mitomycin has been researched along with Sarcoma in 33 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Between March 1994 and October 1997, 20 women and 19 men with primary extremity or limb girdle high-grade soft tissue sarcomas were registered to a study of preoperative ifosfamide, mitomycin, doxorubicin, cisplatin (IMAP) plus granulocyte macrophage-colony-stimulating factor (GM-CSF) followed by preoperative irradiation and subsequent limb-sparing surgery." | 9.10 | Chemotherapy, irradiation, and surgery for function-preserving therapy of primary extremity soft tissue sarcomas: initial treatment with ifosfamide, mitomycin, doxorubicin, and cisplatin plus granulocyte macrophage-colony-stimulating factor. ( Buckner, JC; Edmonson, JH; Foo, ML; Gunderson, LL; Haddock, MG; Mahoney, MR; Maples, WJ; O'Connor, MI; Petersen, IA; Pritchard, DJ; Rock, MG; Shives, TC; Sim, FH; Stafford, SL, 2002) |
| "In all 63 patients were treated monthly with a combination of mitomycin, doxorubicin, and cisplatin, and 27 (43%) experienced objective regression of their advanced sarcomas during a 3-month trial." | 7.67 | Phase II study of a combination of mitomycin, doxorubicin and cisplatin in advanced sarcomas. ( Creagan, ET; Edmonson, JH; Green, SJ; Long, HJ; Richardson, RL, 1985) |
| " Based on preclinical and clinical data, combination with standard chemotherapy has the potential to further increase the antitumor activity of oncolytic virotherapy in a synergistic manner." | 6.74 | Phase I clinical trial of locoregional administration of the oncolytic adenovirus ONYX-015 in combination with mitomycin-C, doxorubicin, and cisplatin chemotherapy in patients with advanced sarcomas. ( Aderca, I; Galanis, E; Opyrchal, M, 2009) |
| "Patients with high-grade soft tissue sarcomas were treated with 2 cycles of ifosfamide, mitomycin, doxorubicin, and cisplatin plus GM-CSF subcutaneous followed by 45 Gy irradiation with concurrent 2 cycles of mitomycin, doxorubicin, and cisplatin followed by surgery +/- intraoperative radiation or brachytherapy." | 5.22 | Chemotherapy, Irradiation, and Surgery for Function-preserving Curative Therapy of Primary Extremity Soft Tissue Sarcomas: Initial Treatment With I-MAP and Inhalation GM-CSF During Preoperative Irradiation and Postoperatively. ( Haddock, M; Mahoney, M; Maples, W; Markovic, SN; O'Connor, MI; Okuno, S; Petersen, I; Shives, T; Sim, F, 2016) |
| "Between March 1994 and October 1997, 20 women and 19 men with primary extremity or limb girdle high-grade soft tissue sarcomas were registered to a study of preoperative ifosfamide, mitomycin, doxorubicin, cisplatin (IMAP) plus granulocyte macrophage-colony-stimulating factor (GM-CSF) followed by preoperative irradiation and subsequent limb-sparing surgery." | 5.10 | Chemotherapy, irradiation, and surgery for function-preserving therapy of primary extremity soft tissue sarcomas: initial treatment with ifosfamide, mitomycin, doxorubicin, and cisplatin plus granulocyte macrophage-colony-stimulating factor. ( Buckner, JC; Edmonson, JH; Foo, ML; Gunderson, LL; Haddock, MG; Mahoney, MR; Maples, WJ; O'Connor, MI; Petersen, IA; Pritchard, DJ; Rock, MG; Shives, TC; Sim, FH; Stafford, SL, 2002) |
