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mitomycin and Strabismus

mitomycin has been researched along with Strabismus in 9 studies

Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.

Strabismus: Misalignment of the visual axes of the eyes. In comitant strabismus the degree of ocular misalignment does not vary with the direction of gaze. In noncomitant strabismus the degree of misalignment varies depending on direction of gaze or which eye is fixating on the target. (Miller, Walsh & Hoyt's Clinical Neuro-Ophthalmology, 4th ed, p641)

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to evaluate the efficacy of mitomycin C in reducing postoperative adhesions following strabismus surgery."9.11Evaluation of mitomycin C in reducing postoperative adhesions in strabismus surgery. ( Chen, PL; Chen, WY; Lu, DW, 2005)
"The present study aimed to investigate the efficacy of mitomycin-C (MMC) and infliximab (INF) in reducing adhesion and fibrosis following strabismus surgery."7.83Efficacy of mitomycin-C and infliximab in reducing adhesionand fibrosis following strabismus surgery. ( Çoşkun Yılmaz, B; Dinç, E; Güçlü, ES; Özcan Metin, T; Sarı, AA; Taşdelen, B, 2016)
"To investigate whether mycophenolic acid (MPA) exerts antifibrotic effects on pterygium fibroblasts (PFB) with and without stimulation with fibrogenic cytokines, and to compare the efficacy of MPA with mitomycin (MMC) and dexamethasone (DXM) on PFB and tenon fibroblasts (TFB)."7.76Mycophenolic acid suppresses human pterygium and normal tenon fibroblast proliferation in vitro. ( Amer, R; Levi-Schaffer, F; Maftsir, G; Puxeddu, I; Rabinowich, L; Solomon, A, 2010)
"To investigate the influence of 5-fluorouracil (5-FU) and mitomycin C (MMC) on the postoperative adhesions following strabismus surgery in rabbits."7.72Effects of intraoperative sponge mitomycin C and 5-fluorouracil on scar formation following strabismus surgery in rabbits. ( Düzcan, E; Eşme, A; Ozden, S; Tatlipinar, S; Yaylali, V; Yildirim, C, 2004)
"To evaluate the efficiency of mitomycin C (MMC) in limiting the postoperative inflammatory response and scarring after strabismus surgery."7.70Histologic effect of mitomycin C on strabismus surgery in the rabbit. ( Akaishi, PM; De Luca, IM; Minguini, N; Monteiro de Carvalho, KM, 2000)
"To determine whether 5-fluorouracil is effective in reducing scarring after strabismus surgery we used rectus muscle surgery in experimental animals to compare a single intraoperative dose of 5-fluorouracil with mitomycin C and to compare results in similarly treated controls not receiving these antimetabolites."7.69Intraoperative sponge 5-fluorouracil to reduce postoperative scarring in strabismus surgery. ( Evan, AP; Helveston, EM; Mora, JS; Sprunger, DT, 1997)
"The aim of this study was to evaluate the efficacy of mitomycin C in reducing postoperative adhesions following strabismus surgery."5.11Evaluation of mitomycin C in reducing postoperative adhesions in strabismus surgery. ( Chen, PL; Chen, WY; Lu, DW, 2005)
"The present study aimed to investigate the efficacy of mitomycin-C (MMC) and infliximab (INF) in reducing adhesion and fibrosis following strabismus surgery."3.83Efficacy of mitomycin-C and infliximab in reducing adhesionand fibrosis following strabismus surgery. ( Çoşkun Yılmaz, B; Dinç, E; Güçlü, ES; Özcan Metin, T; Sarı, AA; Taşdelen, B, 2016)
"To investigate whether mycophenolic acid (MPA) exerts antifibrotic effects on pterygium fibroblasts (PFB) with and without stimulation with fibrogenic cytokines, and to compare the efficacy of MPA with mitomycin (MMC) and dexamethasone (DXM) on PFB and tenon fibroblasts (TFB)."3.76Mycophenolic acid suppresses human pterygium and normal tenon fibroblast proliferation in vitro. ( Amer, R; Levi-Schaffer, F; Maftsir, G; Puxeddu, I; Rabinowich, L; Solomon, A, 2010)
"To investigate the influence of 5-fluorouracil (5-FU) and mitomycin C (MMC) on the postoperative adhesions following strabismus surgery in rabbits."3.72Effects of intraoperative sponge mitomycin C and 5-fluorouracil on scar formation following strabismus surgery in rabbits. ( Düzcan, E; Eşme, A; Ozden, S; Tatlipinar, S; Yaylali, V; Yildirim, C, 2004)
"To evaluate the efficiency of mitomycin C (MMC) in limiting the postoperative inflammatory response and scarring after strabismus surgery."3.70Histologic effect of mitomycin C on strabismus surgery in the rabbit. ( Akaishi, PM; De Luca, IM; Minguini, N; Monteiro de Carvalho, KM, 2000)
"To determine whether 5-fluorouracil is effective in reducing scarring after strabismus surgery we used rectus muscle surgery in experimental animals to compare a single intraoperative dose of 5-fluorouracil with mitomycin C and to compare results in similarly treated controls not receiving these antimetabolites."3.69Intraoperative sponge 5-fluorouracil to reduce postoperative scarring in strabismus surgery. ( Evan, AP; Helveston, EM; Mora, JS; Sprunger, DT, 1997)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (33.33)18.2507
2000's3 (33.33)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Güçlü, ES1
Sarı, AA1
Dinç, E1
Özcan Metin, T1
Çoşkun Yılmaz, B1
Taşdelen, B1
Amer, R1
Rabinowich, L1
Maftsir, G1
Puxeddu, I1
Levi-Schaffer, F1
Solomon, A1
Choi, S1
Cheong, Y1
Shin, JH1
Kim, KA1
Bang, JB1
Jin, KH1
Park, HK1
Eşme, A1
Yildirim, C1
Tatlipinar, S1
Düzcan, E1
Yaylali, V1
Ozden, S1
Chen, PL1
Chen, WY1
Lu, DW1
Oh, SO1
Chang, BL1
Lee, J1
Heilmann, C1
Schönfeld, P1
Schlüter, T1
Bohnensack, R1
Behrens-Baumann, W1
Mora, JS1
Sprunger, DT1
Helveston, EM1
Evan, AP1
Minguini, N1
Monteiro de Carvalho, KM1
Akaishi, PM1
De Luca, IM1

