group study 1879: mitotane and adriamycin in patients with advanced adrenocortical carcinoma. ( Banerjee, TK; Citrin, DL; Decker, RA; Elson, P; Gilchrist, KW; Hogan, TF; Horton, J; Westring, DW, 1991) |
| "A 42-year-old woman with liver metastasis from adrenal cortical carcinoma was treated with mitotane (o,p'DDD) for 11 months with a minimal response." | 7.69 | Treatment of metastatic adrenal cortical carcinoma with etoposide (VP-16) and cisplatin after failure with o,p'DDD. Clinical case reports. ( Robinson, E; Shpendler, M; Zidan, J, 1996) |
| "We found that the distribution of the lipophilic chemotherapeutic agent o,p'-DDD (mitotane) among serum (lipo)proteins was altered in hypertriglyceridemia, with relatively more o,p'-DDD accumulating in the chylomicron and very-low-density lipoprotein (VLDL) fraction." | 7.68 | The distribution of o,p'-DDD (mitotane) among serum lipoproteins in normo- and hypertriglyceridemia. ( Gebhardt, DO; Gevers Leuven, JA; Moolenaar, AJ; van der Velde, EA; van Seters, AP, 1992) |
| "Fourteen patients with progressive metastatic adrenal cortical carcinoma were treated with a combination of 5-fluorouracil (5-FU), doxorubicin, and cisplatin (FAP)." | 7.68 | 5-Fluorouracil, doxorubicin, and cisplatin as treatment for adrenal cortical carcinoma. ( Brugieres, L; Droz, JP; Gicquel, C; Parmentier, C; Schlumberger, M; Travagli, JP, 1991) |
| "Two patients with metastatic adrenal cortical carcinoma were treated with cisplatin and etoposide." | 7.67 | Treatment of metastatic adrenal cortical carcinoma with cisplatin and etoposide (VP-16). ( Greco, FA; Johnson, DH, 1986) |
| "Mitotane treatment was maintained during chemotherapy in 14 patients." | 6.69 | Cytotoxic therapy with etoposide and cisplatin in advanced adrenocortical carcinoma. ( Baudin, E; Bonacci, R; Bonnay, M; Cailleux, AF; Emy, P; Gigliotti, A; Nakib, I; Schlumberger, M; Wion-Barbot, N, 1998) |
| "Adrenocortical carcinoma is a rare tumor with a poor prognosis." | 6.38 | [Adrenocortical carcinoma and its treatment with mitotane. Description of a case]. ( D'Agnolo, B; Parma, A, 1991) |
| "The efficacy of mitotane in providing objective tumour responses in patients with adrenocortical carcinoma (ACC), has been recently questioned." | 6.17 | Cytotoxic chemotherapy for adrenocortical carcinoma. ( Alì, A; Angeli, A; Berruti, A; Dogliotti, L; Paccotti, P; Pia, A, 1995) |
| "By treatment with Mitotane in a dose aiming at completely destroying the adrenal cortex, a complete disappearance of the tumor as well as a dramatic reduction of the size of the metastases could be achieved." | 5.30 | [Mitotane treatment in a dog with a recurring adrenocortical carcinoma--a case report]. ( Flückiger, M; Gardelle, O; Keiser, M; Reusch, C, 1999) |
| "Treatment with mitotane was started shortly after surgical removal of the tumor (three patients) or the tumor and multiple lung metastasis (one patient)." | 5.30 | Is there a role for low doses of mitotane (o,p'-DDD) as adjuvant therapy in adrenocortical carcinoma? ( Arad, E; Best, LA; Dickstein, G; Nativ, O; Shechner, C, 1998) |
| "Mitotane is an important adrenalytic drug for the treatment of adrenal cancer whose use is limited by toxicity." | 5.29 | Comparison of the adrenalytic activity of mitotane and a methylated homolog on normal adrenal cortex and adrenal cortical carcinoma. ( Abrams, GD; Benitez, R; Counsell, RE; Djanegara, T; Hines, J; McClellan, N; Ruangwises, N; Schteingart, DE; Sinsheimer, JE; Wotring, LL, 1993) |
| "Adrenal cortical carcinoma is a rare tumour with a poor prognosis." | 5.28 | Treatment of adrenal cortical carcinoma with mitotane: outcome and complications. ( Cheah, JS; Chong, PY; Lim, MC; Tan, YO, 1990) |
| "From November 1979 to July 1986, 52 patients (27 women and 25 men; median age 52 years) with advanced adrenocortical carcinoma entered a prospective, nonrandomized study evaluating moderate-dose mitotane and doxorubicin hydrochloride (Adriamycin)." | 5.07 | Eastern Cooperative Oncology Group study 1879: mitotane and adriamycin in patients with advanced adrenocortical carcinoma. ( Banerjee, TK; Citrin, DL; Decker, RA; Elson, P; Gilchrist, KW; Hogan, TF; Horton, J; Westring, DW, 1991) |
