Page last updated: 2024-10-31

mitotane and Adrenal Cancer

mitotane has been researched along with Adrenal Cancer in 93 studies

Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.

Research Excerpts

ExcerptRelevanceReference
"Mitotane is used in adrenal cancer as adjuvant therapy, monotherapy or combined with other cytotoxic agents in advanced disease, but only 30% of patients respond."7.78Structural requirements for mitotane activity: development of analogs for treatment of adrenal cancer. ( Benitez, RS; Counsell, RE; Homan, DF; Johnson, TD; Schteingart, DE; Sinsheimer, JE, 2012)
"Whenever adrenal cancer (ACC) is completely removed we should face the dilemma to treat by means of adjuvant therapy or not."6.48Management of adjuvant mitotane therapy following resection of adrenal cancer. ( Ardito, A; Berruti, A; Daffara, F; De Francia, S; Germano, A; Laino, F; Terzolo, M; Zaggia, B, 2012)
" In this study we assessed the impact of RRM1 on the bioavailability and cytotoxic activity of o,p'DDD, o,p'DDE and o,p'DDA in SW13 and H295R cells."5.42RRM1 modulates mitotane activity in adrenal cancer cells interfering with its metabolization. ( Berruti, A; De Francia, S; Germano, A; Migliore, C; Papotti, M; Rapa, I; Terzolo, M; Volante, M, 2015)
"Mitotane has been administered in daily doses of 3."5.33Clinical role of determination of plasma mitotane and its metabolites levels in patients with adrenal cancer: results of a long-term follow-up. ( Cichocki, A; Kasperlik-Zaluska, AA, 2005)
"In 1966, we published the case report of a patient with adrenal carcinoma and wide spread metatasis who, after treatment with mitotane (o,p-DDD) and fluorouracil, developed Addison disease accompanied by a clinical remission."3.65Metastatic adrenal cortical carcinoma. Documented cure with combined chemotherapy. ( Ostuni, JA; Roginsky, MS, 1975)
"Adrenocortical carcinoma is a rare malignancy, often with poor outcomes."2.66American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach. ( Bancos, I; Else, T; Habra, M; Hamrahian, A; Kiseljak-Vassiliades, K; Levine, AC; Vaidya, A, 2020)
"Pheochromocytomas are present in approximately 4-7% of patients with adrenal incidentalomas."2.58Primary malignant tumors of the adrenal glands. ( Almeida, MQ; Bezerra-Neto, JE; Fragoso, MCBV; Latronico, AC; Mendonça, BB, 2018)
"Pheochromocytomas are derived from the adrenal medulla and present with symptoms caused by high secretion of catecholamines."2.50Rare adrenal tumors in children. ( Mihai, R, 2014)
"Adrenal Cancer is an infrequent and very aggressive tumor."2.48Giant adrenal carcinoma associated with renal vein and inferior vena cava thrombus. Case report and literature review. ( Fernández Arjona, M; Garrido Abad, P; Gómez de Vicente, JM; Herranz Fernández, LM; Jiménez Gálvez, M; Santos Arrontes, D; Suárez Fonseca, C, 2012)
" Several important questions remain to be addressed such as the optimal dose and most effective dosing interval, when to use the metronomic approach in the natural history of the disease, the choice of cytotoxic drugs, and the most efficacious way to integrate metronomic chemotherapy with standard therapy protocols."2.47Metronomic therapy concepts in the management of adrenocortical carcinoma. ( Ardito, A; Bellini, E; Berruti, A; Daffara, F; Perotti, P; Saini, A; Sperone, P; Terzolo, M, 2011)
"Androgen-secreting adrenal cancers are extremely rare malignancies, accounting for only a tiny proportion of the total number of women presenting with signs of androgen excess."2.46Androgen- and estrogen-secreting adrenal cancers. ( Bharwani, N; Cavlan, D; Grossman, A, 2010)
"Treatment with metyrapone or o,p'-DDD can always induce a clinical remission but not a cure, and neurotransmitter therapy may be effective in a minority of cases."2.37Cushing's syndrome. ( Besser, GM; Howlett, TA; Rees, LH, 1985)
"Because of the rarity of adrenocortical cancer (ACC), only a few population-based studies are available, and they reported limited details in the characterization of patients and their treatment."1.91New Findings on Presentation and Outcome of Patients With Adrenocortical Cancer: Results From a National Cohort Study. ( Altieri, B; Arvat, E; Basile, V; Berchialla, P; Berruti, A; Calabrese, A; Cannavò, S; Canu, L; Ceccato, F; Di Dalmazi, G; Ferraù, F; Fiori, C; Grisanti, S; Laganà, M; Loli, P; Morelli, V; Perotti, P; Pia, A; Pivonello, R; Porpiglia, F; Puglisi, S; Reimondo, G; Scaroni, C; Stigliano, A; Terzolo, M; Urru, S; Violi, MA, 2023)
"Mitotane has been administered in daily doses of 3."1.33Clinical role of determination of plasma mitotane and its metabolites levels in patients with adrenal cancer: results of a long-term follow-up. ( Cichocki, A; Kasperlik-Zaluska, AA, 2005)
"Adrenocortical carcinoma is a rare disease which is primarily approached surgically."1.28Radiation therapy for adjunctive treatment of adrenal cortical carcinoma. ( Brady, LW; Markoe, AM; Micaily, B; Serber, W, 1991)
"Both patients developed hypoadrenalism while on o,p'-DDD and apparently adequate dexamethasone replacement therapy."1.27The effect of o,p'-DDD on adrenal steroid replacement therapy requirements. ( Hales, IB; Henniker, AJ; Ho, K; Luttrell, BM; Robinson, BG; Smee, IR; Stiel, JN, 1987)
"However, in adrenal cancer, urinary 17OHCS did not correlate with either plasma cortisol or urinary free cortisol, while the latter two parameters did."1.27Effect of o,p'-DDD on cortisol metabolism in Cushing's syndrome of various etiology. ( Inoue, S; Kawai, K; Koide, Y; Murayama, H; Yamashita, K, 1985)
"There months following surgery, liver metastases were documented associated with elevated levels of serum androgens."1.26Virilizing adrenal tumor in a child suppressed with dexamethasone for three years. Effect of o,p'-DDD on serum and urinary androgens. ( Korth-Schutz, S; Levine, LS; New, MI; Roth, JA; Saenger, P, 1977)
"Hyperadrenocorticism was diagnosed in 8 dogs by evaluation of urinary 17-hydroxycorticosteroid (OHCS) excretion rates, urinary 17-OHCS and plasma 11beta-OHCS RESPONSES TO DEXAMETHASONE SUPPRESSION OF ENDOGENOUS ADRENOCORTICOTROPIN (ACTH) secretion, and plasma 11beta-OHCS response to intravenous administration of ACTH."1.26Gamma camera imaging of bilateral adrenocortical hyperplasia and adrenal tumors in the dog. ( de Bruijne, JJ; Lubberink, AA; Mulnix, JA; Rijnberk, A; Van den Brom, WE, 1976)
"Virilism is the major manifestation in children (83 percent of the cases), either isolated or associated with hypercortisolism and/or feminization."1.25[Corticosuprarenaloma in children]. ( Benaily, M; Job, JC; Schweisguth, O, 1975)

