Page last updated: 2024-10-31

mitotane and Carcinoma, Anaplastic

mitotane has been researched along with Carcinoma, Anaplastic in 79 studies

Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.

Research Excerpts

ExcerptRelevanceReference
"From November 1979 to July 1986, 52 patients (27 women and 25 men; median age 52 years) with advanced adrenocortical carcinoma entered a prospective, nonrandomized study evaluating moderate-dose mitotane and doxorubicin hydrochloride (Adriamycin)."9.07Eastern Cooperative Oncology Group study 1879: mitotane and adriamycin in patients with advanced adrenocortical carcinoma. ( Banerjee, TK; Citrin, DL; Decker, RA; Elson, P; Gilchrist, KW; Hogan, TF; Horton, J; Westring, DW, 1991)
"A 42-year-old woman with liver metastasis from adrenal cortical carcinoma was treated with mitotane (o,p'DDD) for 11 months with a minimal response."7.69Treatment of metastatic adrenal cortical carcinoma with etoposide (VP-16) and cisplatin after failure with o,p'DDD. Clinical case reports. ( Robinson, E; Shpendler, M; Zidan, J, 1996)
"We found that the distribution of the lipophilic chemotherapeutic agent o,p'-DDD (mitotane) among serum (lipo)proteins was altered in hypertriglyceridemia, with relatively more o,p'-DDD accumulating in the chylomicron and very-low-density lipoprotein (VLDL) fraction."7.68The distribution of o,p'-DDD (mitotane) among serum lipoproteins in normo- and hypertriglyceridemia. ( Gebhardt, DO; Gevers Leuven, JA; Moolenaar, AJ; van der Velde, EA; van Seters, AP, 1992)
"Fourteen patients with progressive metastatic adrenal cortical carcinoma were treated with a combination of 5-fluorouracil (5-FU), doxorubicin, and cisplatin (FAP)."7.685-Fluorouracil, doxorubicin, and cisplatin as treatment for adrenal cortical carcinoma. ( Brugieres, L; Droz, JP; Gicquel, C; Parmentier, C; Schlumberger, M; Travagli, JP, 1991)
"Two patients with metastatic adrenal cortical carcinoma were treated with cisplatin and etoposide."7.67Treatment of metastatic adrenal cortical carcinoma with cisplatin and etoposide (VP-16). ( Greco, FA; Johnson, DH, 1986)
"Mitotane treatment was maintained during chemotherapy in 14 patients."6.69Cytotoxic therapy with etoposide and cisplatin in advanced adrenocortical carcinoma. ( Baudin, E; Bonacci, R; Bonnay, M; Cailleux, AF; Emy, P; Gigliotti, A; Nakib, I; Schlumberger, M; Wion-Barbot, N, 1998)
"Adrenocortical carcinoma is a rare tumor with a poor prognosis."6.38[Adrenocortical carcinoma and its treatment with mitotane. Description of a case]. ( D'Agnolo, B; Parma, A, 1991)
"The efficacy of mitotane in providing objective tumour responses in patients with adrenocortical carcinoma (ACC), has been recently questioned."6.17Cytotoxic chemotherapy for adrenocortical carcinoma. ( Alì, A; Angeli, A; Berruti, A; Dogliotti, L; Paccotti, P; Pia, A, 1995)
"By treatment with Mitotane in a dose aiming at completely destroying the adrenal cortex, a complete disappearance of the tumor as well as a dramatic reduction of the size of the metastases could be achieved."5.30[Mitotane treatment in a dog with a recurring adrenocortical carcinoma--a case report]. ( Flückiger, M; Gardelle, O; Keiser, M; Reusch, C, 1999)
"Treatment with mitotane was started shortly after surgical removal of the tumor (three patients) or the tumor and multiple lung metastasis (one patient)."5.30Is there a role for low doses of mitotane (o,p'-DDD) as adjuvant therapy in adrenocortical carcinoma? ( Arad, E; Best, LA; Dickstein, G; Nativ, O; Shechner, C, 1998)
"Mitotane is an important adrenalytic drug for the treatment of adrenal cancer whose use is limited by toxicity."5.29Comparison of the adrenalytic activity of mitotane and a methylated homolog on normal adrenal cortex and adrenal cortical carcinoma. ( Abrams, GD; Benitez, R; Counsell, RE; Djanegara, T; Hines, J; McClellan, N; Ruangwises, N; Schteingart, DE; Sinsheimer, JE; Wotring, LL, 1993)
"Adrenal cortical carcinoma is a rare tumour with a poor prognosis."5.28Treatment of adrenal cortical carcinoma with mitotane: outcome and complications. ( Cheah, JS; Chong, PY; Lim, MC; Tan, YO, 1990)
"From November 1979 to July 1986, 52 patients (27 women and 25 men; median age 52 years) with advanced adrenocortical carcinoma entered a prospective, nonrandomized study evaluating moderate-dose mitotane and doxorubicin hydrochloride (Adriamycin)."5.07Eastern Cooperative Oncology Group study 1879: mitotane and adriamycin in patients with advanced adrenocortical carcinoma. ( Banerjee, TK; Citrin, DL; Decker, RA; Elson, P; Gilchrist, KW; Hogan, TF; Horton, J; Westring, DW, 1991)
" Mitotane (Lysodren) is used for treating adrenocortical carcinoma."3.85Oral and vulvo-vaginal lichenoid reactions due to mitotane (Lysodren): A case report. ( Boisramé, S; Fleuret, C; Herry, H; Kerlan, V; Le Toux, G; Schmouchkovitch, A; Thuillier, P, 2017)
"The adrenolytic agent mitotane [o,p'-DDD or 1,1-(o,p'-dichlorodiphenyl)-2, 2-dichloroethane] has been employed in the nonsurgical treatment of patients with adrenal carcinoma for several decades."3.69A high-pressure liquid chromatographic method for measuring mitotane [1,1-(o,p'-Dichlorodiphenyl)-2,2-dichloroethane] and its metabolite 1,1-(o,p'-Dichlorodiphenyl)-2,2-dichloroethene in plasma. ( Andersen, A; Nome, O; Slørdal, L; Vesterhus, L; Warren, DJ, 1995)
"A 42-year-old woman with liver metastasis from adrenal cortical carcinoma was treated with mitotane (o,p'DDD) for 11 months with a minimal response."3.69Treatment of metastatic adrenal cortical carcinoma with etoposide (VP-16) and cisplatin after failure with o,p'DDD. Clinical case reports. ( Robinson, E; Shpendler, M; Zidan, J, 1996)
