mitomycin has been researched along with Uterine Neoplasms in 35 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Uterine Neoplasms: Tumors or cancer of the UTERUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Following a reported 23% response rate (RR) for mitomycin (M), doxorubicin (A), and cisplatin (P) and preliminary data suggesting a superior RR for dacarbazine (D) + MAP + sargramostim, the Gynecologic Oncology Group (GOG) conducted a phase II trial of DMAP + sargramostim in patients with advanced uterine leiomyosarcoma." | 9.11 | Phase II trial of dacarbazine, mitomycin, doxorubicin, and cisplatin with sargramostim in uterine leiomyosarcoma: a Gynecologic Oncology Group study. ( Blessing, JA; Long, HJ; Sorosky, J, 2005) |
| "Adult patients with advanced leiomyosarcomas received intravenous chemotherapy as outpatients with dacarbazine 750 micrograms/m2, mitomycin 6 mg/m2, doxorubicin 40 mg/m2, and cisplatin 60 mg/m2 on day 0, with granulocyte macrophage colony stimulating factor (GM-CSF, sagramostim) 250 mcg/m2 given s." | 9.10 | Contrast of response to dacarbazine, mitomycin, doxorubicin, and cisplatin (DMAP) plus GM-CSF between patients with advanced malignant gastrointestinal stromal tumors and patients with other advanced leiomyosarcomas. ( Buckner, JC; Edmonson, JH; Mahoney, MR; Marks, RS, 2002) |
| "Because of preliminary observations favoring the use of mitomycin, doxorubicin, and cisplatin (MAP) chemotherapy in leiomyosarcomas, the Gynecologic Oncology Group (GOG) decided to conduct a phase II clinical trial of this combination regimen in patients with advanced disease." | 9.10 | Phase II study of mitomycin, doxorubicin, and cisplatin in the treatment of advanced uterine leiomyosarcoma: a Gynecologic Oncology Group study. ( Blessing, JA; Cohn, DE; Cosin, JA; Edmonson, JH; Miller, DS; Rotmensch, J, 2002) |
| "Following a reported 23% response rate (RR) for mitomycin (M), doxorubicin (A), and cisplatin (P) and preliminary data suggesting a superior RR for dacarbazine (D) + MAP + sargramostim, the Gynecologic Oncology Group (GOG) conducted a phase II trial of DMAP + sargramostim in patients with advanced uterine leiomyosarcoma." | 5.11 | Phase II trial of dacarbazine, mitomycin, doxorubicin, and cisplatin with sargramostim in uterine leiomyosarcoma: a Gynecologic Oncology Group study. ( Blessing, JA; Long, HJ; Sorosky, J, 2005) |
| "Adult patients with advanced leiomyosarcomas received intravenous chemotherapy as outpatients with dacarbazine 750 micrograms/m2, mitomycin 6 mg/m2, doxorubicin 40 mg/m2, and cisplatin 60 mg/m2 on day 0, with granulocyte macrophage colony stimulating factor (GM-CSF, sagramostim) 250 mcg/m2 given s." | 5.10 | Contrast of response to dacarbazine, mitomycin, doxorubicin, and cisplatin (DMAP) plus GM-CSF between patients with advanced malignant gastrointestinal stromal tumors and patients with other advanced leiomyosarcomas. ( Buckner, JC; Edmonson, JH; Mahoney, MR; Marks, RS, 2002) |