Research

Studies (93)

TimeframeStudies, this research(%)All Research%
pre-199051 (54.84)18.7374
1990's14 (15.05)18.2507
2000's12 (12.90)29.6817
2010's14 (15.05)24.3611
2020's2 (2.15)2.80

Authors

AuthorsStudies
Puglisi, S1
Calabrese, A1
Ferraù, F1
Violi, MA1
Laganà, M1
Grisanti, S1
Ceccato, F1
Scaroni, C1
Di Dalmazi, G1
Stigliano, A1
Altieri, B1
Canu, L1
Loli, P1
Pivonello, R1
Arvat, E1
Morelli, V1
Perotti, P2
Basile, V1
Berchialla, P1
Urru, S1
Fiori, C1
Porpiglia, F2
Berruti, A5
Pia, A1
Reimondo, G1
Cannavò, S1
Terzolo, M4
Nowak, KM1
Łebek-Szatańska, A1
Samsel, R1
Roszkowska-Purska, K1
Ćwikła, JB1
Papierska, L1
Kiseljak-Vassiliades, K1
Bancos, I1
Hamrahian, A1
Habra, M1
Vaidya, A1
Levine, AC1
Else, T1
Dickson, PV1
Kim, L1
Yen, TWF1
Yang, A1
Grubbs, EG1
Patel, D1
Solórzano, CC1
Almeida, MQ1
Bezerra-Neto, JE1
Mendonça, BB1
Latronico, AC1
Fragoso, MCBV1
Mihai, R1
Germano, A2
Rapa, I1
Volante, M1
De Francia, S2
Migliore, C1
Papotti, M1
Holmes, D1
Cavlan, D1
Bharwani, N1
Grossman, A1
Sperone, P1
Bellini, E1
Daffara, F2
Ardito, A2
Saini, A1
Baudin, E3
Leboulleux, S1
Al Ghuzlan, A1
Chougnet, C1
Young, J1
Deandreis, D1
Dumont, F1
Dechamps, F1
Caramella, C1
Chanson, P1
Lanoy, E1
Borget, I1
Schlumberger, M1
Demeure, MJ1
Bussey, KJ1
Kirschner, LS1
Zaggia, B1
Laino, F1
Garrido Abad, P1
Gómez de Vicente, JM1
Herranz Fernández, LM1
Jiménez Gálvez, M1
Santos Arrontes, D1
Suárez Fonseca, C1
Fernández Arjona, M1
Schteingart, DE2
Sinsheimer, JE1
Benitez, RS1
Homan, DF1
Johnson, TD1
Counsell, RE1
Gelderblom, H1
Haak, HR1
Fassnacht, M1
Pentheroudakis, G1
Ng, WT1
Toohey, MG1
Mulhall, L1
Mackey, DA1
MOLNAR, GD2
MATTOX, VR1
BAHN, RC1
NETTO, AD1
WAJCHENBERG, BL1
RAVAGLIA, C1
PEREIRA, VG1
SHNAIDER, J1
PUPO, AA1
CINTRA, AB1
MONTGOMERY, DA1
WELBOURN, RB1
NUNN, SL1
TAUXE, WN1
Kvacheniuk, AN1
Brauckhoff, M1
Dralle, H1
Martins, AC1
Cologna, AJ1
Tucci, S1
Suaid, HJ1
Falconi, RA1
Lee, YM1
Kang, BT1
Jung, DI1
Park, C1
Kim, HJ1
Kim, JW1
Lim, CY1
Park, EH1
Park, HM1
Kasperlik-Zaluska, AA1
Cichocki, A1
Nader, N1
Raverot, G1
Emptoz-Bonneton, A1
Déchaud, H1
Bonnay, M1
Pugeat, M1
Shibata, H1
Chamuleau, SA1
Corssmit, EP1
Pereira, AM1
van de Berg, BT1
Siegert, CE1
Ozimek, A1
Diebold, J1
Linke, R1
Heyn, J1
Hallfeldt, K1
Mussack, T1
Jacobelli, A1
Agostino, A1
Altomonte, G1
Courvoisier, B1
Aron, DC1
Findling, JW1
Fitzgerald, PA1
Forsham, PH1
Wilson, CB1
Tyrrell, JB1
Boven, E1
Vermorken, JB1
van Slooten, H1
Pinedo, HM1
Kay, R1
Schumacher, OP2
Tank, ES1
Motazedi, A1
Noonan, RA1
Thompson, NW2
Kinouchi, T1
Shimizu, N1
Ibayashi, H1
Demura, H1
Oshima, H1
Karakousis, CP1
Uribe, J1
Moore, R1
Bricaire, H3
Luton, JP5