| " Mitotane (Lysodren) is used for treating adrenocortical carcinoma." | 3.85 | Oral and vulvo-vaginal lichenoid reactions due to mitotane (Lysodren): A case report. ( Boisramé, S; Fleuret, C; Herry, H; Kerlan, V; Le Toux, G; Schmouchkovitch, A; Thuillier, P, 2017) |
| "The adrenolytic agent mitotane [o,p'-DDD or 1,1-(o,p'-dichlorodiphenyl)-2, 2-dichloroethane] has been employed in the nonsurgical treatment of patients with adrenal carcinoma for several decades." | 3.69 | A high-pressure liquid chromatographic method for measuring mitotane [1,1-(o,p'-Dichlorodiphenyl)-2,2-dichloroethane] and its metabolite 1,1-(o,p'-Dichlorodiphenyl)-2,2-dichloroethene in plasma. ( Andersen, A; Nome, O; Slørdal, L; Vesterhus, L; Warren, DJ, 1995) |
| "A 42-year-old woman with liver metastasis from adrenal cortical carcinoma was treated with mitotane (o,p'DDD) for 11 months with a minimal response." | 3.69 | Treatment of metastatic adrenal cortical carcinoma with etoposide (VP-16) and cisplatin after failure with o,p'DDD. Clinical case reports. ( Robinson, E; Shpendler, M; Zidan, J, 1996) |
| "We found that the distribution of the lipophilic chemotherapeutic agent o,p'-DDD (mitotane) among serum (lipo)proteins was altered in hypertriglyceridemia, with relatively more o,p'-DDD accumulating in the chylomicron and very-low-density lipoprotein (VLDL) fraction." | 3.68 | The distribution of o,p'-DDD (mitotane) among serum lipoproteins in normo- and hypertriglyceridemia. ( Gebhardt, DO; Gevers Leuven, JA; Moolenaar, AJ; van der Velde, EA; van Seters, AP, 1992) |
| "In 3 patients with adrenocortical carcinoma the effects of long-term mitotane therapy on the serum levels of three hormone-binding globulins and vitamin D-binding protein were studied." | 3.68 | Mitotane increases the blood levels of hormone-binding proteins. ( Moolenaar, AJ; van Seters, AP, 1991) |
| "Fourteen patients with progressive metastatic adrenal cortical carcinoma were treated with a combination of 5-fluorouracil (5-FU), doxorubicin, and cisplatin (FAP)." | 3.68 | 5-Fluorouracil, doxorubicin, and cisplatin as treatment for adrenal cortical carcinoma. ( Brugieres, L; Droz, JP; Gicquel, C; Parmentier, C; Schlumberger, M; Travagli, JP, 1991) |
| "Two cases are described in which metastatic adrenocortical carcinoma associated with Cushing's syndrome was treated with mitotane (o,p'DDD)." | 3.67 | Hepatic microsomal enzyme induction and adrenal crisis due to o,p'DDD therapy for metastatic adrenocortical carcinoma. ( Cullen, DR; Hague, RV; May, W, 1989) |
| "Two patients with metastatic adrenal cortical carcinoma were treated with cisplatin and etoposide." | 3.67 | Treatment of metastatic adrenal cortical carcinoma with cisplatin and etoposide (VP-16). ( Greco, FA; Johnson, DH, 1986) |
| "In 1966, we published the case report of a patient with adrenal carcinoma and wide spread metatasis who, after treatment with mitotane (o,p-DDD) and fluorouracil, developed Addison disease accompanied by a clinical remission." | 3.65 | Metastatic adrenal cortical carcinoma. Documented cure with combined chemotherapy. ( Ostuni, JA; Roginsky, MS, 1975) |
| "Mitotane treatment was maintained during chemotherapy in 14 patients." | 2.69 | Cytotoxic therapy with etoposide and cisplatin in advanced adrenocortical carcinoma. ( Baudin, E; Bonacci, R; Bonnay, M; Cailleux, AF; Emy, P; Gigliotti, A; Nakib, I; Schlumberger, M; Wion-Barbot, N, 1998) |
| "Adrenal Cancer is an infrequent and very aggressive tumor." | 2.48 | Giant adrenal carcinoma associated with renal vein and inferior vena cava thrombus. Case report and literature review. ( Fernández Arjona, M; Garrido Abad, P; Gómez de Vicente, JM; Herranz Fernández, LM; Jiménez Gálvez, M; Santos Arrontes, D; Suárez Fonseca, C, 2012) |
