mitotane has been researched along with Adrenal Cancer in 93 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mitotane is used in adrenal cancer as adjuvant therapy, monotherapy or combined with other cytotoxic agents in advanced disease, but only 30% of patients respond." | 7.78 | Structural requirements for mitotane activity: development of analogs for treatment of adrenal cancer. ( Benitez, RS; Counsell, RE; Homan, DF; Johnson, TD; Schteingart, DE; Sinsheimer, JE, 2012) |
| "Whenever adrenal cancer (ACC) is completely removed we should face the dilemma to treat by means of adjuvant therapy or not." | 6.48 | Management of adjuvant mitotane therapy following resection of adrenal cancer. ( Ardito, A; Berruti, A; Daffara, F; De Francia, S; Germano, A; Laino, F; Terzolo, M; Zaggia, B, 2012) |
| " In this study we assessed the impact of RRM1 on the bioavailability and cytotoxic activity of o,p'DDD, o,p'DDE and o,p'DDA in SW13 and H295R cells." | 5.42 | RRM1 modulates mitotane activity in adrenal cancer cells interfering with its metabolization. ( Berruti, A; De Francia, S; Germano, A; Migliore, C; Papotti, M; Rapa, I; Terzolo, M; Volante, M, 2015) |
| "Mitotane has been administered in daily doses of 3." | 5.33 | Clinical role of determination of plasma mitotane and its metabolites levels in patients with adrenal cancer: results of a long-term follow-up. ( Cichocki, A; Kasperlik-Zaluska, AA, 2005) |
| "In 1966, we published the case report of a patient with adrenal carcinoma and wide spread metatasis who, after treatment with mitotane (o,p-DDD) and fluorouracil, developed Addison disease accompanied by a clinical remission." | 3.65 | Metastatic adrenal cortical carcinoma. Documented cure with combined chemotherapy. ( Ostuni, JA; Roginsky, MS, 1975) |
| "Adrenocortical carcinoma is a rare malignancy, often with poor outcomes." | 2.66 | American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach. ( Bancos, I; Else, T; Habra, M; Hamrahian, A; Kiseljak-Vassiliades, K; Levine, AC; Vaidya, A, 2020) |
| "Pheochromocytomas are present in approximately 4-7% of patients with adrenal incidentalomas." | 2.58 | Primary malignant tumors of the adrenal glands. ( Almeida, MQ; Bezerra-Neto, JE; Fragoso, MCBV; Latronico, AC; Mendonça, BB, 2018) |
| "Pheochromocytomas are derived from the adrenal medulla and present with symptoms caused by high secretion of catecholamines." | 2.50 | Rare adrenal tumors in children. ( Mihai, R, 2014) |
| "Adrenal Cancer is an infrequent and very aggressive tumor." | 2.48 | Giant adrenal carcinoma associated with renal vein and inferior vena cava thrombus. Case report and literature review. ( Fernández Arjona, M; Garrido Abad, P; Gómez de Vicente, JM; Herranz Fernández, LM; Jiménez Gálvez, M; Santos Arrontes, D; Suárez Fonseca, C, 2012) |
| " Several important questions remain to be addressed such as the optimal dose and most effective dosing interval, when to use the metronomic approach in the natural history of the disease, the choice of cytotoxic drugs, and the most efficacious way to integrate metronomic chemotherapy with standard therapy protocols." | 2.47 | Metronomic therapy concepts in the management of adrenocortical carcinoma. ( Ardito, A; Bellini, E; Berruti, A; Daffara, F; Perotti, P; Saini, A; Sperone, P; Terzolo, M, 2011) |
| "Androgen-secreting adrenal cancers are extremely rare malignancies, accounting for only a tiny proportion of the total number of women presenting with signs of androgen excess." | 2.46 | Androgen- and estrogen-secreting adrenal cancers. ( Bharwani, N; Cavlan, D; Grossman, A, 2010) |