| "Because of preliminary observations favoring the use of mitomycin, doxorubicin, and cisplatin (MAP) chemotherapy in leiomyosarcomas, the Gynecologic Oncology Group (GOG) decided to conduct a phase II clinical trial of this combination regimen in patients with advanced disease." | 5.10 | Phase II study of mitomycin, doxorubicin, and cisplatin in the treatment of advanced uterine leiomyosarcoma: a Gynecologic Oncology Group study. ( Blessing, JA; Cohn, DE; Cosin, JA; Edmonson, JH; Miller, DS; Rotmensch, J, 2002) |
| "A patient with mitomycin-associated hemolytic-uremic syndrome received SPA treatments after her ACE inhibitor, lisinopril, was held." | 3.71 | Hypotensive reaction during staphylococcal protein A column therapy in a patient with anomalous degradation of bradykinin and Des-Arg9-bradykinin after contact activation. ( Adam, A; Eastlund, T; Hammerschmidt, D; Koenigbauer, U; Lepage, Y; Molinaro, G, 2002) |
| "35 ovarian cancer patients with ascites have been treated intraperitoneally with mitomycin C or mitoxantrone or interferon beta or tumor necrosis factor (TNF)." | 3.68 | [Locoregional ascites therapy with cytostatic drugs and immune modulators in gynecologic neoplasms]. ( Chronides, A; Diedrich, K; Krebs, D; Mallmann, P; Wagner, U; Werner, A, 1991) |
| "Among gynecologic cancers, ovarian cancer is treated with chemotherapy as a routine practice." | 2.41 | [Gynecologic cancer-evidenced based chemotherapy]. ( Ochiai, K, 2000) |
| " Based on these findings, the author established a consecutive low-dose CDDP dosing method, which possibly could deliver a higher therapeutic index compared with the bolus-dosing method." | 2.40 | [Consecutive low-dose cisplatin-based chemotherapy for gynecologic malignancies]. ( Shimizu, Y, 1997) |
| "The role in colorectal cancer is less clear, although there are some reports that suggest a benefit." | 1.30 | Peritonectomy and intraperitoneal chemotherapy in appendiceal and colorectal cancer. ( Clingan, P; Horsell, KW; King, DW; Merten, S; Morris, DL, 1999) |
| "There are few reports about the methods, amounts, and kinds of dosage about intermittent intra-arterial chemotherapy of liver metastases from primal pathological type's squamous cell carcinoma." | 1.28 | [Study of intermittent intra-arterial infusion chemotherapy in liver metastases from squamous cell carcinoma]. ( Aoki, T; Kasuya, K; Kimura, K; Koyanagi, Y; Ozawa, T; Sato, S; Tsuchida, A; Yasuda, D; Yoshimatsu, A, 1991) |
| "Of the 15 patients who developed brain metastases after prior chemotherapy, 12 had received MAC at least once prior to the diagnosis of brain metastases, and in 5 patients, MAC was the first chemotherapy given after the diagnosis of brain metastases." | 1.28 | Intracerebral choriocarcinoma. ( Jones, WB; Lewis, JL; Wagner-Reiss, KM, 1990) |
| " At this time the ITC therapy is used in combination with induced-hypertension-chemotherapy (IHC therapy)." | 1.27 | [The clinical effect of hyperthermia combined with induced hypertension chemotherapy]. ( Hayashida, S; Kobayashi, T; Sugimoto, K, 1984) |
| "Twenty-one patients with squamous carcinoma of the genital tract were treated with bleomycin, Oncovin, mitomycin-C, and cisplatin (BOMP)." | 1.27 | Bleomycin, vincristine, mitomycin-C, and cisplatin in the management of gynecological squamous cell carcinomas. ( Belinson, JL; McClure, M; Richards, AL; Stewart, JA, 1985) |