| " One patient with aggressive fibromatosis was treated with TNF alone (200 micrograms/m2, days 1-5 every third week) and 10 patients (four colon cancer, four head and neck cancer; one melanoma; one sarcoma) received mitomycin C (15 mg/m2, day 1) followed by TNF (60-180 micrograms/m2, days 1-3) every sixth week." | 5.08 | Tumor necrosis factor administration is associated with increased endogenous production of M-CSF and G-CSF but not GM-CSF in human cancer patients. ( Gooding, W; Kirkwood, JM; Logan, TF; Shadduck, RK, 1996) |
| " Adenocarcinoma patients receive mitomycin C and 5-fluorouracil; sarcoma patients receive cisplatin and doxorubicin." | 3.69 | Intraperitoneal chemotherapy for treatment and prevention of peritoneal carcinomatosis and sarcomatosis. ( Sugarbaker, PH, 1994) |
| "In all 63 patients were treated monthly with a combination of mitomycin, doxorubicin, and cisplatin, and 27 (43%) experienced objective regression of their advanced sarcomas during a 3-month trial." | 3.67 | Phase II study of a combination of mitomycin, doxorubicin and cisplatin in advanced sarcomas. ( Creagan, ET; Edmonson, JH; Green, SJ; Long, HJ; Richardson, RL, 1985) |
| "Virogenic cell cultures of a hamster ependymoma originally produced by Simian Virus 40 were treated with proflavine, hydrogen peroxide, or mitomycin C." | 3.64 | VIROGENIC HAMSTER TUMOR CELLS: INDUCTION OF VIRUS SYNTHESIS. ( GERBER, P, 1964) |
| " Based on preclinical and clinical data, combination with standard chemotherapy has the potential to further increase the antitumor activity of oncolytic virotherapy in a synergistic manner." | 2.74 | Phase I clinical trial of locoregional administration of the oncolytic adenovirus ONYX-015 in combination with mitomycin-C, doxorubicin, and cisplatin chemotherapy in patients with advanced sarcomas. ( Aderca, I; Galanis, E; Opyrchal, M, 2009) |
| " We, therefore, undertook a phase I/II study of ONYX-015, days 1-5 every month administered intratumorally under radiographic guidance, in combination with MAP (mitomycin-C, doxorubicin, cisplatin) chemotherapy in patients with advanced sarcoma." | 2.71 | Phase I-II trial of ONYX-015 in combination with MAP chemotherapy in patients with advanced sarcomas. ( Atherton, P; Edmonson, JH; Erlichman, C; Freeman, S; Galanis, E; Lee, RA; Lewis, BD; Nascimento, AG; Okuno, SH; Oliveira, AM; Randlev, B; Rubin, J; Sloan, JA; Wang, Q, 2005) |
| "Alveolar soft part sarcoma is a rare soft tissue tumor arising in extremities." | 1.27 | [Pulmonary manifestations of alveolar soft part sarcoma; bronchial arterial embolization for hemoptysis]. ( Kikuchi, K; Masuda, H; Ogata, T; Takagi, K; Tanaka, S, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (63.64) | 18.7374 |
| 1990's | 3 (9.09) | 18.2507 |
| 2000's | 6 (18.18) | 29.6817 |
| 2010's | 3 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ishibashi, F | 1 |
| Tanabe, S | 1 |
| Oda, T | 1 |
| Iwao, M | 1 |
| Okuno, S | 1 |
| Petersen, I | 1 |
| Shives, T | 1 |
| Mahoney, M | 1 |
| Haddock, M | 1 |
| Sim, F | 1 |
| O'Connor, MI | 2 |
| Markovic, SN | 1 |
| Maples, W | 1 |
| Bhagwandin, S | 1 |
| Naffouje, S | 1 |
| Salti, G | 1 |
| Opyrchal, M | 1 |
| Aderca, I | 1 |
| Galanis, E | 2 |
| Baumgartner, JM | 1 |
| Ahrendt, SA | 1 |
| Pingpank, JF | 1 |
| Holtzman, MP | 1 |
| Ramalingam, L | 1 |
| Jones, HL | 1 |
| Zureikat, AH | 1 |
| Zeh, HJ | 1 |
| Bartlett, DL | 1 |
| Choudry, HA | 1 |
| MERKER, PC | 1 |
| REYES, C | 1 |
| ANIDO, P | 1 |
| SATO, M | 1 |
| DAWSON, EM | 1 |
| SAKURAI, Y | 2 |
| MORIWAKI, A | 1 |
| TANIDA, T | 1 |
| FUJIMORI, M | 1 |
| SAKAUCHI, G | 1 |
| IZUO, M | 1 |
| ABE, C | 1 |
| MORITA, S | 1 |
| NASHIMOTO, T | 1 |
| ISHIKAWA, S | 1 |