| "Treatment with metyrapone or o,p'-DDD can always induce a clinical remission but not a cure, and neurotransmitter therapy may be effective in a minority of cases." | 2.37 | Cushing's syndrome. ( Besser, GM; Howlett, TA; Rees, LH, 1985) |
| "Because of the rarity of adrenocortical cancer (ACC), only a few population-based studies are available, and they reported limited details in the characterization of patients and their treatment." | 1.91 | New Findings on Presentation and Outcome of Patients With Adrenocortical Cancer: Results From a National Cohort Study. ( Altieri, B; Arvat, E; Basile, V; Berchialla, P; Berruti, A; Calabrese, A; Cannavò, S; Canu, L; Ceccato, F; Di Dalmazi, G; Ferraù, F; Fiori, C; Grisanti, S; Laganà, M; Loli, P; Morelli, V; Perotti, P; Pia, A; Pivonello, R; Porpiglia, F; Puglisi, S; Reimondo, G; Scaroni, C; Stigliano, A; Terzolo, M; Urru, S; Violi, MA, 2023) |
| "Mitotane has been administered in daily doses of 3." | 1.33 | Clinical role of determination of plasma mitotane and its metabolites levels in patients with adrenal cancer: results of a long-term follow-up. ( Cichocki, A; Kasperlik-Zaluska, AA, 2005) |
| "Adrenocortical carcinoma is a rare disease which is primarily approached surgically." | 1.28 | Radiation therapy for adjunctive treatment of adrenal cortical carcinoma. ( Brady, LW; Markoe, AM; Micaily, B; Serber, W, 1991) |
| "Both patients developed hypoadrenalism while on o,p'-DDD and apparently adequate dexamethasone replacement therapy." | 1.27 | The effect of o,p'-DDD on adrenal steroid replacement therapy requirements. ( Hales, IB; Henniker, AJ; Ho, K; Luttrell, BM; Robinson, BG; Smee, IR; Stiel, JN, 1987) |
| "However, in adrenal cancer, urinary 17OHCS did not correlate with either plasma cortisol or urinary free cortisol, while the latter two parameters did." | 1.27 | Effect of o,p'-DDD on cortisol metabolism in Cushing's syndrome of various etiology. ( Inoue, S; Kawai, K; Koide, Y; Murayama, H; Yamashita, K, 1985) |
| "There months following surgery, liver metastases were documented associated with elevated levels of serum androgens." | 1.26 | Virilizing adrenal tumor in a child suppressed with dexamethasone for three years. Effect of o,p'-DDD on serum and urinary androgens. ( Korth-Schutz, S; Levine, LS; New, MI; Roth, JA; Saenger, P, 1977) |
| "Hyperadrenocorticism was diagnosed in 8 dogs by evaluation of urinary 17-hydroxycorticosteroid (OHCS) excretion rates, urinary 17-OHCS and plasma 11beta-OHCS RESPONSES TO DEXAMETHASONE SUPPRESSION OF ENDOGENOUS ADRENOCORTICOTROPIN (ACTH) secretion, and plasma 11beta-OHCS response to intravenous administration of ACTH." | 1.26 | Gamma camera imaging of bilateral adrenocortical hyperplasia and adrenal tumors in the dog. ( de Bruijne, JJ; Lubberink, AA; Mulnix, JA; Rijnberk, A; Van den Brom, WE, 1976) |
| "Virilism is the major manifestation in children (83 percent of the cases), either isolated or associated with hypercortisolism and/or feminization." | 1.25 | [Corticosuprarenaloma in children]. ( Benaily, M; Job, JC; Schweisguth, O, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 51 (54.84) | 18.7374 |
| 1990's | 14 (15.05) | 18.2507 |
| 2000's | 12 (12.90) | 29.6817 |
| 2010's | 14 (15.05) | 24.3611 |
| 2020's | 2 (2.15) | 2.80 |
| Authors | Studies |
|---|---|
| Puglisi, S | 1 |
| Calabrese, A | 1 |
| Ferraù, F | 1 |
| Violi, MA | 1 |
| Laganà, M | 1 |
| Grisanti, S | 1 |
| Ceccato, F | 1 |
| Scaroni, C | 1 |
| Di Dalmazi, G | 1 |
| Stigliano, A | 1 |
| Altieri, B | 1 |
| Canu, L | 1 |
| Loli, P | 1 |
| Pivonello, R | 1 |
| Arvat, E | 1 |
