mitomycin has been researched along with Neoplasm Seeding in 22 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Neoplasm Seeding: The local implantation of tumor cells by contamination of instruments and surgical equipment during and after surgical resection, resulting in local growth of the cells and tumor formation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the tumoricidal efficacy of meglumine gamma-linolenic acid (MeGLA), mitomycin C, epirubicin and water on two urothelial cell lines, and to establish the effect of serum protein levels derived from bladder cancer resection craters on the action of these agents." | 7.70 | Bladder cancer recurrence by implantation of exfoliated cells: is gamma-linolenic acid an effective tumoricidal agent? ( Birch, BR; Cooper, AJ; Foley, SJ; Jennings, AM; Solomon, LZ, 1998) |
| "A significant reduction in tumor implantation and port-site metastases was observed in all treatment groups (specific oligopeptides and mitomycin)." | 3.74 | Inhibition of tumor implantation after laparoscopy by specific oligopeptides: a novel approach to adjuvant intraperitoneal therapy to prevent tumor implantation in an animal model. ( Fornara, P; Jurczok, A; Schneider, A, 2007) |
| "To compare the tumoricidal efficacy of meglumine gamma-linolenic acid (MeGLA), mitomycin C, epirubicin and water on two urothelial cell lines, and to establish the effect of serum protein levels derived from bladder cancer resection craters on the action of these agents." | 3.70 | Bladder cancer recurrence by implantation of exfoliated cells: is gamma-linolenic acid an effective tumoricidal agent? ( Birch, BR; Cooper, AJ; Foley, SJ; Jennings, AM; Solomon, LZ, 1998) |
| "7." | 2.38 | Rationale for intravesical chemotherapy in the treatment and prophylaxis of superficial transitional cell carcinoma. ( Jordan, AM; Murphy, WM; Soloway, MS, 1989) |
| "A total of 104 patients with primary gastric cancer with peritoneal dissemination were enrolled in this study." | 1.33 | [Effectiveness of intraperitoneal chemotherapy using new-aged drugs for the peritoneal dissemination of gastric cancer]. ( Fujimura, T; Fujita, H; Fushida, S; Kinami, S; Ninomiya, I; Nishimura, G; Ohta, T, 2005) |
| "Mitomycin (10 mg/m) was instilled in 9 rats and saline was used in the control group." | 1.33 | Intraperitoneal chemotherapy for the prevention of transitional cell carcinoma implantation. ( Abaza, R; Keck, RW; Selman, SH, 2006) |
| "Pseudomyxoma peritonei is a rare disease caused by a perforated adenoma of the appendix." | 1.29 | Patterns of failure following treatment of pseudomyxoma peritonei of appendiceal origin. ( Sugarbaker, PH; Zoetmulder, FA, 1996) |
| "Some 74 of 469 patients of gastric cancer, who underwent surgical treatment over the last 7 years in our department, had peritoneal dissemination and 24 of them were treated with the drugs described above." | 1.28 | [Intraoperative intraperitoneal administration of mitomycin C and OK-432 for peritoneal dissemination of gastric cancer]. ( Azuma, S; Furuta, T; Kunieda, K; Miya, K; Saji, S; Sugiyama, Y; Takao, H; Tanemura, H; Yoshida, A, 1990) |
| "For prevention and therapy of peritoneal dissemination, a new dosage from (MMC-CH) comprising carbon particles adsorbing mitomycin C was given to 44 patients (the MMC-CH group) undergoing gastrectomy for gastric cancer, of which advancing stage was classified into the category of H0, and S2 or S3, and P0, P1, P2 or P3 according to the General Rules for the Gastric Cancer Study." | 1.28 | [Intraoperative chemotherapy against peritoneal dissemination of gastric cancer with intraperitoneal activated carbon particles adsorbing mitomycin C]. ( Hagiwara, A; Iwamoto, A; Sawai, K; Takahashi, T; Yamaguchi, T; Yoneyama, C, 1989) |
