mitomycin has been researched along with Leukemia P388 in 59 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Leukemia P388: An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Conjugates of mitomycin C (MMC) with estradiol benzoate and estradiol via glutaric acid, abbreviated to EB-glu-MMC and E-glu-MMC, respectively, as previously reported, were examined concerning their pharmacokinetic behaviors and antitumor effects against two kinds of general and popular tumors, P388 leukemia and Sarcoma 180." | 7.70 | In vivo properties of the conjugates of mitomycin C with estradiol benzoate and estradiol: pharmacokinetics and antitumor characteristics against P388 leukemia and sarcoma 180. ( Ishiki, N; Machida, Y; Onishi, H, 1998) |
| "The antitumor activity of 7-N-phenyl derivatives of mitomycin C was tested in an ip-ip system of mouse leukemia P388 by single administration." | 7.66 | Antitumor activity of 7-N-phenyl derivatives of mitomycin C in the leukemia P388 system. ( Ashizawa, T; Imai, R; Morimoto, M; Nakamura, N; Urakawa, C, 1980) |
| " Nitrotriazole chemosensitizer in ultralow doses increased the sensitivity of leukemia P388/rn substrain with multiple drug resistance phenotype to mitomycin C during combination therapy." | 3.72 | Ultralow doses of various drugs in chemotherapy of experimental tumors. ( Konovalova, NP, 2003) |
| "Conjugates of mitomycin C (MMC) with estradiol bezoate and estradiol via glutaric acid (EB-glu-MMC and E-glu-MMC, respectively) were examined for their antitumor activities against P388 leukemia and sarcoma 180." | 3.71 | Antitumor activities of conjugates of mitomycin C with estradiol benzoate and estradiol via glutaric acid in suspension dosage form. ( Ishiki, N; Machida, Y; Onishi, H, 2002) |
| "Conjugates of mitomycin C (MMC) with estradiol benzoate and estradiol via glutaric acid, abbreviated to EB-glu-MMC and E-glu-MMC, respectively, as previously reported, were examined concerning their pharmacokinetic behaviors and antitumor effects against two kinds of general and popular tumors, P388 leukemia and Sarcoma 180." | 3.70 | In vivo properties of the conjugates of mitomycin C with estradiol benzoate and estradiol: pharmacokinetics and antitumor characteristics against P388 leukemia and sarcoma 180. ( Ishiki, N; Machida, Y; Onishi, H, 1998) |
| " Most of these compounds increased the intracellular uptake of vinblastine in multidrug-resistant mouse leukemia P388/ADR cells without influence upon the vinblastine accumulation in P388/S cells." | 3.69 | Novel inhibitors for multidrug resistance: 1,3,5-triazacycloheptanes. ( Aizawa, T; Miyamoto, K; Murakami, R; Muramatsu, H; Sawanishi, H; Suzuki, H; Takashima, A; Wakusawa, S, 1995) |
| "The water-soluble conjugates of mitomycin C (MMC) with N-succinyl-chitosan (N-Suc-chitosan) and glycol-chitosan (Gly-chitosan), named N-Suc-chitosan-glu-MMC and Gly-chitosan-glu-MMC, respectively, were characterized mainly by the plasma concentration-time profiles of MMC after intraperitoneal administration and their in vivo antitumor effect against P388 leukemia and Sarcoma 180." | 3.69 | In vivo drug release and antitumor characteristics of water-soluble conjugates of mitomycin C with glycol-chitosan and N-succinyl-chitosan. ( Machida, Y; Nagai, T; Onishi, H; Sato, M; Takahara, J, 1996) |