| "Adrenal cortical carcinoma is a rare endocrine tumor, and complete surgical resection is the only potentially curative treatment." | 2.41 | Adrenal cortical carcinoma. ( Boushey, RP; Dackiw, AP, 2001) |
| "Virilizing adrenal carcinoma is a rare disease, especially in women of reproductive age." | 2.39 | Virilizing adrenal carcinoma in a woman of reproductive age: a case presentation and literature review. ( Coonrod, DV; Rizkallah, TH, 1995) |
| "Adrenocortical carcinoma is a rare tumor with a poor prognosis." | 2.38 | [Adrenocortical carcinoma and its treatment with mitotane. Description of a case]. ( D'Agnolo, B; Parma, A, 1991) |
| "Adrenocortical carcinoma is a rare malignancy with poor prognosis and limited response to chemotherapy." | 1.42 | Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma. ( Cortez, MA; Cote, GJ; Fuentes-Mattei, E; Habra, MA; Hai, T; Hofmann, MC; Jimenez, C; Lee, MH; Ozsari, L; Pagliaro, L; Phan, LM; Sircar, K; Velazquez-Torres, G; Verhaak, R; Wood, CG; Wu, W; Yeung, SC; Zheng, S, 2015) |
| "Adrenocortical carcinoma is a highly malignant neoplasm with an incidence of two per million people per year." | 1.31 | Conventional and novel strategies in the treatment of adrenocortical cancer. ( Schteingart, DE, 2000) |
| "Adrenocortical carcinoma is a rare malignancy in children, with a high mortality." | 1.31 | Long-term (15 years) outcome in an infant with metastatic adrenocortical carcinoma. ( De León, DD; Lange, BJ; Moshang, T; Walterhouse, D, 2002) |
| "Treatment with mitotane was started shortly after surgical removal of the tumor (three patients) or the tumor and multiple lung metastasis (one patient)." | 1.30 | Is there a role for low doses of mitotane (o,p'-DDD) as adjuvant therapy in adrenocortical carcinoma? ( Arad, E; Best, LA; Dickstein, G; Nativ, O; Shechner, C, 1998) |
| "By treatment with Mitotane in a dose aiming at completely destroying the adrenal cortex, a complete disappearance of the tumor as well as a dramatic reduction of the size of the metastases could be achieved." | 1.30 | [Mitotane treatment in a dog with a recurring adrenocortical carcinoma--a case report]. ( Flückiger, M; Gardelle, O; Keiser, M; Reusch, C, 1999) |
| "Adrenocortical carcinoma is a rare and aggressive disease with a poor prognosis." | 1.29 | Impact of adjuvant mitotane on the clinical course of patients with adrenocortical cancer. ( Guinee, VF; Hess, KR; Klein, MJ; Samaan, NA; Schultz, PN; Taylor, SH; Vassilopoulou-Sellin, R, 1993) |
| "Mitotane is an important adrenalytic drug for the treatment of adrenal cancer whose use is limited by toxicity." | 1.29 | Comparison of the adrenalytic activity of mitotane and a methylated homolog on normal adrenal cortex and adrenal cortical carcinoma. ( Abrams, GD; Benitez, R; Counsell, RE; Djanegara, T; Hines, J; McClellan, N; Ruangwises, N; Schteingart, DE; Sinsheimer, JE; Wotring, LL, 1993) |
| "Adrenal cortical carcinoma is a rare tumour with a poor prognosis." | 1.28 | Treatment of adrenal cortical carcinoma with mitotane: outcome and complications. ( Cheah, JS; Chong, PY; Lim, MC; Tan, YO, 1990) |
| "Adrenocortical carcinoma is a rare disease which is primarily approached surgically." | 1.28 | Radiation therapy for adjunctive treatment of adrenal cortical carcinoma. ( Brady, LW; Markoe, AM; Micaily, B; Serber, W, 1991) |
| "A rare case of primary hyperaldosteronism due to corticosuprarenal carcinoma is presented." | 1.27 | [Primary hyperaldosteronism due to adrenocortical carcinoma. A clinical case report]. ( Di Paolo, A; Minucci, S; Pavoncello, S; Valentini, F, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (37.97) | 18.7374 |
| 1990's | 33 (41.77) | 18.2507 |
| 2000's | 11 (13.92) | 29.6817 |
| 2010's | 5 (6.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kerkhofs, TM | 1 |
| Ettaieb, MH | 1 |
| Hermsen, IG | 1 |
| Haak, HR | 3 |
| Phan, LM | 1 |
| Fuentes-Mattei, E | 1 |
| Wu, W | 1 |
| Velazquez-Torres, G | 1 |
| Sircar, K | 1 |
| Wood, CG | 1 |
| Hai, T | 1 |
| Jimenez, C | 1 |
| Cote, GJ | 1 |
| Ozsari, L | 1 |