| Morelli, V | 1 |
| Perotti, P | 2 |
| Basile, V | 1 |
| Berchialla, P | 1 |
| Urru, S | 1 |
| Fiori, C | 1 |
| Porpiglia, F | 2 |
| Berruti, A | 5 |
| Pia, A | 1 |
| Reimondo, G | 1 |
| Cannavò, S | 1 |
| Terzolo, M | 4 |
| Nowak, KM | 1 |
| Łebek-Szatańska, A | 1 |
| Samsel, R | 1 |
| Roszkowska-Purska, K | 1 |
| Ćwikła, JB | 1 |
| Papierska, L | 1 |
| Kiseljak-Vassiliades, K | 1 |
| Bancos, I | 1 |
| Hamrahian, A | 1 |
| Habra, M | 1 |
| Vaidya, A | 1 |
| Levine, AC | 1 |
| Else, T | 1 |
| Dickson, PV | 1 |
| Kim, L | 1 |
| Yen, TWF | 1 |
| Yang, A | 1 |
| Grubbs, EG | 1 |
| Patel, D | 1 |
| Solórzano, CC | 1 |
| Almeida, MQ | 1 |
| Bezerra-Neto, JE | 1 |
| Mendonça, BB | 1 |
| Latronico, AC | 1 |
| Fragoso, MCBV | 1 |
| Mihai, R | 1 |
| Germano, A | 2 |
| Rapa, I | 1 |
| Volante, M | 1 |
| De Francia, S | 2 |
| Migliore, C | 1 |
| Papotti, M | 1 |
| Holmes, D | 1 |
| Cavlan, D | 1 |
| Bharwani, N | 1 |
| Grossman, A | 1 |
| Sperone, P | 1 |
| Bellini, E | 1 |
| Daffara, F | 2 |
| Ardito, A | 2 |
| Saini, A | 1 |
| Baudin, E | 3 |
| Leboulleux, S | 1 |
| Al Ghuzlan, A | 1 |
| Chougnet, C | 1 |
| Young, J | 1 |
| Deandreis, D | 1 |
| Dumont, F | 1 |
| Dechamps, F | 1 |
| Caramella, C | 1 |
| Chanson, P | 1 |
| Lanoy, E | 1 |
| Borget, I | 1 |
| Schlumberger, M | 1 |
| Demeure, MJ | 1 |
| Bussey, KJ | 1 |
| Kirschner, LS | 1 |
| Zaggia, B | 1 |
| Laino, F | 1 |
| Garrido Abad, P | 1 |
| Gómez de Vicente, JM | 1 |
| Herranz Fernández, LM | 1 |
| Jiménez Gálvez, M | 1 |
| Santos Arrontes, D | 1 |
| Suárez Fonseca, C | 1 |
| Fernández Arjona, M | 1 |
| Schteingart, DE | 2 |
| Sinsheimer, JE | 1 |
| Benitez, RS | 1 |
| Homan, DF | 1 |
| Johnson, TD | 1 |
| Counsell, RE | 1 |
| Gelderblom, H | 1 |
| Haak, HR | 1 |
| Fassnacht, M | 1 |
| Pentheroudakis, G | 1 |
| Ng, WT | 1 |
| Toohey, MG | 1 |
| Mulhall, L | 1 |
| Mackey, DA | 1 |
| MOLNAR, GD | 2 |
| MATTOX, VR | 1 |
| BAHN, RC | 1 |
| NETTO, AD | 1 |
| WAJCHENBERG, BL | 1 |
| RAVAGLIA, C | 1 |
| PEREIRA, VG | 1 |
| SHNAIDER, J | 1 |
| PUPO, AA | 1 |
| CINTRA, AB | 1 |
| MONTGOMERY, DA | 1 |
| WELBOURN, RB | 1 |
| NUNN, SL | 1 |
| TAUXE, WN | 1 |
| Kvacheniuk, AN | 1 |
| Brauckhoff, M | 1 |
| Dralle, H | 1 |
| Martins, AC | 1 |
| Cologna, AJ | 1 |
| Tucci, S | 1 |
| Suaid, HJ | 1 |
| Falconi, RA | 1 |
| Lee, YM | 1 |
| Kang, BT | 1 |
| Jung, DI | 1 |
| Park, C | 1 |
| Kim, HJ | 1 |
| Kim, JW | 1 |
| Lim, CY | 1 |
| Park, EH | 1 |
| Park, HM | 1 |
| Kasperlik-Zaluska, AA | 1 |
| Cichocki, A | 1 |
| Nader, N | 1 |
| Raverot, G | 1 |
| Emptoz-Bonneton, A | 1 |
| Déchaud, H | 1 |
| Bonnay, M | 1 |
| Pugeat, M | 1 |
| Shibata, H | 1 |
| Chamuleau, SA | 1 |
| Corssmit, EP | 1 |
| Pereira, AM | 1 |
| van de Berg, BT | 1 |
| Siegert, CE | 1 |
| Ozimek, A | 1 |
| Diebold, J | 1 |
| Linke, R | 1 |
| Heyn, J | 1 |
| Hallfeldt, K | 1 |
| Mussack, T | 1 |
| Jacobelli, A | 1 |
| Agostino, A | 1 |
| Altomonte, G | 1 |
| Courvoisier, B | 1 |
| Aron, DC | 1 |
| Findling, JW | 1 |
| Fitzgerald, PA | 1 |
| Forsham, PH | 1 |
| Wilson, CB | 1 |
| Tyrrell, JB | 1 |
| Boven, E | 1 |
| Vermorken, JB | 1 |
| van Slooten, H | 1 |
| Pinedo, HM | 1 |
| Kay, R | 1 |
| Schumacher, OP | 2 |
| Tank, ES | 1 |
| Motazedi, A | 1 |
| Noonan, RA | 1 |
| Thompson, NW | 2 |
| Kinouchi, T | 1 |
| Shimizu, N | 1 |
| Ibayashi, H | 1 |
| Demura, H | 1 |
| Oshima, H | 1 |
| Karakousis, CP | 1 |
| Uribe, J | 1 |
| Moore, R | 1 |
| Bricaire, H | 3 |
| Luton, JP | 5 |
| Bennett, BD | 1 |
| McKenna, TJ | 1 |
| Hough, AJ | 1 |
| Dean, R | 1 |
| Page, DL | 1 |
| Dunnick, NR | 1 |
| Freeman, DA | 2 |
| Ahlman, H | 1 |
| Jansson, S | 1 |