Bennett, BD1
McKenna, TJ1
Hough, AJ1
Dean, R1
Page, DL1
Dunnick, NR1
Freeman, DA2
Ahlman, H1
Jansson, S1
Wängberg, B1
Tisell, LE1
Scherstén, T1
Hansson, G1
Bengtsson, BA1
Ernest, I1
Jakobsson, CE1
Lindstedt, S1
Raux-Demay, MC1
Girard, F1
Gebhardt, DO1
Moolenaar, AJ3
van Seters, AP2
Kintzer, PP1
Peterson, ME1
Bennett, PF1
Norman, EJ1
Schott, M1
Scherbaum, WA1
Feldkamp, J1
Magiakou, MA1
Chrousos, GP1
Besser, GM2
Jeffcoate, WJ1
Benaily, M1
Schweisguth, O2
Job, JC1
Boyar, RM1
Nogeire, C1
Fukushima, D1
Hellman, L2
Fishman, J1
Korth-Schutz, S1
Levine, LS1
Roth, JA1
Saenger, P1
New, MI1
Owens, JM1
Drucker, WD1
Hajjar, RA1
Hickey, RC1
Samaan, NA3
deAsis, DN1
Rappaport, R1
Cachin, O1
Pellerin, D1
Fang, VS1
Kelly, DF1
Darke, PG1
Bulger, AR1
Correa, RJ1
Mulnix, JA1
Van den Brom, WE1
Lubberink, AA1
de Bruijne, JJ1
Rijnberk, A1
Becker, D1
Butez, J1
Bonnin, A1
Pallardy, G1
Ledoux-Lebard, G1
Scott, RD1
Ostuni, JA1
Roginsky, MS1
Feldman, EC1
Nelson, RW1
Feldman, MS1
Farver, TB1
van Aalderen, W1
Backer, ET1
Chang, PC1
van Krieken, JH1
Markoe, AM1
Serber, W1
Micaily, B1
Brady, LW1
Vassilopoulou-Sellin, R1
Schwartz, RW1
Sloan, DA1
Kenady, DE1
Nakamura, S1
Kuzuya, N1
Koide, Y2
Matsumara, M1
Watanabe, Y1
Tomizawa, H1
Murayama, Y1
Okuda, Y1
Takuwa, Y1
Itakura, M1
Donckier, JE1
Michel, LA1
Berbinschi, A1
De Coster, PM1
De Plaen, JF1
Ketelslegers, JM1
Buysschaert, M1
Kuhn, JM1
Proeschel, MF1
Seurin, DJ1
Bertagna, XY1
Girard, FL1
Vierhapper, H1
Mostbeck, G1
Waldhäusl, W1
Cheung, PS1
Robinson, BG1
Hales, IB1
Henniker, AJ1
Ho, K1
Luttrell, BM1
Smee, IR1
Stiel, JN1
Eriksson, B1
Oberg, K1
Curstedt, T1
Hemmingsson, A1
Johansson, H1
Lindh, E1
Lindgren, PG1
Thuomas, KA1
Wilander, E1
Akerström, G1
Howlett, TA1
Rees, LH1
Inoue, S1
Murayama, H1
Kawai, K1
Yamashita, K1
Cuddy, PG1
Loftus, LS1
Touitou, Y1
Bogdan, A1
Auzéby, A1
Judy, JC1
Scardino, PL1
Bradlow, HL1
Zumoff, B1
Schein, PS1
Yamada, S1
Harrison, JH1
Mahoney, EM1
Bennett, AH1
Downing, V1
Eule, J1
Huseby, RA1
Lubitz, JA1
Freeman, L1
Okun, R1
Metz, SA1
Schick, M1
Lewinsky, BS1
Grigor, KM1
Symington, T1
Neville, AM1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Mitotane With or Without Cisplatin and Etoposide After Surgery in Treating Participants With Stage I-III Adrenocortical Cancer With High Risk of Recurrence[NCT03723941]Phase 3240 participants (Anticipated)Interventional2018-07-01Recruiting
Activity of Abiraterone Acetate in the Management of Cushing's Syndrome in Patients With Adrenocortical Carcinoma[NCT03145285]Phase 210 participants (Anticipated)Interventional2017-04-18Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

