Page last updated: 2024-10-31

mitotane and Adrenal Cortex Diseases

mitotane has been researched along with Adrenal Cortex Diseases in 5 studies

Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.

Adrenal Cortex Diseases: Pathological processes of the ADRENAL CORTEX.

Research Excerpts

ExcerptRelevanceReference
"In untreated hyperadrenocorticism, clinical problems may result from metastasis of an adrenocortical carcinoma, growth of a pituitary tumor, or complications associated with sustained hypercortisolemia itself, such as hypertension, cardiovascular disease, thromboembolism, glucose intolerance, and increased susceptibility to infection."2.40Complications and concurrent disease associated with canine hyperadrenocorticism. ( Nichols, R, 1997)
" This dosage was maintained for an additional 16 weeks (cumulative dose 602 g, plasma MT maximum level 12 microg/ml), and then stopped because of sustained signs of hypoadrenalism requiring prednisone replacement."1.33A six month mitotane course induced sustained correction of hypercortisolism in a young woman with PPNAD and Carney complex. ( Campo, M; Cignarelli, M; Giorgino, F; Logoluso, F; Margaglione, M; Marino, A; Picca, G, 2005)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's2 (40.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Liu, X1
Zhang, S1
Guo, Y1
Gang, X1
Wang, G1
Cignarelli, M1
Picca, G1
Campo, M1
Margaglione, M1
Marino, A1
Logoluso, F1
Giorgino, F1
Peterson, ME1
Kintzer, PP1
Nichols, R1
van den Broek, AH1
Lida, J1

Reviews

3 reviews available for mitotane and Adrenal Cortex Diseases

ArticleYear
Treatment of Primary Pigmented Nodular Adrenocortical Disease.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2022, Volume: 54, Issue:11

    Topics: Adrenal Cortex Diseases; Adrenalectomy; Adrenocorticotropic Hormone; Child; Cushing Syndrome; Humans

2022
Medical treatment of pituitary-dependent hyperadrenocorticism. Mitotane.
    The Veterinary clinics of North America. Small animal practice, 1997, Volume: 27, Issue:2

    Topics: Adrenal Cortex Diseases; Adrenocortical Hyperfunction; Animals; Antineoplastic Agents, Hormonal; Dia

1997
Complications and concurrent disease associated with canine hyperadrenocorticism.
    The Veterinary clinics of North America. Small animal practice, 1997, Volume: 27, Issue:2

    Topics: Adrenal Cortex Diseases; Adrenocortical Hyperfunction; Animals; Antineoplastic Agents; Diabetes Comp

1997

Other Studies

2 other studies available for mitotane and Adrenal Cortex Diseases

ArticleYear
A six month mitotane course induced sustained correction of hypercortisolism in a young woman with PPNAD and Carney complex.
    Journal of endocrinological investigation, 2005, Volume: 28, Issue:1

    Topics: Adrenal Cortex Diseases; Adrenal Glands; Adult; Antineoplastic Agents, Hormonal; DNA; Female; Humans

2005
Serum protein electrophoresis in spontaneous canine hyperadrenocorticalism.
    Research in veterinary science, 1989, Volume: 46, Issue:1

    Topics: Adrenal Cortex Diseases; Alpha-Globulins; Animals; Beta-Globulins; Blood Protein Electrophoresis; Bl

1989