| Wängberg, B | 1 |
| Tisell, LE | 1 |
| Scherstén, T | 1 |
| Hansson, G | 1 |
| Bengtsson, BA | 1 |
| Ernest, I | 1 |
| Jakobsson, CE | 1 |
| Lindstedt, S | 1 |
| Raux-Demay, MC | 1 |
| Girard, F | 1 |
| Gebhardt, DO | 1 |
| Moolenaar, AJ | 3 |
| van Seters, AP | 2 |
| Kintzer, PP | 1 |
| Peterson, ME | 1 |
| Bennett, PF | 1 |
| Norman, EJ | 1 |
| Schott, M | 1 |
| Scherbaum, WA | 1 |
| Feldkamp, J | 1 |
| Magiakou, MA | 1 |
| Chrousos, GP | 1 |
| Besser, GM | 2 |
| Jeffcoate, WJ | 1 |
| Benaily, M | 1 |
| Schweisguth, O | 2 |
| Job, JC | 1 |
| Boyar, RM | 1 |
| Nogeire, C | 1 |
| Fukushima, D | 1 |
| Hellman, L | 2 |
| Fishman, J | 1 |
| Korth-Schutz, S | 1 |
| Levine, LS | 1 |
| Roth, JA | 1 |
| Saenger, P | 1 |
| New, MI | 1 |
| Owens, JM | 1 |
| Drucker, WD | 1 |
| Hajjar, RA | 1 |
| Hickey, RC | 1 |
| Samaan, NA | 3 |
| deAsis, DN | 1 |
| Rappaport, R | 1 |
| Cachin, O | 1 |
| Pellerin, D | 1 |
| Fang, VS | 1 |
| Kelly, DF | 1 |
| Darke, PG | 1 |
| Bulger, AR | 1 |
| Correa, RJ | 1 |
| Mulnix, JA | 1 |
| Van den Brom, WE | 1 |
| Lubberink, AA | 1 |
| de Bruijne, JJ | 1 |
| Rijnberk, A | 1 |
| Becker, D | 1 |
| Butez, J | 1 |
| Bonnin, A | 1 |
| Pallardy, G | 1 |
| Ledoux-Lebard, G | 1 |
| Scott, RD | 1 |
| Ostuni, JA | 1 |
| Roginsky, MS | 1 |
| Feldman, EC | 1 |
| Nelson, RW | 1 |
| Feldman, MS | 1 |
| Farver, TB | 1 |
| van Aalderen, W | 1 |
| Backer, ET | 1 |
| Chang, PC | 1 |
| van Krieken, JH | 1 |
| Markoe, AM | 1 |
| Serber, W | 1 |
| Micaily, B | 1 |
| Brady, LW | 1 |
| Vassilopoulou-Sellin, R | 1 |
| Schwartz, RW | 1 |
| Sloan, DA | 1 |
| Kenady, DE | 1 |
| Nakamura, S | 1 |
| Kuzuya, N | 1 |
| Koide, Y | 2 |
| Matsumara, M | 1 |
| Watanabe, Y | 1 |
| Tomizawa, H | 1 |
| Murayama, Y | 1 |
| Okuda, Y | 1 |
| Takuwa, Y | 1 |
| Itakura, M | 1 |
| Donckier, JE | 1 |
| Michel, LA | 1 |
| Berbinschi, A | 1 |
| De Coster, PM | 1 |
| De Plaen, JF | 1 |
| Ketelslegers, JM | 1 |
| Buysschaert, M | 1 |
| Kuhn, JM | 1 |
| Proeschel, MF | 1 |
| Seurin, DJ | 1 |
| Bertagna, XY | 1 |
| Girard, FL | 1 |
| Vierhapper, H | 1 |
| Mostbeck, G | 1 |
| Waldhäusl, W | 1 |
| Cheung, PS | 1 |
| Robinson, BG | 1 |
| Hales, IB | 1 |
| Henniker, AJ | 1 |
| Ho, K | 1 |
| Luttrell, BM | 1 |
| Smee, IR | 1 |
| Stiel, JN | 1 |
| Eriksson, B | 1 |
| Oberg, K | 1 |
| Curstedt, T | 1 |
| Hemmingsson, A | 1 |
| Johansson, H | 1 |
| Lindh, E | 1 |
| Lindgren, PG | 1 |
| Thuomas, KA | 1 |
| Wilander, E | 1 |
| Akerström, G | 1 |
| Howlett, TA | 1 |
| Rees, LH | 1 |
| Inoue, S | 1 |
| Murayama, H | 1 |
| Kawai, K | 1 |
| Yamashita, K | 1 |
| Cuddy, PG | 1 |
| Loftus, LS | 1 |
| Touitou, Y | 1 |
| Bogdan, A | 1 |
| Auzéby, A | 1 |
| Judy, JC | 1 |
| Scardino, PL | 1 |
| Bradlow, HL | 1 |
| Zumoff, B | 1 |
| Schein, PS | 1 |
| Yamada, S | 1 |
| Harrison, JH | 1 |
| Mahoney, EM | 1 |
| Bennett, AH | 1 |
| Downing, V | 1 |
| Eule, J | 1 |
| Huseby, RA | 1 |
| Lubitz, JA | 1 |
| Freeman, L | 1 |
| Okun, R | 1 |
| Metz, SA | 1 |
| Schick, M | 1 |
| Lewinsky, BS | 1 |
| Grigor, KM | 1 |
| Symington, T | 1 |
| Neville, AM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mitotane With or Without Cisplatin and Etoposide After Surgery in Treating Participants With Stage I-III Adrenocortical Cancer With High Risk of Recurrence[NCT03723941] | Phase 3 | 240 participants (Anticipated) | Interventional | 2018-07-01 | Recruiting | ||
| Activity of Abiraterone Acetate in the Management of Cushing's Syndrome in Patients With Adrenocortical Carcinoma[NCT03145285] | Phase 2 | 10 participants (Anticipated) | Interventional | 2017-04-18 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
