mitotane and Adenoma studies

Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.

Research Excerpts

Excerpt	Relevance	Reference
"Hypercortisolism induced by Cushing disease causes high morbidity and mortality."	2.48	New prospects for drug treatment in Cushing disease. ( Barahona Constanzo, MJ; del Pozo Picó, C, 2012)
"Mitotane was administered in 12 (71 %) patients with stage III-IV ACCs with a 5-year survival rate 25 % compared to 20 % in patients who did not receive Mitotane."	1.42	Risk of adrenocortical carcinoma in adrenal tumours greater than 8 cm. ( Abdel-Aziz, TE; Mihai, R; Rajeev, P; Sadler, G; Weaver, A, 2015)
"Adrenocortical carcinoma is a rare malignancy with poor prognosis and limited response to chemotherapy."	1.42	Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma. ( Cortez, MA; Cote, GJ; Fuentes-Mattei, E; Habra, MA; Hai, T; Hofmann, MC; Jimenez, C; Lee, MH; Ozsari, L; Pagliaro, L; Phan, LM; Sircar, K; Velazquez-Torres, G; Verhaak, R; Wood, CG; Wu, W; Yeung, SC; Zheng, S, 2015)
"Multiple endocrine neoplasia type 1 was diagnosed in a 12-year-old male crossbred dog."	1.31	Multiple endocrine neoplasia type 1 in a crossbred dog. ( Alley, MR; Burbidge, HM; Guildford, WG; Jones, BR; Walker, MC, 2000)
"However, in adrenal cancer, urinary 17OHCS did not correlate with either plasma cortisol or urinary free cortisol, while the latter two parameters did."	1.27	Effect of o,p'-DDD on cortisol metabolism in Cushing's syndrome of various etiology. ( Inoue, S; Kawai, K; Koide, Y; Murayama, H; Yamashita, K, 1985)
"Hyperadrenocorticism was diagnosed in 8 dogs by evaluation of urinary 17-hydroxycorticosteroid (OHCS) excretion rates, urinary 17-OHCS and plasma 11beta-OHCS RESPONSES TO DEXAMETHASONE SUPPRESSION OF ENDOGENOUS ADRENOCORTICOTROPIN (ACTH) secretion, and plasma 11beta-OHCS response to intravenous administration of ACTH."	1.26	Gamma camera imaging of bilateral adrenocortical hyperplasia and adrenal tumors in the dog. ( de Bruijne, JJ; Lubberink, AA; Mulnix, JA; Rijnberk, A; Van den Brom, WE, 1976)
"Virilism is the major manifestation in children (83 percent of the cases), either isolated or associated with hypercortisolism and/or feminization."	1.25	[Corticosuprarenaloma in children]. ( Benaily, M; Job, JC; Schweisguth, O, 1975)
"Amelioration of the hypercortisolism occurred after removal of the bronchial adenoma."	1.25	Cushing's syndrome associated with a bronchial adenoma. Possible periodic hormonogenesis. ( Bruderman, I; Griffel, WB; Gutman, A; Myers, B; Shapiro, MS, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	19 (52.78)	18.7374
1990's	8 (22.22)	18.2507
2000's	3 (8.33)	29.6817
2010's	5 (13.89)	24.3611
2020's	1 (2.78)	2.80