| " A yellow crystalline product, named rebeccamycin, was isolated from the mycelium and was found to have activity against P388 leukemia, L1210 leukemia and B16 melanoma implanted in mice." | 3.67 | Production and biological activity of rebeccamycin, a novel antitumor agent. ( Bradner, WT; Bush, JA; Catino, JJ; Long, BH; Tomita, K, 1987) |
| "The antitumor activity of 7-N-phenyl derivatives of mitomycin C was tested in an ip-ip system of mouse leukemia P388 by single administration." | 3.66 | Antitumor activity of 7-N-phenyl derivatives of mitomycin C in the leukemia P388 system. ( Ashizawa, T; Imai, R; Morimoto, M; Nakamura, N; Urakawa, C, 1980) |
| "The sensitivity of various human tumors xenografted to nude mice has been tested to antitumor agents to establish the system which could select the clinically active drugs." | 2.37 | [Recent advanced studies on mitomycins, antitumor activity and mode of action]. ( Morimoto, M; Taguchi, T, 1987) |
| " EPO used in combination with MMC significantly decreased SCE levels and increased PRI and MI values induced by MMC alone both in vitro and in vivo." | 1.36 | In vitro and in vivo cytogenetic effects of recombinant human erythropoietin on the frequency of sister chromatid exchanges alone or in combination with mitomycin C. ( Chrisafi, S; Digkas, EN; Hatzimichail, A; Lialiaris, TS; Passadaki, T; Tsalkidis, A; Vargemezis, V, 2010) |
| " The seven agents combined with CI-973 were mitomycin C, cyclophosphamide, doxorubicin, vinblastine, etoposide, ifosfamide, and methotrexate." | 1.29 | Chemotherapy with [SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2-)](2- methyl-1,4-butanediamine-N,N')platinum (CI-973, NK121) in combination with standard agents against murine tumors in vivo. ( Elliott, WL; Howard, CT; Leopold, WR; Roberts, BJ, 1994) |
| "BMY 25067 was > 100 times more cytotoxic than MMC in both the cells." | 1.28 | Effect of buthionine sulfoximine and ethacrynic acid on cytotoxic activity of mitomycin C analogues BMY 25282 and BMY 25067. ( Singh, SV; Xu, BH, 1992) |
| "Treatment of mitomycin C with pyrimidine nucleotides in acidic media produced derivatives of 2,7-diaminomitosene in which C-1 was covalently bound to the phosphate group of the nucleotides." | 1.27 | Nucleotide derivatives of 2,7-diaminomitosene. ( Dorr, RT; Iyengar, BS; Kowal, CD; Remers, WA, 1988) |
| "Mitomycin C (MMC) has been evaluated in combination with several antitumor agents." | 1.27 | Mitomycin C combination therapy against murine tumor systems. Effectiveness with cyclophosphamide and methotrexate. ( Mabel, JA; Wodinsky, I, 1983) |
| " These results indicate that JTX enhances the anti-tumor activity of MMC and lessens the adverse effects of it." | 1.27 | Protective effects of juzentaihoto, dried decoctum of 10 Chinese herbs mixture, upon the adverse effects of mitomycin C in mice. ( Aburada, M; Hosoya, E; Ito, E; Nakamura, M; Takeda, S, 1983) |
| "A new dosage form of mitomycin C (MMC-CH) was tested for toxicity and therapeutic efficacy against intraperitoneally inoculated cancer cells in mice." | 1.27 | Enhanced anticancer efficacy by use of mitomycin C adsorbed on small activated carbon particles in mice. ( Hagiwara, A; Nakagawa, Y; Takahashi, T; Ueda, T, 1987) |
