mitotane has been researched along with Adrenal Cortex Diseases in 5 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Adrenal Cortex Diseases: Pathological processes of the ADRENAL CORTEX.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In untreated hyperadrenocorticism, clinical problems may result from metastasis of an adrenocortical carcinoma, growth of a pituitary tumor, or complications associated with sustained hypercortisolemia itself, such as hypertension, cardiovascular disease, thromboembolism, glucose intolerance, and increased susceptibility to infection." | 2.40 | Complications and concurrent disease associated with canine hyperadrenocorticism. ( Nichols, R, 1997) |
| " This dosage was maintained for an additional 16 weeks (cumulative dose 602 g, plasma MT maximum level 12 microg/ml), and then stopped because of sustained signs of hypoadrenalism requiring prednisone replacement." | 1.33 | A six month mitotane course induced sustained correction of hypercortisolism in a young woman with PPNAD and Carney complex. ( Campo, M; Cignarelli, M; Giorgino, F; Logoluso, F; Margaglione, M; Marino, A; Picca, G, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, X | 1 |
| Zhang, S | 1 |
| Guo, Y | 1 |
| Gang, X | 1 |
| Wang, G | 1 |
| Cignarelli, M | 1 |
| Picca, G | 1 |
| Campo, M | 1 |
| Margaglione, M | 1 |
| Marino, A | 1 |
| Logoluso, F | 1 |
| Giorgino, F | 1 |
| Peterson, ME | 1 |
| Kintzer, PP | 1 |
| Nichols, R | 1 |
| van den Broek, AH | 1 |
| Lida, J | 1 |
3 reviews available for mitotane and Adrenal Cortex Diseases
| Article | Year |
|---|---|
Treatment of Primary Pigmented Nodular Adrenocortical Disease.
Topics: Adrenal Cortex Diseases; Adrenalectomy; Adrenocorticotropic Hormone; Child; Cushing Syndrome; Humans | 2022 |
Medical treatment of pituitary-dependent hyperadrenocorticism. Mitotane.
Topics: Adrenal Cortex Diseases; Adrenocortical Hyperfunction; Animals; Antineoplastic Agents, Hormonal; Dia | 1997 |
Complications and concurrent disease associated with canine hyperadrenocorticism.
Topics: Adrenal Cortex Diseases; Adrenocortical Hyperfunction; Animals; Antineoplastic Agents; Diabetes Comp | 1997 |
2 other studies available for mitotane and Adrenal Cortex Diseases
| Article | Year |
|---|---|
A six month mitotane course induced sustained correction of hypercortisolism in a young woman with PPNAD and Carney complex.
Topics: Adrenal Cortex Diseases; Adrenal Glands; Adult; Antineoplastic Agents, Hormonal; DNA; Female; Humans | 2005 |
Serum protein electrophoresis in spontaneous canine hyperadrenocorticalism.
Topics: Adrenal Cortex Diseases; Alpha-Globulins; Animals; Beta-Globulins; Blood Protein Electrophoresis; Bl | 1989 |