"We found that the distribution of the lipophilic chemotherapeutic agent o,p'-DDD (mitotane) among serum (lipo)proteins was altered in hypertriglyceridemia, with relatively more o,p'-DDD accumulating in the chylomicron and very-low-density lipoprotein (VLDL) fraction."3.68The distribution of o,p'-DDD (mitotane) among serum lipoproteins in normo- and hypertriglyceridemia. ( Gebhardt, DO; Gevers Leuven, JA; Moolenaar, AJ; van der Velde, EA; van Seters, AP, 1992)
"In 3 patients with adrenocortical carcinoma the effects of long-term mitotane therapy on the serum levels of three hormone-binding globulins and vitamin D-binding protein were studied."3.68Mitotane increases the blood levels of hormone-binding proteins. ( Moolenaar, AJ; van Seters, AP, 1991)
"Fourteen patients with progressive metastatic adrenal cortical carcinoma were treated with a combination of 5-fluorouracil (5-FU), doxorubicin, and cisplatin (FAP)."3.685-Fluorouracil, doxorubicin, and cisplatin as treatment for adrenal cortical carcinoma. ( Brugieres, L; Droz, JP; Gicquel, C; Parmentier, C; Schlumberger, M; Travagli, JP, 1991)
"Two cases are described in which metastatic adrenocortical carcinoma associated with Cushing's syndrome was treated with mitotane (o,p'DDD)."3.67Hepatic microsomal enzyme induction and adrenal crisis due to o,p'DDD therapy for metastatic adrenocortical carcinoma. ( Cullen, DR; Hague, RV; May, W, 1989)
"Two patients with metastatic adrenal cortical carcinoma were treated with cisplatin and etoposide."3.67Treatment of metastatic adrenal cortical carcinoma with cisplatin and etoposide (VP-16). ( Greco, FA; Johnson, DH, 1986)
"In 1966, we published the case report of a patient with adrenal carcinoma and wide spread metatasis who, after treatment with mitotane (o,p-DDD) and fluorouracil, developed Addison disease accompanied by a clinical remission."3.65Metastatic adrenal cortical carcinoma. Documented cure with combined chemotherapy. ( Ostuni, JA; Roginsky, MS, 1975)
"Mitotane treatment was maintained during chemotherapy in 14 patients."2.69Cytotoxic therapy with etoposide and cisplatin in advanced adrenocortical carcinoma. ( Baudin, E; Bonacci, R; Bonnay, M; Cailleux, AF; Emy, P; Gigliotti, A; Nakib, I; Schlumberger, M; Wion-Barbot, N, 1998)
"Adrenal Cancer is an infrequent and very aggressive tumor."2.48Giant adrenal carcinoma associated with renal vein and inferior vena cava thrombus. Case report and literature review. ( Fernández Arjona, M; Garrido Abad, P; Gómez de Vicente, JM; Herranz Fernández, LM; Jiménez Gálvez, M; Santos Arrontes, D; Suárez Fonseca, C, 2012)
"Adrenal cortical carcinoma is a rare endocrine tumor, and complete surgical resection is the only potentially curative treatment."2.41Adrenal cortical carcinoma. ( Boushey, RP; Dackiw, AP, 2001)
"Virilizing adrenal carcinoma is a rare disease, especially in women of reproductive age."2.39Virilizing adrenal carcinoma in a woman of reproductive age: a case presentation and literature review. ( Coonrod, DV; Rizkallah, TH, 1995)
"Adrenocortical carcinoma is a rare tumor with a poor prognosis."2.38[Adrenocortical carcinoma and its treatment with mitotane. Description of a case]. ( D'Agnolo, B; Parma, A, 1991)
"Adrenocortical carcinoma is a rare malignancy with poor prognosis and limited response to chemotherapy."1.42Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma. ( Cortez, MA; Cote, GJ; Fuentes-Mattei, E; Habra, MA; Hai, T; Hofmann, MC; Jimenez, C; Lee, MH; Ozsari, L; Pagliaro, L; Phan, LM; Sircar, K; Velazquez-Torres, G; Verhaak, R; Wood, CG; Wu, W; Yeung, SC; Zheng, S, 2015)
"Adrenocortical carcinoma is a highly malignant neoplasm with an incidence of two per million people per year."1.31Conventional and novel strategies in the treatment of adrenocortical cancer. ( Schteingart, DE, 2000)
"Adrenocortical carcinoma is a rare malignancy in children, with a high mortality."1.31Long-term (15 years) outcome in an infant with metastatic adrenocortical carcinoma. ( De León, DD; Lange, BJ; Moshang, T; Walterhouse, D, 2002)
"Treatment with mitotane was started shortly after surgical removal of the tumor (three patients) or the tumor and multiple lung metastasis (one patient)."1.30Is there a role for low doses of mitotane (o,p'-DDD) as adjuvant therapy in adrenocortical carcinoma? ( Arad, E; Best, LA; Dickstein, G; Nativ, O; Shechner, C, 1998)
"By treatment with Mitotane in a dose aiming at completely destroying the adrenal cortex, a complete disappearance of the tumor as well as a dramatic reduction of the size of the metastases could be achieved."1.30[Mitotane treatment in a dog with a recurring adrenocortical carcinoma--a case report]. ( Flückiger, M; Gardelle, O; Keiser, M; Reusch, C, 1999)
"Adrenocortical carcinoma is a rare and aggressive disease with a poor prognosis."1.29Impact of adjuvant mitotane on the clinical course of patients with adrenocortical cancer. ( Guinee, VF; Hess, KR; Klein, MJ; Samaan, NA; Schultz, PN; Taylor, SH; Vassilopoulou-Sellin, R, 1993)
"Mitotane is an important adrenalytic drug for the treatment of adrenal cancer whose use is limited by toxicity."1.29Comparison of the adrenalytic activity of mitotane and a methylated homolog on normal adrenal cortex and adrenal cortical carcinoma. ( Abrams, GD; Benitez, R; Counsell, RE; Djanegara, T; Hines, J; McClellan, N; Ruangwises, N; Schteingart, DE; Sinsheimer, JE; Wotring, LL, 1993)
"Adrenal cortical carcinoma is a rare tumour with a poor prognosis."1.28Treatment of adrenal cortical carcinoma with mitotane: outcome and complications. ( Cheah, JS; Chong, PY; Lim, MC; Tan, YO, 1990)
"Adrenocortical carcinoma is a rare disease which is primarily approached surgically."1.28Radiation therapy for adjunctive treatment of adrenal cortical carcinoma. ( Brady, LW; Markoe, AM; Micaily, B; Serber, W, 1991)
"A rare case of primary hyperaldosteronism due to corticosuprarenal carcinoma is presented."1.27[Primary hyperaldosteronism due to adrenocortical carcinoma. A clinical case report]. ( Di Paolo, A; Minucci, S; Pavoncello, S; Valentini, F, 1986)

