mitotane has been researched along with Adverse Drug Event in 3 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Low-dose mitotane has been widely used for many decades in patients with advanced adrenocortical carcinoma (ACC), which exhibited good safety profiles compared with the high-dose regimen." | 3.96 | A case report of neurological adverse events caused by short-term and low-dose treatment of mitotane: The role of therapeutic drug monitoring. ( Deng, JH; Fu, Q; Liu, X; Mei, D; Tang, Y; Zhang, B, 2020) |
| "Mitotane is a cytostatic antineoplastic agent that is used in the treatment of adrenocortical carcinoma and Cushing's syndrome." | 3.88 | Mitotane-induced dyspnoea: an unusual side effect. ( Adhikari, S; Amjad, W; Farooq, AU; Kochar, T, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Liu, X | 1 |
| Fu, Q | 1 |
| Tang, Y | 1 |
| Deng, JH | 1 |
| Mei, D | 1 |
| Zhang, B | 1 |
| Farooq, AU | 1 |
| Amjad, W | 1 |
| Kochar, T | 1 |
| Adhikari, S | 1 |
3 other studies available for mitotane and Adverse Drug Event
| Article | Year |
|---|---|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A case report of neurological adverse events caused by short-term and low-dose treatment of mitotane: The role of therapeutic drug monitoring.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; Asian People; D | 2020 |
Mitotane-induced dyspnoea: an unusual side effect.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Aged; Antineoplastic Agents, Hormonal; Diagnosis | 2018 |