mitotane has been researched along with Adrenocortical Hyperfunction in 51 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Adrenocortical Hyperfunction: Excess production of ADRENAL CORTEX HORMONES such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE. Hyperadrenal syndromes include CUSHING SYNDROME; HYPERALDOSTERONISM; and VIRILISM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate urine protein content in dogs with pituitary-dependent hyperadrenocorticism (PDHAC) and to determine the effect of mitotane administration on proteinuria in these dogs." | 3.70 | Evaluation of urine protein content in dogs with pituitary-dependent hyperadrenocorticism. ( Hurley, KJ; Vaden, SL, 1998) |
| "Surgery with immediate adjuvant long term mitotane administration was the most effective form of therapy for patients with adrenocortical carcinoma." | 3.69 | Adrenocortical carcinoma. A clinical study and treatment results of 52 patients. ( Kasperlik-Załuska, AA; Makowska, AM; Migdalska, BM; Zgliczyński, S, 1995) |
| "Thirty-two dogs with hyperadrenocorticism caused by cortisol-secreting adrenocortical neoplasia were treated with mitotane at an initial daily induction dosage of 27." | 2.67 | Mitotane treatment of 32 dogs with cortisol-secreting adrenocortical neoplasms. ( Kintzer, PP; Peterson, ME, 1994) |
| "Pituitary-dependent hyperadrenocorticism is a common endocrine disorder in dogs in the United States." | 2.44 | Medical management of pituitary-dependent hyperadrenocorticism: mitotane versus trilostane. ( Reine, NJ, 2007) |
| "In untreated hyperadrenocorticism, clinical problems may result from metastasis of an adrenocortical carcinoma, growth of a pituitary tumor, or complications associated with sustained hypercortisolemia itself, such as hypertension, cardiovascular disease, thromboembolism, glucose intolerance, and increased susceptibility to infection." | 2.40 | Complications and concurrent disease associated with canine hyperadrenocorticism. ( Nichols, R, 1997) |
| "To describe a case of spontaneous pneumothorax secondary to pulmonary thromboembolism possibly associated with pituitary dependent hyperadrenocorticism." | 1.35 | Pneumothorax secondary to pulmonary thromboembolism in a dog. ( Sobel, KE; Williams, JE, 2009) |
| "Six to 10 months after hypercorticism was cured with ketoconazole and bilateral adrenalectomy, a thymic mass 2 to 5 cm in length was detected by computerized tomography or magnetic resonance imaging in all 3 patients." | 1.29 | [Paraneoplastic Cushing's syndrome. Pseudotumors of the thymus occurring after correction of hypercorticism. 3 cases]. ( Caillé, JM; Catargi, B; Drouillard, J; Greselle, JF; Laurent, F; Martigne, C; Roger, P; Tabarin, A, 1993) |
| "61 Lysodren -treated dogs with hyperadrenocorticism are compared with 36 untreated dogs with the same disease." | 1.28 | [Formal pathogenesis, average age and breed distribution in the comparison of 61 Lysodren-treated and 36 untreated cases of canine hyperadrenocorticism which were dissected in the years 1975 to 1991 at the Institute for Veterinary Pathology of the Free Un ( Nothelfer, HB; Weinhold, K, 1992) |
| "There months following surgery, liver metastases were documented associated with elevated levels of serum androgens." | 1.26 | Virilizing adrenal tumor in a child suppressed with dexamethasone for three years. Effect of o,p'-DDD on serum and urinary androgens. ( Korth-Schutz, S; Levine, LS; New, MI; Roth, JA; Saenger, P, 1977) |