Research

Studies (79)

TimeframeStudies, this research(%)All Research%
pre-199030 (37.97)18.7374
1990's33 (41.77)18.2507
2000's11 (13.92)29.6817
2010's5 (6.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kerkhofs, TM1
Ettaieb, MH1
Hermsen, IG1
Haak, HR3
Phan, LM1
Fuentes-Mattei, E1
Wu, W1
Velazquez-Torres, G1
Sircar, K1
Wood, CG1
Hai, T1
Jimenez, C1
Cote, GJ1
Ozsari, L1
Hofmann, MC1
Zheng, S1
Verhaak, R1
Pagliaro, L1
Cortez, MA1
Lee, MH1
Yeung, SC1
Habra, MA1
Schmouchkovitch, A1
Herry, H1
Thuillier, P1
Kerlan, V1
Fleuret, C1
Le Toux, G1
Boisramé, S1
Huang, H1
Fojo, T1
Lee, JO1
Lee, KW1
Kim, CJ1
Kim, YJ1
Lee, HE1
Kim, H1
Kim, JH1
Bang, SM1
Kim, JS1
Lee, JS1
Terzolo, M2
Fassnacht, M1
Ciccone, G1
Allolio, B1
Berruti, A4
De Francia, S1
Ardito, A1
Daffara, F1
Zaggia, B1
Germano, A1
Di Carlo, F1
Garrido Abad, P1
Gómez de Vicente, JM1
Herranz Fernández, LM1
Jiménez Gálvez, M1
Santos Arrontes, D1
Suárez Fonseca, C1
Fernández Arjona, M1
De León, DD1
Lange, BJ1
Walterhouse, D1
Moshang, T1
NETTO, AD1
WAJCHENBERG, BL1
RAVAGLIA, C1
PEREIRA, VG1
SHNAIDER, J1
PUPO, AA1
CINTRA, AB1
Martins, AC1
Cologna, AJ1
Tucci, S1
Suaid, HJ1
Falconi, RA1
Sperone, P1
Gorzegno, G1
Paccotti, P2
Porpiglia, F1
Angeli, A2
Dogliotti, L2
Chamuleau, SA1
Corssmit, EP1
Pereira, AM1
van de Berg, BT1
Siegert, CE1
Naruse, T1
Koike, A1
Kato, K1
Ishii, T1
Suzumura, K1
Matsumoto, K1
Appelqvist, P1
Kostianinen, S1
Boven, E1
Vermorken, JB1
van Slooten, H1
Pinedo, HM2
Kay, R1
Schumacher, OP2
Tank, ES1
Schteingart, DE3
Motazedi, A1
Noonan, RA1
Thompson, NW2
Tattersall, MH1
Lander, H1
Bain, B1
Stocks, AE1
Woods, RL1
Fox, RM1
Byrne, E1
Trotten, JR1
Roos, I1
Jarabak, J1
Rice, K1
Charbonnel, B2
Guillon, J1
Chupin, M1
Gutierrez, ML1
Crooke, ST1
Lee, JE1
Berger, DH1
el-Naggar, AK1
Hickey, RC2
Vassilopoulou-Sellin, R2
Gagel, RF1
Burgess, MA2
Evans, DB1
Pia, A1
Alì, A1
Favia, G1
Lumachi, F1
Carraro, P1
D'Amico, DF1
Freeman, DA2
Coonrod, DV1
Rizkallah, TH1
Ahlman, H1
Jansson, S1
Wängberg, B1
Tisell, LE1
Scherstén, T1
Hansson, G1
Bengtsson, BA1
Ernest, I1
Jakobsson, CE1
Lindstedt, S1
Cornelisse, CJ1
Hermans, J1
Cobben, L1
Fleuren, GJ1
Bukowski, RM1
Wolfe, M1
Levine, HS1
Crawford, DE1
Stephens, RL1
Gaynor, E1
Harker, WG1
Sinsheimer, JE1
Counsell, RE1
Abrams, GD1
McClellan, N1
Djanegara, T1
Hines, J1
Ruangwises, N1
Benitez, R1
Wotring, LL1
Guinee, VF1
Klein, MJ1
Taylor, SH1
Hess, KR1
Schultz, PN1
Samaan, NA2
Andersen, A1
Warren, DJ1
Nome, O1
Vesterhus, L1
Slørdal, L1
Zidan, J1
Shpendler, M1
Robinson, E1
Bonacci, R1
Gigliotti, A1
Baudin, E1
Wion-Barbot, N1
Emy, P1
Bonnay, M1
Cailleux, AF1
Nakib, I1
Schlumberger, M2
Dickstein, G1
Shechner, C1
Arad, E1
Best, LA1
Nativ, O1
Feller, N1
Hoekman, K1
Kuiper, CM1
Linn, SC1
