Page last updated: 2024-11-06

mitomycin and Liver Cirrhosis

mitomycin has been researched along with Liver Cirrhosis in 14 studies

Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.

Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.

Research Excerpts

ExcerptRelevanceReference
"1-Hexylcarbamoyl-5-fluorouracil (HCFU) was orally administered at doses of 300-600 mg daily for 7-360 days to 27 inoperable cirrhotics with hepatocellular carcinoma."7.67[Role of oral administration of 1-hexyl-carbamoyl-5-fluorouracil (HCFU) for multimodal treatment of inoperable cirrhotics with hepatocellular carcinoma]. ( Akiharu, W; Fujiwara, M; Higashi, T; Ito, T; Kobayashi, M; Nagashima, H; Nakatsukasa, H; Shiota, T; Yamamoto, H; Yamauchi, Y, 1984)
"Survival period of 28 cases with unresectable hepatocellular carcinoma treated with transhepatic arterial one-shot infusion of 30 mg mitomycin C (MMC) were retrospectively reviewed from the standpoint of hepatic angiographic findings, scintigraphic existence of liver cirrhosis and changes of AFP value."7.66[Treatment of hepatocellular carcinoma with one-shot arterial infusion of mitomycin C]. ( Kobayashi, H, 1982)
"From 1986 to 1988, 35 patients with a hepatoma judged either inoperable or unresectable because of coexistent cirrhosis were treated with hepatic arterial embolization of mitomycin C microcapsules."5.28Hepatic arterial embolization with microencapsulated mitomycin C for unresectable hepatocellular carcinoma in cirrhosis. ( Audisio, RA; Bellegotti, L; Damascelli, B; DeFazio, C; Doci, R; Marchianò, A; Mazzaferro, V; Montalto, F; Piva, A; Tommasini, M, 1990)
"Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy."4.40Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023)
"1-Hexylcarbamoyl-5-fluorouracil (HCFU) was orally administered at doses of 300-600 mg daily for 7-360 days to 27 inoperable cirrhotics with hepatocellular carcinoma."3.67[Role of oral administration of 1-hexyl-carbamoyl-5-fluorouracil (HCFU) for multimodal treatment of inoperable cirrhotics with hepatocellular carcinoma]. ( Akiharu, W; Fujiwara, M; Higashi, T; Ito, T; Kobayashi, M; Nagashima, H; Nakatsukasa, H; Shiota, T; Yamamoto, H; Yamauchi, Y, 1984)
"Survival period of 28 cases with unresectable hepatocellular carcinoma treated with transhepatic arterial one-shot infusion of 30 mg mitomycin C (MMC) were retrospectively reviewed from the standpoint of hepatic angiographic findings, scintigraphic existence of liver cirrhosis and changes of AFP value."3.66[Treatment of hepatocellular carcinoma with one-shot arterial infusion of mitomycin C]. ( Kobayashi, H, 1982)
"Thirty-six hepatocellular carcinoma patients not indicated for surgical resection underwent super- selective transcatheter arterial chemoembolization, divided into small dose (n=15) and conventional dose (n=21) chemotherapy groups."1.38Liver fibrosis and five year survival of hepatocellular cancer cases undergoing transcatheter arterial chemo embolization using small doses. ( Hu, Y; Li, H; Li, N; Zhou, Y, 2012)
"From 1986 to 1988, 35 patients with a hepatoma judged either inoperable or unresectable because of coexistent cirrhosis were treated with hepatic arterial embolization of mitomycin C microcapsules."1.28Hepatic arterial embolization with microencapsulated mitomycin C for unresectable hepatocellular carcinoma in cirrhosis. ( Audisio, RA; Bellegotti, L; Damascelli, B; DeFazio, C; Doci, R; Marchianò, A; Mazzaferro, V; Montalto, F; Piva, A; Tommasini, M, 1990)
"Fourty eight patients with cancer of head of pancreas have been treated by the intra-arterial infusion of 5-FU and Mitomycin C alone or in combination with regional hyperthermia, employing microwave machine operating at a frequency of 2450 MHz."1.27[Hyperthermia: microwave hyperthermia in combination with intra-arterial infusion chemotherapy of cancer of the pancreas]. ( Endo, Y; Funatomi, H; Hatta, Y; Hirose, N; Miura, T; Sassa, T; Taguchi, S; Yoshikawa, N, 1985)
"Twenty-two patients with hepatocellular carcinoma were treated with transcatheter arterial embolization therapy."1.27[Retrospective study of short survival cases in hepatocellular carcinoma after transcatheter arterial embolization therapy]. ( Fujii, H; Iwai, M; Miyoshi, M; Suyama, Y, 1985)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19905 (35.71)18.7374
1990's5 (35.71)18.2507
2000's1 (7.14)29.6817
2010's2 (14.29)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Lim, EJ1
Chin, R1
Nachbur, U1
Silke, J1
Jia, Z1
Angus, PW1
Torresi, J1
Li, H1
Hu, Y1
Li, N1
Zhou, Y1
Akiharu, W1
Higashi, T1
Kobayashi, M1
Nakatsukasa, H1
Fujiwara, M1
Shiota, T1
Yamauchi, Y1
Ito, T1
Yamamoto, H1
Nagashima, H1
Kobayashi, H1
Kato, S1
Onda, M1
Tokunaga, A1
Yoshiyuki, T1
Matsukura, N1
Kim, DY1
Tajiri, T1
Yamashita, K1
Solomon, B1
Soulen, MC1
Baum, RA1
Haskal, ZJ1
Shlansky-Goldberg, RD1
Cope, C1
Kakumu, S1
Ito, S1
Ishikawa, T1
Mita, Y1
Tagaya, T1
Fukuzawa, Y1
Yoshioka, K1
Furukawa, H1
Hara, T1
Taniguchi, T1
Matsuda, H1
Audisio, RA1
Doci, R1
Mazzaferro, V1
Bellegotti, L1
Tommasini, M1
Montalto, F1
Marchianò, A1
Piva, A1
DeFazio, C1
Damascelli, B1
Miura, T1
Hatta, Y1
Endo, Y1
Sassa, T1
Yoshikawa, N1
Hirose, N1
Funatomi, H1
Taguchi, S1
Adachi, S1
Todoroki, T1
Ishikawa, A1
Nosue, M1
Fukao, K1
Iwasaki, Y1
Saida, Y1
Yamaguchi, T1
Osuga, T1
Doi, M1
Suyama, Y1
Iwai, M1
Fujii, H1
Miyoshi, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Humanitarian Device Exemption Use Protocol of Therasphere® for Treatment of Unresectable Hepatocellular and Metastatic Liver Tumors - HDE #980006[NCT00701168]0 participants Expanded AccessNo longer available
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for mitomycin and Liver Cirrhosis