25 reviews available for mitotane and Adrenal Cancer

ArticleYear
American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach.
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2020, Volume: 26, Issue:11

    Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Adult; Humans; Mitotane

2020
Adjuvant and Neoadjuvant Therapy, Treatment for Advanced Disease, and Genetic Considerations for Adrenocortical Carcinoma: An Update from the SSO Endocrine and Head and Neck Disease Site Working Group.
    Annals of surgical oncology, 2018, Volume: 25, Issue:12

    Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Combined Chemothera

2018
Primary malignant tumors of the adrenal glands.
    Clinics (Sao Paulo, Brazil), 2018, 12-10, Volume: 73, Issue:suppl 1

    Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents,

2018
Rare adrenal tumors in children.
    Seminars in pediatric surgery, 2014, Volume: 23, Issue:2

    Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenalectomy; A

2014
Androgen- and estrogen-secreting adrenal cancers.
    Seminars in oncology, 2010, Volume: 37, Issue:6

    Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Adult; Algorithms; Androgens; Anti

2010
Metronomic therapy concepts in the management of adrenocortical carcinoma.
    Hormones & cancer, 2011, Volume: 2, Issue:6

    Topics: Administration, Metronomic; Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Animals; Antineoplast

2011
Therapeutic management of advanced adrenocortical carcinoma: what do we know in 2011?
    Hormones & cancer, 2011, Volume: 2, Issue:6

    Topics: Adrenal Gland Neoplasms; Adult; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma,

2011
Targeted therapies for adrenocortical carcinoma: IGF and beyond.
    Hormones & cancer, 2011, Volume: 2, Issue:6

    Topics: Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Animals; Antibodies, Monoclonal; Antibodies, Mono

2011
Management of adjuvant mitotane therapy following resection of adrenal cancer.
    Endocrine, 2012, Volume: 42, Issue:3

    Topics: Adrenal Gland Neoplasms; Antineoplastic Agents, Hormonal; Case Management; Chemotherapy, Adjuvant; C

2012
Giant adrenal carcinoma associated with renal vein and inferior vena cava thrombus. Case report and literature review.
    Archivos espanoles de urologia, 2012, Volume: 65, Issue:5

    Topics: Adrenal Gland Neoplasms; Adrenalectomy; Aged; Antineoplastic Agents; Carcinoma; Contraindications; F

2012
[Recurrent operations on the adrenal glands].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2005, Volume: 76, Issue:3

    Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Adult; Anti

2005
[Deoxycorticosterone-producing adrenal tumor].
    Nihon rinsho. Japanese journal of clinical medicine, 2006, May-28, Volume: Suppl 1

    Topics: Adrenal Gland Neoplasms; Adrenalectomy; Antineoplastic Agents, Hormonal; Desoxycorticosterone; Diagn

2006
Bilateral primary adrenal non-Hodgkin's lymphoma and primary adrenocortical carcinoma--review of the literature preoperative differentiation of adrenal tumors.
    Endocrine journal, 2008, Volume: 55, Issue:4

    Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Aged, 80

2008
Cushing's syndrome: problems in management.
    Endocrine reviews, 1982,Summer, Volume: 3, Issue:3

    Topics: ACTH Syndrome, Ectopic; Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone

1982
Complete response of metastasized adrenal cortical carcinoma with o,p'-DDD. Case report and literature review.
    Cancer, 1984, Jan-01, Volume: 53, Issue:1

    Topics: Adrenal Cortex; Adrenal Gland Neoplasms; Carcinoma; Humans; Laparotomy; Lymphatic Metastasis; Male;

1984
[Cushing syndrome in children].
    Annales de pediatrie, 1993, Volume: 40, Issue:7

    Topics: Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hor

1993
Diagnosis and management of canine cortisol-secreting adrenal tumors.
    The Veterinary clinics of North America. Small animal practice, 1997, Volume: 27, Issue:2

    Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Antifungal A

1997
Adrenal carcinoma.
    Current therapy in endocrinology and metabolism, 1997, Volume: 6

    Topics: Adrenal Gland Neoplasms; Animals; Antineoplastic Agents, Hormonal; Humans; Mitotane

