mitomycin has been researched along with Sarcoma 180 in 43 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Sarcoma 180: An experimental sarcoma of mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Conjugates of mitomycin C (MMC) with estradiol benzoate and estradiol via glutaric acid, abbreviated to EB-glu-MMC and E-glu-MMC, respectively, as previously reported, were examined concerning their pharmacokinetic behaviors and antitumor effects against two kinds of general and popular tumors, P388 leukemia and Sarcoma 180." | 7.70 | In vivo properties of the conjugates of mitomycin C with estradiol benzoate and estradiol: pharmacokinetics and antitumor characteristics against P388 leukemia and sarcoma 180. ( Ishiki, N; Machida, Y; Onishi, H, 1998) |
| "Conjugates of mitomycin C (MMC) with estradiol bezoate and estradiol via glutaric acid (EB-glu-MMC and E-glu-MMC, respectively) were examined for their antitumor activities against P388 leukemia and sarcoma 180." | 3.71 | Antitumor activities of conjugates of mitomycin C with estradiol benzoate and estradiol via glutaric acid in suspension dosage form. ( Ishiki, N; Machida, Y; Onishi, H, 2002) |
| "Conjugates of mitomycin C (MMC) with estradiol benzoate and estradiol via glutaric acid, abbreviated to EB-glu-MMC and E-glu-MMC, respectively, as previously reported, were examined concerning their pharmacokinetic behaviors and antitumor effects against two kinds of general and popular tumors, P388 leukemia and Sarcoma 180." | 3.70 | In vivo properties of the conjugates of mitomycin C with estradiol benzoate and estradiol: pharmacokinetics and antitumor characteristics against P388 leukemia and sarcoma 180. ( Ishiki, N; Machida, Y; Onishi, H, 1998) |
| "Highly-succinylated N-succinyl-chitosan (Suc) was fluorescein-labeled, and the labeled product (Suc-FTC) was examined for biodisposition in Sarcoma 180-bearing mice after i." | 3.70 | Biological fate of highly-succinylated N-succinyl-chitosan and antitumor characteristics of its water-soluble conjugate with mitomycin C at i.v. and i.p. administration into tumor-bearing mice. ( Kato, Y; Machida, Y; Onishi, H, 2000) |
| "Chuling (Polyporus umbellatus), one of the commonly used Chinese medical herbs, was combined with mitomycin C and then studied against intrahepatic implantation of sarcoma 180 tumor cells in mice." | 3.69 | Combined effects of chuling (Polyporus umbellatus) extract and mitomycin C on experimental liver cancer. ( Chen, KT; Hau, DM; Huang, HF; You, JS, 1994) |
| "The water-soluble conjugates of mitomycin C (MMC) with N-succinyl-chitosan (N-Suc-chitosan) and glycol-chitosan (Gly-chitosan), named N-Suc-chitosan-glu-MMC and Gly-chitosan-glu-MMC, respectively, were characterized mainly by the plasma concentration-time profiles of MMC after intraperitoneal administration and their in vivo antitumor effect against P388 leukemia and Sarcoma 180." | 3.69 | In vivo drug release and antitumor characteristics of water-soluble conjugates of mitomycin C with glycol-chitosan and N-succinyl-chitosan. ( Machida, Y; Nagai, T; Onishi, H; Sato, M; Takahara, J, 1996) |
| "Enhancement of the cytotoxicity of mitomycin C (MMC) and carboquone (CQ) by hypoxia at elevated temperature was examined using the SDI test of mouse Sarcoma 180 and Ehrlich cells and clonogenic assay of HeLa cells." | 3.68 | Cytotoxicity of mitomycin C and carboquone combined with hyperthermia against hypoxic tumor cells in vitro. ( Emi, Y; Kohnoe, S; Kusumoto, T; Maehara, Y; Sakaguchi, Y; Sugimachi, K, 1992) |