Verheul, HM1
Wolthers, BG1
Popp-Snijders, C1
Keiser, M1
Flückiger, M1
Gardelle, O1
Reusch, C1
Kunieda, K1
Saji, S1
Mori, S1
Katoh, M1
Miya, K1
Yasuda, K1
Mune, T1
Shimokawa, K1
Kasperlik-Zaluska, AA1
Boushey, RP1
Dackiw, AP1
Besser, GM1
Jeffcoate, WJ1
Kelly, WF1
Barnes, AJ1
Cassar, J1
White, M1
Mashiter, K1
Loizou, S1
Welbourn, RB1
Joplin, GF1
Bricaire, H1
Luton, JP2
Becker, D1
Ostuni, JA1
Roginsky, MS1
Feldman, EC1
Nelson, RW1
Feldman, MS1
Farver, TB1
Pommier, RF1
Brennan, MF1
Icard, P1
Chapuis, Y1
Andreassian, B1
Bernard, A1
Proye, C1
van Aalderen, W1
van Seters, AP4
Backer, ET1
Chang, PC1
van Krieken, JH1
Moolenaar, AJ4
Remond, S1
Bardet, S1
Gebhardt, DO1
van der Velde, EA1
Gevers Leuven, JA1
Giraldi, T1
Perissin, L1
Zorzet, S1
Rapozzi, V1
Markoe, AM1
Serber, W1
Micaily, B1
Brady, LW1
Decker, RA2
Elson, P1
Hogan, TF1
Citrin, DL1
Westring, DW1
Banerjee, TK1
Gilchrist, KW1
Horton, J1
Parma, A1
D'Agnolo, B1
Caekebeke-Peerlinck, KM1
Briët, E1
Kuehner, ME1
Schwartz, RW1
Sloan, DA1
Kenady, DE1
Brugieres, L1
Gicquel, C1
Travagli, JP1
Droz, JP1
Parmentier, C1
Lim, MC1
Tan, YO1
Chong, PY1
Cheah, JS1
Donckier, JE1
Michel, LA1
Berbinschi, A1
De Coster, PM1
De Plaen, JF1
Ketelslegers, JM1
Buysschaert, M1
Vierhapper, H1
Mostbeck, G1
Waldhäusl, W1
Hague, RV1
May, W1
Cullen, DR1
Cheung, PS1
Bodie, B1
Novick, AC1
Pontes, JE1
Straffon, RA1
Montie, JE1
Babiak, T1
Sheeler, L1
Schumacher, P1
Krzisnik, C1
Petric, G1
Jereb, B1
Johnson, DH1
Greco, FA1
Valentini, F1
Pavoncello, S1
Di Paolo, A1
Minucci, S1
Touitou, Y1
Bogdan, A1
Auzéby, A1
Judy, JC1
Scardino, PL1
Yamada, S1
Harrison, JH1
Mahoney, EM1
Bennett, AH1
Lewinsky, BS1
Grigor, KM1
Symington, T1
Neville, AM1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multicenter, Open-label, Phase II Study to Evaluate the Efficacy and Safety of Cabozantinib in Advanced (Unresectable or Metastatic) Adrenocortical Carcinoma[NCT03612232]Phase 237 participants (Anticipated)Interventional2019-06-04Recruiting
Mitotane With or Without Cisplatin and Etoposide After Surgery in Treating Participants With Stage I-III Adrenocortical Cancer With High Risk of Recurrence[NCT03723941]Phase 3240 participants (Anticipated)Interventional2018-07-01Recruiting
The Impact of Mitotane Therapy on Serum Free Proteins in Patients With Adrenocortical Carcinoma[NCT05344027]35 participants (Actual)Observational2022-04-11Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

14 reviews available for mitotane and Carcinoma, Anaplastic

ArticleYear
Developing treatment for adrenocortical carcinoma.
    Endocrine-related cancer, 2015, Volume: 22, Issue:6

    Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Antineoplastic Agents, Hormonal; Antineoplastic Combined Ch

