mitomycin has been researched along with Leukemia in 22 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Since cytochalasin B has shown in vitro efficacy against anchorage-independent growth, as well as against attached malignancies, both U937 human monocytic leukemia and MCF7 human breast carcinoma cells were evaluated." | 3.81 | Enlargement and multinucleation of u937 leukemia and MCF7 breast carcinoma cells by antineoplastic agents to enhance sensitivity to low frequency ultrasound and to DNA-directed anticancer agents. ( Fondy, TP; Trendowski, M; Wong, V; Yu, G, 2015) |
| " Conceptually, it is accepted that MTX and folic acid are transported by folate receptors (FRs) in cancerous cells, but the exact mechanism of MTX uptake in human leukemia is unknown." | 3.75 | Differential usage of the transport systems for folic acid and methotrexate in normal human T-lymphocytes and leukemic cells. ( Biswal, BK; Verma, RS, 2009) |
| "BCR/ABL-positive leukemia cells accumulated more replication-dependent DNA double-strand breaks (DSBs) than normal counterparts after treatment with cisplatin and mitomycin C (MMC, as assessed by pulse field gel electrophoresis (PFGE) and neutral comet assay." | 3.73 | ATR-Chk1 axis protects BCR/ABL leukemia cells from the lethal effect of DNA double-strand breaks. ( Blasiak, J; Czechowska, A; Datta, M; Koptyra, M; Krszyna, K; Nieborowska-Skorska, M; Rink, L; Seferynska, I; Skorski, T; Slupianek, A; Stoklosa, T, 2006) |
| "The generation time of this cancer cell line had a distribution with a long tail and a heritability across generations." | 1.62 | Intrinsic growth heterogeneity of mouse leukemia cells underlies differential susceptibility to a growth-inhibiting anticancer drug. ( Nakaoka, H; Okura, R; Seita, A; Wakamoto, Y, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (59.09) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Awang, K | 1 |
| Lim, CS | 1 |
| Mohamad, K | 1 |
| Morita, H | 1 |
| Hirasawa, Y | 1 |
| Takeya, K | 1 |
| Thoison, O | 1 |
| Hadi, AH | 1 |
| Seita, A | 1 |
| Nakaoka, H | 1 |
| Okura, R | 1 |
| Wakamoto, Y | 1 |
| Trendowski, M | 1 |
| Wong, V | 1 |
| Yu, G | 1 |
| Fondy, TP | 1 |
| Salustiano, EJ | 1 |
| Netto, CD | 1 |
| Fernandes, RF | 1 |
| da Silva, AJ | 1 |
| Bacelar, TS | 1 |
| Castro, CP | 1 |
| Buarque, CD | 1 |
| Maia, RC | 1 |
| Rumjanek, VM | 1 |
| Costa, PR | 1 |
| Biswal, BK | 1 |
| Verma, RS | 1 |
| Blalock, WL | 1 |
| Bavelloni, A | 1 |
| Piazzi, M | 1 |
| Tagliavini, F | 1 |
| Faenza, I | 1 |
| Martelli, AM | 1 |
| Follo, MY | 1 |
| Cocco, L | 1 |
| SAMPEY, JR | 1 |
| HIBINO, S | 1 |
| ISHIBASHI, Y | 1 |
| WAKISAKA, G | 1 |
| UCHINO, H | 1 |
| NAKAMURA, T | 1 |
| SHIRAKAWA, S | 1 |
| ADACHI, A | 1 |
| SAKURAI, M | 1 |
| MIYAMOTO, K | 1 |
| KOISO, K | 1 |
| SAKAI, S | 1 |
| SAITO, G | 1 |
| SUGAYAMA, J | 1 |
| KAMASUKA, T | 1 |
| TAKANO, T | 1 |
| TAKADA, S | 1 |
| EVANS, JS | 1 |
| BOSTWICK, L | 1 |
| MENGEL, GD | 1 |
| KOSHIURA, R | 1 |
| KOSHIMURA, S | 1 |
| BANDO, Y | 1 |
| DAWSON, PJ | 1 |
| FIELDSTEEL, AH | 1 |
| BOSTICK, WL | 1 |
| Chen, J | 1 |
| Du, D | 1 |
| Yan, F | 1 |
| Ju, HX | 1 |
| Lian, HZ | 1 |
| Nieborowska-Skorska, M | 1 |
| Stoklosa, T | 1 |
| Datta, M | 1 |
| Czechowska, A | 1 |
| Rink, L | 1 |
| Slupianek, A | 1 |
| Koptyra, M | 1 |
| Seferynska, I | 1 |
| Krszyna, K | 1 |
| Blasiak, J | 1 |
| Skorski, T | 1 |
| Imaizumi, M | 1 |
| Tsuchiya, S | 1 |
| Kobayashi, Y | 1 |
| Yamaguchi, Y | 1 |
| Minegishi, M | 1 |
| Tamura, M | 1 |
| Konno, T | 1 |
| Tada, K | 1 |
| Mourelatos, D | 1 |
| Dozi-Vassiliades, J | 1 |
| Tsigalidou-Balla, V | 1 |
| Granitsas, A | 1 |
| Uchida, A | 1 |
| Micksche, M | 1 |
| Böhmer, RM | 1 |
| Konstantinov, SM | 1 |
| Topashka-Ancheva, M | 1 |
| Benner, A | 1 |
| Berger, MR | 1 |
22 other studies available for mitomycin and Leukemia
| Article | Year |
|---|---|
Erythrocarpines A-E, new cytotoxic limonoids from Chisocheton erythrocarpus.
