mitomycin has been researched along with Squamous Cell Carcinoma of Head and Neck in 3 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Squamous Cell Carcinoma of Head and Neck: The most common type of head and neck carcinoma that originates from cells on the surface of the NASAL CAVITY; MOUTH; PARANASAL SINUSES, SALIVARY GLANDS, and LARYNX. Mutations in TNFRSF10B, PTEN, and ING1 genes are associated with this cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Locally advanced head and neck squamous cell carcinoma (LA-HNSCC) often requires postoperative chemoradiation with high risk of toxicity." | 2.94 | Phase III study of nivolumab alone or combined with ipilimumab as immunotherapy versus standard of care in resectable head and neck squamous cell carcinoma. ( Betz, CS; Binder, M; Boettcher, A; Bokemeyer, C; Busch, CJ; Moeckelmann, N; Muenscher, A; Schafhausen, P; Vettorazzi, E; Zech, HB, 2020) |
| "Oral squamous cell carcinoma (OSCC) may develop in young adults." | 1.43 | Sensitivity to chromosomal breakage as risk factor in young adults with oral squamous cell carcinoma. ( Braakhuis, BJ; Brakenhoff, RH; Flach, GB; Graveland, AP; Joenje, H; Leemans, CR; Nieuwint, AW; Oostra, AB, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Zech, HB | 1 |
| Moeckelmann, N | 1 |
| Boettcher, A | 1 |
| Muenscher, A | 1 |
| Binder, M | 1 |
| Vettorazzi, E | 1 |
| Bokemeyer, C | 1 |
| Schafhausen, P | 1 |
| Betz, CS | 1 |
| Busch, CJ | 1 |
| Vossen, DM | 1 |
| Verhagen, CVM | 1 |
| Grénman, R | 1 |
| Kluin, RJC | 1 |
| Verheij, M | 1 |
| van den Brekel, MWM | 1 |
| Wessels, LFA | 1 |
| Vens, C | 1 |
| Braakhuis, BJ | 1 |
| Nieuwint, AW | 1 |
| Oostra, AB | 1 |
| Joenje, H | 1 |
| Flach, GB | 1 |
| Graveland, AP | 1 |
| Brakenhoff, RH | 1 |
| Leemans, CR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter Randomized Controlled Phase III Study of Nivolumab Alone or in Combination With Ipilimumab as Immunotherapy vs Standard Follow-up in Surgical Resectable HNSCC After Adjuvant Therapy[NCT03700905] | Phase 3 | 276 participants (Anticipated) | Interventional | 2018-08-21 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for mitomycin and Squamous Cell Carcinoma of Head and Neck
| Article | Year |
|---|---|
Phase III study of nivolumab alone or combined with ipilimumab as immunotherapy versus standard of care in resectable head and neck squamous cell carcinoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy, Adjuvant; Chemotherapy, Ad | 2020 |
2 other studies available for mitomycin and Squamous Cell Carcinoma of Head and Neck
| Article | Year |
|---|---|
Role of variant allele fraction and rare SNP filtering to improve cellular DNA repair endpoint association.
Topics: Alleles; Cell Line, Tumor; DNA Repair; DNA, Neoplasm; Fanconi Anemia Complementation Group Proteins; | 2018 |
Sensitivity to chromosomal breakage as risk factor in young adults with oral squamous cell carcinoma.
Topics: Adult; Carcinoma, Squamous Cell; Chromosome Breakage; DNA Damage; Fanconi Anemia; Female; Genetic Pr | 2016 |