2015
Mitotane treatment for adrenocortical carcinoma: an overview.
    Minerva endocrinologica, 2012, Volume: 37, Issue:1

    Topics: Adrenal Cortex Neoplasms; Adrenal Insufficiency; Adrenalectomy; Antineoplastic Agents, Hormonal; Ant

2012
Giant adrenal carcinoma associated with renal vein and inferior vena cava thrombus. Case report and literature review.
    Archivos espanoles de urologia, 2012, Volume: 65, Issue:5

    Topics: Adrenal Gland Neoplasms; Adrenalectomy; Aged; Antineoplastic Agents; Carcinoma; Contraindications; F

2012
Multiple thoracotomy combined with chemotherapy in metastatic adrenal cortical carcinoma: a case report and review of the literature.
    Journal of surgical oncology, 1983, Volume: 24, Issue:1

    Topics: Adolescent; Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Carcinoma; Cortisone; Cushing Syndrom

1983
Complete response of metastasized adrenal cortical carcinoma with o,p'-DDD. Case report and literature review.
    Cancer, 1984, Jan-01, Volume: 53, Issue:1

    Topics: Adrenal Cortex; Adrenal Gland Neoplasms; Carcinoma; Humans; Laparotomy; Lymphatic Metastasis; Male;

1984
Cytotoxic chemotherapy for adrenocortical carcinoma.
    Minerva endocrinologica, 1995, Volume: 20, Issue:1

    Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Animals; Antineoplastic Combined Chemotherapy Protocols

1995
Adrenal cortical carcinoma: the role of adjuvant postoperative chemotherapy.
    Minerva endocrinologica, 1995, Volume: 20, Issue:1

    Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Antineoplastic Combined Chemotherapy Protocols; Carcinoma;

1995
Adrenocortical carcinoma. Our experience.
    Minerva endocrinologica, 1995, Volume: 20, Issue:1

    Topics: Adolescent; Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Aged; Antineoplastic Combined Chemothera

1995
Virilizing adrenal carcinoma in a woman of reproductive age: a case presentation and literature review.
    American journal of obstetrics and gynecology, 1995, Volume: 172, Issue:6

    Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Carcinoma; Female; Hirsutism; Humans; Infertility, F

1995
Adrenal cortical carcinoma.
    Current treatment options in oncology, 2001, Volume: 2, Issue:4

    Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Algorithms; Antineoplastic Agents; Carcinoma; Chemot

2001
[Adrenocortical carcinoma and its treatment with mitotane. Description of a case].
    Minerva medica, 1991, Volume: 82, Issue:12

    Topics: Adrenal Cortex Neoplasms; Adult; Carcinoma; Humans; Male; Mitotane

1991
Diagnosis and treatment of primary adrenal tumors.
    Current opinion in oncology, 1991, Volume: 3, Issue:1

    Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Carcinoma; Cushing Syndrome; Diagnosis

1991
Steroid hormone-producing tumors in man.
    Endocrine reviews, 1986, Volume: 7, Issue:2

    Topics: 17-Ketosteroids; Adenoma; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Adult; Androgens; C

1986
Adrenal cortical carcinoma.
    Seminars in oncology, 1987, Volume: 14, Issue:3

    Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Androgens; Antineoplastic Agents; Carcinoma; Estrogens; Fem

1987

Trials

4 trials available for mitotane and Carcinoma, Anaplastic

ArticleYear
Cytotoxic chemotherapy for adrenocortical carcinoma.
    Minerva endocrinologica, 1995, Volume: 20, Issue:1

    Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Animals; Antineoplastic Combined Chemotherapy Protocols

1995
Phase II trial of mitotane and cisplatin in patients with adrenal carcinoma: a Southwest Oncology Group study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1993, Volume: 11, Issue:1

    Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; C

1993
Cytotoxic therapy with etoposide and cisplatin in advanced adrenocortical carcinoma.
    British journal of cancer, 1998, Volume: 78, Issue:4

    Topics: Adrenal Cortex Neoplasms; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Ci

1998
Eastern Cooperative Oncology Group study 1879: mitotane and adriamycin in patients with advanced adrenocortical carcinoma.
    Surgery, 1991, Volume: 110, Issue:6

    Topics: Adrenal Cortex Neoplasms; Adult; Aged; Carcinoma; Doxorubicin; Drug Evaluation; Female; Humans; Male

1991

Other Studies

62 other studies available for mitotane and Carcinoma, Anaplastic

ArticleYear
Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma.
    Cancer research, 2015, Oct-01, Volume: 75, Issue:19

    Topics: Adenoma; Adrenal Cortex Neoplasms; Adult; Aged; Aged, 80 and over; Anilides; Animals; Antineoplastic

2015
Oral and vulvo-vaginal lichenoid reactions due to mitotane (Lysodren): A case report.
    Medicine, 2017, Volume: 96, Issue:2

    Topics: Adrenal Cortex Neoplasms; Antineoplastic Agents, Hormonal; Carcinoma; Female; Humans; Lichenoid Erup

2017
Adjuvant mitotane for adrenocortical cancer--a recurring controversy.
    The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:10

    Topics: Adrenal Cortex Neoplasms; Antineoplastic Agents, Hormonal; Carcinoma; Chemotherapy, Adjuvant; Dose-R

2008
Metastatic adrenocortical carcinoma treated with sunitinib: a case report.
    Japanese journal of clinical oncology, 2009, Volume: 39, Issue:3

    Topics: Adrenal Cortex Neoplasms; Angiogenesis Inhibitors; Antineoplastic Agents; Antineoplastic Combined Ch

2009
Adjuvant mitotane for adrenocortical cancer--working through uncertainty.
    The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:6