| "The effects of oxygen concentration on the chemosensitivity of mouse sarcoma-180 (S-180) cells and human colorectal cancer tissues to mitomycin C (MMC) or carboquone (CQ) were determined in vitro, since evidence had been obtained that these drugs are more effective in HeLa cells." | 3.68 | Sarcoma-180 cells and human colorectal tumor cells under in vitro hypoxic conditions are more sensitive to mitomycin C and carboquone. ( Emi, Y; Kohnoe, S; Kusumoto, T; Maehara, Y; Sakaguchi, Y; Sugimachi, K, 1991) |
| "Mitomycin C-Dextran conjugates (MMC-D) were intravenously (iv) injected in mice bearing subcutaneous sarcoma 180." | 3.67 | Disposition and tumor localization of mitomycin C-dextran conjugates in mice. ( Hashida, M; Sezaki, H; Takagi, A; Takakura, Y, 1987) |
| "The murine ascites sarcoma 180 cells were used to test the in vivo effectiveness of mitomycin C (MMC) and gamma-radiation applied in combination." | 3.67 | Changes in the template activity of chromatin isolated from sarcoma-180 ascites cells treated with mitomycin C and gamma irradiation in vivo. ( Karuri, A; Mukherji, S, 1989) |
| "The antitumor and toxic side effects of mitomycin C-estradiol conjugates (EB-glu-MMC and E-glu-MMC) were evaluated in detail for solutions in propylene glycol and suspensions in 10% (v/v) propylene glycol." | 1.32 | Evaluation of antitumor and toxic side effects of mitomycin C-estradiol conjugates. ( Ishiki, N; Machida, Y; Onishi, H, 2004) |
| " By the use of 3 % gelatin solution, mean residence time (MRT) and Tmax values were significantly prolonged, and Cmax was decreased as compared with the administration of MMC solution." | 1.30 | Pharmacokinetics of mitomycin C (MMC) after intraperitoneal administration of MMC-gelatin gel and its anti-tumor effects against sarcoma-180 bearing mice. ( Fujita, T; Muranishi, S; Tamura, T; Yamada, H; Yamamoto, A, 1997) |
| "Mitomycin G (2) was derived from porfiromycin (10b) in 3 steps via the methanesulfonate (14b) in an overall yield of 39%." | 1.28 | The derivation of 1a-demethylmitomycin G from mitomycin C. ( Kasai, M; Kono, M; Morimoto, M; Shirahata, K, 1990) |
| "Similar results were observed against B16 melanoma inoculated into BDF1 mice." | 1.28 | [Potentiation of the therapeutic effect of chemotherapy and hyperthermia on experimental tumor and reduction of immunotoxicity of mitomycin C by juzen-taiho-toh, a Chinese herbal medicine]. ( Komiyama, K; Umezawa, I; Zhibo, Y, 1989) |
| " The killing ability of macrophages and polymorphonuclear leukocytes of the immunosuppressed mice was also markedly enhanced by dosing with FK-156." | 1.27 | Immunoactive peptides, FK-156 and FK-565. II. Restoration of host resistance to microbial infection in immunosuppressed mice. ( Goto, S; Kuwahara, S; Mine, Y; Nishida, M; Wakai, Y; Watanabe, Y; Yokota, Y, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (51.16) | 18.7374 |
| 1990's | 17 (39.53) | 18.2507 |
| 2000's | 4 (9.30) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arai, H | 2 |
| Ashizawa, T | 2 |
| Gomi, K | 2 |
| Kono, M | 2 |
| Saito, H | 2 |
| Kasai, M | 3 |
| Ishiki, N | 3 |
| Onishi, H | 5 |
| Machida, Y | 5 |
| THIELE, EH | 1 |
| ARISON, RN | 1 |
| BOXER, GE | 1 |
| SAKAI, S | 2 |
| SAITO, G | 2 |
| SUGAYAMA, J | 2 |
| KAMASUKA, T | 2 |
| TAKADA, S | 2 |
| TAKANO, T | 2 |
| SOKOLOFF, B | 1 |
| MCCONNELL, B | 1 |
| PALMA, V | 1 |
| REYERS-DEGLIINNOCENTI, I | 1 |
| GARATTINI, S | 1 |
| KOSHIURA, R | 1 |
| KOSHIMURA, S | 1 |
| BANDO, Y | 1 |
