Page last updated: 2024-11-06

mitomycin and Menopause

mitomycin has been researched along with Menopause in 10 studies

Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.

Menopause: The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.

Research Excerpts

ExcerptRelevanceReference
"Mitozantrone (Novantrone) has recently been incorporated into a new combination chemotherapy regimen with mitomycin-C and methotrexate (MMM) against advanced breast cancer."9.07A randomised comparative trial of mitozantrone/methotrexate/mitomycin C (MMM) and cyclophosphamide/methotrexate/5 FU (CMF) in the treatment of advanced breast cancer. ( Ashley, S; Jodrell, DI; Mansi, JL; McKinna, JA; Pearson, MC; Sinnett, HD; Smith, IE; Walsh, G, 1991)
"Since June 1984, 23 cases of progressive or recurrent breast cancers were treated with combination chemotherapy of VAM-UFT consisting of vincristine, adriamycin, mitomycin C and UFT."7.67[Vincristine, adriamycin, mitomycin-C and UFT (VAM-UFT) therapy in progressive or recurrent breast cancer]. ( Hozumi, T; Imamura, Y; Irie, K; Katou, J; Matsushita, K; Okutani, T; Oya, M; Yasutake, K; Yoshimura, Y, 1989)
"According to estrogen receptor (ER) and menopausal status, operable breast cancer patients were randomized for adjuvant endocrine therapy with tamoxifen (TAM) in premenopausal patients, after oophorectomy (OVEX), chemotherapy, CHEM (mitomycin C+ oral cyclophosphamide), or chemo-endocrine therapy (TAM + CHEM)."5.09[A randomized study of adjuvant treatments for operable breast cancer patients stratified by estrogen receptor and menopausal status]. ( Murakami, S; Nomura, Y; Takenaka, Y; Tsutsui, S, 1999)
"Mitozantrone (Novantrone) has recently been incorporated into a new combination chemotherapy regimen with mitomycin-C and methotrexate (MMM) against advanced breast cancer."5.07A randomised comparative trial of mitozantrone/methotrexate/mitomycin C (MMM) and cyclophosphamide/methotrexate/5 FU (CMF) in the treatment of advanced breast cancer. ( Ashley, S; Jodrell, DI; Mansi, JL; McKinna, JA; Pearson, MC; Sinnett, HD; Smith, IE; Walsh, G, 1991)
"Two hundred and sixteen T2 breast cancer patients were treated consecutively with surgery followed by 5'DFUR (600 mg/body/day) + tamoxifen (20 mg/body/day) for 2 years."3.70Intratumoral pyrimidine nucleoside phosphorylase (PyNPase) activity predicts a selective effect of adjuvant 5'-deoxy-5-fluorouridine (5'DFUR) on breast cancer. ( Akasaka, Y; Hata, Y; Nakanishi, Y; Ogita, M; Sasaki, F; Sawada, Y; Takahashi, H; Uchino, J; Yoshimoto, M, 2000)
"Since June 1984, 23 cases of progressive or recurrent breast cancers were treated with combination chemotherapy of VAM-UFT consisting of vincristine, adriamycin, mitomycin C and UFT."3.67[Vincristine, adriamycin, mitomycin-C and UFT (VAM-UFT) therapy in progressive or recurrent breast cancer]. ( Hozumi, T; Imamura, Y; Irie, K; Katou, J; Matsushita, K; Okutani, T; Oya, M; Yasutake, K; Yoshimura, Y, 1989)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19904 (40.00)18.7374
1990's5 (50.00)18.2507
2000's1 (10.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Smith, IE2
Powles, TJ2
Nomura, Y3
Shirouzu, M1
Takayama, T1
Makris, A1
Dowsett, M1
Osborne, CK1
Trott, PA1
Fernando, IN1
Ashley, SE1
Ormerod, MG1
Titley, JC1
Gregory, RK1
Allred, DC1
Tsutsui, S1
Murakami, S1
Takenaka, Y1
Hata, Y1
Takahashi, H1
Sasaki, F1
Ogita, M1
Uchino, J1
Yoshimoto, M1
Akasaka, Y1
Nakanishi, Y1
Sawada, Y1
Jodrell, DI1
Mansi, JL1
Pearson, MC1
Walsh, G1
Ashley, S1
Sinnett, HD1
McKinna, JA1
Yasutake, K1
Imamura, Y1
Yoshimura, Y1
Oya, M1
Matsushita, K1
Hozumi, T1
Katou, J1
Okutani, T1
Irie, K1
Di Costanzo, F1
Gori, S1
Tonato, M1
Buzzi, F1
Crino, L1
Grignani, F1
Davis, S1
Tashiro, H1
Hisamatsu, K1
Shinozuka, K1
Perren, TJ1
Blackledge, G1
Mould, JJ1
Chetiyawardana, AD1
Morrison, M1
Hancock, A1

Trials

6 trials available for mitomycin and Menopause

ArticleYear
MMM (mitomycin/mitoxantrone/methotrexate): an effective new regimen in the treatment of metastatic breast cancer.
    Oncology, 1993, Volume: 50 Suppl 1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Cyclophosp

1993
Direct comparisons of adjuvant endocrine therapy, chemotherapy, and chemoendocrine therapy for operable breast cancer patients stratified by estrogen receptor and menopausal status.
    Breast cancer research and treatment, 1998, Volume: 49, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast

1998
Prediction of response to neoadjuvant chemoendocrine therapy in primary breast carcinomas.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:4

    Topics: Adult; Age Factors; Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Prot

1997
[A randomized study of adjuvant treatments for operable breast cancer patients stratified by estrogen receptor and menopausal status].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:5

    Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast

1999
A randomised comparative trial of mitozantrone/methotrexate/mitomycin C (MMM) and cyclophosphamide/methotrexate/5 FU (CMF) in the treatment of advanced breast cancer.
    British journal of cancer, 1991, Volume: 63, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Fem

1991
A randomized trial of adjuvant endocrine therapy, chemotherapy, and chemoendocrine therapy for operable breast cancer stratified by estrogen receptors.
    Cancer, 1988, Jun-01, Volume: 61, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Female; Humans;

1988

Other Studies

4 other studies available for mitomycin and Menopause

ArticleYear
Intratumoral pyrimidine nucleoside phosphorylase (PyNPase) activity predicts a selective effect of adjuvant 5'-deoxy-5-fluorouridine (5'DFUR) on breast cancer.
    Breast cancer (Tokyo, Japan), 2000, Volume: 7, Issue:1

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineoplastic Combin

2000
[Vincristine, adriamycin, mitomycin-C and UFT (VAM-UFT) therapy in progressive or recurrent breast cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:7

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Doxorubicin; Drug Adm

1989
Vindesine and mitomycin C in chemotherapy: refractory advanced breast cancer.
    Cancer, 1986, Mar-01, Volume: 57, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Leuko

1986
Phase II study of vincristine, mitomycin-C and mitoxantrone in advanced breast cancer: a preliminary report of response and toxicity.
    Investigational new drugs, 1985, Volume: 3, Issue:2

    Topics: Adolescent; Adult; Aged; Anthraquinones; Antineoplastic Combined Chemotherapy Protocols; Breast Neop

1985