25 reviews available for mitotane and Adrenal Cancer
| Article | Year |
|---|---|
American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach.
Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Adult; Humans; Mitotane | 2020 |
Adjuvant and Neoadjuvant Therapy, Treatment for Advanced Disease, and Genetic Considerations for Adrenocortical Carcinoma: An Update from the SSO Endocrine and Head and Neck Disease Site Working Group.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Combined Chemothera | 2018 |
Primary malignant tumors of the adrenal glands.
Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents, | 2018 |
Rare adrenal tumors in children.
Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenalectomy; A | 2014 |
Androgen- and estrogen-secreting adrenal cancers.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Adult; Algorithms; Androgens; Anti | 2010 |
Metronomic therapy concepts in the management of adrenocortical carcinoma.
Topics: Administration, Metronomic; Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Animals; Antineoplast | 2011 |
Therapeutic management of advanced adrenocortical carcinoma: what do we know in 2011?
Topics: Adrenal Gland Neoplasms; Adult; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, | 2011 |
Targeted therapies for adrenocortical carcinoma: IGF and beyond.
Topics: Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Animals; Antibodies, Monoclonal; Antibodies, Mono | 2011 |
Management of adjuvant mitotane therapy following resection of adrenal cancer.
Topics: Adrenal Gland Neoplasms; Antineoplastic Agents, Hormonal; Case Management; Chemotherapy, Adjuvant; C | 2012 |
Giant adrenal carcinoma associated with renal vein and inferior vena cava thrombus. Case report and literature review.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Aged; Antineoplastic Agents; Carcinoma; Contraindications; F | 2012 |
[Recurrent operations on the adrenal glands].
Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Adult; Anti | 2005 |
[Deoxycorticosterone-producing adrenal tumor].
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Antineoplastic Agents, Hormonal; Desoxycorticosterone; Diagn | 2006 |
Bilateral primary adrenal non-Hodgkin's lymphoma and primary adrenocortical carcinoma--review of the literature preoperative differentiation of adrenal tumors.
Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Aged, 80 | 2008 |
Cushing's syndrome: problems in management.
Topics: ACTH Syndrome, Ectopic; Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone | 1982 |
Complete response of metastasized adrenal cortical carcinoma with o,p'-DDD. Case report and literature review.
Topics: Adrenal Cortex; Adrenal Gland Neoplasms; Carcinoma; Humans; Laparotomy; Lymphatic Metastasis; Male; | 1984 |
[Cushing syndrome in children].
Topics: Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hor | 1993 |
Diagnosis and management of canine cortisol-secreting adrenal tumors.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Antifungal A | 1997 |
Adrenal carcinoma.
Topics: Adrenal Gland Neoplasms; Animals; Antineoplastic Agents, Hormonal; Humans; Mitotane | 1997 |
[Drug therapy of endocrine neoplasms. Part I: Thyroid neoplasms, adrenal neoplasms and parathyroid neoplasms].
Topics: Adrenal Gland Neoplasms; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Proto | 2000 |
Cushing's syndrome in children and adolescents: current diagnostic and therapeutic strategies.
Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Antineopla | 2002 |
Hyperadrenocorticism in the dog: canine Cushing's syndrome.