| Zhang, SH | 1 |
| Su, J | 1 |
| Zhen, YS | 1 |
| Kennedy, KA | 1 |
| Siegfried, JM | 1 |
| Sartorelli, AC | 1 |
| Tritton, TR | 1 |
| Yokota, Y | 1 |
| Mine, Y | 1 |
| Wakai, Y | 1 |
| Watanabe, Y | 1 |
| Nishida, M | 1 |
| Goto, S | 1 |
| Kuwahara, S | 1 |
| Tung, YC | 1 |
| Hsu, SM | 1 |
| Lee, YE | 1 |
| Su, CM | 1 |
| Pal, AK | 1 |
| Neogi, LN | 1 |
| Chakrabarti, A | 1 |
| Chakrabarti, S | 1 |
| Iwaguchi, T | 2 |
| Mori, T | 1 |
| Kohsaki, G | 1 |
| Imai, R | 1 |
| Morimoto, M | 2 |
| Marumo, H | 1 |
| Kobayashi, T | 1 |
| Tsuruo, T | 1 |
| Inaba, M | 1 |
| Tsukagoshi, S | 1 |
| Sakurai, Y | 1 |
| Isshi, K | 1 |
| Kuroda, T | 1 |
| Takahashi, N | 1 |
| Takamura, S | 1 |
| Miho, O | 1 |
| Usui, S | 1 |
| Murashima, K | 1 |
| Sakai, M | 1 |
| Kiho, T | 2 |
| Ukai, S | 2 |
| You, JS | 2 |
| Hau, DM | 2 |
| Chen, KT | 1 |
| Huang, HF | 1 |
| Chen, TH | 1 |
| Cheng, JF | 1 |
| Tanaka, T | 2 |
| Kaneo, Y | 2 |
| Miyashita, M | 2 |
| Shiramoto, S | 1 |
| Okamoto, A | 1 |
| Okabe, M | 1 |
| Kobayashi, S | 1 |
| Sato, M | 1 |
| Takahara, J | 1 |
| Nagai, T | 1 |
| Fujita, T | 1 |
| Tamura, T | 1 |
| Yamada, H | 1 |
| Yamamoto, A | 1 |
| Muranishi, S | 1 |
| Kato, Y | 1 |
| Zhang, YH | 1 |
| Qi, QJ | 1 |
| Miyazaki, S | 1 |
| Ohkawa, Y | 1 |
| Takada, M | 1 |
| Attwood, D | 1 |
| Kiriki, H | 1 |
| Nagai, K | 2 |
| Sakaguchi, Y | 2 |
| Kohnoe, S | 2 |
| Emi, Y | 2 |
| Maehara, Y | 2 |
| Kusumoto, T | 2 |
| Sugimachi, K | 2 |
| Shirahata, K | 1 |
| Takakura, Y | 1 |
| Takagi, A | 1 |
| Hashida, M | 1 |
| Sezaki, H | 1 |
| Komiyama, K | 2 |
| Zhibo, Y | 2 |
| Umezawa, I | 2 |
| Karuri, A | 3 |
| Mukherji, S | 3 |
| Chowdhury, T | 1 |
| Lahiri, T | 1 |
| Hayashi, H | 1 |
| Toyama, N | 1 |
| Fujii, T | 1 |
| Fujii, M | 1 |
| Yoshikumi, C | 1 |
| Kawai, Y | 1 |
| Suda, T | 1 |
| Hirokawa, Y | 1 |
| Hata, T | 1 |
| Bhattacharya, K | 1 |
| Shibata, T | 1 |
| Nakayama, O | 1 |
| Okuhara, M | 1 |
| Tsurumi, Y | 1 |
| Terano, H | 1 |
| Kohsaka, M | 1 |
43 other studies available for mitomycin and Sarcoma 180
| Article | Year |
|---|---|
Synthesis and antitumor activity of various 6-demethylmitomycins and 6-demethyl-6-halomitomycins.
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Mice; Mitomyci | 1995 |
Antitumor activities of conjugates of mitomycin C with estradiol benzoate and estradiol via glutaric acid in suspension dosage form.
Topics: Animals; Antibiotics, Antineoplastic; Dosage Forms; Estradiol; Female; Glutarates; Injections, Intra | 2002 |
ONCOLYSIS BY CLOSTRIDIA. III. EFFECTS OF CLOSTRIDIA AND CHEMOTHERAPEUTIC AGENTS ON RODENT TUMORS.
Topics: Adenocarcinoma; Animals; Antimetabolites; Antineoplastic Agents; Aziridines; Bacteriological Techniq | 1964 |
[ON THE ANTICANCER ACTION OF BAMBOO EXTRACT].
Topics: Animals; Antineoplastic Agents; Carcinoma; Carcinoma, Ehrlich Tumor; Ion Exchange Resins; Mechloreth | 1963 |
HOST DEFENCE AND CHEMOTHERAPY IN EXPERIMENTAL CANCER.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Dactinomycin; Flavonoids; Lymphoma; Lymphoma, | 1964 |
ANTICANCER EFFECT OF POLYSACCHARIDE FRACTION PREPARED FROM BAMBOO GRASS.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Japan; Leukemia; Leukemia Virus, Murine; L | 1964 |
INTERACTION BETWEEN 5-HYDROXYTRYPTAMINE AND ANTITUMOURAL DRUGS.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cyclophosphamide; Fluorouracil; Melphalan; | 1964 |
[EXPERIMENTAL ANTICANCER STUDIES. 23. FURTHER EXPERIMENTS ON THE ANTITUMOR ACTIVITY OF 4-AMINO-6-OCTYLRESORCINOL HYDROCHLORIDE].