| "Hyperadrenocorticism was diagnosed in 8 dogs by evaluation of urinary 17-hydroxycorticosteroid (OHCS) excretion rates, urinary 17-OHCS and plasma 11beta-OHCS RESPONSES TO DEXAMETHASONE SUPPRESSION OF ENDOGENOUS ADRENOCORTICOTROPIN (ACTH) secretion, and plasma 11beta-OHCS response to intravenous administration of ACTH." | 1.26 | Gamma camera imaging of bilateral adrenocortical hyperplasia and adrenal tumors in the dog. ( de Bruijne, JJ; Lubberink, AA; Mulnix, JA; Rijnberk, A; Van den Brom, WE, 1976) |
| "Virilism is the major manifestation in children (83 percent of the cases), either isolated or associated with hypercortisolism and/or feminization." | 1.25 | [Corticosuprarenaloma in children]. ( Benaily, M; Job, JC; Schweisguth, O, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (35.29) | 18.7374 |
| 1990's | 21 (41.18) | 18.2507 |
| 2000's | 9 (17.65) | 29.6817 |
| 2010's | 2 (3.92) | 24.3611 |
| 2020's | 1 (1.96) | 2.80 |
| Authors | Studies |
|---|---|
| Park, SM | 1 |
| Kim, KB | 1 |
| Song, WJ | 1 |
| Youn, HY | 1 |
| Griffies, JD | 1 |
| Aldridge, C | 1 |
| Behrend, EN | 2 |
| Kemppainen, RJ | 2 |
| Lee-Fowler, TM | 1 |
| Martin, LG | 1 |
| Ward, CR | 1 |
| Bruyette, D | 1 |
| Pannu, J | 1 |
| Gaillard, P | 1 |
| Lee, HP | 1 |
| Veytsman, I | 1 |
| Nieman, L | 1 |
| Fojo, T | 1 |
| Sobel, KE | 1 |
| Williams, JE | 1 |
| Goy-Thollot, I | 1 |
| Péchereau, D | 1 |
| Kéroack, S | 1 |
| Dezempte, JC | 1 |
| Bonnet, JM | 1 |
| MOLNAR, GD | 1 |
| MATTOX, VR | 1 |
| BAHN, RC | 1 |
| Lee, YM | 1 |
| Kang, BT | 1 |
| Jung, DI | 1 |
| Park, C | 1 |
| Kim, HJ | 1 |
| Kim, JW | 1 |
| Lim, CY | 1 |
| Park, EH | 1 |
| Park, HM | 1 |
| Reine, NJ | 1 |
| Brown, CG | 1 |
| Graves, TK | 1 |
| Clemente, M | 1 |
| De Andrés, PJ | 1 |
| Arenas, C | 1 |
| Melián, C | 1 |
| Morales, M | 1 |
| Pérez-Alenza, MD | 1 |
| Jacobelli, A | 1 |
| Agostino, A | 1 |
| Altomonte, G | 1 |
| Perigli, G | 1 |
| Borrelli, D | 1 |
| Salvatore, S | 1 |
| Cicchi, P | 1 |
| Burci, P | 1 |
| Peterson, ME | 4 |
| Altszuler, N | 1 |
| Nichols, CE | 1 |
| Keller, E | 1 |
| Willgerodt, H | 1 |
| Teichmann, B | 1 |
| Hoepffner, W | 1 |
| Kasperlik-Załuska, AA | 1 |
| Migdalska, BM | 1 |
| Zgliczyński, S | 1 |
| Makowska, AM | 1 |
| Watson, AD | 2 |
| Kintzer, PP | 2 |
| Tabarin, A | 1 |
| Catargi, B | 1 |
| Laurent, F | 1 |
| Greselle, JF | 1 |
| Martigne, C | 1 |
| Caillé, JM | 1 |
| Drouillard, J | 1 |
| Roger, P | 1 |
| Dunn, KJ | 1 |
| Herrtage, ME | 1 |
| Dunn, JK | 1 |
| Bertoy, EH | 1 |
| Feldman, EC | 6 |
| Nelson, RW | 5 |
| Dublin, AB | 1 |
| Reid, MH | 1 |
| Feldman, MS | 3 |
| Nichols, R | 2 |
| Guptill, L | 1 |
| Scott-Moncrieff, JC | 2 |
| Bottoms, G | 1 |
| Glickman, L | 1 |
| Johnson, M | 1 |
| Glickman, N | 1 |
| Nelson, R | 1 |
| Bertoy, E | 1 |
| Angles, JM | 1 |
| Schwedes, CS | 1 |
| Hurley, KJ | 1 |
| Vaden, SL | 1 |
| Randolph, JF | 1 |
| Toomey, J | 1 |
| Center, SA | 1 |
| Scarlett, JM | 1 |
| Reimers, T | 1 |
| Graham, P | 1 |
| Nachreiner, RF | 1 |
| Bennett, PF | 1 |
| Norman, EJ | 1 |
| Théon, AP | 1 |
| Swinney, GR | 1 |
| Malik, R | 1 |
| Clark, TP | 1 |
| Salman, MD | 1 |
| Syme, HM | 1 |
| Treadwell, NG | 1 |
| Thompson, MF | 1 |
| Snyder, PW | 1 |
| White, MR | 1 |
| Oliver, JW | 1 |
| Laus, JL | 1 |
| dos Santos, C | 1 |