Topics: 17-Hydroxycorticosteroids; Adenoma; Adrenal Cortex Function Tests; Adrenal Gland Neoplasms; Adrenal | 1977 |
Cushing's syndrome in the dog.
Topics: 17-Hydroxycorticosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Animals; Calcinosis; Cu | 1976 |
Diagnosis and treatment of primary adrenal tumors.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Carcinoma; Cushing Syndrome; Diagnosis | 1991 |
Cushing's syndrome.
Topics: Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Alcoho | 1985 |
Chemotherapeutic management of the hormone-secreting endocrine malignancies.
Topics: Adenoma, Islet Cell; Adrenal Gland Neoplasms; Aminoglutethimide; Aniline Compounds; Antibiotics, Ant | 1972 |
68 other studies available for mitotane and Adrenal Cancer
| Article | Year |
|---|---|
New Findings on Presentation and Outcome of Patients With Adrenocortical Cancer: Results From a National Cohort Study.
Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Cohort Studies; Female; | 2023 |
Adrenocortical carcinoma mimicking pheochromocytoma on iodine 123-labeled metaiodobenzylguanidine scintigraphy.
Topics: Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Adult; Antineoplastic Agents, Hormonal; Four-Dime | 2019 |
RRM1 modulates mitotane activity in adrenal cancer cells interfering with its metabolization.
Topics: Adrenal Gland Neoplasms; Antineoplastic Agents, Hormonal; Biological Availability; Cell Line, Tumor; | 2015 |
Adrenal gland: Cancer target of mitotane identified.
Topics: Adrenal Gland Neoplasms; Adrenal Glands; Antineoplastic Agents, Hormonal; Humans; Mitotane; Sterol O | 2015 |
Structural requirements for mitotane activity: development of analogs for treatment of adrenal cancer.
Topics: Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Antineoplastic Agents | 2012 |
Adrenal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; A | 2012 |
Adrenal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; A | 2012 |
Adrenal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; A | 2012 |
Adrenal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; A | 2012 |
Pigmentary retinopathy, macular oedema, and abnormal ERG with mitotane treatment.
Topics: Adrenal Gland Neoplasms; Adult; Antineoplastic Agents, Hormonal; Electroretinography; Female; Fluore | 2003 |
Clinical and therapeutic observations in the adrenal cancer: a report on 7 patients treated with o,p'-DDD.
Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Ant | 1963 |
TREATMENT OF ADRENOCORTICAL CANCER WITH O,P'-DDD.
Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenogenital Syndrome; Antineoplastic Agents; Ca | 1963 |
ADRENOCORTICAL CARCINOMA TREATED WITH O,P' -DDD.
Topics: Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents; Child; Cushing Syndrome; D | 1965 |
The effect of o,p'-DDD therapy on plasma cholesterol in adrenal carcinoma.
Topics: Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortical Carcinoma; Cholesterol; Dichlorodiphenyldich | 1961 |
[Analysis of postoperative recurrence of malignant tumors of adrenal glands].
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Antineoplastic Agents, Hormonal; Female; Humans; Male | 2004 |
Clinical features and immunoexpression of p53, MIB-1 and proliferating cell nuclear antigen in adrenal neoplasms.
Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Adult; Antineoplastic C | 2005 |
A case of adrenal gland dependent hyperadrenocorticism with mitotane therapy in a Yorkshire terrier dog.
Topics: Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Animals; Antineo | 2005 |
Clinical role of determination of plasma mitotane and its metabolites levels in patients with adrenal cancer: results of a long-term follow-up.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Antineoplastic Agents, Hormonal; Child; Female; Fo | 2005 |
Mitotane has an estrogenic effect on sex hormone-binding globulin and corticosteroid-binding globulin in humans.
Topics: Adrenal Gland Neoplasms; Antineoplastic Agents, Hormonal; Estradiol; Estrogen Receptor alpha; Humans | 2006 |
A young woman with a severe bilateral pneumonia as the presenting sign of an adrenal carcinoma.
Topics: Adrenal Gland Neoplasms; Adult; Antineoplastic Agents, Hormonal; Carcinoma; Cushing Syndrome; Female | 2008 |
[Treatment of glycoactive hypercorticism].
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; A | 1984 |
[Clinical reports: pseudohypoparathyroidism, pituitary nanism, and adrenal carcinoma].
Topics: 17-Hydroxycorticosteroids; Acne Vulgaris; Adrenal Gland Neoplasms; Adult; Androgens; Dihydrotachyste | 1982 |
Adrenocortical carcinoma in children.
Topics: Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Antineoplastic Agents; Carcinoma; Child; Child, | 1983 |
Treatment of adrenal carcinomas.