| Hofmann, MC | 1 |
| Zheng, S | 1 |
| Verhaak, R | 1 |
| Pagliaro, L | 1 |
| Cortez, MA | 1 |
| Lee, MH | 1 |
| Yeung, SC | 1 |
| Habra, MA | 1 |
| Schmouchkovitch, A | 1 |
| Herry, H | 1 |
| Thuillier, P | 1 |
| Kerlan, V | 1 |
| Fleuret, C | 1 |
| Le Toux, G | 1 |
| Boisramé, S | 1 |
| Huang, H | 1 |
| Fojo, T | 1 |
| Lee, JO | 1 |
| Lee, KW | 1 |
| Kim, CJ | 1 |
| Kim, YJ | 1 |
| Lee, HE | 1 |
| Kim, H | 1 |
| Kim, JH | 1 |
| Bang, SM | 1 |
| Kim, JS | 1 |
| Lee, JS | 1 |
| Terzolo, M | 2 |
| Fassnacht, M | 1 |
| Ciccone, G | 1 |
| Allolio, B | 1 |
| Berruti, A | 4 |
| De Francia, S | 1 |
| Ardito, A | 1 |
| Daffara, F | 1 |
| Zaggia, B | 1 |
| Germano, A | 1 |
| Di Carlo, F | 1 |
| Garrido Abad, P | 1 |
| Gómez de Vicente, JM | 1 |
| Herranz Fernández, LM | 1 |
| Jiménez Gálvez, M | 1 |
| Santos Arrontes, D | 1 |
| Suárez Fonseca, C | 1 |
| Fernández Arjona, M | 1 |
| De León, DD | 1 |
| Lange, BJ | 1 |
| Walterhouse, D | 1 |
| Moshang, T | 1 |
| NETTO, AD | 1 |
| WAJCHENBERG, BL | 1 |
| RAVAGLIA, C | 1 |
| PEREIRA, VG | 1 |
| SHNAIDER, J | 1 |
| PUPO, AA | 1 |
| CINTRA, AB | 1 |
| Martins, AC | 1 |
| Cologna, AJ | 1 |
| Tucci, S | 1 |
| Suaid, HJ | 1 |
| Falconi, RA | 1 |
| Sperone, P | 1 |
| Gorzegno, G | 1 |
| Paccotti, P | 2 |
| Porpiglia, F | 1 |
| Angeli, A | 2 |
| Dogliotti, L | 2 |
| Chamuleau, SA | 1 |
| Corssmit, EP | 1 |
| Pereira, AM | 1 |
| van de Berg, BT | 1 |
| Siegert, CE | 1 |
| Naruse, T | 1 |
| Koike, A | 1 |
| Kato, K | 1 |
| Ishii, T | 1 |
| Suzumura, K | 1 |
| Matsumoto, K | 1 |
| Appelqvist, P | 1 |
| Kostianinen, S | 1 |
| Boven, E | 1 |
| Vermorken, JB | 1 |
| van Slooten, H | 1 |
| Pinedo, HM | 2 |
| Kay, R | 1 |
| Schumacher, OP | 2 |
| Tank, ES | 1 |
| Schteingart, DE | 3 |
| Motazedi, A | 1 |
| Noonan, RA | 1 |
| Thompson, NW | 2 |
| Tattersall, MH | 1 |
| Lander, H | 1 |
| Bain, B | 1 |
| Stocks, AE | 1 |
| Woods, RL | 1 |
| Fox, RM | 1 |
| Byrne, E | 1 |
| Trotten, JR | 1 |
| Roos, I | 1 |
| Jarabak, J | 1 |
| Rice, K | 1 |
| Charbonnel, B | 2 |
| Guillon, J | 1 |
| Chupin, M | 1 |
| Gutierrez, ML | 1 |
| Crooke, ST | 1 |
| Lee, JE | 1 |
| Berger, DH | 1 |
| el-Naggar, AK | 1 |
| Hickey, RC | 2 |
| Vassilopoulou-Sellin, R | 2 |
| Gagel, RF | 1 |
| Burgess, MA | 2 |
| Evans, DB | 1 |
| Pia, A | 1 |
| Alì, A | 1 |
| Favia, G | 1 |
| Lumachi, F | 1 |
| Carraro, P | 1 |
| D'Amico, DF | 1 |
| Freeman, DA | 2 |
| Coonrod, DV | 1 |
| Rizkallah, TH | 1 |
| Ahlman, H | 1 |
| Jansson, S | 1 |
| Wängberg, B | 1 |
| Tisell, LE | 1 |
| Scherstén, T | 1 |
| Hansson, G | 1 |
| Bengtsson, BA | 1 |
| Ernest, I | 1 |
| Jakobsson, CE | 1 |
| Lindstedt, S | 1 |
| Cornelisse, CJ | 1 |
| Hermans, J | 1 |
| Cobben, L | 1 |
| Fleuren, GJ | 1 |
| Bukowski, RM | 1 |
| Wolfe, M | 1 |
| Levine, HS | 1 |
| Crawford, DE | 1 |
| Stephens, RL | 1 |
| Gaynor, E | 1 |
| Harker, WG | 1 |
| Sinsheimer, JE | 1 |
| Counsell, RE | 1 |
| Abrams, GD | 1 |
| McClellan, N | 1 |
| Djanegara, T | 1 |
| Hines, J | 1 |
| Ruangwises, N | 1 |
| Benitez, R | 1 |
| Wotring, LL | 1 |
| Guinee, VF | 1 |
| Klein, MJ | 1 |
| Taylor, SH | 1 |
| Hess, KR | 1 |
| Schultz, PN | 1 |
| Samaan, NA | 2 |
| Andersen, A | 1 |
| Warren, DJ | 1 |
| Nome, O | 1 |
| Vesterhus, L | 1 |
| Slørdal, L | 1 |
| Zidan, J | 1 |
| Shpendler, M | 1 |
| Robinson, E | 1 |
| Bonacci, R | 1 |
| Gigliotti, A | 1 |
| Baudin, E | 1 |
| Wion-Barbot, N | 1 |
| Emy, P | 1 |
| Bonnay, M | 1 |
| Cailleux, AF | 1 |
| Nakib, I | 1 |
| Schlumberger, M | 2 |
| Dickstein, G | 1 |
| Shechner, C | 1 |
| Arad, E | 1 |
| Best, LA | 1 |
| Nativ, O | 1 |
| Feller, N | 1 |
| Hoekman, K | 1 |
| Kuiper, CM | 1 |
| Linn, SC | 1 |
| Verheul, HM | 1 |
| Wolthers, BG | 1 |
| Popp-Snijders, C | 1 |
| Keiser, M | 1 |
| Flückiger, M | 1 |
| Gardelle, O | 1 |
| Reusch, C | 1 |
| Kunieda, K | 1 |
| Saji, S | 1 |
| Mori, S | 1 |
| Katoh, M | 1 |
| Miya, K | 1 |
| Yasuda, K | 1 |
| Mune, T | 1 |
| Shimokawa, K | 1 |
| Kasperlik-Zaluska, AA | 1 |
| Boushey, RP | 1 |
| Dackiw, AP | 1 |
| Besser, GM | 1 |
