Page last updated: 2024-10-31

mitotane and Adrenal Hyperplasia, Congenital

mitotane has been researched along with Adrenal Hyperplasia, Congenital in 4 studies

Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.

Adrenal Hyperplasia, Congenital: A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.

Research Excerpts

ExcerptRelevanceReference
"Pheochromocytomas are derived from the adrenal medulla and present with symptoms caused by high secretion of catecholamines."2.50Rare adrenal tumors in children. ( Mihai, R, 2014)
"UA induced remission of hypercortisolism in all patients, with sustained significant clinical improvement."1.42Unilateral Adrenalectomy as a First-Line Treatment of Cushing's Syndrome in Patients With Primary Bilateral Macronodular Adrenal Hyperplasia. ( Benoit, M; Caron, P; Chabre, O; Chaffanjon, P; Debillon, E; Lambert, B; Massoutier, M; Salenave, S; Tabarin, A; Velayoudom-Cephise, FL; Wagner, T; Young, J, 2015)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (75.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Bachelot, A1
Lapoirie, M1
Dulon, J1
Leban, M1
Renard Penna, R1
Touraine, P1
Mihai, R1
Bry-Gauillard, H1
Cartes, A1
Young, J2
Debillon, E1
Velayoudom-Cephise, FL1
Salenave, S1
Caron, P1
Chaffanjon, P1
Wagner, T1
Massoutier, M1
Lambert, B1
Benoit, M1
Tabarin, A1
Chabre, O1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Metabolic, Pressor and Neuropsychological Effects of Metyrapone Treatment in Patients With Hypercortisolism[NCT05255900]20 participants (Anticipated)Observational2022-04-28Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for mitotane and Adrenal Hyperplasia, Congenital

ArticleYear
Rare adrenal tumors in children.
    Seminars in pediatric surgery, 2014, Volume: 23, Issue:2

    Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenalectomy; A

2014

Other Studies

3 other studies available for mitotane and Adrenal Hyperplasia, Congenital

ArticleYear
Effects of mitotane on testicular adrenal rest tumors in congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a retrospective series of five patients.
    European journal of endocrinology, 2021, Volume: 184, Issue:3

    Topics: Adrenal Hyperplasia, Congenital; Adrenal Rest Tumor; Adult; Antineoplastic Agents, Hormonal; Humans;

2021
Mitotane for 21-hydroxylase deficiency in an infertile man.
    The New England journal of medicine, 2014, Nov-20, Volume: 371, Issue:21

    Topics: Adrenal Hyperplasia, Congenital; Adrenal Rest Tumor; Adult; Antineoplastic Agents, Hormonal; Azoospe

2014
Unilateral Adrenalectomy as a First-Line Treatment of Cushing's Syndrome in Patients With Primary Bilateral Macronodular Adrenal Hyperplasia.
    The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:12

    Topics: Adrenal Hyperplasia, Congenital; Adrenal Insufficiency; Adrenalectomy; Adrenocorticotropic Hormone;

2015