| Talieri, IC | 1 |
| Oriá, AP | 1 |
| Bechara, GH | 1 |
| Benaily, M | 1 |
| Schweisguth, O | 1 |
| Job, JC | 1 |
| Korth-Schutz, S | 1 |
| Levine, LS | 1 |
| Roth, JA | 1 |
| Saenger, P | 1 |
| New, MI | 1 |
| Chastain, CB | 1 |
| Mulnix, JA | 1 |
| Van den Brom, WE | 1 |
| Lubberink, AA | 1 |
| de Bruijne, JJ | 1 |
| Rijnberk, A | 3 |
| Butez, J | 1 |
| Bonnin, A | 1 |
| Luton, JP | 1 |
| Pallardy, G | 1 |
| Ledoux-Lebard, G | 1 |
| Bricaire, H | 1 |
| Schrub, JC | 1 |
| Courtois, H | 1 |
| Farver, TB | 1 |
| Nothelfer, HB | 1 |
| Weinhold, K | 1 |
| Simpson, JW | 1 |
| van den Broek, AH | 1 |
| Ihle, SL | 1 |
| Dow, SW | 1 |
| Olson, PN | 1 |
| Rosychuk, RA | 1 |
| Withrow, SJ | 1 |
| Shinsako, J | 1 |
| Belshaw, BE | 1 |
| Moolenaar, AJ | 1 |
| Carey, RM | 1 |
| Orth, DN | 1 |
| Hartmann, WH | 1 |
| Raith, L | 1 |
6 reviews available for mitotane and Adrenocortical Hyperfunction
| Article | Year |
|---|---|
Management of endocrine manifestations and the use of mitotane as a chemotherapeutic agent for adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adrenocortical Hyperfunction; Antineoplastic Age | 2009 |
Medical management of pituitary-dependent hyperadrenocorticism: mitotane versus trilostane.
Topics: Adrenocortical Hyperfunction; Animals; Antineoplastic Agents, Hormonal; Dihydrotestosterone; Dog Dis | 2007 |
Hyperadrenocorticism: treating dogs.
Topics: Adrenal Cortex Function Tests; Adrenalectomy; Adrenocortical Hyperfunction; Animals; Dihydrotestoste | 2007 |
Medical treatment of pituitary-dependent hyperadrenocorticism. Mitotane.
Topics: Adrenal Cortex Diseases; Adrenocortical Hyperfunction; Animals; Antineoplastic Agents, Hormonal; Dia | 1997 |
Complications and concurrent disease associated with canine hyperadrenocorticism.
Topics: Adrenal Cortex Diseases; Adrenocortical Hyperfunction; Animals; Antineoplastic Agents; Diabetes Comp | 1997 |
Problems associated with medical therapy of canine hyperadrenocorticism.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Hyperfunction; Animals; Cushing Syndrome; Diabetes Mellitus | 1990 |
3 trials available for mitotane and Adrenocortical Hyperfunction
| Article | Year |
|---|---|
Comparison of 2 Doses for ACTH Stimulation Testing in Dogs Suspected of or Treated for Hyperadrenocorticism.
Topics: Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Animals; Antineoplastic Agents; Case-Cont | 2016 |
Mitotane treatment of 32 dogs with cortisol-secreting adrenocortical neoplasms.
Topics: Addison Disease; Adrenal Cortex Neoplasms; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone | 1994 |
Megavoltage irradiation of pituitary macrotumors in dogs with neurologic signs.
Topics: Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Animals; Antineoplastic Agents, Hormonal; | 1998 |
42 other studies available for mitotane and Adrenocortical Hyperfunction
| Article | Year |
|---|---|
Successful treatment of occult hyperadrenocorticism with mitotane but not trilostane in a dog.
Topics: Adrenocortical Hyperfunction; Animals; Antineoplastic Agents; Dihydrotestosterone; Dog Diseases; Dog | 2021 |
Old or new? A comparison of mitotane and trilostane for the management of hyperadrenocorticism.
Topics: Adrenocortical Hyperfunction; Animals; Antineoplastic Agents, Hormonal; Dihydrotestosterone; Dog Dis | 2013 |
Pneumothorax secondary to pulmonary thromboembolism in a dog.