| Jeffcoate, WJ | 1 |
| Kelly, WF | 1 |
| Barnes, AJ | 1 |
| Cassar, J | 1 |
| White, M | 1 |
| Mashiter, K | 1 |
| Loizou, S | 1 |
| Welbourn, RB | 1 |
| Joplin, GF | 1 |
| Bricaire, H | 1 |
| Luton, JP | 2 |
| Becker, D | 1 |
| Ostuni, JA | 1 |
| Roginsky, MS | 1 |
| Feldman, EC | 1 |
| Nelson, RW | 1 |
| Feldman, MS | 1 |
| Farver, TB | 1 |
| Pommier, RF | 1 |
| Brennan, MF | 1 |
| Icard, P | 1 |
| Chapuis, Y | 1 |
| Andreassian, B | 1 |
| Bernard, A | 1 |
| Proye, C | 1 |
| van Aalderen, W | 1 |
| van Seters, AP | 4 |
| Backer, ET | 1 |
| Chang, PC | 1 |
| van Krieken, JH | 1 |
| Moolenaar, AJ | 4 |
| Remond, S | 1 |
| Bardet, S | 1 |
| Gebhardt, DO | 1 |
| van der Velde, EA | 1 |
| Gevers Leuven, JA | 1 |
| Giraldi, T | 1 |
| Perissin, L | 1 |
| Zorzet, S | 1 |
| Rapozzi, V | 1 |
| Markoe, AM | 1 |
| Serber, W | 1 |
| Micaily, B | 1 |
| Brady, LW | 1 |
| Decker, RA | 2 |
| Elson, P | 1 |
| Hogan, TF | 1 |
| Citrin, DL | 1 |
| Westring, DW | 1 |
| Banerjee, TK | 1 |
| Gilchrist, KW | 1 |
| Horton, J | 1 |
| Parma, A | 1 |
| D'Agnolo, B | 1 |
| Caekebeke-Peerlinck, KM | 1 |
| Briët, E | 1 |
| Kuehner, ME | 1 |
| Schwartz, RW | 1 |
| Sloan, DA | 1 |
| Kenady, DE | 1 |
| Brugieres, L | 1 |
| Gicquel, C | 1 |
| Travagli, JP | 1 |
| Droz, JP | 1 |
| Parmentier, C | 1 |
| Lim, MC | 1 |
| Tan, YO | 1 |
| Chong, PY | 1 |
| Cheah, JS | 1 |
| Donckier, JE | 1 |
| Michel, LA | 1 |
| Berbinschi, A | 1 |
| De Coster, PM | 1 |
| De Plaen, JF | 1 |
| Ketelslegers, JM | 1 |
| Buysschaert, M | 1 |
| Vierhapper, H | 1 |
| Mostbeck, G | 1 |
| Waldhäusl, W | 1 |
| Hague, RV | 1 |
| May, W | 1 |
| Cullen, DR | 1 |
| Cheung, PS | 1 |
| Bodie, B | 1 |
| Novick, AC | 1 |
| Pontes, JE | 1 |
| Straffon, RA | 1 |
| Montie, JE | 1 |
| Babiak, T | 1 |
| Sheeler, L | 1 |
| Schumacher, P | 1 |
| Krzisnik, C | 1 |
| Petric, G | 1 |
| Jereb, B | 1 |
| Johnson, DH | 1 |
| Greco, FA | 1 |
| Valentini, F | 1 |
| Pavoncello, S | 1 |
| Di Paolo, A | 1 |
| Minucci, S | 1 |
| Touitou, Y | 1 |
| Bogdan, A | 1 |
| Auzéby, A | 1 |
| Judy, JC | 1 |
| Scardino, PL | 1 |
| Yamada, S | 1 |
| Harrison, JH | 1 |
| Mahoney, EM | 1 |
| Bennett, AH | 1 |
| Lewinsky, BS | 1 |
| Grigor, KM | 1 |
| Symington, T | 1 |
| Neville, AM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter, Open-label, Phase II Study to Evaluate the Efficacy and Safety of Cabozantinib in Advanced (Unresectable or Metastatic) Adrenocortical Carcinoma[NCT03612232] | Phase 2 | 37 participants (Anticipated) | Interventional | 2019-06-04 | Recruiting | ||
| Mitotane With or Without Cisplatin and Etoposide After Surgery in Treating Participants With Stage I-III Adrenocortical Cancer With High Risk of Recurrence[NCT03723941] | Phase 3 | 240 participants (Anticipated) | Interventional | 2018-07-01 | Recruiting | ||
| The Impact of Mitotane Therapy on Serum Free Proteins in Patients With Adrenocortical Carcinoma[NCT05344027] | 35 participants (Actual) | Observational | 2022-04-11 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 reviews available for mitotane and Carcinoma, Anaplastic
| Article | Year |
|---|---|
Developing treatment for adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Antineoplastic Agents, Hormonal; Antineoplastic Combined Ch | 2015 |
Mitotane treatment for adrenocortical carcinoma: an overview.
Topics: Adrenal Cortex Neoplasms; Adrenal Insufficiency; Adrenalectomy; Antineoplastic Agents, Hormonal; Ant | 2012 |
Giant adrenal carcinoma associated with renal vein and inferior vena cava thrombus. Case report and literature review.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Aged; Antineoplastic Agents; Carcinoma; Contraindications; F | 2012 |
Multiple thoracotomy combined with chemotherapy in metastatic adrenal cortical carcinoma: a case report and review of the literature.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Carcinoma; Cortisone; Cushing Syndrom | 1983 |
Complete response of metastasized adrenal cortical carcinoma with o,p'-DDD. Case report and literature review.