Trials

1 trial available for mitomycin and Strabismus

ArticleYear
Evaluation of mitomycin C in reducing postoperative adhesions in strabismus surgery.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2005, Volume: 21, Issue:5

    Topics: Adult; Aged; Double-Blind Method; Humans; Middle Aged; Mitomycin; Postoperative Complications; Prosp

2005

Other Studies

8 other studies available for mitomycin and Strabismus

ArticleYear
Efficacy of mitomycin-C and infliximab in reducing adhesionand fibrosis following strabismus surgery.
    Turkish journal of medical sciences, 2016, Nov-17, Volume: 46, Issue:5

    Topics: Animals; Infliximab; Mitomycin; Oculomotor Muscles; Postoperative Complications; Rabbits; Strabismus

2016
Mycophenolic acid suppresses human pterygium and normal tenon fibroblast proliferation in vitro.
    The British journal of ophthalmology, 2010, Volume: 94, Issue:10

    Topics: Adult; Aged; Analysis of Variance; Apoptosis; Cell Proliferation; Cells, Cultured; Dexamethasone; Do

2010
Short-term response of mitomycin C on the human rectus muscle following strabismus surgery: histological, ultrastructural, and biomechanical evaluation.
    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 2013, Volume: 19, Issue:1

    Topics: Histocytochemistry; Humans; Immunohistochemistry; Inflammation; Microscopy, Atomic Force; Microscopy

2013
Effects of intraoperative sponge mitomycin C and 5-fluorouracil on scar formation following strabismus surgery in rabbits.
    Strabismus, 2004, Volume: 12, Issue:3

    Topics: Animals; Cicatrix; Connective Tissue Diseases; Fluorouracil; Intraoperative Care; Mitomycin; Oculomo

2004
Effects of mitomycin C on delayed adjustment in experimental strabismus surgery.
    Korean journal of ophthalmology : KJO, 1995, Volume: 9, Issue:1

    Topics: Administration, Topical; Animals; Chemotherapy, Adjuvant; Conjunctiva; Mitomycin; Oculomotor Muscles

1995
Effect of the cytostatic agent idarubicin on fibroblasts of the human Tenon's capsule compared with mitomycin C.
    The British journal of ophthalmology, 1999, Volume: 83, Issue:8

    Topics: Antibiotics, Antineoplastic; Apoptosis; Cell Count; Cell Division; Dose-Response Relationship, Drug;

1999
Intraoperative sponge 5-fluorouracil to reduce postoperative scarring in strabismus surgery.
    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 1997, Volume: 1, Issue:2

    Topics: Administration, Topical; Animals; Antimetabolites; Cicatrix; Conjunctiva; Fluorouracil; Intraoperati

1997
Histologic effect of mitomycin C on strabismus surgery in the rabbit.
    Investigative ophthalmology & visual science, 2000, Volume: 41, Issue:11

    Topics: Animals; Antimetabolites; Cicatrix; Granuloma; Intraoperative Care; Mitomycin; Oculomotor Muscles; P

2000