Authors	Studies
Tritos, NA	1
Biller, BMK	1
Broder, MS	1
Neary, MP	1
Chang, E	1
Cherepanov, D	1
Sun, GH	1
Ludlam, WH	1
Abdel-Aziz, TE	1
Rajeev, P	1
Sadler, G	1
Weaver, A	1
Mihai, R	1
Phan, LM	1
Fuentes-Mattei, E	1
Wu, W	1
Velazquez-Torres, G	1
Sircar, K	1
Wood, CG	1
Hai, T	1
Jimenez, C	1
Cote, GJ	1
Ozsari, L	1
Hofmann, MC	1
Zheng, S	1
Verhaak, R	1
Pagliaro, L	1
Cortez, MA	1
Lee, MH	1
Yeung, SC	1
Habra, MA	1
Murao, K	1
Imachi, H	1
Ishida, T	1
Hosomi, N	1
Masugata, H	1
Barahona Constanzo, MJ	1
del Pozo Picó, C	1
Martins, AC	1
Cologna, AJ	1
Tucci, S	1
Suaid, HJ	1
Falconi, RA	1
Aron, DC	1
Findling, JW	1
Fitzgerald, PA	1
Forsham, PH	1
Wilson, CB	1
Tyrrell, JB	1
Simonin, R	1
Heim, M	1
Grisoli, F	1
Brindisi, G	1
Lee, JE	1
Berger, DH	1
el-Naggar, AK	1
Hickey, RC	2
Vassilopoulou-Sellin, R	1
Gagel, RF	1
Burgess, MA	1
Evans, DB	1
Freeman, DA	2
Haak, HR	1
Cornelisse, CJ	1
Hermans, J	1
Cobben, L	1
Fleuren, GJ	1
Ihle, SL	2
Kintzer, PP	1
Peterson, ME	1
Walker, MC	1
Jones, BR	1
Guildford, WG	1
Burbidge, HM	1
Alley, MR	1
Magiakou, MA	1
Chrousos, GP	1
Besser, GM	1
Jeffcoate, WJ	1
Benaily, M	1
Schweisguth, O	1
Job, JC	1
Kishi, DT	1
Owens, JM	1
Drucker, WD	1
Hajjar, RA	1
Samaan, NA	1
Cooper, PR	1
Shucart, WA	1
Kelly, DF	1
Darke, PG	1
Mulnix, JA	1
Van den Brom, WE	1
Lubberink, AA	1
de Bruijne, JJ	1
Rijnberk, A	2
Butez, J	1
Bonnin, A	1
Luton, JP	2
Pallardy, G	1
Ledoux-Lebard, G	1
Bricaire, H	1
Shapiro, MS	1
Gutman, A	1
Bruderman, I	1
Myers, B	1
Griffel, WB	1
Feldman, EC	2
Nelson, RW	2
Feldman, MS	1
Farver, TB	1
Voorhout, G	1
Mol, JA	1
Schwartz, RW	1
Sloan, DA	1
Kenady, DE	1
Kuhn, JM	1
Proeschel, MF	1
Seurin, DJ	1
Bertagna, XY	1
Girard, FL	1
Dow, SW	1
Olson, PN	1
Rosychuk, RA	1
Withrow, SJ	1
Koide, Y	1
Inoue, S	1
Murayama, H	1
Kawai, K	1
Yamashita, K	1
Yamada, S	1
Harrison, JH	1
Mahoney, EM	1
Bennett, AH	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
A Multicenter, Open-label, Phase II Study to Evaluate the Efficacy and Safety of Cabozantinib in Advanced (Unresectable or Metastatic) Adrenocortical Carcinoma[NCT03612232]			Phase 2	37 participants (Anticipated)	Interventional	2019-06-04	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Advances in the Medical Treatment of Cushing Disease. Endocrinology and metabolism clinics of North America, 2020, Volume: 49, Issue:3 Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Cabergoline; Endocrinology; Humans; Mifepristone; Mitotan	2020
New prospects for drug treatment in Cushing disease. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2012, Volume: 59, Issue:10 Topics: Adenoma; Adrenocorticotropic Hormone; Animals; Cabergoline; Clinical Trials as Topic; Clinical Trial	2012
Cushing's syndrome: problems in management. Endocrine reviews, 1982,Summer, Volume: 3, Issue:3 Topics: ACTH Syndrome, Ectopic; Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone	1982
Pituitary corticotroph macrotumors. Diagnosis and treatment. The Veterinary clinics of North America. Small animal practice, 1997, Volume: 27, Issue:2 Topics: Adenoma; Animals; Bromocriptine; Dog Diseases; Dogs; Dopamine Agonists; Mitotane; Monoamine Oxidase	1997
Diagnosis and management of canine cortisol-secreting adrenal tumors. The Veterinary clinics of North America. Small animal practice, 1997, Volume: 27, Issue:2 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Antifungal A	1997
Cushing's syndrome in children and adolescents: current diagnostic and therapeutic strategies. Journal of endocrinological investigation, 2002, Volume: 25, Issue:2 Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Antineopla	2002
Current therapeutic concepts--Cushing's syndrome. Journal of the American Pharmaceutical Association, 1975, Volume: 15, Issue:5 Topics: Adenoma; Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Aminoglutethimide; Ci	1975
Hyperadrenocorticism in the dog: canine Cushing's syndrome. The Veterinary clinics of North America, 1977, Volume: 7, Issue:3 Topics: 17-Hydroxycorticosteroids; Adenoma; Adrenal Cortex Function Tests; Adrenal Gland Neoplasms; Adrenal	1977
Cushing's syndrome in the dog. The Veterinary record, 1976, Jan-10, Volume: 98, Issue:2 Topics: 17-Hydroxycorticosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Animals; Calcinosis; Cu	1976
Diagnosis and treatment of primary adrenal tumors. Current opinion in oncology, 1991, Volume: 3, Issue:1 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Carcinoma; Cushing Syndrome; Diagnosis	1991
Steroid hormone-producing tumors in man. Endocrine reviews, 1986, Volume: 7, Issue:2 Topics: 17-Ketosteroids; Adenoma; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Adult; Androgens; C	1986

