mitotane has been researched along with Alopecia in 3 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Alopecia: Absence of hair from areas where it is normally present.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of the study was to evaluate intermediate adrenal steroid hormones (ISH) in neutered dogs with hair cycle arrest (Alopecia X) during treatment with melatonin, and to see if hair re-growth is associated with sex hormone concentrations within the normal ranges." | 9.11 | Adrenal steroid hormone concentrations in dogs with hair cycle arrest (Alopecia X) before and during treatment with melatonin and mitotane. ( Frank, LA; Hnilica, KA; Oliver, JW, 2004) |
| "The purpose of the study was to evaluate intermediate adrenal steroid hormones (ISH) in neutered dogs with hair cycle arrest (Alopecia X) during treatment with melatonin, and to see if hair re-growth is associated with sex hormone concentrations within the normal ranges." | 5.11 | Adrenal steroid hormone concentrations in dogs with hair cycle arrest (Alopecia X) before and during treatment with melatonin and mitotane. ( Frank, LA; Hnilica, KA; Oliver, JW, 2004) |
| " On the other hand, Mitometh resisted side-chain oxidative metabolism and was less toxic than Lysodren." | 1.27 | Toxicity, ultrastructural effects, and metabolic studies with 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane(o,p'-DDD) and its methyl analog in the guinea pig and rat. ( Briggs, DG; Caldwell, MW; French, LG; Jensen, BL, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Frank, LA | 1 |
| Hnilica, KA | 1 |
| Oliver, JW | 1 |
| Owens, JM | 1 |
| Drucker, WD | 1 |
| Jensen, BL | 1 |
| Caldwell, MW | 1 |
| French, LG | 1 |
| Briggs, DG | 1 |
1 review available for mitotane and Alopecia
| Article | Year |
|---|---|
Hyperadrenocorticism in the dog: canine Cushing's syndrome.
Topics: 17-Hydroxycorticosteroids; Adenoma; Adrenal Cortex Function Tests; Adrenal Gland Neoplasms; Adrenal | 1977 |
1 trial available for mitotane and Alopecia
| Article | Year |
|---|---|
Adrenal steroid hormone concentrations in dogs with hair cycle arrest (Alopecia X) before and during treatment with melatonin and mitotane.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Alopecia; Androstenedion | 2004 |
1 other study available for mitotane and Alopecia
| Article | Year |
|---|---|
Toxicity, ultrastructural effects, and metabolic studies with 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane(o,p'-DDD) and its methyl analog in the guinea pig and rat.
Topics: Adrenal Cortex; Alopecia; Animals; Diarrhea; Guinea Pigs; Male; Mitochondria; Mitotane; Rats; Rats, | 1987 |