1997
[Drug therapy of endocrine neoplasms. Part I: Thyroid neoplasms, adrenal neoplasms and parathyroid neoplasms].
    Medizinische Klinik (Munich, Germany : 1983), 2000, Jan-15, Volume: 95, Issue:1

    Topics: Adrenal Gland Neoplasms; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Proto

2000
Cushing's syndrome in children and adolescents: current diagnostic and therapeutic strategies.
    Journal of endocrinological investigation, 2002, Volume: 25, Issue:2

    Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Antineopla

2002
Hyperadrenocorticism in the dog: canine Cushing's syndrome.
    The Veterinary clinics of North America, 1977, Volume: 7, Issue:3

    Topics: 17-Hydroxycorticosteroids; Adenoma; Adrenal Cortex Function Tests; Adrenal Gland Neoplasms; Adrenal

1977
Cushing's syndrome in the dog.
    The Veterinary record, 1976, Jan-10, Volume: 98, Issue:2

    Topics: 17-Hydroxycorticosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Animals; Calcinosis; Cu

1976
Diagnosis and treatment of primary adrenal tumors.
    Current opinion in oncology, 1991, Volume: 3, Issue:1

    Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Carcinoma; Cushing Syndrome; Diagnosis

1991
Cushing's syndrome.
    Clinics in endocrinology and metabolism, 1985, Volume: 14, Issue:4

    Topics: Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Alcoho

1985
Chemotherapeutic management of the hormone-secreting endocrine malignancies.
    Cancer, 1972, Volume: 30, Issue:6

    Topics: Adenoma, Islet Cell; Adrenal Gland Neoplasms; Aminoglutethimide; Aniline Compounds; Antibiotics, Ant

1972

Other Studies

68 other studies available for mitotane and Adrenal Cancer

ArticleYear
New Findings on Presentation and Outcome of Patients With Adrenocortical Cancer: Results From a National Cohort Study.
    The Journal of clinical endocrinology and metabolism, 2023, 09-18, Volume: 108, Issue:10

    Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Cohort Studies; Female;

2023
Adrenocortical carcinoma mimicking pheochromocytoma on iodine 123-labeled metaiodobenzylguanidine scintigraphy.
    Polish archives of internal medicine, 2019, 11-29, Volume: 129, Issue:11

    Topics: Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Adult; Antineoplastic Agents, Hormonal; Four-Dime

2019
RRM1 modulates mitotane activity in adrenal cancer cells interfering with its metabolization.
    Molecular and cellular endocrinology, 2015, Feb-05, Volume: 401

    Topics: Adrenal Gland Neoplasms; Antineoplastic Agents, Hormonal; Biological Availability; Cell Line, Tumor;

2015
Adrenal gland: Cancer target of mitotane identified.
    Nature reviews. Endocrinology, 2015, Volume: 11, Issue:11

    Topics: Adrenal Gland Neoplasms; Adrenal Glands; Antineoplastic Agents, Hormonal; Humans; Mitotane; Sterol O

2015
Structural requirements for mitotane activity: development of analogs for treatment of adrenal cancer.
    Anticancer research, 2012, Volume: 32, Issue:7

    Topics: Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Antineoplastic Agents

2012
Adrenal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Volume: 23 Suppl 7

    Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; A

2012
Adrenal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Volume: 23 Suppl 7

    Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; A

2012
Adrenal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Volume: 23 Suppl 7

    Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; A

2012
Adrenal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Volume: 23 Suppl 7

    Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; A

2012
Pigmentary retinopathy, macular oedema, and abnormal ERG with mitotane treatment.
    The British journal of ophthalmology, 2003, Volume: 87, Issue:4

    Topics: Adrenal Gland Neoplasms; Adult; Antineoplastic Agents, Hormonal; Electroretinography; Female; Fluore

2003
Clinical and therapeutic observations in the adrenal cancer: a report on 7 patients treated with o,p'-DDD.
    Cancer, 1963, Volume: 16

    Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Ant

1963
TREATMENT OF ADRENOCORTICAL CANCER WITH O,P'-DDD.
    Annals of internal medicine, 1963, Volume: 59

    Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenogenital Syndrome; Antineoplastic Agents; Ca

1963
ADRENOCORTICAL CARCINOMA TREATED WITH O,P' -DDD.
    British medical journal, 1965, May-22, Volume: 1, Issue:5446

    Topics: Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents; Child; Cushing Syndrome; D

1965
The effect of o,p'-DDD therapy on plasma cholesterol in adrenal carcinoma.
    Proceedings of the staff meetings. Mayo Clinic, 1961, Nov-22, Volume: 36

    Topics: Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortical Carcinoma; Cholesterol; Dichlorodiphenyldich

1961
[Analysis of postoperative recurrence of malignant tumors of adrenal glands].
    Klinichna khirurhiia, 2004, Issue:2

    Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Antineoplastic Agents, Hormonal; Female; Humans; Male

2004
Clinical features and immunoexpression of p53, MIB-1 and proliferating cell nuclear antigen in adrenal neoplasms.
    The Journal of urology, 2005, Volume: 173, Issue:6

    Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Adult; Antineoplastic C

2005
A case of adrenal gland dependent hyperadrenocorticism with mitotane therapy in a Yorkshire terrier dog.
    Journal of veterinary science, 2005, Volume: 6, Issue:4

    Topics: Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Animals; Antineo

2005
Clinical role of determination of plasma mitotane and its metabolites levels in patients with adrenal cancer: results of a long-term follow-up.
    Journal of experimental therapeutics & oncology, 2005, Volume: 5, Issue:2

    Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Antineoplastic Agents, Hormonal; Child; Female; Fo

2005
Mitotane has an estrogenic effect on sex hormone-binding globulin and corticosteroid-binding globulin in humans.
    The Journal of clinical endocrinology and metabolism, 2006, Volume: 91, Issue:6

    Topics: Adrenal Gland Neoplasms; Antineoplastic Agents, Hormonal; Estradiol; Estrogen Receptor alpha; Humans

2006
A young woman with a severe bilateral pneumonia as the presenting sign of an adrenal carcinoma.
    The Netherlands journal of medicine, 2008, Volume: 66, Issue:3

    Topics: Adrenal Gland Neoplasms; Adult; Antineoplastic Agents, Hormonal; Carcinoma; Cushing Syndrome; Female

2008
[Treatment of glycoactive hypercorticism].
    La Clinica terapeutica, 1984, Nov-30, Volume: 111, Issue:4

    Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; A

1984
[Clinical reports: pseudohypoparathyroidism, pituitary nanism, and adrenal carcinoma].
    Schweizerische medizinische Wochenschrift. Supplementum, 1982, Volume: 13

    Topics: 17-Hydroxycorticosteroids; Acne Vulgaris; Adrenal Gland Neoplasms; Adult; Androgens; Dihydrotachyste

1982
Adrenocortical carcinoma in children.
    The Journal of urology, 1983, Volume: 130, Issue:6

    Topics: Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Antineoplastic Agents; Carcinoma; Child; Child,

1983
Treatment of adrenal carcinomas.
    Archives of surgery (Chicago, Ill. : 1960), 1982, Volume: 117, Issue:9

    Topics: Adrenal Gland Neoplasms; Adult; Carcinoma; Female; Humans; Liver Neoplasms; Lung Neoplasms; Male; Mi

1982
[Treatment of Cushing's syndrome and adrenal cancer with O,p-DDD].
    Horumon to rinsho. Clinical endocrinology, 1982, Volume: 30, Issue:8

    Topics: Adrenal Gland Neoplasms; Adult; Aged; Cushing Syndrome; Drug Evaluation; Female; Humans; Male; Middl

1982
Adrenal adenocarcinomas: diagnosis and management.
    Journal of surgical oncology, 1981, Volume: 16, Issue:4

    Topics: Adenocarcinoma; Adrenal Gland Neoplasms; Adult; Aged; Female; Hormones; Humans; Male; Middle Aged; M

1981
[Cushing's syndrome. Medical treatment of adrenal hypercorticism].
    Hormone research, 1980, Volume: 13, Issue:4-5

    Topics: Adrenal Gland Neoplasms; Aminoglutethimide; Androstanols; Bromocriptine; Cushing Syndrome; Cyprohept

1980
Adrenal myelolipoma associated with Cushing's disease.
    American journal of clinical pathology, 1980, Volume: 73, Issue:3

    Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Gland Neoplasms; Cushing Syndrome; Humans; Male; Mito

1980
Adrenal carcinoma.
    Radiologic clinics of North America, 1994, Volume: 32, Issue:1

    Topics: Adolescent; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Age Factors; Ag

1994
Adrenal carcinoma.
    Current therapy in endocrinology and metabolism, 1994, Volume: 5

    Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Aminoglutethimide; Carcinoma; Cushing Syndrome; Dia

1994
Adrenocortical carcinoma--diagnostic and therapeutical implications.
    The European journal of surgery = Acta chirurgica, 1993, Volume: 159, Issue:3

    Topics: Adrenal Gland Neoplasms; Adrenal Rest Tumor; Adult; Aged; Carcinoma; Chemotherapy, Adjuvant; Female;

1993
Mitotane (o,p'-DDD) administration raises the serum level of high density lipoprotein (HDL) in normotriglyceridemia.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1993, Volume: 25, Issue:4

    Topics: Adrenal Gland Neoplasms; Humans; Hyperlipidemias; Lipoproteins, HDL; Mitotane; Stimulation, Chemical

1993
Mitotane (o,p'-DDD) resistance in a dog with pituitary-dependent hyperadrenocorticism and phaeochromocytoma.
    Australian veterinary journal, 1998, Volume: 76, Issue:2

    Topics: Adrenal Cortex Function Tests; Adrenal Gland Neoplasms; Adrenal Medulla; Adrenocortical Hyperfunctio

1998
Endocrine and metabolic diseases. Adrenal diseases.
    British medical journal, 1976, Feb-21, Volume: 1, Issue:6007