| " This extensive surgery combined with IPHP using MMC and MIS was well tolerated and is a safe antitumor treatment for gastric cancer with peritoneal dissemination." | 1.27 | Intraperitoneal hyperthermic perfusion combined with surgery effective for gastric cancer patients with peritoneal seeding. ( Arimizu, N; Fujimoto, S; Kiuchi, S; Kobayashi, K; Kokubun, M; Miyoshi, T; Ohta, M; Okui, K; Shrestha, RD; Takahashi, M, 1988) |
| "Fourteen patients with far-advanced gastric cancer were treated surgically followed by intraperitoneal hyperthermic perfusion (IPHP) with mitomycin C (MMC) and misonidazole (MIS), a thermosensitizing drug." | 1.27 | [Extended treatment for gastric cancer patients with peritoneal seeding]. ( Fujimoto, S; Kiuchi, S; Kobayashi, K; Kokubun, M; Ohta, M; Okui, K; Shrestha, RD, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (22.73) | 18.7374 |
| 1990's | 7 (31.82) | 18.2507 |
| 2000's | 9 (40.91) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shimizu, T | 1 |
| Sonoda, H | 1 |
| Murata, S | 1 |
| Takebayashi, K | 1 |
| Ohta, H | 1 |
| Miyake, T | 1 |
| Mekata, E | 1 |
| Shiomi, H | 1 |
| Naka, S | 1 |
| Tani, T | 1 |
| Abaza, R | 2 |
| Miocinovic, R | 1 |
| Keck, RW | 2 |
| Selman, SH | 2 |
| Zhuchenko, AP | 1 |
| Kalganov, ID | 1 |
| Filon, AF | 1 |
| Chung, NC | 1 |
| Liu, YC | 1 |
| Ye, XD | 1 |
| Wang, YM | 1 |
| Kuo, MC | 1 |
| Liu, K | 1 |
| Fushida, S | 1 |
| Fujita, H | 1 |
| Kinami, S | 1 |
| Ninomiya, I | 1 |
| Fujimura, T | 1 |
| Nishimura, G | 1 |
| Ohta, T | 1 |
| Jurczok, A | 1 |
| Schneider, A | 1 |
| Fornara, P | 1 |
| Liedberg, F | 1 |
| Ost, MC | 1 |
| Patel, KP | 1 |
| Rastinehad, AR | 1 |
| Chu, PY | 1 |
| Anderson, AE | 1 |
| Smith, AD | 1 |
| Lee, BR | 1 |
| Elias, D | 1 |
| Di Pietrantonio, D | 1 |
| Boulet, T | 1 |
| Honore, C | 1 |
| Bonnet, S | 1 |
| Goere, D | 1 |
| Kohneh-Shahri, N | 1 |
| Raynard, B | 1 |
| Erdmann, WD | 1 |
| Harzmann, R | 1 |
| Flüchter, SH | 1 |
| Bichler, KH | 1 |
| Zoetmulder, FA | 1 |
| Sugarbaker, PH | 1 |
| O'Hagan, S | 1 |
| Diamond, T | 1 |
| Solomon, LZ | 1 |
| Jennings, AM | 1 |
| Foley, SJ | 1 |
| Birch, BR | 1 |
| Cooper, AJ | 1 |
| Fass, J | 1 |
| Jansen, M | 1 |
| Zengel, K | 1 |
| Reinecke, T | 1 |
| Asshoff, G | 1 |
| Schumpelick, V | 1 |
| Sugiyama, Y | 1 |
| Yoshida, A | 1 |
| Takao, H | 1 |
| Kunieda, K | 1 |
| Miya, K | 1 |
| Azuma, S | 1 |
| Tanemura, H | 1 |
| Furuta, T | 1 |
| Saji, S | 1 |
| Kiuchi, S | 4 |
| Fujimoto, S | 4 |
| Shrestha, RD | 4 |
| Kokubun, M | 4 |
| Kobayashi, K | 4 |
| Konno, C | 2 |
| Ohta, M | 4 |
| Takahashi, M | 3 |
| Okui, K | 4 |
| Hagiwara, A | 1 |
| Takahashi, T | 1 |
| Sawai, K | 1 |
| Yamaguchi, T | 1 |
| Iwamoto, A | 1 |
| Yoneyama, C | 1 |
| Soloway, MS | 1 |
| Jordan, AM | 1 |
| Murphy, WM | 1 |
| Miyoshi, T | 1 |
| Arimizu, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I Trial of Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Cisplatin Plus Early Postoperative Intraperitoneal Paclitaxel and 5-FU for Peritoneal Carcinomatosis[NCT00001569] | Phase 1 | 74 participants | Interventional | 1997-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for mitomycin and Neoplasm Seeding
| Article | Year |
|---|---|
Rationale for intravesical chemotherapy in the treatment and prophylaxis of superficial transitional cell carcinoma.
Topics: Administration, Intravesical; Antineoplastic Agents; BCG Vaccine; Carcinoma in Situ; Carcinoma, Tran | 1989 |
3 trials available for mitomycin and Neoplasm Seeding
| Article | Year |
|---|---|
Hyperthermic intraperitoneal chemotherapy using a combination of mitomycin C,5-fluorouracil, and oxaliplatin in patients at high risk of colorectal peritoneal metastasis: A Phase I clinical study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Colorectal Neo | 2014 |
[Cytoreductive surgery with intraperitoneal chemotherapy in patients with colon cancer and peritoneal carcinomatosis].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colonic Neoplasms; Combined | 2003 |
[Results of intraperitoneal active charcoal-mitomycin C therapy of stomach carcinoma with serosa invasion].