    Topics: Adrenal Cortex Neoplasms; Antineoplastic Agents, Hormonal; Carcinoma; Chemotherapy, Adjuvant; Dose-R

2009
Long-term (15 years) outcome in an infant with metastatic adrenocortical carcinoma.
    The Journal of clinical endocrinology and metabolism, 2002, Volume: 87, Issue:10

    Topics: Adrenal Cortex Neoplasms; Antineoplastic Agents, Hormonal; Carcinoma; Cortodoxone; Growth Disorders;

2002
TREATMENT OF ADRENOCORTICAL CANCER WITH O,P'-DDD.
    Annals of internal medicine, 1963, Volume: 59

    Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenogenital Syndrome; Antineoplastic Agents; Ca

1963
Clinical features and immunoexpression of p53, MIB-1 and proliferating cell nuclear antigen in adrenal neoplasms.
    The Journal of urology, 2005, Volume: 173, Issue:6

    Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Adult; Antineoplastic C

2005
Long-term disease free survival in a patient with metastatic adreno-cortical carcinoma after complete pathological response to chemotherapy plus mitotane.
    Journal of endocrinological investigation, 2006, Volume: 29, Issue:6

    Topics: Adrenal Cortex Neoplasms; Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplati

2006
A young woman with a severe bilateral pneumonia as the presenting sign of an adrenal carcinoma.
    The Netherlands journal of medicine, 2008, Volume: 66, Issue:3

    Topics: Adrenal Gland Neoplasms; Adult; Antineoplastic Agents, Hormonal; Carcinoma; Cushing Syndrome; Female

2008
Adrenocortical carcinoma responded to treatment with o,p'-DDD--a case report.
    Endocrinologia japonica, 1984, Volume: 31, Issue:4

    Topics: Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Adult; Carcinoma; Circadian Rhythm; Cytidine

1984
Adrenocortical carcinoma in children.
    The Journal of urology, 1983, Volume: 130, Issue:6

    Topics: Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Antineoplastic Agents; Carcinoma; Child; Child,

1983
Treatment of adrenal carcinomas.
    Archives of surgery (Chicago, Ill. : 1960), 1982, Volume: 117, Issue:9

    Topics: Adrenal Gland Neoplasms; Adult; Carcinoma; Female; Humans; Liver Neoplasms; Lung Neoplasms; Male; Mi

1982
Cis-platinum treatment of metastatic adrenal carcinoma.
    The Medical journal of Australia, 1980, May-03, Volume: 1, Issue:9

    Topics: Abdominal Neoplasms; Adrenal Cortex Neoplasms; Adult; Carcinoma; Cisplatin; Cushing Syndrome; Female

1980
Metastatic adrenal cortical carcinoma. Prolonged regression with mitotane therapy.
    JAMA, 1981, Oct-09, Volume: 246, Issue:15

    Topics: Adrenal Cortex Neoplasms; Breast Neoplasms; Carcinoma; Female; Humans; Middle Aged; Mitotane; Neopla

1981
[Regression under the influence of OP'DDD of a malignant cortico-adrenaloma and of its metastases (author's transl)].
    La Nouvelle presse medicale, 1980, Jan-19, Volume: 9, Issue:4

    Topics: Adrenal Cortex Neoplasms; Carcinoma; Cushing Syndrome; Female; Humans; Liver Neoplasms; Middle Aged;

1980
Mitotane (o,p'-DDD).
    Cancer treatment reviews, 1980, Volume: 7, Issue:1

    Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Animals; Carcinoma; Dogs; Drug Administration Schedule; Dr

1980
Surgical management, DNA content, and patient survival in adrenal cortical carcinoma.
    Surgery, 1995, Volume: 118, Issue:6

    Topics: Adenoma; Adolescent; Adrenal Cortex Neoplasms; Adult; Aged; Aneuploidy; Carcinoma; Combined Modality

1995
Adrenal carcinoma.
    Current therapy in endocrinology and metabolism, 1994, Volume: 5

    Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Aminoglutethimide; Carcinoma; Cushing Syndrome; Dia

1994
Adrenocortical carcinoma--diagnostic and therapeutical implications.
    The European journal of surgery = Acta chirurgica, 1993, Volume: 159, Issue:3

    Topics: Adrenal Gland Neoplasms; Adrenal Rest Tumor; Adult; Aged; Carcinoma; Chemotherapy, Adjuvant; Female;

1993
Nuclear DNA content and morphological characteristics in the prognosis of adrenocortical carcinoma.
    British journal of cancer, 1993, Volume: 68, Issue:1

    Topics: Actuarial Analysis; Adenoma; Adrenal Cortex Neoplasms; Adult; Carcinoma; Cell Nucleus; DNA, Neoplasm

1993
Comparison of the adrenalytic activity of mitotane and a methylated homolog on normal adrenal cortex and adrenal cortical carcinoma.
    Cancer chemotherapy and pharmacology, 1993, Volume: 31, Issue:6

    Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Animals; Carcinoma; Cell Division; Dogs; Female; Guinea Pi

1993
Impact of adjuvant mitotane on the clinical course of patients with adrenocortical cancer.
    Cancer, 1993, May-15, Volume: 71, Issue:10

    Topics: Adrenal Cortex Neoplasms; Adult; Aged; Carcinoma; Combined Modality Therapy; Female; Humans; Male; M

1993
A high-pressure liquid chromatographic method for measuring mitotane [1,1-(o,p'-Dichlorodiphenyl)-2,2-dichloroethane] and its metabolite 1,1-(o,p'-Dichlorodiphenyl)-2,2-dichloroethene in plasma.
    Therapeutic drug monitoring, 1995, Volume: 17, Issue:5