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Leukemia; Leuke | 1964 |
Evaluation of antitumor and toxic side effects of mitomycin C-estradiol conjugates.
Topics: Animals; Antibiotics, Antineoplastic; Body Weight; Chromatography, High Pressure Liquid; Estradiol; | 2004 |
[Salvianolic acid A inhibits nucleoside transport and potentiates the antitumor activity of chemotherapeutic drugs].
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Biological Transport; Caffeic Aci | 2004 |
Effects of anthracyclines on oxygenated and hypoxic tumor cells.
Topics: Animals; Antibiotics, Antineoplastic; Carmustine; Cell Survival; Chromatography, High Pressure Liqui | 1983 |
Immunoactive peptides, FK-156 and FK-565. II. Restoration of host resistance to microbial infection in immunosuppressed mice.
Topics: Adjuvants, Immunologic; Amino Acids, Diamino; Animals; Antibiotics, Antineoplastic; Bacterial Infect | 1983 |
Effects of Canavalia lineata lectin-bound "vaccine" on the proliferation of S-180 sarcoma cells in mice.
Topics: Animals; Cell Division; Immunization; Immunotherapy; Lectins; Male; Mice; Mice, Inbred ICR; Mitomyci | 1983 |
C-band-like effect produced by mitomycin C on mouse ascites tumour chromosomes in vivo.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line; Chromosome Banding; Chromosomes; Metaphase; Mice; M | 1984 |
Evaluation of PSK, an antitumor protein-bound polysaccharides, by thymocyte electrophoresis.
Topics: Animals; Antibiotics, Antineoplastic; Cell Movement; Electrophoresis; Female; Mice; Mice, Inbred ICR | 1984 |
Antitumor activity of 7-n-(p-hydroxyphenyl)-mitomycin C in experimental tumor systems.
Topics: Animals; Carcinoma; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fibrosarcoma; Le | 1981 |
[Experimental study of the development of chemosensitivity test by FDA assay].
Topics: Animals; Cell Division; Cisplatin; Doxorubicin; Drug Screening Assays, Antitumor; Fluoresceins; Huma | 1993 |
Preparation and antitumor activities of mitomycin C beta-(1-->6)-branched (1-->3)-beta-D-glucan conjugate.
Topics: Animals; Antibiotics, Antineoplastic; Chemotaxis, Leukocyte; Chromatography, Gel; Drug Carriers; Fem | 1994 |
Combined effects of chuling (Polyporus umbellatus) extract and mitomycin C on experimental liver cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Body Wei | 1994 |
Combined therapy of mitomycin C and Chinese medical herbs on experimental liver cancer.
Topics: Animals; Body Weight; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combinatio | 1993 |
Synthesis of transferrin-mitomycin C conjugate as a receptor-mediated drug targeting system.
Topics: Animals; Antineoplastic Agents; Drug Carriers; Macromolecular Substances; Mitomycin; Protein Binding | 1996 |
Properties of water-insoluble mitomycin C-albumin conjugate as a sustained release drug delivery system in mice inoculated with Sarcoma 180.
Topics: Albumins; Animals; Antibiotics, Antineoplastic; Delayed-Action Preparations; Mice; Mitomycin; Sarcom | 1995 |
Characteristics of the antitumor activity of M-16 and M-18, major metabolites of a new mitomycin C derivative KW-2149, in mice.
Topics: Animals; Antineoplastic Agents; Biotransformation; Breast Neoplasms; Cell Survival; HeLa Cells; Huma | 1995 |
In vivo drug release and antitumor characteristics of water-soluble conjugates of mitomycin C with glycol-chitosan and N-succinyl-chitosan.
Topics: Animals; Antibiotics, Antineoplastic; Biopolymers; Body Weight; Chemical Phenomena; Chemistry, Physi | 1996 |
Pharmacokinetics of mitomycin C (MMC) after intraperitoneal administration of MMC-gelatin gel and its anti-tumor effects against sarcoma-180 bearing mice.
Topics: Animals; Antibiotics, Antineoplastic; Body Weight; Gelatin; Gels; Injections, Intraperitoneal; Male; | 1997 |
In vivo properties of the conjugates of mitomycin C with estradiol benzoate and estradiol: pharmacokinetics and antitumor characteristics against P388 leukemia and sarcoma 180.
