Page last updated: 2024-10-31

mitotane and Angiogenesis, Pathologic

mitotane has been researched along with Angiogenesis, Pathologic in 2 studies

Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.

Research Excerpts

ExcerptRelevanceReference
" Several important questions remain to be addressed such as the optimal dose and most effective dosing interval, when to use the metronomic approach in the natural history of the disease, the choice of cytotoxic drugs, and the most efficacious way to integrate metronomic chemotherapy with standard therapy protocols."2.47Metronomic therapy concepts in the management of adrenocortical carcinoma. ( Ardito, A; Bellini, E; Berruti, A; Daffara, F; Perotti, P; Saini, A; Sperone, P; Terzolo, M, 2011)
"Adrenocortical carcinoma is a rare malignancy with poor prognosis and limited response to chemotherapy."1.42Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma. ( Cortez, MA; Cote, GJ; Fuentes-Mattei, E; Habra, MA; Hai, T; Hofmann, MC; Jimenez, C; Lee, MH; Ozsari, L; Pagliaro, L; Phan, LM; Sircar, K; Velazquez-Torres, G; Verhaak, R; Wood, CG; Wu, W; Yeung, SC; Zheng, S, 2015)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Phan, LM1
Fuentes-Mattei, E1
Wu, W1
Velazquez-Torres, G1
Sircar, K1
Wood, CG1
Hai, T1
Jimenez, C1
Cote, GJ1
Ozsari, L1
Hofmann, MC1
Zheng, S1
Verhaak, R1
Pagliaro, L1
Cortez, MA1
Lee, MH1
Yeung, SC1
Habra, MA1
Berruti, A1
Sperone, P1
Bellini, E1
Daffara, F1
Perotti, P1
Ardito, A1
Saini, A1
Terzolo, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multicenter, Open-label, Phase II Study to Evaluate the Efficacy and Safety of Cabozantinib in Advanced (Unresectable or Metastatic) Adrenocortical Carcinoma[NCT03612232]Phase 237 participants (Anticipated)Interventional2019-06-04Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for mitotane and Angiogenesis, Pathologic

ArticleYear
Metronomic therapy concepts in the management of adrenocortical carcinoma.
    Hormones & cancer, 2011, Volume: 2, Issue:6

    Topics: Administration, Metronomic; Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Animals; Antineoplast

2011

Other Studies

1 other study available for mitotane and Angiogenesis, Pathologic

ArticleYear
Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma.
    Cancer research, 2015, Oct-01, Volume: 75, Issue:19

    Topics: Adenoma; Adrenal Cortex Neoplasms; Adult; Aged; Aged, 80 and over; Anilides; Animals; Antineoplastic

2015