| "In the amputation system of the same metastasis model at a dose of 4 mg/kg/d i." | 1.27 | A novel antitumor cyclic hexapeptide (RA-700) obtained from Rubiae radix. ( Hamanaka, T; Kawahara, K; Ohgoshi, M; Tsukagoshi, S; Tsuruo, T; Yamakawa, K, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (45.76) | 18.7374 |
| 1990's | 26 (44.07) | 18.2507 |
| 2000's | 5 (8.47) | 29.6817 |
| 2010's | 1 (1.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kanda, Y | 2 |
| Arai, H | 4 |
| Ashizawa, T | 4 |
| Morimoto, M | 9 |
| Kasai, M | 5 |
| Kunz, KR | 1 |
| Iyengar, BS | 7 |
| Dorr, RT | 2 |
| Alberts, DS | 1 |
| Remers, WA | 10 |
| Sengupta, SK | 2 |
| Kelly, C | 2 |
| Sehgal, RK | 1 |
| Sami, SM | 4 |
| Takahashi, T | 3 |
| Sikorski, EE | 1 |
| Bradner, WT | 10 |
| Kogan, Y | 1 |
| Szabo, J | 1 |
| Kowal, CD | 1 |
| Rao, SN | 1 |
| Wunz, TP | 1 |
| Kollman, PA | 1 |
| Casner, ML | 1 |
| Tarnow, SE | 2 |
| Schurig, JE | 5 |
| Hodges, JC | 1 |
| Gomi, K | 4 |
| Kono, M | 3 |
| Sawanishi, H | 1 |
| Wakusawa, S | 1 |
| Murakami, R | 1 |
| Muramatsu, H | 1 |
| Suzuki, H | 1 |
| Takashima, A | 1 |
| Aizawa, T | 1 |
| Miyamoto, K | 1 |
| Ariyasena, J | 1 |
| Baek, SH | 1 |
| Perry, NB | 1 |
| Weavers, RT | 1 |
| Digkas, EN | 1 |
| Chrisafi, S | 1 |
| Passadaki, T | 1 |
| Tsalkidis, A | 1 |
| Hatzimichail, A | 1 |
| Vargemezis, V | 1 |
| Lialiaris, TS | 1 |
| Ishiki, N | 2 |
| Onishi, H | 3 |
| Machida, Y | 3 |
| Konovalova, NP | 3 |
| Mabel, JA | 1 |
| Wodinsky, I | 1 |
| Aburada, M | 1 |
| Takeda, S | 1 |
| Ito, E | 1 |
| Nakamura, M | 1 |
| Hosoya, E | 1 |
| Ohno, R | 1 |
| Kodera, Y | 1 |
| Ogura, M | 1 |
| Yamada, H | 1 |
| Rose, WC | 2 |
| Schlein, A | 1 |
| Huftalen, JB | 1 |
| Okabe, M | 3 |
| Imai, R | 3 |
| Marumo, H | 1 |
| Kobayashi, T | 2 |
| Tsuruo, T | 5 |
| Inaba, M | 3 |
| Tsukagoshi, S | 3 |
| Sakurai, Y | 1 |
| Urakawa, C | 1 |
| Nakamura, N | 1 |
| Izumi, H | 1 |
| Hirano, S | 1 |
| Matsushita, Y | 1 |
| Iguchi, H | 1 |
| Tone, H | 1 |
| Takeuchi, T | 2 |
| Elliott, WL | 1 |
| Roberts, BJ | 1 |
| Howard, CT | 1 |
| Leopold, WR | 1 |
| Kobayashi, E | 1 |
| Lee, JH | 1 |
| Krivobok, S | 1 |
| Seigle-Murandi, F | 1 |
| Steiman, R | 1 |
| Benoit-Guyod, JL | 1 |
| Bartoli, MH | 1 |
| Kobayashi, S | 2 |
| Ushiki, J | 1 |
| Takai, K | 1 |
| Okumura, S | 1 |
| Ueno, H | 1 |
| Hirata, T | 1 |
| Seymour, LW | 1 |
| Soyez, H | 1 |
| De Marre, A | 1 |
| Shoaibi, MA | 1 |
| Schacht, EH | 1 |
| Okamoto, A | 1 |
| Saito, H | 1 |
| Sato, M | 1 |
| Takahara, J | 1 |
| Nagai, T | 1 |
| Hanaoka, K | 1 |
| Suzuki, M | 1 |
| Tanzawa, F | 1 |
| Tanaka, K | 1 |
| Shibayama, T | 1 |
| Miura, S | 1 |
| Ikeda, T | 1 |
| Iwabuchi, H | 1 |
| Nakagawa, A | 1 |
| Mitsuhashi, Y | 1 |
| Hisaoka, M | 1 |
| Kaneko, M | 1 |
| Tomida, A | 1 |
| Wataya, Y | 1 |
| Nomura, T | 1 |
| Sasaki, T | 1 |
| Matsuda, A | 1 |
| Kurakata, S | 1 |
| Goncharova, SA | 2 |
| Raevskaia, TA | 1 |
| Kagiia, VT | 1 |
| Rajewskaya, TA | 1 |
| Kagiya, TV | 1 |
| Xu, BH | 3 |
| Singh, SV | 3 |
| Maurya, AK | 1 |
| Mian, AM | 1 |
| Ukai, S | 1 |
| Kiriki, H | 1 |
| Nagai, K | 1 |
| Kiho, T | 1 |
| Nemoto, K | 1 |
| Sugawara, Y | 1 |
| Ogino, M | 1 |
| Mae, T | 1 |
| Abe, F | 1 |
| Nakajima, T | 1 |
| Masuda, H | 1 |
| Okamoto, T | 1 |
| Watanabe, M | 1 |
| Yokoyama, K | 1 |
| Yamada, N | 1 |