Topics: Adrenal Cortex; Adrenal Gland Neoplasms; Carcinoma; Humans; Laparotomy; Lymphatic Metastasis; Male; | 1984 |
Cytotoxic chemotherapy for adrenocortical carcinoma.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Animals; Antineoplastic Combined Chemotherapy Protocols | 1995 |
Adrenal cortical carcinoma: the role of adjuvant postoperative chemotherapy.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; | 1995 |
Adrenocortical carcinoma. Our experience.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Aged; Antineoplastic Combined Chemothera | 1995 |
Virilizing adrenal carcinoma in a woman of reproductive age: a case presentation and literature review.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Carcinoma; Female; Hirsutism; Humans; Infertility, F | 1995 |
Adrenal cortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Algorithms; Antineoplastic Agents; Carcinoma; Chemot | 2001 |
[Adrenocortical carcinoma and its treatment with mitotane. Description of a case].
Topics: Adrenal Cortex Neoplasms; Adult; Carcinoma; Humans; Male; Mitotane | 1991 |
Diagnosis and treatment of primary adrenal tumors.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Carcinoma; Cushing Syndrome; Diagnosis | 1991 |
Steroid hormone-producing tumors in man.
Topics: 17-Ketosteroids; Adenoma; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Adult; Androgens; C | 1986 |
Adrenal cortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Androgens; Antineoplastic Agents; Carcinoma; Estrogens; Fem | 1987 |
4 trials available for mitotane and Carcinoma, Anaplastic
| Article | Year |
|---|---|
Cytotoxic chemotherapy for adrenocortical carcinoma.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Animals; Antineoplastic Combined Chemotherapy Protocols | 1995 |
Phase II trial of mitotane and cisplatin in patients with adrenal carcinoma: a Southwest Oncology Group study.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; C | 1993 |
Cytotoxic therapy with etoposide and cisplatin in advanced adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Ci | 1998 |
Eastern Cooperative Oncology Group study 1879: mitotane and adriamycin in patients with advanced adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adult; Aged; Carcinoma; Doxorubicin; Drug Evaluation; Female; Humans; Male | 1991 |
62 other studies available for mitotane and Carcinoma, Anaplastic
| Article | Year |
|---|---|
Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma.
Topics: Adenoma; Adrenal Cortex Neoplasms; Adult; Aged; Aged, 80 and over; Anilides; Animals; Antineoplastic | 2015 |
Oral and vulvo-vaginal lichenoid reactions due to mitotane (Lysodren): A case report.
Topics: Adrenal Cortex Neoplasms; Antineoplastic Agents, Hormonal; Carcinoma; Female; Humans; Lichenoid Erup | 2017 |
Adjuvant mitotane for adrenocortical cancer--a recurring controversy.
Topics: Adrenal Cortex Neoplasms; Antineoplastic Agents, Hormonal; Carcinoma; Chemotherapy, Adjuvant; Dose-R | 2008 |
Metastatic adrenocortical carcinoma treated with sunitinib: a case report.
Topics: Adrenal Cortex Neoplasms; Angiogenesis Inhibitors; Antineoplastic Agents; Antineoplastic Combined Ch | 2009 |
Adjuvant mitotane for adrenocortical cancer--working through uncertainty.
Topics: Adrenal Cortex Neoplasms; Antineoplastic Agents, Hormonal; Carcinoma; Chemotherapy, Adjuvant; Dose-R | 2009 |
Long-term (15 years) outcome in an infant with metastatic adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Antineoplastic Agents, Hormonal; Carcinoma; Cortodoxone; Growth Disorders; | 2002 |
TREATMENT OF ADRENOCORTICAL CANCER WITH O,P'-DDD.
Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenogenital Syndrome; Antineoplastic Agents; Ca | 1963 |
Clinical features and immunoexpression of p53, MIB-1 and proliferating cell nuclear antigen in adrenal neoplasms.
Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Adult; Antineoplastic C | 2005 |
Long-term disease free survival in a patient with metastatic adreno-cortical carcinoma after complete pathological response to chemotherapy plus mitotane.
Topics: Adrenal Cortex Neoplasms; Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplati | 2006 |
A young woman with a severe bilateral pneumonia as the presenting sign of an adrenal carcinoma.
Topics: Adrenal Gland Neoplasms; Adult; Antineoplastic Agents, Hormonal; Carcinoma; Cushing Syndrome; Female | 2008 |
Adrenocortical carcinoma responded to treatment with o,p'-DDD--a case report.
Topics: Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Adult; Carcinoma; Circadian Rhythm; Cytidine | 1984 |
Adrenocortical carcinoma in children.
Topics: Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Antineoplastic Agents; Carcinoma; Child; Child, | 1983 |
Treatment of adrenal carcinomas.
Topics: Adrenal Gland Neoplasms; Adult; Carcinoma; Female; Humans; Liver Neoplasms; Lung Neoplasms; Male; Mi | 1982 |
Cis-platinum treatment of metastatic adrenal carcinoma.