    Topics: Absorption; Adolescent; Adrenal Cortex Neoplasms; Antineoplastic Agents, Hormonal; Carcinoma; Chroma

1995
Treatment of metastatic adrenal cortical carcinoma with etoposide (VP-16) and cisplatin after failure with o,p'DDD. Clinical case reports.
    American journal of clinical oncology, 1996, Volume: 19, Issue:3

    Topics: Adrenal Cortex Neoplasms; Adult; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemothera

1996
Is there a role for low doses of mitotane (o,p'-DDD) as adjuvant therapy in adrenocortical carcinoma?
    The Journal of clinical endocrinology and metabolism, 1998, Volume: 83, Issue:9

    Topics: Adrenal Cortex Neoplasms; Adult; Aged; Antineoplastic Agents, Hormonal; Carcinoma; Chemotherapy, Adj

1998
A patient with adrenocortical carcinoma: characterization of its biological activity and drug resistance profile.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:3

    Topics: Adrenal Cortex Neoplasms; Adult; Androgens; Antineoplastic Agents; Antineoplastic Combined Chemother

1997
[Mitotane treatment in a dog with a recurring adrenocortical carcinoma--a case report].
    Schweizer Archiv fur Tierheilkunde, 1999, Volume: 141, Issue:6

    Topics: Adrenal Cortex Neoplasms; Animals; Antineoplastic Agents, Hormonal; Carcinoma; Cushing Syndrome; Dog

1999
Recurrence of giant adrenocortical carcinoma in the contralateral adrenal gland 6 years after surgery: report of a case.
    Surgery today, 2000, Volume: 30, Issue:3

    Topics: Adrenal Cortex Neoplasms; Antineoplastic Agents, Hormonal; Carcinoma; Humans; Male; Middle Aged; Mit

2000
Clinical results of the use of mitotane for adrenocortical carcinoma.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2000, Volume: 33, Issue:10

    Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Aged; Antineoplastic Agents, Hormonal; Carcinoma; Cushi

2000
Conventional and novel strategies in the treatment of adrenocortical cancer.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2000, Volume: 33, Issue:10

    Topics: Adrenal Cortex Neoplasms; Antineoplastic Agents, Hormonal; Carcinoma; Humans; Mitotane

2000
Endocrine and metabolic diseases. Adrenal diseases.
    British medical journal, 1976, Feb-21, Volume: 1, Issue:6007

    Topics: Adenoma; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Insuffici

1976
Cushing's syndrome due to adrenocortical carcinoma - a comphrensive clinical and biochemical study of patients treated by surgery and chemotherapy.
    Acta endocrinologica, 1979, Volume: 91, Issue:2

    Topics: 17-Ketosteroids; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Aldosterone; Carcinoma; Cort

1979
[Does Op'DDD possess an antimitotic action? Remarks apropos of its use in the treatment of adrenal adenocarcinomas].
    La Nouvelle presse medicale, 1977, Nov-19, Volume: 6, Issue:39

    Topics: Adrenal Gland Neoplasms; Carcinoma; Humans; Mitosis; Mitotane

1977
o,p'DDD therapy in invasive adrenocortical carcinoma.
    Annals of internal medicine, 1975, Volume: 82, Issue:5

    Topics: Adrenal Cortex; Adrenal Gland Neoplasms; Adrenal Glands; Aged; Carcinoma; Child, Preschool; Dichloro

1975
Metastatic adrenal cortical carcinoma. Documented cure with combined chemotherapy.
    Archives of internal medicine, 1975, Volume: 135, Issue:9

    Topics: Adolescent; Adrenal Gland Neoplasms; Carcinoma; Drug Therapy, Combination; Female; Fluorouracil; Hum

1975
Comparison of mitotane treatment for adrenal tumor versus pituitary-dependent hyperadrenocorticism in dogs.
    Journal of the American Veterinary Medical Association, 1992, Jun-01, Volume: 200, Issue:11

    Topics: Adenoma; Adrenal Cortex; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adrenocorticotropic

1992
An eleven-year experience with adrenocortical carcinoma.
    Surgery, 1992, Volume: 112, Issue:6

    Topics: Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Adult; Carcinoma; Combined Modality Therapy; Fema

1992
Adrenocortical carcinoma in surgically treated patients: a retrospective study on 156 cases by the French Association of Endocrine Surgery.
    Surgery, 1992, Volume: 112, Issue:6

    Topics: Adrenal Cortex Neoplasms; Adult; Aged; Carcinoma; Combined Modality Therapy; Female; Humans; Male; M

1992
A case of recurrent adrenocortical carcinoma, with observations on long-term o,p'-DDD therapy and complications.
    The Netherlands journal of medicine, 1992, Volume: 41, Issue:3-4

    Topics: Adrenal Gland Neoplasms; Carcinoma; Carcinosarcoma; Combined Modality Therapy; Female; Humans; Lung

1992
[Complete and lasting remission of a metastatic malignant adrenocortical carcinoma under treatment with OP'DDD alone].
    Presse medicale (Paris, France : 1983), 1992, May-16, Volume: 21, Issue:18

    Topics: Adrenal Cortex Neoplasms; Carcinoma; Female; Humans; Liver Neoplasms; Lung Neoplasms; Middle Aged; M

1992
The distribution of o,p'-DDD (mitotane) among serum lipoproteins in normo- and hypertriglyceridemia.
    Cancer chemotherapy and pharmacology, 1992, Volume: 29, Issue:4