| Fujimoto, S | 1 |
| Taguchi, T | 2 |
| Tsujinaka, T | 1 |
| Ogawa, M | 1 |
| Shiozaki, H | 1 |
| Kido, Y | 1 |
| Murata, A | 1 |
| Nishijima, J | 1 |
| Kobayashi, K | 1 |
| Matsuura, N | 1 |
| Mori, T | 1 |
| Uchida, T | 1 |
| Nagahata, T | 1 |
| Arakawa, M | 1 |
| Ekimoto, H | 1 |
| Takahashi, K | 1 |
| Sudo, Y | 1 |
| Asami, N | 1 |
| Talebian, A | 1 |
| Green, D | 1 |
| Hammer, CF | 1 |
| McPherson, E | 1 |
| Schein, PS | 1 |
| Hirayama, N | 1 |
| Florczyk, AP | 1 |
| Fujimoto, K | 1 |
| Oka, T | 1 |
| Ishizeki, S | 1 |
| Ohtsuka, M | 1 |
| Irinoda, K | 1 |
| Kukita, K | 1 |
| Nagaoka, K | 1 |
| Nakashima, T | 1 |
| Hagiwara, A | 1 |
| Ueda, T | 1 |
| Nakagawa, Y | 1 |
| Bush, JA | 1 |
| Long, BH | 1 |
| Catino, JJ | 1 |
| Tomita, K | 1 |
| Fishbein, PL | 1 |
| Kohn, H | 1 |
| Hamanaka, T | 1 |
| Ohgoshi, M | 1 |
| Kawahara, K | 1 |
| Yamakawa, K | 1 |
| Tokunaga, Y | 1 |
| Iwasa, T | 1 |
| Fujisaki, J | 1 |
| Sawai, S | 1 |
| Kagayama, A | 1 |
| Machida, S | 1 |
| Ito, Y | 1 |
| Hoshino, A | 1 |
1 review available for mitomycin and Leukemia P388
| Article | Year |
|---|---|
[Recent advanced studies on mitomycins, antitumor activity and mode of action].
Topics: Animals; Cell Line; Colonic Neoplasms; Humans; Leukemia P388; Mitomycin; Mitomycins; Neoplasms; Panc | 1987 |
58 other studies available for mitomycin and Leukemia P388
| Article | Year |
|---|---|
New potent mitomycin derivatives: synthesis and antitumor activity of 7,7-(ethylenedioxy)mitomycins.
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Leukemia P388; | 1992 |
Structure-activity relationships for mitomycin C and mitomycin A analogues.
Topics: Animals; Breast Neoplasms; Chemical Phenomena; Chemistry; Colonic Neoplasms; Female; Humans; Leukemi | 1991 |
"Reverse" and "symmetrical" analogues of actinomycin D: metabolic activation and in vitro and in vivo tumor growth inhibitory activities.
Topics: Animals; Biotransformation; Cattle; Chemical Phenomena; Chemistry, Physical; Dactinomycin; DNA; DNA, | 1985 |
Mitomycin C analogues with increased metal complexing ability.
Topics: Animals; Chemical Phenomena; Chemistry; Cobalt; Copper; Leukemia P388; Metals; Mice; Mitomycin; Mito | 1986 |
New actinomycin D analogues as superior chemotherapeutic agents against primary and advanced colon tumors and colon xenografts in nude mice.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Dactinomycin; Humans; Leukemia L1210; Leukemia P3 | 1988 |
Nucleotide derivatives of 2,7-diaminomitosene.
Topics: Alkylation; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Leukemia L1210; Leukemia | 1988 |
Conformations of complexes between mitomycins and decanucleotides. 3. Sequence specificity, binding at C-10, and mitomycin analogues.
Topics: Animals; Base Sequence; Binding Sites; Chemical Phenomena; Chemistry; DNA; Leukemia P388; Mice; Mito | 1988 |
Synthesis and biological activity of 6-substituted mitosene analogues of the mitomycins.
Topics: Animals; Bacteriophages; Chemical Phenomena; Chemistry; Escherichia coli; Female; Leukemia P388; Leu | 1985 |
Mitomycin C analogues with aryl substituents on the 7-amino group.
Topics: Animals; Antibiotics, Antineoplastic; Indicators and Reagents; Leukemia P388; Leukopenia; Magnetic R | 1984 |
Mitomycin C analogues with secondary amines at position 7.