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Estradiol; Female; Injections, Int | 1998 |
Biological fate of highly-succinylated N-succinyl-chitosan and antitumor characteristics of its water-soluble conjugate with mitomycin C at i.v. and i.p. administration into tumor-bearing mice.
Topics: Animals; Antineoplastic Agents; Cell Division; Chitin; Chitosan; Drug Carriers; Injections, Intraper | 2000 |
[Anti-tumour study of combined therapy of yi kang ling with chemotherapeutic agents].
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemothe | 1992 |
Antitumor effect of pluronic F-127 gel containing mitomycin C on sarcoma-180 ascites tumor in mice.
Topics: Animals; Male; Mice; Mice, Inbred Strains; Mitomycin; Poloxalene; Sarcoma 180 | 1992 |
[Synthesis and antitumor activities of conjugates of mitomycin C-polysaccharide from Tremella fuciformis].
Topics: Animals; Antineoplastic Agents; Drug Carriers; Leukemia P388; Leukocyte Count; Male; Mice; Mitomycin | 1992 |
Cytotoxicity of mitomycin C and carboquone combined with hyperthermia against hypoxic tumor cells in vitro.
Topics: Aerobiosis; Anaerobiosis; Animals; Antineoplastic Combined Chemotherapy Protocols; Carbazilquinone; | 1992 |
Sarcoma-180 cells and human colorectal tumor cells under in vitro hypoxic conditions are more sensitive to mitomycin C and carboquone.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Carbazilquinone; Cell Hypoxia; Colorectal Neoplas | 1991 |
The derivation of 1a-demethylmitomycin G from mitomycin C.
Topics: Animals; Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry; Mice; Mitomycin; Mitomycins; Mo | 1990 |
Disposition and tumor localization of mitomycin C-dextran conjugates in mice.
Topics: Animals; Dextrans; Male; Mice; Mice, Inbred Strains; Mitomycin; Mitomycins; Molecular Weight; Prodru | 1987 |
[Potentiation of the therapeutic effect of chemotherapy and hyperthermia on experimental tumor and reduction of immunotoxicity of mitomycin C by juzen-taiho-toh, a Chinese herbal medicine].
Topics: Animals; Combined Modality Therapy; Drug Synergism; Drugs, Chinese Herbal; Female; Hyperthermia, Ind | 1989 |
Changes in the template activity of chromatin isolated from sarcoma-180 ascites cells treated with mitomycin C and gamma irradiation in vivo.
Topics: Animals; Cell Division; Cell Line; Chromatin; Combined Modality Therapy; DNA Damage; Endodeoxyribonu | 1989 |
Drug responses of S-180 tumours in syngeneic and xenogeneic hosts.
Topics: Animals; Cyclophosphamide; DNA Replication; Female; Mice; Mice, Inbred Strains; Mitomycin; Mitomycin | 1986 |
Evaluation of anticancer drugs by lymphocyte electrophoresis.
Topics: Animals; Antibiotics, Antineoplastic; Cell Fractionation; Doxorubicin; Electrophoresis; Female; Flow | 1986 |
[Antineoplastic effects of carnosine and beta-alanine--physiological considerations of its antineoplastic effects].
Topics: Alanine; Animals; Antineoplastic Agents; beta-Alanine; Carnosine; Dipeptides; Male; Mice; Mitomycin; | 1986 |
[Potentiation of chemotherapeutic activity by a Chinese herb medicine juzen-taiho-toh].
Topics: Animals; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Synergism; Drugs, Chinese Herbal; Female; Fi | 1988 |
Effect of gamma radiation alone or in combination with mitomycin C on endogenous nuclease activity of sarcoma 180 nuclei.
Topics: Animals; Combined Modality Therapy; Deoxyribonucleases; Gamma Rays; Mice; Mice, Inbred Strains; Mito | 1987 |
Uptake of uridine and its incorporation in RNA of Sarcoma 180 ascites tumour cells following in vivo gamma radiation and mitomycin C treatment.
Topics: Animals; Gamma Rays; Male; Mice; Mitomycin; Mitomycins; RNA, Neoplasm; Sarcoma 180; Uridine | 1987 |
A new immunomodulator, FR-900490.
Topics: Adjuvants, Immunologic; Animals; Anti-Bacterial Agents; Bone Marrow; Colony-Forming Units Assay; Fem | 1988 |