| SADMITSU, H | 1 |
| KAWAI, T | 1 |
| HANDLER, AH | 1 |
| SARRIS, TG | 1 |
| WILLS, C | 1 |
| KONDO, T | 1 |
| USUBUCHI, I | 1 |
| ISHIBASHI, Y | 1 |
| SUGIMURA, K | 1 |
| MYHRE, K | 1 |
| FJAERLI, J | 1 |
| GERBER, P | 1 |
| HAGIHARA, K | 1 |
| DAWSON, PJ | 1 |
| FIELDSTEEL, AH | 1 |
| BOSTICK, WL | 1 |
| Mohindra, A | 1 |
| Bolderson, E | 1 |
| Stone, J | 1 |
| Wells, M | 1 |
| Helleday, T | 1 |
| Meuth, M | 1 |
| Okuno, SH | 1 |
| Nascimento, AG | 1 |
| Lewis, BD | 1 |
| Lee, RA | 1 |
| Oliveira, AM | 1 |
| Sloan, JA | 1 |
| Atherton, P | 1 |
| Edmonson, JH | 3 |
| Erlichman, C | 1 |
| Randlev, B | 1 |
| Wang, Q | 1 |
| Freeman, S | 1 |
| Rubin, J | 1 |
| Kusamura, S | 1 |
| Raspagliesi, F | 1 |
| Baratti, D | 1 |
| Gronchi, A | 1 |
| Casali, P | 1 |
| Deraco, M | 1 |
| Kelm, C | 1 |
| Henneking, K | 1 |
| Zimmermann, T | 1 |
| Vollerthun, M | 1 |
| Padberg, W | 1 |
| Sugarbaker, PH | 1 |
| Logan, TF | 1 |
| Gooding, W | 1 |
| Kirkwood, JM | 1 |
| Shadduck, RK | 1 |
| Petersen, IA | 1 |
| Shives, TC | 1 |
| Mahoney, MR | 1 |
| Rock, MG | 1 |
| Haddock, MG | 1 |
| Sim, FH | 1 |
| Maples, WJ | 1 |
| Gunderson, LL | 1 |
| Foo, ML | 1 |
| Pritchard, DJ | 1 |
| Buckner, JC | 1 |
| Stafford, SL | 1 |
| Yamauchi, T | 1 |
| Raffin, TA | 1 |
| Yang, P | 1 |
| Sikic, BI | 1 |
| Long, HJ | 1 |
| Richardson, RL | 1 |
| Creagan, ET | 1 |
| Green, SJ | 1 |
| Masuda, H | 1 |
| Ogata, T | 1 |
| Kikuchi, K | 1 |
| Takagi, K | 1 |
| Tanaka, S | 1 |
| van Oosterom, AT | 1 |
| Santoro, A | 1 |
| Bramwell, V | 1 |
| Davy, M | 1 |
| Mouridsen, HT | 1 |
| Thomas, D | 1 |
| Sylvester, R | 1 |
| Di Lauro, L | 1 |
| Balice, A | 1 |
| Papaldo, P | 1 |
| Lopez, M | 1 |
5 trials available for mitomycin and Sarcoma
28 other studies available for mitomycin and Sarcoma
| Article | Year |
|---|---|
Synthesis and structure-activity relationship study of lamellarin derivatives.
Topics: Alkaloids; Animals; Chlorocebus aethiops; Coumarins; Dogs; Drug Screening Assays, Antitumor; Female; | 2002 |
Utility of Chemoresponse Assay in Patients Undergoing Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cytoreductio | 2015 |
Aggressive locoregional management of recurrent peritoneal sarcomatosis.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Chemo | 2013 |
A mitomycin C-resistant Jensen rat sarcoma: isolation and transplantation studies.
Topics: Animals; Mitomycin; Mitomycins; Neoplasms; Rats; Sarcoma; Sarcoma, Experimental | 1962 |
[BASIC AND CLINICAL INVESTIGATION OF CANCER CHEMOTHERAPY].
Topics: Adolescent; Antineoplastic Agents; Child; Cyclophosphamide; Geriatrics; Infant; Mitomycin; Mitomycin | 1962 |
OSTEOGENIC SARCOMA IN CHILDHOOD.
Topics: Adolescent; Bone Neoplasms; Child; Humans; Infant; Methotrexate; Mitomycin; Mitomycins; Neoplasms; O | 1963 |
THE IN VITRO INDUCTION OF DRUG RESISTANCE OF YOSHIDA SARCOMA TO ANTITUMOR AGENTS.
Topics: Animals; Antineoplastic Agents; DNA; DNA, Neoplasm; Drug Resistance; In Vitro Techniques; Mechloreth | 1963 |
[HISTOPATHOLOGICAL EFFECTS OF ANTINEOPLASTIC AGENTS ON MALIGNANT LYMPHOMA].
Topics: Antineoplastic Agents; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Geriatrics; Hodgkin Dise | 1964 |
STUDIES ON REGIONAL PERFUSION AND INTRA-ARTERIAL INFUSION FOR CANCER CHEMOTHERAPY.
Topics: Antineoplastic Agents; Breast Neoplasms; Celiac Artery; Chemotherapy, Cancer, Regional Perfusion; Co | 1964 |
CHEMOTHERAPY STUDIES ON PRIMARY TUMOR GRAFTS AND METASTASES IN HAMSTERS AND MICE.