Topics: Animals; Cell Line; Cell Survival; Leukemia; Limonins; Magnetic Resonance Spectroscopy; Meliaceae; M | 2007 |
Intrinsic growth heterogeneity of mouse leukemia cells underlies differential susceptibility to a growth-inhibiting anticancer drug.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Leu | 2021 |
Enlargement and multinucleation of u937 leukemia and MCF7 breast carcinoma cells by antineoplastic agents to enhance sensitivity to low frequency ultrasound and to DNA-directed anticancer agents.
Topics: Antineoplastic Agents; Cell Enlargement; Cell Nucleus; Cytarabine; Cytochalasin B; Doxorubicin; Drug | 2015 |
Comparison of the cytotoxic effect of lapachol, alpha-lapachone and pentacyclic 1,4-naphthoquinones on human leukemic cells.
Topics: Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; H | 2010 |
Differential usage of the transport systems for folic acid and methotrexate in normal human T-lymphocytes and leukemic cells.
Topics: Antibodies; Biological Transport; Buffers; Carrier Proteins; Cell Line, Tumor; Folate Receptors, GPI | 2009 |
Multiple forms of PKR present in the nuclei of acute leukemia cells represent an active kinase that is responsive to stress.
Topics: Acute Disease; Amino Acid Sequence; Cell Line, Tumor; Cell Nucleus; DNA Damage; eIF-2 Kinase; Humans | 2011 |
Antibiotics in the control of Hodgkin's disease and the leukemias.
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Azaserine; Dactinomycin; Hodgkin Disease; Humans | 1962 |
CHEMOTHERAPY OF LEUKEMIA AND ALLIED DISEASES, WITH SPECIAL REFERENCE TO MYTOMYCIN C.
Topics: Blood; Bone Marrow; Hodgkin Disease; Humans; Leukemia; Leukemia, Myeloid; Mitomycin; Neoplasms | 1964 |
CANCER CHEMOTHERAPY (MITOMYCIN-C) FOLLOWED BY BONE MARROW TRANSPLANTATION.
Topics: Bone Marrow Transplantation; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Bronchogenic; Choriocarci | 1964 |
PRESENT STATUS OF LEUKEMIA IN JAPAN WITH SPECIAL REFERENCE TO EPIDEMIOLOGY AND STUDIES ON THE EFFECT OF CHEMOTHERAPY.
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Asian People; Busulfan; DNA; DNA, Neoplasm; Epidemio | 1964 |
[STUDIES ON THE NUCLEIC ACID METABOLISM OF HUMAN LEUKEMIC LEUKOCYTES IN VITRO].
Topics: Adenine Nucleotides; Bone Marrow; Cyclophosphamide; DNA; Formates; Guanine Nucleotides; Humans; In V | 1964 |
ANTICANCER EFFECT OF POLYSACCHARIDE FRACTION PREPARED FROM BAMBOO GRASS.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Japan; Leukemia; Leukemia Virus, Murine; L | 1964 |
SYNERGISM OF THE ANTINEOPLASTIC ACTIVITY OF CYTOSINE ARABINOSIDE BY PORFIROMYCIN.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Body Weight; Cytarabine; Cytosine; Leukemia; | 1964 |
[EXPERIMENTAL ANTICANCER STUDIES. 23. FURTHER EXPERIMENTS ON THE ANTITUMOR ACTIVITY OF 4-AMINO-6-OCTYLRESORCINOL HYDROCHLORIDE].
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Leukemia; Leuke | 1964 |
EFFECT OF DRUGS ON CELL AND VIRUS GROWTH IN FRIEND LEUKEMIA AND A TUMOR VARIANT.
Topics: Animals; Estradiol; Friends; Leukemia; Leukemia Virus, Murine; Leukemia, Experimental; Lymphoma, Lar | 1965 |
Electrochemical antitumor drug sensitivity test for leukemia K562 cells at a carbon-nanotube-modified electrode.
Topics: Antineoplastic Agents; Doxorubicin; Drug Screening Assays, Antitumor; Electrochemistry; Fluorouracil | 2005 |
ATR-Chk1 axis protects BCR/ABL leukemia cells from the lethal effect of DNA double-strand breaks.
Topics: Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Checkpoint Kinas | 2006 |
An Ia-like antigen positive null cell leukemia cell line (THP-5) lacking in the stimulating capacity in autologous and allogeneic mixed lymphocyte reaction.
Topics: Adolescent; Cell Line; Female; Histocompatibility Antigens Class II; Humans; Leukemia; Lymphocyte Ac | 1984 |
Enhancement by methylxanthines of sister-chromatid exchange frequency induced by cytostatics in normal and leukemic human lymphocytes.
Topics: Caffeine; Cells, Cultured; Crossing Over, Genetic; Cytarabine; Drug Synergism; Humans; Leukemia; Lym | 1983 |
Lysis of fresh human tumor cells by autologous peripheral blood lymphocytes and pleural effusion lymphocytes activated by OK432.
Topics: Adenocarcinoma; Adult; Aged; Biological Products; Cytotoxicity, Immunologic; Dactinomycin; Female; H | 1983 |
Two-step cell-death kinetics in vitro during cis-platinum, hydroxyurea and mitomycin incubation.
Topics: Antibiotics, Antineoplastic; Cell Line; Cell Survival; Cisplatin; Flow Cytometry; Humans; Hydroxyure | 1984 |
Alkylphosphocholines: Effects on human leukemic cell lines and normal bone marrow cells.
Topics: Alkylation; Animals; Antineoplastic Agents; Apoptosis; Bone Marrow Cells; Cell Cycle; Cell Division; | 1998 |