| " Anticancer agents (ADM, CDDP, CHA3, CQ, MMC) at 1/3 LD50 dosage for mice were administered intraperitoneally on a schedule of 3 doses for every 4 days." | 1.27 | Efficacy of anticancer agents in vitro and in vivo using cultured human endometrial carcinoma cells--study of therapeutic index. ( Yasui, Y, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (48.57) | 18.7374 |
| 1990's | 8 (22.86) | 18.2507 |
| 2000's | 9 (25.71) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baratti, D | 2 |
| Pennacchioli, E | 1 |
| Kusamura, S | 2 |
| Fiore, M | 1 |
| Balestra, MR | 1 |
| Colombo, C | 1 |
| Mingrone, E | 1 |
| Gronchi, A | 2 |
| Alessanrdro, G | 1 |
| Deraco, M | 2 |
| Edmonson, JH | 2 |
| Marks, RS | 1 |
| Buckner, JC | 1 |
| Mahoney, MR | 1 |
| Molinaro, G | 1 |
| Adam, A | 1 |
| Lepage, Y | 1 |
| Hammerschmidt, D | 1 |
| Koenigbauer, U | 1 |
| Eastlund, T | 1 |
| KOGA, K | 1 |
| MAEDA, K | 1 |
| ISHIHARA, M | 1 |
| TERAO, S | 1 |
| HASHIGO, H | 1 |
| FUJIMORI, M | 1 |
| SAKAUCHI, G | 1 |
| IZUO, M | 1 |
| ABE, C | 1 |
| MORITA, S | 1 |
| NASHIMOTO, T | 1 |
| ISHIKAWA, S | 1 |
| SADMITSU, H | 1 |
| KAWAI, T | 1 |
| CENTARO, A | 1 |
| GASPARRI, F | 1 |
| MAIJNELLI, M | 1 |
| PERITI, P | 1 |
| Mohindra, A | 1 |
| Bolderson, E | 1 |
| Stone, J | 1 |
| Wells, M | 1 |
| Helleday, T | 1 |
| Meuth, M | 1 |
| Raspagliesi, F | 1 |
| Casali, P | 1 |
| Long, HJ | 1 |
| Blessing, JA | 2 |
| Sorosky, J | 1 |
| Copas, P | 1 |
| Dyer, M | 1 |
| Smithson, LG | 1 |
| Hall, DJ | 1 |
| Hayashida, S | 1 |
| Sugimoto, K | 1 |
| Kobayashi, T | 1 |
| Takada, M | 1 |
| Xu, ZD | 1 |
| Yajima, A | 1 |
| Abe, Y | 1 |
| Soh, K | 1 |
| Ozawa, N | 1 |
| Takabayashi, T | 1 |
| Sato, S | 2 |
| Uehara, S | 1 |
| Suzuki, M | 1 |
| Shimizu, Y | 1 |
| Horsell, KW | 1 |
| Merten, S | 1 |
| Clingan, P | 1 |
| King, DW | 1 |
| Morris, DL | 1 |
| Ochiai, K | 1 |
| Manivit, P | 1 |
| Polo, R | 1 |
| Tabary, D | 1 |
| Nabet, M | 1 |
| Polo, M | 1 |
| Adamy, M | 1 |
| Rubini, B | 1 |
| Fromaget, JM | 1 |
| Chipponi, PN | 1 |
| Untereiner, M | 1 |
| Vermorken, JB | 1 |
| Zanetta, G | 1 |
| De Oliveira, CF | 1 |
| van der Burg, ME | 1 |
| Lacave, AJ | 1 |
| Teodorovic, I | 1 |
| Boes, GH | 1 |
| Colombo, N | 1 |
| Fushiki, H | 1 |
| Yuuki, H | 1 |
| Nakashima, A | 1 |
| Fujimura, M | 1 |
| Saito, S | 1 |
| Izumi, R | 1 |
| Cosin, JA | 1 |
| Miller, DS | 1 |
| Cohn, DE | 1 |
| Rotmensch, J | 1 |
| Wada, Y | 1 |
| Tomiyoshi, Y | 1 |
| Fujimaru, J | 1 |
| Ogura, M | 1 |
| Hirabayashi, K | 1 |
| Yoshida, S | 1 |
| Takeda, Y | 2 |
| Nguyen, HN | 1 |
| Sevin, BU | 1 |
| Averette, HE | 1 |
| Perras, J | 1 |
| Donato, D | 1 |
| Penalver, M | 1 |
| Werner, A | 2 |
| Mallmann, P | 1 |
| Chronides, A | 1 |
| Diedrich, K | 2 |
| Wagner, U | 1 |
| Krebs, D | 2 |
| Aoki, T | 2 |
| Kimura, K | 1 |
| Koyanagi, Y | 1 |
| Tsuchida, A | 1 |
| Yoshimatsu, A | 1 |
| Ozawa, T | 1 |
| Yasuda, D | 1 |
| Kasuya, K | 1 |
| Jones, WB | 1 |
| Wagner-Reiss, KM | 1 |
| Lewis, JL | 1 |
| Yasui, Y | 2 |
| Suzumori, K | 1 |
| Asai, H | 1 |
| Yagami, Y | 1 |
| Belinson, JL | 1 |
| Stewart, JA | 1 |
| Richards, AL | 1 |
| McClure, M | 1 |
| Yokota, K | 1 |
| Ueda, K | 1 |
| Takenaka, M | 1 |
| Fujiwara, A | 1 |
| Ohama, K | 1 |
| Takizawa, K | 1 |
| Ino, Y | 1 |
| Isono, T | 1 |
| Sato, M | 1 |