Topics: Abdominal Neoplasms; Adrenal Cortex Neoplasms; Adult; Carcinoma; Cisplatin; Cushing Syndrome; Female | 1980 |
Metastatic adrenal cortical carcinoma. Prolonged regression with mitotane therapy.
Topics: Adrenal Cortex Neoplasms; Breast Neoplasms; Carcinoma; Female; Humans; Middle Aged; Mitotane; Neopla | 1981 |
[Regression under the influence of OP'DDD of a malignant cortico-adrenaloma and of its metastases (author's transl)].
Topics: Adrenal Cortex Neoplasms; Carcinoma; Cushing Syndrome; Female; Humans; Liver Neoplasms; Middle Aged; | 1980 |
Mitotane (o,p'-DDD).
Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Animals; Carcinoma; Dogs; Drug Administration Schedule; Dr | 1980 |
Surgical management, DNA content, and patient survival in adrenal cortical carcinoma.
Topics: Adenoma; Adolescent; Adrenal Cortex Neoplasms; Adult; Aged; Aneuploidy; Carcinoma; Combined Modality | 1995 |
Adrenal carcinoma.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Aminoglutethimide; Carcinoma; Cushing Syndrome; Dia | 1994 |
Adrenocortical carcinoma--diagnostic and therapeutical implications.
Topics: Adrenal Gland Neoplasms; Adrenal Rest Tumor; Adult; Aged; Carcinoma; Chemotherapy, Adjuvant; Female; | 1993 |
Nuclear DNA content and morphological characteristics in the prognosis of adrenocortical carcinoma.
Topics: Actuarial Analysis; Adenoma; Adrenal Cortex Neoplasms; Adult; Carcinoma; Cell Nucleus; DNA, Neoplasm | 1993 |
Comparison of the adrenalytic activity of mitotane and a methylated homolog on normal adrenal cortex and adrenal cortical carcinoma.
Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Animals; Carcinoma; Cell Division; Dogs; Female; Guinea Pi | 1993 |
Impact of adjuvant mitotane on the clinical course of patients with adrenocortical cancer.
Topics: Adrenal Cortex Neoplasms; Adult; Aged; Carcinoma; Combined Modality Therapy; Female; Humans; Male; M | 1993 |
A high-pressure liquid chromatographic method for measuring mitotane [1,1-(o,p'-Dichlorodiphenyl)-2,2-dichloroethane] and its metabolite 1,1-(o,p'-Dichlorodiphenyl)-2,2-dichloroethene in plasma.
Topics: Absorption; Adolescent; Adrenal Cortex Neoplasms; Antineoplastic Agents, Hormonal; Carcinoma; Chroma | 1995 |
Treatment of metastatic adrenal cortical carcinoma with etoposide (VP-16) and cisplatin after failure with o,p'DDD. Clinical case reports.
Topics: Adrenal Cortex Neoplasms; Adult; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemothera | 1996 |
Is there a role for low doses of mitotane (o,p'-DDD) as adjuvant therapy in adrenocortical carcinoma?
Topics: Adrenal Cortex Neoplasms; Adult; Aged; Antineoplastic Agents, Hormonal; Carcinoma; Chemotherapy, Adj | 1998 |
A patient with adrenocortical carcinoma: characterization of its biological activity and drug resistance profile.
Topics: Adrenal Cortex Neoplasms; Adult; Androgens; Antineoplastic Agents; Antineoplastic Combined Chemother | 1997 |
[Mitotane treatment in a dog with a recurring adrenocortical carcinoma--a case report].
Topics: Adrenal Cortex Neoplasms; Animals; Antineoplastic Agents, Hormonal; Carcinoma; Cushing Syndrome; Dog | 1999 |
Recurrence of giant adrenocortical carcinoma in the contralateral adrenal gland 6 years after surgery: report of a case.
Topics: Adrenal Cortex Neoplasms; Antineoplastic Agents, Hormonal; Carcinoma; Humans; Male; Middle Aged; Mit | 2000 |
Clinical results of the use of mitotane for adrenocortical carcinoma.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Aged; Antineoplastic Agents, Hormonal; Carcinoma; Cushi | 2000 |
Conventional and novel strategies in the treatment of adrenocortical cancer.
Topics: Adrenal Cortex Neoplasms; Antineoplastic Agents, Hormonal; Carcinoma; Humans; Mitotane | 2000 |
Endocrine and metabolic diseases. Adrenal diseases.
Topics: Adenoma; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Insuffici | 1976 |
Cushing's syndrome due to adrenocortical carcinoma - a comphrensive clinical and biochemical study of patients treated by surgery and chemotherapy.
Topics: 17-Ketosteroids; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Aldosterone; Carcinoma; Cort | 1979 |
[Does Op'DDD possess an antimitotic action? Remarks apropos of its use in the treatment of adrenal adenocarcinomas].
Topics: Adrenal Gland Neoplasms; Carcinoma; Humans; Mitosis; Mitotane | 1977 |
o,p'DDD therapy in invasive adrenocortical carcinoma.
Topics: Adrenal Cortex; Adrenal Gland Neoplasms; Adrenal Glands; Aged; Carcinoma; Child, Preschool; Dichloro | 1975 |
Metastatic adrenal cortical carcinoma. Documented cure with combined chemotherapy.
Topics: Adolescent; Adrenal Gland Neoplasms; Carcinoma; Drug Therapy, Combination; Female; Fluorouracil; Hum | 1975 |
Comparison of mitotane treatment for adrenal tumor versus pituitary-dependent hyperadrenocorticism in dogs.