Article	Year
Treatment patterns in Cushing's disease patients in two large United States nationwide databases: application of a novel, graphical methodology. Pituitary, 2015, Volume: 18, Issue:4 Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adrenalectomy; Adult; Antineoplastic Agents, Hormonal; Co	2015
Risk of adrenocortical carcinoma in adrenal tumours greater than 8 cm. World journal of surgery, 2015, Volume: 39, Issue:5 Topics: Adenoma; Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Adult; Aged; Antineoplas	2015
Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma. Cancer research, 2015, Oct-01, Volume: 75, Issue:19 Topics: Adenoma; Adrenal Cortex Neoplasms; Adult; Aged; Aged, 80 and over; Anilides; Animals; Antineoplastic	2015
Successful therapy of Cushing's disease caused by an extrapituitary parasellar adenoma. Clinical endocrinology, 2010, Volume: 73, Issue:1 Topics: Adenoma; Aged; Female; Humans; Magnetic Resonance Imaging; Mitotane; Pituitary ACTH Hypersecretion;	2010
Clinical features and immunoexpression of p53, MIB-1 and proliferating cell nuclear antigen in adrenal neoplasms. The Journal of urology, 2005, Volume: 173, Issue:6 Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Adult; Antineoplastic C	2005
[Disclosure of a pituitary microadenoma during treatment of Cushing's disease]. La Nouvelle presse medicale, 1981, Jan-31, Volume: 10, Issue:4 Topics: Adenoma; Adult; Cushing Syndrome; Female; Humans; Mitotane; Pituitary Neoplasms	1981
Surgical management, DNA content, and patient survival in adrenal cortical carcinoma. Surgery, 1995, Volume: 118, Issue:6 Topics: Adenoma; Adolescent; Adrenal Cortex Neoplasms; Adult; Aged; Aneuploidy; Carcinoma; Combined Modality	1995
Adrenal carcinoma. Current therapy in endocrinology and metabolism, 1994, Volume: 5 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Aminoglutethimide; Carcinoma; Cushing Syndrome; Dia	1994
Nuclear DNA content and morphological characteristics in the prognosis of adrenocortical carcinoma. British journal of cancer, 1993, Volume: 68, Issue:1 Topics: Actuarial Analysis; Adenoma; Adrenal Cortex Neoplasms; Adult; Carcinoma; Cell Nucleus; DNA, Neoplasm	1993
Multiple endocrine neoplasia type 1 in a crossbred dog. The Journal of small animal practice, 2000, Volume: 41, Issue:2 Topics: Adenoma; Animals; Antineoplastic Agents, Hormonal; Diagnosis, Differential; Dog Diseases; Dogs; Male	2000
Endocrine and metabolic diseases. Adrenal diseases. British medical journal, 1976, Feb-21, Volume: 1, Issue:6007 Topics: Adenoma; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Insuffici	1976
[Corticosuprarenaloma in children]. Archives francaises de pediatrie, 1975, Volume: 32, Issue:5 Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adolescent; Adrenal Cortex Neoplasms; Adrenal G	1975
Adrenal cortical carcinoma. A study of 32 patients. Cancer, 1975, Volume: 35, Issue:2 Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adult; Age Factors; Aged; Bone Neoplasms; Female; Hepa	1975
Treatment of Cushing's disease with o,p'-DDD. The New England journal of medicine, 1979, Jul-05, Volume: 301, Issue:1 Topics: Adenoma; Aged; Cushing Syndrome; Humans; Mitotane; Pituitary Neoplasms	1979