    Topics: Adrenal Cortex Neoplasms; Carcinoma; Chromatography, Gas; Chylomicrons; Humans; Hypertriglyceridemia

1992
Metastasis and neuroendocrine system in stressed mice.
    Annals of the New York Academy of Sciences, 1992, Apr-15, Volume: 650

    Topics: Animals; Bromocriptine; Carcinoma; Female; Guanethidine; Lung Neoplasms; Mice; Mitotane; Naltrexone;

1992
Radiation therapy for adjunctive treatment of adrenal cortical carcinoma.
    American journal of clinical oncology, 1991, Volume: 14, Issue:2

    Topics: Adrenal Gland Neoplasms; Aged; Aged, 80 and over; Carcinoma; Child; Combined Modality Therapy; Femal

1991
Prolonged bleeding time due to mitotane therapy.
    European journal of cancer (Oxford, England : 1990), 1991, Volume: 27, Issue:5

    Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Aged; Bleeding Time; Carcinoma; Female; Humans; Male; M

1991
Mitotane increases the blood levels of hormone-binding proteins.
    Acta endocrinologica, 1991, Volume: 124, Issue:5

    Topics: Adrenal Cortex Neoplasms; Adult; Carcinoma; Carrier Proteins; Dose-Response Relationship, Drug; Fema

1991
Adrenocortical carcinoma.
    The American surgeon, 1991, Volume: 57, Issue:8

    Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols

1991
5-Fluorouracil, doxorubicin, and cisplatin as treatment for adrenal cortical carcinoma.
    Cancer, 1991, Jun-15, Volume: 67, Issue:12

    Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Antineoplastic Combined Chemotherapy Protocols; Carcino

1991
Treatment of adrenal cortical carcinoma with mitotane: outcome and complications.
    Annals of the Academy of Medicine, Singapore, 1990, Volume: 19, Issue:4

    Topics: Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Carcinoma; Cortisone; Female; Humans; Hydroco

1990
Late recurrence of operated adrenocortical carcinoma: atrial natriuretic factor before and after treatment with mitotane.
    Surgery, 1989, Volume: 105, Issue:5

    Topics: Adrenal Gland Neoplasms; Atrial Natriuretic Factor; Carcinoma; Combined Modality Therapy; Cushing Sy

1989
Effect of suramin in a patient with adrenocortical carcinoma.
    Lancet (London, England), 1989, May-27, Volume: 1, Issue:8648

    Topics: Adrenal Gland Neoplasms; Adult; Carcinoma; Drug Therapy, Combination; Humans; Male; Mitotane; Surami

1989
Hepatic microsomal enzyme induction and adrenal crisis due to o,p'DDD therapy for metastatic adrenocortical carcinoma.
    Clinical endocrinology, 1989, Volume: 31, Issue:1

    Topics: Addison Disease; Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Alanine Transaminase; Aspartate Ami

1989
Right atrial extension of adrenocortical carcinoma. Surgical management using hypothermia and cardiopulmonary bypass.
    Cancer, 1989, Aug-15, Volume: 64, Issue:4

    Topics: Adrenal Gland Neoplasms; Adult; Carcinoma; Cardiopulmonary Bypass; Combined Modality Therapy; Female

1989
The Cleveland Clinic experience with adrenal cortical carcinoma.
    The Journal of urology, 1989, Volume: 141, Issue:2

    Topics: Actuarial Analysis; Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Carcinoma; Child; Combined Modal

1989
Complete response of metastatic adrenal cortical carcinoma to o,p'-DDD in a child.
    Pediatric hematology and oncology, 1988, Volume: 5, Issue:1

    Topics: Adolescent; Adrenal Cortex Neoplasms; Carcinoma; Female; Humans; Lung Neoplasms; Mitotane; Tomograph

1988
Treatment of metastatic adrenal cortical carcinoma with cisplatin and etoposide (VP-16).
    Cancer, 1986, Nov-15, Volume: 58, Issue:10

    Topics: Adrenal Cortex Neoplasms; Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplati

1986
[Primary hyperaldosteronism due to adrenocortical carcinoma. A clinical case report].
    Minerva medica, 1986, Oct-13, Volume: 77, Issue:39

    Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Adult; Carcinoma; Combined Modality Therapy; Cortisone; Dr

1986
o,p'-DDD (mitotane) treatment for Cushing's syndrome: adrenal drug concentration and inhibition in vitro of steroid synthesis.
    European journal of clinical pharmacology, 1985, Volume: 29, Issue:4

    Topics: 17-alpha-Hydroxyprogesterone; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Carcinoma; Child; Cort

1985
Adrenal cortical carcinoma: a case report.
    Journal of the Medical Association of Georgia, 1973, Volume: 62, Issue:11

    Topics: Adrenal Gland Neoplasms; Carcinoma; Female; Humans; Middle Aged; Mitotane; Neoplasm Metastasis; Pall

1973
[Urinary 6beta-hydroxycortisol. II. Urinary 6beta-hydroxycortisol in different diseases and after administration of drugs].
    Nihon Naibunpi Gakkai zasshi, 1973, Jun-20, Volume: 49, Issue:6

    Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Carcinoma; Cushing Syndrome; F

1973
Proceedings: Tumors of the adrenal cortex.
    Cancer, 1973, Volume: 32, Issue:5

    Topics: Adenoma; Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortico

1973
The clinical and pathologic features of "non-hormonal" adrenocortical tumors. Report of twenty new cases and review of the literature.
    Cancer, 1974, Volume: 33, Issue:3

    Topics: Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adult; Aged; Angiography; Antineoplast

1974