Topics: Adenoma; Adrenal Cortex; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adrenocorticotropic | 1992 |
An eleven-year experience with adrenocortical carcinoma.
Topics: Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Adult; Carcinoma; Combined Modality Therapy; Fema | 1992 |
Adrenocortical carcinoma in surgically treated patients: a retrospective study on 156 cases by the French Association of Endocrine Surgery.
Topics: Adrenal Cortex Neoplasms; Adult; Aged; Carcinoma; Combined Modality Therapy; Female; Humans; Male; M | 1992 |
A case of recurrent adrenocortical carcinoma, with observations on long-term o,p'-DDD therapy and complications.
Topics: Adrenal Gland Neoplasms; Carcinoma; Carcinosarcoma; Combined Modality Therapy; Female; Humans; Lung | 1992 |
[Complete and lasting remission of a metastatic malignant adrenocortical carcinoma under treatment with OP'DDD alone].
Topics: Adrenal Cortex Neoplasms; Carcinoma; Female; Humans; Liver Neoplasms; Lung Neoplasms; Middle Aged; M | 1992 |
The distribution of o,p'-DDD (mitotane) among serum lipoproteins in normo- and hypertriglyceridemia.
Topics: Adrenal Cortex Neoplasms; Carcinoma; Chromatography, Gas; Chylomicrons; Humans; Hypertriglyceridemia | 1992 |
Metastasis and neuroendocrine system in stressed mice.
Topics: Animals; Bromocriptine; Carcinoma; Female; Guanethidine; Lung Neoplasms; Mice; Mitotane; Naltrexone; | 1992 |
Radiation therapy for adjunctive treatment of adrenal cortical carcinoma.
Topics: Adrenal Gland Neoplasms; Aged; Aged, 80 and over; Carcinoma; Child; Combined Modality Therapy; Femal | 1991 |
Prolonged bleeding time due to mitotane therapy.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Aged; Bleeding Time; Carcinoma; Female; Humans; Male; M | 1991 |
Mitotane increases the blood levels of hormone-binding proteins.
Topics: Adrenal Cortex Neoplasms; Adult; Carcinoma; Carrier Proteins; Dose-Response Relationship, Drug; Fema | 1991 |
Adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols | 1991 |
5-Fluorouracil, doxorubicin, and cisplatin as treatment for adrenal cortical carcinoma.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Antineoplastic Combined Chemotherapy Protocols; Carcino | 1991 |
Treatment of adrenal cortical carcinoma with mitotane: outcome and complications.
Topics: Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Carcinoma; Cortisone; Female; Humans; Hydroco | 1990 |
Late recurrence of operated adrenocortical carcinoma: atrial natriuretic factor before and after treatment with mitotane.
Topics: Adrenal Gland Neoplasms; Atrial Natriuretic Factor; Carcinoma; Combined Modality Therapy; Cushing Sy | 1989 |
Effect of suramin in a patient with adrenocortical carcinoma.
Topics: Adrenal Gland Neoplasms; Adult; Carcinoma; Drug Therapy, Combination; Humans; Male; Mitotane; Surami | 1989 |
Hepatic microsomal enzyme induction and adrenal crisis due to o,p'DDD therapy for metastatic adrenocortical carcinoma.
Topics: Addison Disease; Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Alanine Transaminase; Aspartate Ami | 1989 |
Right atrial extension of adrenocortical carcinoma. Surgical management using hypothermia and cardiopulmonary bypass.
Topics: Adrenal Gland Neoplasms; Adult; Carcinoma; Cardiopulmonary Bypass; Combined Modality Therapy; Female | 1989 |
The Cleveland Clinic experience with adrenal cortical carcinoma.
Topics: Actuarial Analysis; Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Carcinoma; Child; Combined Modal | 1989 |
Complete response of metastatic adrenal cortical carcinoma to o,p'-DDD in a child.
Topics: Adolescent; Adrenal Cortex Neoplasms; Carcinoma; Female; Humans; Lung Neoplasms; Mitotane; Tomograph | 1988 |
Treatment of metastatic adrenal cortical carcinoma with cisplatin and etoposide (VP-16).
Topics: Adrenal Cortex Neoplasms; Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplati | 1986 |
[Primary hyperaldosteronism due to adrenocortical carcinoma. A clinical case report].
Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Adult; Carcinoma; Combined Modality Therapy; Cortisone; Dr | 1986 |
o,p'-DDD (mitotane) treatment for Cushing's syndrome: adrenal drug concentration and inhibition in vitro of steroid synthesis.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Carcinoma; Child; Cort | 1985 |
Adrenal cortical carcinoma: a case report.
Topics: Adrenal Gland Neoplasms; Carcinoma; Female; Humans; Middle Aged; Mitotane; Neoplasm Metastasis; Pall | 1973 |
[Urinary 6beta-hydroxycortisol. II. Urinary 6beta-hydroxycortisol in different diseases and after administration of drugs].
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Carcinoma; Cushing Syndrome; F | 1973 |
Proceedings: Tumors of the adrenal cortex.
Topics: Adenoma; Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortico | 1973 |
The clinical and pathologic features of "non-hormonal" adrenocortical tumors. Report of twenty new cases and review of the literature.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adult; Aged; Angiography; Antineoplast | 1974 |