| Iguchi, T | 1 |
| Yamashita, S | 1 |
| Ito, T | 1 |
| Kinashi, N | 1 |
| Yakabe, A | 1 |
| Bode, U | 1 |
| Musch, E | 1 |
| Adhvaryu, SG | 1 |
| Vyas, RC | 1 |
| Dave, BJ | 1 |
| Trivedi, AH | 1 |
| Parikh, BN | 1 |
| Senapad, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Evaluation of DMAP Plus GM-CSF in the Treatment of Advanced, Persistent, or Recurrent Leiomyosarcoma of the Uterus[NCT00033644] | Phase 2 | 0 participants | Interventional | 2002-03-31 | Terminated | ||
| Evaluation of Mitomycin, Doxorubicin and Cisplatin in the Treatment of Recurrent or Advanced Uterine Sarcomas[NCT00002993] | Phase 2 | 30 participants (Anticipated) | Interventional | 1997-08-31 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for mitomycin and Uterine Neoplasms
| Article | Year |
|---|---|
[Consecutive low-dose cisplatin-based chemotherapy for gynecologic malignancies].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Cyclophosphamide; Doxorubicin; | 1997 |
[Gynecologic cancer-evidenced based chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Evidence-Based Medicine; Femal | 2000 |
4 trials available for mitomycin and Uterine Neoplasms
29 other studies available for mitomycin and Uterine Neoplasms
| Article | Year |
|---|---|
Peritoneal sarcomatosis: is there a subset of patients who may benefit from cytoreductive surgery and hyperthermic intraperitoneal chemotherapy?
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusio | 2010 |
Hypotensive reaction during staphylococcal protein A column therapy in a patient with anomalous degradation of bradykinin and Des-Arg9-bradykinin after contact activation.
Topics: Acute Disease; Aminopeptidases; Angiotensin-Converting Enzyme Inhibitors; Antineoplastic Combined Ch | 2002 |
[PRACTICAL ASPECTS OF CHEMOTHERAPY IN HYDATIDIFORM MOLE AND CHORIOCARCINOMA].
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Choriocarcinoma; Cyclophosphamide; Desoxycorticosteron | 1963 |
[DRUG THERAPY OF UTERINE CANCER].
Topics: Antineoplastic Agents; Azaguanine; Blood Chemical Analysis; Catalase; Clinical Enzyme Tests; Deoxyri | 1964 |
STUDIES ON REGIONAL PERFUSION AND INTRA-ARTERIAL INFUSION FOR CANCER CHEMOTHERAPY.
Topics: Antineoplastic Agents; Breast Neoplasms; Celiac Artery; Chemotherapy, Cancer, Regional Perfusion; Co | 1964 |
[PRESENT POSSIBILITIES OF CHEMOPROPHYLAXIS, COMPLEMENTARY AND PALLIATIVE CHEMOTHERAPY IN ASSOCIATION WITH SURGERY IN THE TREATMENT OF UTERINE NEOPLASMS].
Topics: Adenocarcinoma; Antineoplastic Agents; Aziridines; Chemoprevention; Female; Fluorouracil; Humans; Mi | 1964 |
A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks.
Topics: Base Pair Mismatch; Camptothecin; DNA; DNA Repair; DNA Replication; DNA-Binding Proteins; Female; Ge | 2004 |
Uterine sarcoma treated by cytoreductive surgery and intraperitoneal hyperthermic perfusion: a feasiblity study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusio | 2004 |
Bleomycin-mitomycin C in advanced squamous cell carcinoma of the female genital tract.
Topics: Adult; Aged; Bleomycin; Carcinoma, Squamous Cell; Drug Therapy, Combination; Female; Genital Neoplas | 1983 |
[The clinical effect of hyperthermia combined with induced hypertension chemotherapy].