Topics: Adrenocortical Hyperfunction; Animals; Antineoplastic Agents, Hormonal; Blood Coagulation; Dog Disea | 2009 |
Investigation of the role of aldosterone in hypertension associated with spontaneous pituitary-dependent hyperadrenocorticism in dogs.
Topics: Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Aldosterone; Animals; Antineoplastic Agen | 2002 |
Clinical and therapeutic observations in the adrenal cancer: a report on 7 patients treated with o,p'-DDD.
Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Ant | 1963 |
A case of adrenal gland dependent hyperadrenocorticism with mitotane therapy in a Yorkshire terrier dog.
Topics: Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Animals; Antineo | 2005 |
Comparison of non-selective adrenocorticolysis with mitotane or trilostane for the treatment of dogs with pituitary-dependent hyperadrenocorticism.
Topics: Adrenocortical Hyperfunction; Age Factors; Animals; Antineoplastic Agents, Hormonal; Body Weight; Di | 2007 |
[Treatment of glycoactive hypercorticism].
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; A | 1984 |
[Associated role of surgery and antimitotic o, p'-DDD treatment in hyperfunctioning adrenal cancers with diffuse metastases].
Topics: Adolescent; Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Hyperfunction; Cushing Syndrome; | 1981 |
Decreased insulin sensitivity and glucose tolerance in spontaneous canine hyperadrenocorticism.
Topics: Adrenalectomy; Adrenocortical Hyperfunction; Animals; Blood Glucose; Dog Diseases; Dogs; Female; Glu | 1984 |
[O.p. DDD (lysodren) in treatment of adrenal cortex hyperfunction in childhood].
Topics: Adrenocortical Hyperfunction; Adult; Cushing Syndrome; Female; Humans; Microsomes, Liver; Mitotane | 1981 |
Adrenocortical carcinoma. A clinical study and treatment results of 52 patients.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex Neoplasms; Adrenocortical Car | 1995 |
Comments on use of mitotane.
Topics: Adrenocortical Hyperfunction; Animals; Dog Diseases; Dogs; Mitotane | 1995 |
[Paraneoplastic Cushing's syndrome. Pseudotumors of the thymus occurring after correction of hypercorticism. 3 cases].
Topics: Adrenalectomy; Adrenocortical Hyperfunction; Adult; Carcinoid Tumor; Cushing Syndrome; Drug Therapy, | 1993 |
Use of ACTH stimulation tests to monitor the treatment of canine hyperadrenocorticism.
Topics: Adrenal Cortex Function Tests; Adrenal Glands; Adrenocortical Hyperfunction; Adrenocorticotropic Hor | 1995 |
One-year follow-up evaluation of magnetic resonance imaging of the brain in dogs with pituitary-dependent hyperadrenocorticism.
Topics: Adrenocortical Hyperfunction; Animals; Antineoplastic Agents, Hormonal; Dog Diseases; Dogs; Female; | 1996 |
Use of the urine cortisol: creatinine ratio to monitor treatment response in dogs with pituitary-dependent hyperadrenocorticism.
Topics: Adrenocortical Hyperfunction; Animals; Antineoplastic Agents, Hormonal; Creatinine; Dog Diseases; Do | 1997 |
Use of urine cortisol:creatinine ratio versus adrenocorticotropic hormone stimulation testing for monitoring mitotane treatment of pituitary-dependent hyperadrenocorticism in dogs.
Topics: Adrenal Cortex; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Animals; Antineoplastic A | 1997 |
Mitotane (o,p'-DDD) treatment in a cat with hyperadrenocorticism.
Topics: Adrenal Cortex; Adrenocortical Hyperfunction; Animals; Antineoplastic Agents, Hormonal; Blood Glucos | 1997 |
Evaluation of urine protein content in dogs with pituitary-dependent hyperadrenocorticism.
Topics: Adrenocortical Hyperfunction; Animals; Antineoplastic Agents, Hormonal; Dog Diseases; Dogs; Female; | 1998 |
Use of the urine cortisol-to-creatinine ratio for monitoring dogs with pituitary-dependent hyperadrenocorticism during induction treatment with mitotane (o,p'-DDD).
Topics: Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Animals; Antineoplastic Agents, Hormonal; | 1998 |
Mitotane (o,p'-DDD) resistance in a dog with pituitary-dependent hyperadrenocorticism and phaeochromocytoma.
