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mitomycin and Leukemia

mitomycin has been researched along with Leukemia in 22 studies

Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
"Since cytochalasin B has shown in vitro efficacy against anchorage-independent growth, as well as against attached malignancies, both U937 human monocytic leukemia and MCF7 human breast carcinoma cells were evaluated."3.81Enlargement and multinucleation of u937 leukemia and MCF7 breast carcinoma cells by antineoplastic agents to enhance sensitivity to low frequency ultrasound and to DNA-directed anticancer agents. ( Fondy, TP; Trendowski, M; Wong, V; Yu, G, 2015)
" Conceptually, it is accepted that MTX and folic acid are transported by folate receptors (FRs) in cancerous cells, but the exact mechanism of MTX uptake in human leukemia is unknown."3.75Differential usage of the transport systems for folic acid and methotrexate in normal human T-lymphocytes and leukemic cells. ( Biswal, BK; Verma, RS, 2009)
"BCR/ABL-positive leukemia cells accumulated more replication-dependent DNA double-strand breaks (DSBs) than normal counterparts after treatment with cisplatin and mitomycin C (MMC, as assessed by pulse field gel electrophoresis (PFGE) and neutral comet assay."3.73ATR-Chk1 axis protects BCR/ABL leukemia cells from the lethal effect of DNA double-strand breaks. ( Blasiak, J; Czechowska, A; Datta, M; Koptyra, M; Krszyna, K; Nieborowska-Skorska, M; Rink, L; Seferynska, I; Skorski, T; Slupianek, A; Stoklosa, T, 2006)
"The generation time of this cancer cell line had a distribution with a long tail and a heritability across generations."1.62Intrinsic growth heterogeneity of mouse leukemia cells underlies differential susceptibility to a growth-inhibiting anticancer drug. ( Nakaoka, H; Okura, R; Seita, A; Wakamoto, Y, 2021)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199013 (59.09)18.7374
1990's1 (4.55)18.2507
2000's4 (18.18)29.6817
2010's3 (13.64)24.3611
2020's1 (4.55)2.80

Authors

AuthorsStudies
Awang, K1
Lim, CS1
Mohamad, K1
Morita, H1
Hirasawa, Y1
Takeya, K1
Thoison, O1
Hadi, AH1
Seita, A1
Nakaoka, H1
Okura, R1
Wakamoto, Y1
Trendowski, M1
Wong, V1
Yu, G1
Fondy, TP1
Salustiano, EJ1
Netto, CD1
Fernandes, RF1
da Silva, AJ1
Bacelar, TS1
Castro, CP1
Buarque, CD1
Maia, RC1
Rumjanek, VM1
Costa, PR1
Biswal, BK1
Verma, RS1
Blalock, WL1
Bavelloni, A1
Piazzi, M1
Tagliavini, F1
Faenza, I1
Martelli, AM1
Follo, MY1
Cocco, L1
SAMPEY, JR1
HIBINO, S1
ISHIBASHI, Y1
WAKISAKA, G1
UCHINO, H1
NAKAMURA, T1
SHIRAKAWA, S1
ADACHI, A1
SAKURAI, M1
MIYAMOTO, K1
KOISO, K1
SAKAI, S1
SAITO, G1
SUGAYAMA, J1
KAMASUKA, T1
TAKANO, T1
TAKADA, S1
EVANS, JS1
BOSTWICK, L1
MENGEL, GD1
KOSHIURA, R1
KOSHIMURA, S1
BANDO, Y1
DAWSON, PJ1
FIELDSTEEL, AH1
BOSTICK, WL1
Chen, J1
Du, D1
Yan, F1
Ju, HX1
Lian, HZ1
Nieborowska-Skorska, M1
Stoklosa, T1
Datta, M1
Czechowska, A1
Rink, L1
Slupianek, A1
Koptyra, M1
Seferynska, I1
Krszyna, K1
Blasiak, J1
Skorski, T1
Imaizumi, M1
Tsuchiya, S1
Kobayashi, Y1
Yamaguchi, Y1
Minegishi, M1
Tamura, M1
Konno, T1
Tada, K1
Mourelatos, D1
Dozi-Vassiliades, J1
Tsigalidou-Balla, V1
Granitsas, A1
Uchida, A1
Micksche, M1
Böhmer, RM1
Konstantinov, SM1
Topashka-Ancheva, M1
Benner, A1
Berger, MR1

Other Studies

22 other studies available for mitomycin and Leukemia

ArticleYear
Erythrocarpines A-E, new cytotoxic limonoids from Chisocheton erythrocarpus.
    Bioorganic & medicinal chemistry, 2007, Sep-01, Volume: 15, Issue:17

    Topics: Animals; Cell Line; Cell Survival; Leukemia; Limonins; Magnetic Resonance Spectroscopy; Meliaceae; M

2007
Intrinsic growth heterogeneity of mouse leukemia cells underlies differential susceptibility to a growth-inhibiting anticancer drug.
    PloS one, 2021, Volume: 16, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Leu

2021
Enlargement and multinucleation of u937 leukemia and MCF7 breast carcinoma cells by antineoplastic agents to enhance sensitivity to low frequency ultrasound and to DNA-directed anticancer agents.
    Anticancer research, 2015, Volume: 35, Issue:1

    Topics: Antineoplastic Agents; Cell Enlargement; Cell Nucleus; Cytarabine; Cytochalasin B; Doxorubicin; Drug

2015
Comparison of the cytotoxic effect of lapachol, alpha-lapachone and pentacyclic 1,4-naphthoquinones on human leukemic cells.
    Investigational new drugs, 2010, Volume: 28, Issue:2