    Topics: Adenoma; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Insuffici

1976
[Corticosuprarenaloma in children].
    Archives francaises de pediatrie, 1975, Volume: 32, Issue:5

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adolescent; Adrenal Cortex Neoplasms; Adrenal G

1975
Studies of the diurnal pattern of plasma corticosteroids and gonadotropins in two cases of feminizing adrenal carcinoma: measurements of estrogen and corticosteroid production.
    The Journal of clinical endocrinology and metabolism, 1977, Volume: 44, Issue:1

    Topics: Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adult; Androgens; Circad

1977
Virilizing adrenal tumor in a child suppressed with dexamethasone for three years. Effect of o,p'-DDD on serum and urinary androgens.
    The Journal of clinical endocrinology and metabolism, 1977, Volume: 44, Issue:3

    Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Androgens; Child, Preschool;

1977
Adrenal cortical carcinoma. A study of 32 patients.
    Cancer, 1975, Volume: 35, Issue:2

    Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adult; Age Factors; Aged; Bone Neoplasms; Female; Hepa

1975
[Does Op'DDD possess an antimitotic action? Remarks apropos of its use in the treatment of adrenal adenocarcinomas].
    La Nouvelle presse medicale, 1977, Nov-19, Volume: 6, Issue:39

    Topics: Adrenal Gland Neoplasms; Carcinoma; Humans; Mitosis; Mitotane

1977
Feminizing adrenocortical carcinoma with Cushing's syndrome and pseudohyperparathyroidism.
    Archives of internal medicine, 1978, Volume: 138, Issue:2

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adult

1978
[Malignant adrenal carcinoma with metastases: exeresis and treatment with op'DD followed by cure].
    Archives francaises de pediatrie, 1978, Volume: 35, Issue:5

    Topics: Adrenal Gland Neoplasms; Child; Female; Follow-Up Studies; Humans; Mitotane; Neoplasm Metastasis; Ne

1978
Cytotoxic activity of 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane (mitotane) and its analogs on feminizing adrenal neoplastic cells in culture.
    Cancer research, 1979, Volume: 39, Issue:1

    Topics: Adrenal Gland Neoplasms; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Estrogens; Femi

1979
Experience with adrenal cortical carcinoma.
    Urology, 1977, Volume: 10, Issue:1

    Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adult; Aged; Female; Humans; Male

1977
Gamma camera imaging of bilateral adrenocortical hyperplasia and adrenal tumors in the dog.
    American journal of veterinary research, 1976, Volume: 37, Issue:12

    Topics: 11-Hydroxycorticosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortical Hyperfun

1976
o,p'DDD therapy in invasive adrenocortical carcinoma.
    Annals of internal medicine, 1975, Volume: 82, Issue:5

    Topics: Adrenal Cortex; Adrenal Gland Neoplasms; Adrenal Glands; Aged; Carcinoma; Child, Preschool; Dichloro

1975
[Value of retropneumoperitoneum in the exploration of Cushing's syndrome. 155 cases].
    La Nouvelle presse medicale, 1975, Mar-29, Volume: 4, Issue:13

    Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortical Hyperfunction; Angiography; Cushing

1975
Treatment of an adrenal cortical carcinoma with a combination of o,p'-DDD and aminoglutethimide.
    Postgraduate medical journal, 1975, Volume: 51, Issue:591

    Topics: 11-Hydroxycorticosteroids; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenalectomy; Adult;

1975
Metastatic adrenal cortical carcinoma. Documented cure with combined chemotherapy.
    Archives of internal medicine, 1975, Volume: 135, Issue:9

    Topics: Adolescent; Adrenal Gland Neoplasms; Carcinoma; Drug Therapy, Combination; Female; Fluorouracil; Hum

1975
Comparison of mitotane treatment for adrenal tumor versus pituitary-dependent hyperadrenocorticism in dogs.
    Journal of the American Veterinary Medical Association, 1992, Jun-01, Volume: 200, Issue:11

    Topics: Adenoma; Adrenal Cortex; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adrenocorticotropic

1992
A case of recurrent adrenocortical carcinoma, with observations on long-term o,p'-DDD therapy and complications.
    The Netherlands journal of medicine, 1992, Volume: 41, Issue:3-4

    Topics: Adrenal Gland Neoplasms; Carcinoma; Carcinosarcoma; Combined Modality Therapy; Female; Humans; Lung

1992
Radiation therapy for adjunctive treatment of adrenal cortical carcinoma.
    American journal of clinical oncology, 1991, Volume: 14, Issue:2

    Topics: Adrenal Gland Neoplasms; Aged; Aged, 80 and over; Carcinoma; Child; Combined Modality Therapy; Femal

1991
Mitotane administration: an unusual cause of hypercholesterolemia.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1991, Volume: 23, Issue:12

    Topics: Adrenal Gland Neoplasms; Female; Humans; Hypercholesterolemia; Male; Middle Aged; Mitotane

1991
Successful treatment of a metastatic hormone-producing adrenal cancer by a combination of mitotane, tegafur and surgical resection.
    Endocrinologia japonica, 1990, Volume: 37, Issue:5