Topics: Adrenal Cortex Function Tests; Adrenal Gland Neoplasms; Adrenal Medulla; Adrenocortical Hyperfunctio | 1998 |
Intermittent heart block in a lethargic dog.
Topics: Adrenocortical Hyperfunction; Animals; Dog Diseases; Dogs; Drug Therapy, Combination; Electrocardiog | 1998 |
Treatment of hyperadrenocorticism in dogs: a survey of internists and dermatologists.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; | 1999 |
Hyperadrenocorticism associated with excessive sex hormone production by an adrenocortical tumor in two dogs.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Adrenocortical Hyperfunction; Adr | 2001 |
Combined corneal lipid and calcium degeneration in a dog with hyperadrenocorticism: a case report.
Topics: Adrenocortical Hyperfunction; Animals; Antineoplastic Agents, Hormonal; Calcinosis; Corneal Diseases | 2002 |
[Corticosuprarenaloma in children].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adolescent; Adrenal Cortex Neoplasms; Adrenal G | 1975 |
Virilizing adrenal tumor in a child suppressed with dexamethasone for three years. Effect of o,p'-DDD on serum and urinary androgens.
Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Androgens; Child, Preschool; | 1977 |
Hair chewing associated with suspected hyperadrenocorticism in a dog.
Topics: Adrenocortical Hyperfunction; Animals; Behavior, Animal; Dog Diseases; Dogs; Female; Hair; Masticati | 1978 |
Gamma camera imaging of bilateral adrenocortical hyperplasia and adrenal tumors in the dog.
Topics: 11-Hydroxycorticosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortical Hyperfun | 1976 |
[Value of retropneumoperitoneum in the exploration of Cushing's syndrome. 155 cases].
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortical Hyperfunction; Angiography; Cushing | 1975 |
[Letter: Idiopathic hemochromatosis and Cushing's disease].
Topics: Adrenocortical Hyperfunction; Adult; Cushing Syndrome; Female; Hemochromatosis; Humans; Mitotane; Sp | 1975 |
Comparison of mitotane treatment for adrenal tumor versus pituitary-dependent hyperadrenocorticism in dogs.
Topics: Adenoma; Adrenal Cortex; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adrenocorticotropic | 1992 |
[Formal pathogenesis, average age and breed distribution in the comparison of 61 Lysodren-treated and 36 untreated cases of canine hyperadrenocorticism which were dissected in the years 1975 to 1991 at the Institute for Veterinary Pathology of the Free Un
Topics: Adrenal Cortex Neoplasms; Adrenocortical Hyperfunction; Age Factors; Animals; Breeding; Cushing Synd | 1992 |
Assessment of fat absorption in normal dogs and in dogs with hyperadrenocorticalism.
Topics: Adrenocortical Hyperfunction; Animals; Dietary Fats; Dog Diseases; Dogs; Female; Intestinal Absorpti | 1990 |
Pituitary macroadenomas and macroadenocarcinomas in dogs treated with mitotane for pituitary-dependent hyperadrenocorticism: 13 cases (1981-1986).
Topics: Adenocarcinoma; Adenoma; Adrenocortical Hyperfunction; Animals; Dog Diseases; Dogs; Mitotane; Pituit | 1989 |
Perianal adenomas and hypertestosteronemia in a spayed bitch with pituitary-dependent hyperadrenocorticism.
Topics: Adenoma; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Anal Gland Neoplasms; Animals; C | 1988 |
Effect of o,p'DDD therapy on endogenous ACTH concentrations in dogs with hypophysis-dependent hyperadrenocorticism.
Topics: Adrenal Cortex Function Tests; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Animals; D | 1985 |
An alternative protocol for the medical management of canine pituitary-dependent hyperadrenocorticism.
Topics: Adrenal Cortex; Adrenocortical Hyperfunction; Animals; Cortisone; Dog Diseases; Dogs; Female; Fludro | 1988 |
Systemic availability of o,p'-DDD in normal dogs, fasted and fed, and in dogs with hyperadrenocorticism.
Topics: Administration, Oral; Adrenocortical Hyperfunction; Animals; Biological Availability; Dog Diseases; | 1987 |
Malignant melanoma with ectopic production of adrenocorticotropic hormone. Palliative treatment with inhibitors of adrenal steroid biosynthesis.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocortical Hyperfunction; Adrenocorticotropic Hormon | 1973 |
[Medical therapy of hyperadrenalism].
Topics: Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Aminoglutethimide; Cushing Syndrome; Huma | 1973 |