    Topics: Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; H

2010
Differential usage of the transport systems for folic acid and methotrexate in normal human T-lymphocytes and leukemic cells.
    Journal of biochemistry, 2009, Volume: 146, Issue:5

    Topics: Antibodies; Biological Transport; Buffers; Carrier Proteins; Cell Line, Tumor; Folate Receptors, GPI

2009
Multiple forms of PKR present in the nuclei of acute leukemia cells represent an active kinase that is responsive to stress.
    Leukemia, 2011, Volume: 25, Issue:2

    Topics: Acute Disease; Amino Acid Sequence; Cell Line, Tumor; Cell Nucleus; DNA Damage; eIF-2 Kinase; Humans

2011
Antibiotics in the control of Hodgkin's disease and the leukemias.
    American journal of pharmacy and the sciences supporting public health, 1962, Volume: 134

    Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Azaserine; Dactinomycin; Hodgkin Disease; Humans

1962
CHEMOTHERAPY OF LEUKEMIA AND ALLIED DISEASES, WITH SPECIAL REFERENCE TO MYTOMYCIN C.
    Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20

    Topics: Blood; Bone Marrow; Hodgkin Disease; Humans; Leukemia; Leukemia, Myeloid; Mitomycin; Neoplasms

1964
CANCER CHEMOTHERAPY (MITOMYCIN-C) FOLLOWED BY BONE MARROW TRANSPLANTATION.
    Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20

    Topics: Bone Marrow Transplantation; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Bronchogenic; Choriocarci

1964
PRESENT STATUS OF LEUKEMIA IN JAPAN WITH SPECIAL REFERENCE TO EPIDEMIOLOGY AND STUDIES ON THE EFFECT OF CHEMOTHERAPY.
    Acta haematologica, 1964, Volume: 31

    Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Asian People; Busulfan; DNA; DNA, Neoplasm; Epidemio

1964
[STUDIES ON THE NUCLEIC ACID METABOLISM OF HUMAN LEUKEMIC LEUKOCYTES IN VITRO].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1964, May-10, Volume: 53

    Topics: Adenine Nucleotides; Bone Marrow; Cyclophosphamide; DNA; Formates; Guanine Nucleotides; Humans; In V

1964
ANTICANCER EFFECT OF POLYSACCHARIDE FRACTION PREPARED FROM BAMBOO GRASS.
    Gan, 1964, Volume: 55

    Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Japan; Leukemia; Leukemia Virus, Murine; L

1964
SYNERGISM OF THE ANTINEOPLASTIC ACTIVITY OF CYTOSINE ARABINOSIDE BY PORFIROMYCIN.
    Biochemical pharmacology, 1964, Volume: 13

    Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Body Weight; Cytarabine; Cytosine; Leukemia;

1964
[EXPERIMENTAL ANTICANCER STUDIES. 23. FURTHER EXPERIMENTS ON THE ANTITUMOR ACTIVITY OF 4-AMINO-6-OCTYLRESORCINOL HYDROCHLORIDE].
    Gan, 1964, Volume: 55

    Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Leukemia; Leuke

1964
EFFECT OF DRUGS ON CELL AND VIRUS GROWTH IN FRIEND LEUKEMIA AND A TUMOR VARIANT.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1965, Volume: 119

    Topics: Animals; Estradiol; Friends; Leukemia; Leukemia Virus, Murine; Leukemia, Experimental; Lymphoma, Lar

1965
Electrochemical antitumor drug sensitivity test for leukemia K562 cells at a carbon-nanotube-modified electrode.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2005, Feb-18, Volume: 11, Issue:5

    Topics: Antineoplastic Agents; Doxorubicin; Drug Screening Assays, Antitumor; Electrochemistry; Fluorouracil

2005
ATR-Chk1 axis protects BCR/ABL leukemia cells from the lethal effect of DNA double-strand breaks.
    Cell cycle (Georgetown, Tex.), 2006, Volume: 5, Issue:9

    Topics: Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Checkpoint Kinas

2006
An Ia-like antigen positive null cell leukemia cell line (THP-5) lacking in the stimulating capacity in autologous and allogeneic mixed lymphocyte reaction.
    The Tohoku journal of experimental medicine, 1984, Volume: 142, Issue:1

    Topics: Adolescent; Cell Line; Female; Histocompatibility Antigens Class II; Humans; Leukemia; Lymphocyte Ac

1984
Enhancement by methylxanthines of sister-chromatid exchange frequency induced by cytostatics in normal and leukemic human lymphocytes.
    Mutation research, 1983, Volume: 121, Issue:2

    Topics: Caffeine; Cells, Cultured; Crossing Over, Genetic; Cytarabine; Drug Synergism; Humans; Leukemia; Lym

1983
Lysis of fresh human tumor cells by autologous peripheral blood lymphocytes and pleural effusion lymphocytes activated by OK432.
    Journal of the National Cancer Institute, 1983, Volume: 71, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Biological Products; Cytotoxicity, Immunologic; Dactinomycin; Female; H

1983
Two-step cell-death kinetics in vitro during cis-platinum, hydroxyurea and mitomycin incubation.
    Cell and tissue kinetics, 1984, Volume: 17, Issue:6

    Topics: Antibiotics, Antineoplastic; Cell Line; Cell Survival; Cisplatin; Flow Cytometry; Humans; Hydroxyure

1984
Alkylphosphocholines: Effects on human leukemic cell lines and normal bone marrow cells.
    International journal of cancer, 1998, Aug-31, Volume: 77, Issue:5

    Topics: Alkylation; Animals; Antineoplastic Agents; Apoptosis; Bone Marrow Cells; Cell Cycle; Cell Division;

1998