mitomycin has been researched along with Neuroblastoma in 12 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Anti-tumor effects of etoposide (VP-16), vincristine and mitomycin C were evaluated with four human neuroblastoma xenograft, according to Battelle Columbus Laboratories protocol." | 7.68 | [In vivo assessment on the therapeutic effects of etoposide, vincristine and mitomycin C against human neuroblastoma]. ( Kaneko, M; Kaneko, S; Ohkawa, H, 1991) |
| " Using mouse cortical neurons and SH-SY5Y human neuroblastoma cells, we identify a critical role of ERK signaling in neuronal death induced by DNA damage upon mitomycin C treatment." | 3.74 | Regulation of cyclin-dependent kinase 5 and p53 by ERK1/2 pathway in the DNA damage-induced neuronal death. ( Kim, KT; Lee, JH, 2007) |
| "Mitomycin C pretreatment also significantly increased the sensitivity of cancer cells to subsequent killing by the P-glycoprotein substrate doxorubicin, decreasing the ED50 by 5- to 10-fold." | 1.30 | Suppression of P-glycoprotein expression and multidrug resistance by DNA cross-linking agents. ( Blaxall, JR; Hamilton, JW; Ihnat, MA; La Ronde, N; Lariviere, JP; Pierre, KM; Turpie, BW; Warren, AJ, 1997) |
| "Treatment with mitomycin/5-bromodeoxyuridine and PGE1/cAMP inhibited growth as seen by the growth curves and caused morphological differentiation as seen by the extension of long neurites." | 1.27 | Differentiation characteristics of human neuroblastoma cells in the presence of growth modulators and antimitotic drugs. ( Felten, S; Gash, DM; Gupta, M; Notter, MF, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (50.00) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Habibi, L | 1 |
| Shokrgozar, MA | 1 |
| Motamedi, M | 1 |
| Akrami, SM | 1 |
| KOOP, CE | 1 |
| ISHIBASHI, Y | 1 |
| Lee, JH | 1 |
| Kim, KT | 1 |
| Rosen, EM | 1 |
| Cassady, JR | 1 |
| Frantz, CN | 1 |
| Kretschmar, C | 1 |
| Levey, R | 1 |
| Vawter, G | 1 |
| Sallan, SE | 1 |
| Ihnat, MA | 1 |
| Lariviere, JP | 1 |
| Warren, AJ | 1 |
| La Ronde, N | 1 |
| Blaxall, JR | 1 |
| Pierre, KM | 1 |
| Turpie, BW | 1 |
| Hamilton, JW | 1 |
| Gopas, J | 1 |
| Itzhaky, D | 1 |
| Segev, Y | 1 |
| Salzberg, S | 1 |
| Trink, B | 1 |
| Isakov, N | 1 |
| Rager-Zisman, B | 1 |
| Marsden, KM | 1 |
| Kershaw, TR | 1 |
| Sinden, JD | 1 |
| Lantos, PL | 1 |
| Kaneko, M | 1 |
| Kaneko, S | 1 |
| Ohkawa, H | 1 |
| Gupta, M | 1 |
| Notter, MF | 2 |
| Felten, S | 1 |
| Gash, DM | 1 |
| Leary, JF | 1 |
| Shimizu, Y | 1 |
| Todo, S | 1 |
| Imashuku, S | 1 |
12 other studies available for mitomycin and Neuroblastoma
| Article | Year |
|---|---|
Effect of heavy metals on silencing of engineered long interspersed element-1 retrotransposon in nondividing neuroblastoma cell line.
Topics: Cell Division; Cell Line, Tumor; Flow Cytometry; G2 Phase; Gene Silencing; Genetic Engineering; Gene | 2013 |
CURRENT MANAGEMENT OF NEPHROBLASTOMA AND NEUROBLASTOMA.
Topics: Antineoplastic Agents; Child; Dactinomycin; Fluorouracil; Infant; Infant, Newborn; Kidney Neoplasms; | 1964 |
CANCER CHEMOTHERAPY (MITOMYCIN-C) FOLLOWED BY BONE MARROW TRANSPLANTATION.
Topics: Bone Marrow Transplantation; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Bronchogenic; Choriocarci | 1964 |
Regulation of cyclin-dependent kinase 5 and p53 by ERK1/2 pathway in the DNA damage-induced neuronal death.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cells, Cultured; Cyclin-Dependent Kinase 5; DNA Damage; Early | 2007 |
Improved survival in neuroblastoma using multimodality therapy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cisplatin; Comb | 1984 |
Suppression of P-glycoprotein expression and multidrug resistance by DNA cross-linking agents.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; ATP Binding Cassette Transporter, | 1997 |
Persistent measles virus infection enhances major histocompatibility complex class I expression and immunogenicity of murine neuroblastoma cells.
Topics: 2',5'-Oligoadenylate Synthetase; Animals; Cell Line; eIF-2 Kinase; Enzyme Activation; Gene Expressio | 1992 |
Survival and distribution of transplanted human IMR-32 neuroblastoma cells.
Topics: Animals; Bromodeoxyuridine; Cell Line; Cell Survival; Cerebral Cortex; Hippocampus; Humans; Ibotenic | 1991 |
[In vivo assessment on the therapeutic effects of etoposide, vincristine and mitomycin C against human neuroblastoma].
Topics: Animals; Child, Preschool; Drug Screening Assays, Antitumor; Etoposide; Female; Humans; Infant; Male | 1991 |
Differentiation characteristics of human neuroblastoma cells in the presence of growth modulators and antimitotic drugs.
Topics: Acetylcholinesterase; Bromodeoxyuridine; Bucladesine; Cell Line; Cells, Cultured; Dopamine; Humans; | 1985 |
Tetanus toxin binding to neuroblastoma cells differentiated by antimitotic agents.
Topics: Alprostadil; Animals; Antineoplastic Agents; Bromodeoxyuridine; Cell Differentiation; Clone Cells; C | 1986 |
Cycloheximide reduces PGD2 or delta 12-PGJ2 cytotoxicity on NCG cells.
Topics: Amanitins; Cell Line; Cell Survival; Cycloheximide; Drug Interactions; Emetine; Humans; Mitomycin; M | 1986 |