mitotane has been researched along with Addison's Disease in 4 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two cases are described in which metastatic adrenocortical carcinoma associated with Cushing's syndrome was treated with mitotane (o,p'DDD)." | 3.67 | Hepatic microsomal enzyme induction and adrenal crisis due to o,p'DDD therapy for metastatic adrenocortical carcinoma. ( Cullen, DR; Hague, RV; May, W, 1989) |
| "Thirty-two dogs with hyperadrenocorticism caused by cortisol-secreting adrenocortical neoplasia were treated with mitotane at an initial daily induction dosage of 27." | 2.67 | Mitotane treatment of 32 dogs with cortisol-secreting adrenocortical neoplasms. ( Kintzer, PP; Peterson, ME, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| BLEDSOE, T | 1 |
| ISLAND, DP | 1 |
| NEY, RL | 1 |
| LIDDLE, GW | 1 |
| Willard, MD | 1 |
| Schall, WD | 1 |
| Nachreiner, RF | 1 |
| Shelton, DG | 1 |
| Kintzer, PP | 1 |
| Peterson, ME | 1 |
| Hague, RV | 1 |
| May, W | 1 |
| Cullen, DR | 1 |
1 trial available for mitotane and Addison's Disease
| Article | Year |
|---|---|
Mitotane treatment of 32 dogs with cortisol-secreting adrenocortical neoplasms.
Topics: Addison Disease; Adrenal Cortex Neoplasms; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone | 1994 |
3 other studies available for mitotane and Addison's Disease
| Article | Year |
|---|---|
AN EFFECT OF O,P'-DDD ON THE EXTRA-ADRENAL METABOLISM OF CORTISOL IN MAN.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adrenal Insufficiency; Adrenalectomy; A | 1964 |
Hypoadrenocorticism following therapy with o,p-DDD for hyperadrenocorticism in four dogs.
Topics: Addison Disease; Animals; Cushing Syndrome; Dog Diseases; Dogs; Female; Male; Mitotane | 1982 |
Hepatic microsomal enzyme induction and adrenal crisis due to o,p'DDD therapy for metastatic adrenocortical carcinoma.
Topics: Addison Disease; Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Alanine Transaminase; Aspartate Ami | 1989 |