ArticleYear
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023

Trials

1 trial available for mitomycin and Liver Cirrhosis

ArticleYear
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023

Other Studies

13 other studies available for mitomycin and Liver Cirrhosis

ArticleYear
Effect of Immunosuppressive Agents on Hepatocyte Apoptosis Post-Liver Transplantation.
    PloS one, 2015, Volume: 10, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis;

2015
Liver fibrosis and five year survival of hepatocellular cancer cases undergoing transcatheter arterial chemo embolization using small doses.
    Asian Pacific journal of cancer prevention : APJCP, 2012, Volume: 13, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chemoembolization, Therap

2012
[Role of oral administration of 1-hexyl-carbamoyl-5-fluorouracil (HCFU) for multimodal treatment of inoperable cirrhotics with hepatocellular carcinoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:12 Pt 1

    Topics: Administration, Oral; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; C

1984
[Treatment of hepatocellular carcinoma with one-shot arterial infusion of mitomycin C].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:3

    Topics: Adult; Aged; alpha-Fetoproteins; Angiography; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular

1982
[Mitomycin C-DNA adduct detection in rat organs and human liver].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:8

    Topics: Adult; Animals; Carcinoma, Hepatocellular; DNA Adducts; Female; Humans; Liver; Liver Cirrhosis; Live

1996
Chemoembolization of hepatocellular carcinoma with cisplatin, doxorubicin, mitomycin-C, ethiodol, and polyvinyl alcohol: prospective evaluation of response and survival in a U.S. population.
    Journal of vascular and interventional radiology : JVIR, 1999, Volume: 10, Issue:6

    Topics: alpha-Fetoproteins; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chem

1999
Decreased function of peripheral blood dendritic cells in patients with hepatocellular carcinoma with hepatitis B and C virus infection.
    Journal of gastroenterology and hepatology, 2000, Volume: 15, Issue:4

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Biomarkers, Tumor; Carcinoma, Hepatocellular; Dendritic Ce

2000
[Comparative changes in hepatic function induced by transhepatic arterial chemoimmunoembolization among liver cancer patients].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:13

    Topics: Chemoembolization, Therapeutic; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver; Liver Cirr

1992
[Serial changes in serum levels of laminin and type III procollagen N-terminal peptide after transarterial embolization (TAE) in hepatocellular carcinoma].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1991, Volume: 88, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Doxorubicin;

1991
Hepatic arterial embolization with microencapsulated mitomycin C for unresectable hepatocellular carcinoma in cirrhosis.
    Cancer, 1990, Jul-15, Volume: 66, Issue:2

    Topics: Aged; Carcinoma, Hepatocellular; Combined Modality Therapy; Delayed-Action Preparations; Embolizatio

1990
[Hyperthermia: microwave hyperthermia in combination with intra-arterial infusion chemotherapy of cancer of the pancreas].
    Gan no rinsho. Japan journal of cancer clinics, 1985, Volume: 31, Issue:6 Suppl

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Hepatocellular; Combined

1985
[Transcatheter arterial infusion therapy using lipiodol and mitomycin C for hepatocellular carcinoma with liver cirrhosis].
    Nihon Gan Chiryo Gakkai shi, 1988, Aug-20, Volume: 23, Issue:8

    Topics: Adult; Aged; Carcinoma, Hepatocellular; Evaluation Studies as Topic; Female; Humans; Infusions, Intr

1988
[Retrospective study of short survival cases in hepatocellular carcinoma after transcatheter arterial embolization therapy].
    Gan no rinsho. Japan journal of cancer clinics, 1985, Volume: 31, Issue:4

    Topics: Adult; Aged; Carcinoma, Hepatocellular; Embolization, Therapeutic; Gelatin Sponge, Absorbable; Human

1985