Topics: Adrenal Gland Neoplasms; Adult; Carcinoma; Female; Humans; Liver Neoplasms; Lung Neoplasms; Male; Mi | 1982 |
[Treatment of Cushing's syndrome and adrenal cancer with O,p-DDD].
Topics: Adrenal Gland Neoplasms; Adult; Aged; Cushing Syndrome; Drug Evaluation; Female; Humans; Male; Middl | 1982 |
Adrenal adenocarcinomas: diagnosis and management.
Topics: Adenocarcinoma; Adrenal Gland Neoplasms; Adult; Aged; Female; Hormones; Humans; Male; Middle Aged; M | 1981 |
[Cushing's syndrome. Medical treatment of adrenal hypercorticism].
Topics: Adrenal Gland Neoplasms; Aminoglutethimide; Androstanols; Bromocriptine; Cushing Syndrome; Cyprohept | 1980 |
Adrenal myelolipoma associated with Cushing's disease.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Gland Neoplasms; Cushing Syndrome; Humans; Male; Mito | 1980 |
Adrenal carcinoma.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Age Factors; Ag | 1994 |
Adrenal carcinoma.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Aminoglutethimide; Carcinoma; Cushing Syndrome; Dia | 1994 |
Adrenocortical carcinoma--diagnostic and therapeutical implications.
Topics: Adrenal Gland Neoplasms; Adrenal Rest Tumor; Adult; Aged; Carcinoma; Chemotherapy, Adjuvant; Female; | 1993 |
Mitotane (o,p'-DDD) administration raises the serum level of high density lipoprotein (HDL) in normotriglyceridemia.
Topics: Adrenal Gland Neoplasms; Humans; Hyperlipidemias; Lipoproteins, HDL; Mitotane; Stimulation, Chemical | 1993 |
Mitotane (o,p'-DDD) resistance in a dog with pituitary-dependent hyperadrenocorticism and phaeochromocytoma.
Topics: Adrenal Cortex Function Tests; Adrenal Gland Neoplasms; Adrenal Medulla; Adrenocortical Hyperfunctio | 1998 |
Endocrine and metabolic diseases. Adrenal diseases.
Topics: Adenoma; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Insuffici | 1976 |
[Corticosuprarenaloma in children].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adolescent; Adrenal Cortex Neoplasms; Adrenal G | 1975 |
Studies of the diurnal pattern of plasma corticosteroids and gonadotropins in two cases of feminizing adrenal carcinoma: measurements of estrogen and corticosteroid production.
Topics: Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adult; Androgens; Circad | 1977 |
Virilizing adrenal tumor in a child suppressed with dexamethasone for three years. Effect of o,p'-DDD on serum and urinary androgens.
Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Androgens; Child, Preschool; | 1977 |
Adrenal cortical carcinoma. A study of 32 patients.
Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adult; Age Factors; Aged; Bone Neoplasms; Female; Hepa | 1975 |
[Does Op'DDD possess an antimitotic action? Remarks apropos of its use in the treatment of adrenal adenocarcinomas].
Topics: Adrenal Gland Neoplasms; Carcinoma; Humans; Mitosis; Mitotane | 1977 |
Feminizing adrenocortical carcinoma with Cushing's syndrome and pseudohyperparathyroidism.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adult | 1978 |
[Malignant adrenal carcinoma with metastases: exeresis and treatment with op'DD followed by cure].
Topics: Adrenal Gland Neoplasms; Child; Female; Follow-Up Studies; Humans; Mitotane; Neoplasm Metastasis; Ne | 1978 |
Cytotoxic activity of 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane (mitotane) and its analogs on feminizing adrenal neoplastic cells in culture.
Topics: Adrenal Gland Neoplasms; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Estrogens; Femi | 1979 |
Experience with adrenal cortical carcinoma.
Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adult; Aged; Female; Humans; Male | 1977 |
Gamma camera imaging of bilateral adrenocortical hyperplasia and adrenal tumors in the dog.
Topics: 11-Hydroxycorticosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortical Hyperfun | 1976 |
o,p'DDD therapy in invasive adrenocortical carcinoma.
Topics: Adrenal Cortex; Adrenal Gland Neoplasms; Adrenal Glands; Aged; Carcinoma; Child, Preschool; Dichloro | 1975 |
[Value of retropneumoperitoneum in the exploration of Cushing's syndrome. 155 cases].
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortical Hyperfunction; Angiography; Cushing | 1975 |
Treatment of an adrenal cortical carcinoma with a combination of o,p'-DDD and aminoglutethimide.
Topics: 11-Hydroxycorticosteroids; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenalectomy; Adult; | 1975 |
Metastatic adrenal cortical carcinoma. Documented cure with combined chemotherapy.
Topics: Adolescent; Adrenal Gland Neoplasms; Carcinoma; Drug Therapy, Combination; Female; Fluorouracil; Hum | 1975 |
Comparison of mitotane treatment for adrenal tumor versus pituitary-dependent hyperadrenocorticism in dogs.