Topics: Angiotensin II; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Blood Pressure; Cisplatin | 1984 |
[Nonspecific cell-mediated immunity of gynecologic cancer patients and related effects of chemotherapy and immunotherapy].
Topics: Female; Fluorouracil; Humans; Immunity, Cellular; Leukocyte Count; Mitomycin; Mitomycins; Ovarian Ne | 1983 |
Effects of radiotherapy and chemotherapy on sister chromatid exchanges in peripheral lymphocytes of the patients with gynecologic cancer.
Topics: Choriocarcinoma; Crossing Over, Genetic; Female; Genital Neoplasms, Female; Humans; Lymphocytes; Mit | 1983 |
Peritonectomy and intraperitoneal chemotherapy in appendiceal and colorectal cancer.
Topics: Abscess; Adenocarcinoma; Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; | 1999 |
[Initial locoregional chemotherapy in recurrent and locoregional advanced or inoperable stages of pelvic uterine and anorectal cancers].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Bleomycin; Cisplatin; D | 1995 |
[Apoptosis as a measure of chemosensitivity to anti-cancer drugs in gynecological cancer].
Topics: Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Cisplatin; Drug Screening Assays, Antitumor | 2002 |
[Sensitivity test for anti-tumor agents-3. MTT assay and its clinical effect].
Topics: Antineoplastic Agents; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Screening Assays, Antitumor; F | 1992 |
The use of ATP bioluminescence assays in selecting a drug screen panel for chemosensitivity testing of uterine cancer cell lines.
Topics: Adenocarcinoma; Adenosine Triphosphate; Alkaloids; Antineoplastic Agents; Cisplatin; Cyclophosphamid | 1992 |
[Locoregional ascites therapy with cytostatic drugs and immune modulators in gynecologic neoplasms].
Topics: Ascites; Breast Neoplasms; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Interferon- | 1991 |
[Study of intermittent intra-arterial infusion chemotherapy in liver metastases from squamous cell carcinoma].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Doxorubic | 1991 |
Intracerebral choriocarcinoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Choriocarcinoma; Cisplatin; | 1990 |
[Combination chemotherapy with peplomycin, cis-platinum and mitomycin C in gynecologic cancer].
Topics: Adenocarcinoma; Adult; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; | 1985 |
Bleomycin, vincristine, mitomycin-C, and cisplatin in the management of gynecological squamous cell carcinomas.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, S | 1985 |
[Sister chromatid exchange (SCE) in lymphocytes of patients with cancer of the cervix uteri].
Topics: Adult; Aged; Female; Humans; Leiomyoma; Lymphocytes; Middle Aged; Mitomycin; Mitomycins; Sister Chro | 1987 |
Efficacy of anticancer agents in vitro and in vivo using cultured human endometrial carcinoma cells--study of therapeutic index.
Topics: Animals; Antineoplastic Agents; Cell Line; Cisplatin; Colony-Forming Units Assay; Doxorubicin; Femal | 1987 |
[Side effects and anti-cancer effects following intraperitoneal (ip) administration of mitomycin C (MMC)].
Topics: Female; Humans; Mitomycin; Mitomycins; Neoplasm Recurrence, Local; Ovarian Neoplasms; Peritoneum; Ut | 1987 |
[Clinical study of intraperitoneal chemotherapeutic perfusion (IPCP) of mitomycin C (MMC) and intraperitoneal administration of cisplatin].
Topics: Ascites; Chemotherapy, Cancer, Regional Perfusion; Cisplatin; Drug Therapy, Combination; Evaluation | 1987 |
[Tolerance of intraoperative, intraperitoneal chemotherapy in advanced gynecologic malignancies].
Topics: Adolescent; Adult; Aged; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Female | 1988 |
Spontaneous and induced sister chromatid exchange frequencies and cell cycle progression in lymphocytes of patients with carcinoma of the uterine cervix.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Cell Cycle; Female; Humans; Lymphocytes; Metaphase; Middle | 1985 |
Chemotherapy for gynecologic malignancies at Siriraj Hospital, Bangkok.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Cyclophosphamid | 1985 |