Gamma camera imaging of bilateral adrenocortical hyperplasia and adrenal tumors in the dog. American journal of veterinary research, 1976, Volume: 37, Issue:12 Topics: 11-Hydroxycorticosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortical Hyperfun	1976
[Value of retropneumoperitoneum in the exploration of Cushing's syndrome. 155 cases]. La Nouvelle presse medicale, 1975, Mar-29, Volume: 4, Issue:13 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortical Hyperfunction; Angiography; Cushing	1975
Cushing's syndrome associated with a bronchial adenoma. Possible periodic hormonogenesis. Israel journal of medical sciences, 1975, Volume: 11, Issue:9 Topics: Adenoma; Adrenalectomy; Adult; Aminoglutethimide; Bronchial Neoplasms; Cushing Syndrome; Dexamethaso	1975
Comparison of mitotane treatment for adrenal tumor versus pituitary-dependent hyperadrenocorticism in dogs. Journal of the American Veterinary Medical Association, 1992, Jun-01, Volume: 200, Issue:11 Topics: Adenoma; Adrenal Cortex; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adrenocorticotropic	1992
Corticoid production by four dogs with hyperfunctioning adrenocortical tumours during treatment with mitotane (o,p'-DDD). The Veterinary record, 1992, Nov-21, Volume: 131, Issue:21 Topics: Adenoma; Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Animals; Creatinine; Dog Diseases; Dogs;	1992
Comparative assessment of ACTH and lipotropin plasma levels in the diagnosis and follow-up of patients with Cushing's syndrome: a study of 210 cases. The American journal of medicine, 1989, Volume: 86, Issue:6 Pt 1 Topics: ACTH Syndrome, Ectopic; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotr	1989
Pituitary macroadenomas and macroadenocarcinomas in dogs treated with mitotane for pituitary-dependent hyperadrenocorticism: 13 cases (1981-1986). Journal of the American Veterinary Medical Association, 1989, Jun-01, Volume: 194, Issue:11 Topics: Adenocarcinoma; Adenoma; Adrenocortical Hyperfunction; Animals; Dog Diseases; Dogs; Mitotane; Pituit	1989
Perianal adenomas and hypertestosteronemia in a spayed bitch with pituitary-dependent hyperadrenocorticism. Journal of the American Veterinary Medical Association, 1988, May-15, Volume: 192, Issue:10 Topics: Adenoma; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Anal Gland Neoplasms; Animals; C	1988
Effect of o,p'-DDD on cortisol metabolism in Cushing's syndrome of various etiology. Endocrinologia japonica, 1985, Volume: 32, Issue:5 Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Ho	1985
[Urinary 6beta-hydroxycortisol. II. Urinary 6beta-hydroxycortisol in different diseases and after administration of drugs]. Nihon Naibunpi Gakkai zasshi, 1973, Jun-20, Volume: 49, Issue:6 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Carcinoma; Cushing Syndrome; F	1973
Proceedings: Tumors of the adrenal cortex. Cancer, 1973, Volume: 32, Issue:5 Topics: Adenoma; Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortico	1973

mitotane and Adenoma

Research Excerpts

Research

Studies (36)

Authors

Clinical Trials (1)

Trial Overview

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Other Studies