Topics: Adenoma; Adrenal Cortex; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adrenocorticotropic | 1992 |
A case of recurrent adrenocortical carcinoma, with observations on long-term o,p'-DDD therapy and complications.
Topics: Adrenal Gland Neoplasms; Carcinoma; Carcinosarcoma; Combined Modality Therapy; Female; Humans; Lung | 1992 |
Radiation therapy for adjunctive treatment of adrenal cortical carcinoma.
Topics: Adrenal Gland Neoplasms; Aged; Aged, 80 and over; Carcinoma; Child; Combined Modality Therapy; Femal | 1991 |
Mitotane administration: an unusual cause of hypercholesterolemia.
Topics: Adrenal Gland Neoplasms; Female; Humans; Hypercholesterolemia; Male; Middle Aged; Mitotane | 1991 |
Successful treatment of a metastatic hormone-producing adrenal cancer by a combination of mitotane, tegafur and surgical resection.
Topics: 17-alpha-Hydroxypregnenolone; Adrenal Gland Neoplasms; Adult; Aldosterone; Androstenedione; Antineop | 1990 |
Late recurrence of operated adrenocortical carcinoma: atrial natriuretic factor before and after treatment with mitotane.
Topics: Adrenal Gland Neoplasms; Atrial Natriuretic Factor; Carcinoma; Combined Modality Therapy; Cushing Sy | 1989 |
Comparative assessment of ACTH and lipotropin plasma levels in the diagnosis and follow-up of patients with Cushing's syndrome: a study of 210 cases.
Topics: ACTH Syndrome, Ectopic; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotr | 1989 |
Effect of suramin in a patient with adrenocortical carcinoma.
Topics: Adrenal Gland Neoplasms; Adult; Carcinoma; Drug Therapy, Combination; Humans; Male; Mitotane; Surami | 1989 |
Right atrial extension of adrenocortical carcinoma. Surgical management using hypothermia and cardiopulmonary bypass.
Topics: Adrenal Gland Neoplasms; Adult; Carcinoma; Cardiopulmonary Bypass; Combined Modality Therapy; Female | 1989 |
The effect of o,p'-DDD on adrenal steroid replacement therapy requirements.
Topics: Adrenal Gland Neoplasms; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Dexamethasone; F | 1987 |
Treatment of hormone-producing adrenocortical cancer with o,p'DDD and streptozocin.
Topics: Adrenal Cortex; Adrenal Gland Neoplasms; Adult; Antineoplastic Combined Chemotherapy Protocols; Cort | 1987 |
Effect of o,p'-DDD on cortisol metabolism in Cushing's syndrome of various etiology.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Ho | 1985 |
Influence of mitotane on the hypoprothrombinemic effect of warfarin.
Topics: Adrenal Gland Neoplasms; Brain Neoplasms; Drug Interactions; Female; Humans; Hypoprothrombinemias; M | 1986 |
o,p'-DDD (mitotane) treatment for Cushing's syndrome: adrenal drug concentration and inhibition in vitro of steroid synthesis.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Carcinoma; Child; Cort | 1985 |
Adrenal cortical carcinoma: a case report.
Topics: Adrenal Gland Neoplasms; Carcinoma; Female; Humans; Middle Aged; Mitotane; Neoplasm Metastasis; Pall | 1973 |
Decreased conversion of androgens to normal 17-ketosteroid metabolites as a result of treatment with o,p'-DDD.
Topics: Adrenal Gland Neoplasms; Androsterone; Anemia, Pernicious; Carbon Isotopes; Dehydroepiandrosterone; | 1973 |
[Urinary 6beta-hydroxycortisol. II. Urinary 6beta-hydroxycortisol in different diseases and after administration of drugs].
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Carcinoma; Cushing Syndrome; F | 1973 |
Proceedings: Tumors of the adrenal cortex.
Topics: Adenoma; Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortico | 1973 |
Regression of an adrenal cortical carcinoma and its neovascular bed following mitotane therapy: a case report.
Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Aortography; Blood Pressure; Catheterization; Fem | 1974 |
Mitotane use in inoperable adrenal cortical carcinoma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Diabetic Retinopathy; Female; Follow-Up Studies; Gastroi | 1973 |
Drug treatment of inoperable adrenocortical carcinoma.
Topics: Adrenal Gland Neoplasms; Humans; Mitotane | 1973 |
Survival with adrenal carcinoma.
Topics: Adrenal Gland Neoplasms; Female; Fluorouracil; Humans; Mitotane; Neoplasm Metastasis | 1973 |
The clinical and pathologic features of "non-hormonal" adrenocortical tumors. Report of twenty new cases and review of the literature.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adult; Aged; Angiography; Antineoplast | 1974 |