Topics: Antineoplastic Agents; Cricetinae; Cyclophosphamide; Dactinomycin; Melphalan; Mice; Mitomycin; Mitom | 1964 |
THE ADVERSE EFFECTS OF CANCER CHEMOTHERAPY.
Topics: Animals; Antineoplastic Agents; Azaguanine; Carcinoma, Ehrlich Tumor; Cortisone; Cyclophosphamide; D | 1964 |
ADMINISTRATION METHOD OF MITOMYCIN C.
Topics: Carcinoma, Hepatocellular; Liver Neoplasms; Methylcholanthrene; Mitomycin; Mitomycins; Neoplasms; Ne | 1964 |
CANCER CHEMOTHERAPY (MITOMYCIN-C) FOLLOWED BY BONE MARROW TRANSPLANTATION.
Topics: Bone Marrow Transplantation; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Bronchogenic; Choriocarci | 1964 |
[RENAL SARCOMA IN BOURNEVILLE-PRINGLE'S PHACOMATOSIS: CASE REPORT].
Topics: Humans; Kidney Neoplasms; Mitomycin; Mitomycins; Neoplasms; Nephrectomy; Neurocutaneous Syndromes; P | 1964 |
TREATMENT OF MALIGNANT TUMOURS WITH 5-FLUOROURACIL IN 80 PATIENTS.
Topics: Biomedical Research; Breast Neoplasms; Colonic Neoplasms; Drug Therapy; Esophageal Neoplasms; Female | 1964 |
VIROGENIC HAMSTER TUMOR CELLS: INDUCTION OF VIRUS SYNTHESIS.
Topics: Acridines; Adenoviridae; Adenoviridae Infections; Complement Fixation Tests; Cricetinae; Ependymoma; | 1964 |
THE USE OF RAT ASCITES TUMORS HETEROGRAFTED IN MICE FOR SCREENING OF ANTICANCEROUS AGENTS.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Ascites; Carcinoma, Ehrlich Tumor; Carcinoma, | 1963 |
IN VITRO CULTURE OF YOSHIDA SARCOMA CELLS: METHODS FOR DETERMINING ACQUIRED RESISTANCE TO DRUGS.
Topics: Animals; Antineoplastic Agents; Azaguanine; Culture Media; Cyclophosphamide; Dactinomycin; Drug Tole | 1964 |
EFFECT OF DRUGS ON CELL AND VIRUS GROWTH IN FRIEND LEUKEMIA AND A TUMOR VARIANT.
Topics: Animals; Estradiol; Friends; Leukemia; Leukemia Virus, Murine; Leukemia, Experimental; Lymphoma, Lar | 1965 |
A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks.
Topics: Base Pair Mismatch; Camptothecin; DNA; DNA Repair; DNA Replication; DNA-Binding Proteins; Female; Ge | 2004 |
Uterine sarcoma treated by cytoreductive surgery and intraperitoneal hyperthermic perfusion: a feasiblity study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusio | 2004 |
[Palliative therapy of primary liver tumors].
Topics: Adenoma, Bile Duct; Adolescent; Adult; Aged; alpha-Fetoproteins; Angiography; Antineoplastic Combine | 1993 |
Intraperitoneal chemotherapy for treatment and prevention of peritoneal carcinomatosis and sarcomatosis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Chemotherapy, Adjuvant; Cisplatin; Doxoru | 1994 |
Differential protective effects of varying degrees of hypoxia on the cytotoxicities of etoposide and bleomycin.
Topics: Bleomycin; Cell Line; Cell Survival; Doxorubicin; Drug Resistance; Etoposide; Humans; Mitomycin; Mit | 1987 |
Phase II study of a combination of mitomycin, doxorubicin and cisplatin in advanced sarcomas.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Dru | 1985 |
[Pulmonary manifestations of alveolar soft part sarcoma; bronchial arterial embolization for hemoptysis].
Topics: Adult; Bronchial Arteries; Combined Modality Therapy; Embolization, Therapeutic; Hemoptysis; Humans; | 1988 |
Mitomycin C (MCC) in advanced soft tissue sarcoma: a phase II study of the EORTC Soft Tissue and Bone Sarcoma Group.
Topics: Adult; Aged; Drug Evaluation; Female; Humans; Male; Middle Aged; Mitomycin; Mitomycins; Sarcoma; Sof | 1985 |
[Mitomycin C in the treatment of sarcomas of the soft tissues in the adult in an advanced phase].
Topics: Adult; Aged; Drug Evaluation; Female; Humans; Male; Middle Aged; Mitomycin; Mitomycins; Sarcoma; Sof | 1985 |