    Topics: 17-alpha-Hydroxypregnenolone; Adrenal Gland Neoplasms; Adult; Aldosterone; Androstenedione; Antineop

1990
Late recurrence of operated adrenocortical carcinoma: atrial natriuretic factor before and after treatment with mitotane.
    Surgery, 1989, Volume: 105, Issue:5

    Topics: Adrenal Gland Neoplasms; Atrial Natriuretic Factor; Carcinoma; Combined Modality Therapy; Cushing Sy

1989
Comparative assessment of ACTH and lipotropin plasma levels in the diagnosis and follow-up of patients with Cushing's syndrome: a study of 210 cases.
    The American journal of medicine, 1989, Volume: 86, Issue:6 Pt 1

    Topics: ACTH Syndrome, Ectopic; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotr

1989
Effect of suramin in a patient with adrenocortical carcinoma.
    Lancet (London, England), 1989, May-27, Volume: 1, Issue:8648

    Topics: Adrenal Gland Neoplasms; Adult; Carcinoma; Drug Therapy, Combination; Humans; Male; Mitotane; Surami

1989
Right atrial extension of adrenocortical carcinoma. Surgical management using hypothermia and cardiopulmonary bypass.
    Cancer, 1989, Aug-15, Volume: 64, Issue:4

    Topics: Adrenal Gland Neoplasms; Adult; Carcinoma; Cardiopulmonary Bypass; Combined Modality Therapy; Female

1989
The effect of o,p'-DDD on adrenal steroid replacement therapy requirements.
    Clinical endocrinology, 1987, Volume: 27, Issue:4

    Topics: Adrenal Gland Neoplasms; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Dexamethasone; F

1987
Treatment of hormone-producing adrenocortical cancer with o,p'DDD and streptozocin.
    Cancer, 1987, Apr-15, Volume: 59, Issue:8

    Topics: Adrenal Cortex; Adrenal Gland Neoplasms; Adult; Antineoplastic Combined Chemotherapy Protocols; Cort

1987
Effect of o,p'-DDD on cortisol metabolism in Cushing's syndrome of various etiology.
    Endocrinologia japonica, 1985, Volume: 32, Issue:5

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Ho

1985
Influence of mitotane on the hypoprothrombinemic effect of warfarin.
    Southern medical journal, 1986, Volume: 79, Issue:3

    Topics: Adrenal Gland Neoplasms; Brain Neoplasms; Drug Interactions; Female; Humans; Hypoprothrombinemias; M

1986
o,p'-DDD (mitotane) treatment for Cushing's syndrome: adrenal drug concentration and inhibition in vitro of steroid synthesis.
    European journal of clinical pharmacology, 1985, Volume: 29, Issue:4

    Topics: 17-alpha-Hydroxyprogesterone; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Carcinoma; Child; Cort

1985
Adrenal cortical carcinoma: a case report.
    Journal of the Medical Association of Georgia, 1973, Volume: 62, Issue:11

    Topics: Adrenal Gland Neoplasms; Carcinoma; Female; Humans; Middle Aged; Mitotane; Neoplasm Metastasis; Pall

1973
Decreased conversion of androgens to normal 17-ketosteroid metabolites as a result of treatment with o,p'-DDD.
    The Journal of clinical endocrinology and metabolism, 1973, Volume: 36, Issue:5

    Topics: Adrenal Gland Neoplasms; Androsterone; Anemia, Pernicious; Carbon Isotopes; Dehydroepiandrosterone;

1973
[Urinary 6beta-hydroxycortisol. II. Urinary 6beta-hydroxycortisol in different diseases and after administration of drugs].
    Nihon Naibunpi Gakkai zasshi, 1973, Jun-20, Volume: 49, Issue:6

    Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Carcinoma; Cushing Syndrome; F

1973
Proceedings: Tumors of the adrenal cortex.
    Cancer, 1973, Volume: 32, Issue:5

    Topics: Adenoma; Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortico

1973
Regression of an adrenal cortical carcinoma and its neovascular bed following mitotane therapy: a case report.
    Cancer, 1974, Volume: 34, Issue:6

    Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Aortography; Blood Pressure; Catheterization; Fem

1974
Mitotane use in inoperable adrenal cortical carcinoma.
    JAMA, 1973, Mar-05, Volume: 223, Issue:10

    Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Diabetic Retinopathy; Female; Follow-Up Studies; Gastroi

1973
Drug treatment of inoperable adrenocortical carcinoma.
    JAMA, 1973, Apr-23, Volume: 224, Issue:4

    Topics: Adrenal Gland Neoplasms; Humans; Mitotane

1973
Survival with adrenal carcinoma.
    JAMA, 1973, Jun-25, Volume: 224, Issue:13

    Topics: Adrenal Gland Neoplasms; Female; Fluorouracil; Humans; Mitotane; Neoplasm Metastasis

1973
The clinical and pathologic features of "non-hormonal" adrenocortical tumors. Report of twenty new cases and review of the literature.
    Cancer, 1974, Volume: 33, Issue:3

    Topics: Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adult; Aged; Angiography; Antineoplast

1974