mitotane has been researched along with Adrenal Hyperplasia, Congenital in 4 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Adrenal Hyperplasia, Congenital: A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pheochromocytomas are derived from the adrenal medulla and present with symptoms caused by high secretion of catecholamines." | 2.50 | Rare adrenal tumors in children. ( Mihai, R, 2014) |
| "UA induced remission of hypercortisolism in all patients, with sustained significant clinical improvement." | 1.42 | Unilateral Adrenalectomy as a First-Line Treatment of Cushing's Syndrome in Patients With Primary Bilateral Macronodular Adrenal Hyperplasia. ( Benoit, M; Caron, P; Chabre, O; Chaffanjon, P; Debillon, E; Lambert, B; Massoutier, M; Salenave, S; Tabarin, A; Velayoudom-Cephise, FL; Wagner, T; Young, J, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bachelot, A | 1 |
| Lapoirie, M | 1 |
| Dulon, J | 1 |
| Leban, M | 1 |
| Renard Penna, R | 1 |
| Touraine, P | 1 |
| Mihai, R | 1 |
| Bry-Gauillard, H | 1 |
| Cartes, A | 1 |
| Young, J | 2 |
| Debillon, E | 1 |
| Velayoudom-Cephise, FL | 1 |
| Salenave, S | 1 |
| Caron, P | 1 |
| Chaffanjon, P | 1 |
| Wagner, T | 1 |
| Massoutier, M | 1 |
| Lambert, B | 1 |
| Benoit, M | 1 |
| Tabarin, A | 1 |
| Chabre, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Metabolic, Pressor and Neuropsychological Effects of Metyrapone Treatment in Patients With Hypercortisolism[NCT05255900] | 20 participants (Anticipated) | Observational | 2022-04-28 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for mitotane and Adrenal Hyperplasia, Congenital
| Article | Year |
|---|---|
Rare adrenal tumors in children.
Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenalectomy; A | 2014 |
3 other studies available for mitotane and Adrenal Hyperplasia, Congenital
| Article | Year |
|---|---|
Effects of mitotane on testicular adrenal rest tumors in congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a retrospective series of five patients.
Topics: Adrenal Hyperplasia, Congenital; Adrenal Rest Tumor; Adult; Antineoplastic Agents, Hormonal; Humans; | 2021 |
Mitotane for 21-hydroxylase deficiency in an infertile man.
Topics: Adrenal Hyperplasia, Congenital; Adrenal Rest Tumor; Adult; Antineoplastic Agents, Hormonal; Azoospe | 2014 |
Unilateral Adrenalectomy as a First-Line Treatment of Cushing's Syndrome in Patients With Primary Bilateral Macronodular Adrenal Hyperplasia.
Topics: Adrenal Hyperplasia, Congenital; Adrenal Insufficiency; Adrenalectomy; Adrenocorticotropic Hormone; | 2015 |