Topics: Adenocarcinoma; Adult; Aged; Antibiotics, Antineoplastic; Charcoal; Chemotherapy, Cancer, Regional P | 1998 |
18 other studies available for mitomycin and Neoplasm Seeding
| Article | Year |
|---|---|
Prevention and treatment of transitional cell carcinomatosis with intraperitoneal chemotherapy in a rat model.
Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Transitional Cell; Disease Models, Animal; Mitomyci | 2009 |
Fatal arrhythmia following intraoperative continuous hyperthermic peritoneal perfusion chemotherapy.
Topics: Abdominal Neoplasms; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Chemotherapy, | 2003 |
[Effectiveness of intraperitoneal chemotherapy using new-aged drugs for the peritoneal dissemination of gastric cancer].
Topics: Antineoplastic Agents; Cisplatin; Combined Modality Therapy; Humans; Infusions, Parenteral; Mitomyci | 2005 |
Intraperitoneal chemotherapy for the prevention of transitional cell carcinoma implantation.
Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Transitional Cell; Injections, Intraperitoneal; Mit | 2006 |
Inhibition of tumor implantation after laparoscopy by specific oligopeptides: a novel approach to adjuvant intraperitoneal therapy to prevent tumor implantation in an animal model.
Topics: Analysis of Variance; Animals; Chi-Square Distribution; Female; Injections, Intraperitoneal; Laparos | 2007 |
The present article describes decreased intraperitoneal urothelial tumor cell growth by administration of antiadhesive oligopeptides or mitomycin.
Topics: Animals; Female; Injections, Intraperitoneal; Laparoscopy; Mice; Mice, Inbred C57BL; Mitomycin; Mode | 2007 |
Pneumoperitoneum with carbon dioxide inhibits macrophage tumor necrosis factor-alpha secretion: source of transitional-cell carcinoma port-site metastasis, with prophylactic irrigation strategies to decrease laparoscopic oncologic risks.
Topics: Animals; Anti-Infective Agents, Local; Antibiotics, Antineoplastic; Carbon Dioxide; Carcinoma, Trans | 2008 |
"Natural history" of complete cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Disease Progression; Drainage; | 2009 |
[Local mitomycin-C therapy of infiltrating bladder cancer].
Topics: Administration, Topical; Combined Modality Therapy; Cystitis; Humans; Mitomycin; Mitomycins; Neoplas | 1984 |
Patterns of failure following treatment of pseudomyxoma peritonei of appendiceal origin.
Topics: Abdomen; Adult; Antineoplastic Combined Chemotherapy Protocols; Appendiceal Neoplasms; Chemotherapy, | 1996 |
Cutaneous metastasis as a complication of hepatic intra-arterial chemotherapy.
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorourac | 1997 |
Bladder cancer recurrence by implantation of exfoliated cells: is gamma-linolenic acid an effective tumoricidal agent?
Topics: Antibiotics, Antineoplastic; Carcinoma, Transitional Cell; Cell Adhesion; Drug Resistance, Neoplasm; | 1998 |
[Intraoperative intraperitoneal administration of mitomycin C and OK-432 for peritoneal dissemination of gastric cancer].
Topics: Adult; Aged; Biological Products; Female; Gastrectomy; Humans; Infusions, Parenteral; Intraoperative | 1990 |
[Clinical evaluation of recurrent patterns of gastric cancer after intraperitoneal hyperthermic perfusion].
Topics: Aged; Ascitic Fluid; Combined Modality Therapy; Female; Humans; Hyperthermia, Induced; Infusions, Pa | 1990 |
[Clinical effect of intraperitoneal hyperthermochemotherapy on the survival rate for advanced gastric cancer patients].
Topics: Aged; Combined Modality Therapy; Female; Humans; Hyperthermia, Induced; Infusions, Parenteral; Male; | 1990 |
[Intraoperative chemotherapy against peritoneal dissemination of gastric cancer with intraperitoneal activated carbon particles adsorbing mitomycin C].
Topics: Adsorption; Carbon; Gastrectomy; Humans; Intraoperative Care; Mitomycin; Mitomycins; Neoplasm Seedin | 1989 |
Intraperitoneal hyperthermic perfusion combined with surgery effective for gastric cancer patients with peritoneal seeding.
Topics: Adult; Aged; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Female; Humans; Hy | 1988 |
[Extended treatment for gastric cancer patients with peritoneal seeding].
Topics: Combined Modality Therapy; Female; Humans; Hyperthermia, Induced; Infusions, Parenteral; Male; Middl | 1988 |