Topics: Animals; Antibiotics, Antineoplastic; Drug Evaluation, Preclinical; Indicators and Reagents; Leukemi | 1983 |
Mitomycin C and porfiromycin analogues with substituted ethylamines at position 7.
Topics: Animals; Ethylamines; Female; Leukemia L1210; Leukemia P388; Leukopenia; Melanoma; Mice; Mitomycins; | 1983 |
Synthesis and antineoplastic activity of mitosene analogues of the mitomycins.
Topics: Animals; Antineoplastic Agents; Leukemia L1210; Leukemia P388; Mice; Mitomycins; Structure-Activity | 1981 |
Synthesis and antitumor activity of novel mitomycin derivatives containing functional groups at the C-6-methyl position.
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Leukemia P388; | 1994 |
Novel inhibitors for multidrug resistance: 1,3,5-triazacycloheptanes.
Topics: Animals; Antineoplastic Agents; Azepines; Cisplatin; Cycloheptanes; Doxorubicin; Drug Resistance, Mu | 1995 |
Ether-linked biflavonoids from Quintinia acutifolia.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; Bacillus subtilis; Biflavonoids; | 2004 |
In vitro and in vivo cytogenetic effects of recombinant human erythropoietin on the frequency of sister chromatid exchanges alone or in combination with mitomycin C.
Topics: Adolescent; Adult; Animals; Cells, Cultured; Cytogenetic Analysis; Drug Combinations; Erythropoietin | 2010 |
Antitumor activities of conjugates of mitomycin C with estradiol benzoate and estradiol via glutaric acid in suspension dosage form.
Topics: Animals; Antibiotics, Antineoplastic; Dosage Forms; Estradiol; Female; Glutarates; Injections, Intra | 2002 |
Ultralow doses of various drugs in chemotherapy of experimental tumors.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Resp | 2003 |
Mitomycin C combination therapy against murine tumor systems. Effectiveness with cyclophosphamide and methotrexate.
Topics: Animals; Antibiotics, Antineoplastic; Cyclophosphamide; Doxorubicin; Drug Synergism; Drug Therapy, C | 1983 |
Protective effects of juzentaihoto, dried decoctum of 10 Chinese herbs mixture, upon the adverse effects of mitomycin C in mice.
Topics: Animals; Body Weight; Drug Interactions; Drugs, Chinese Herbal; Leukemia P388; Leukopenia; Male; Mic | 1983 |
Induction of transplantation resistance to murine L1210 leukemia cells in BCG-primed mice by immunization with tuberculin protein-coupled L1210 cells.
Topics: Animals; Immunization; Immunotherapy; Leukemia L1210; Leukemia P388; Male; Mice; Mice, Inbred DBA; M | 1984 |
Antitumor activity and toxicity in animals of RR-150 (7-cysteaminomitosane), a new mitomycin derivative.
Topics: Animals; Antibiotics, Antineoplastic; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Resistan | 1984 |
The action of 7-N-(p-hydroxyphenyl)mitomycin C [M-83] in suppressing murine immune response.
Topics: Animals; Antibiotics, Antineoplastic; Hemolytic Plaque Technique; Hypersensitivity, Delayed; Immunos | 1982 |
Antitumor activity of 7-n-(p-hydroxyphenyl)-mitomycin C in experimental tumor systems.
Topics: Animals; Carcinoma; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fibrosarcoma; Le | 1981 |
Antitumor activity of 7-N-phenyl derivatives of mitomycin C in the leukemia P388 system.
Topics: Animals; Leukemia P388; Leukemia, Experimental; Mice; Mitomycin; Mitomycins; Structure-Activity Rela | 1980 |
Experimental combination chemotherapy of pirarubicin with various antitumor drugs against P388 murine leukemia.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Cytarabine; Do | 1994 |
Chemotherapy with [SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2-)](2- methyl-1,4-butanediamine-N,N')platinum (CI-973, NK121) in combination with standard agents against murine tumors in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Colonic Neoplasms; Cyclophosph | 1994 |
Comparison of uptake of mitomycin C and KW-2149 by murine P388 leukemia cells sensitive or resistant to mitomycin C.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; DNA, Neoplasm; Drug | 1993 |
Antitumoral activity of patulin and patulin-cysteine adducts.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cysteine; Female; Leukemia L1210; Leukemia P388; Mice; M | 1994 |
Disposition and metabolism of KW-2149, a novel anticancer agent.
Topics: Animals; Antineoplastic Agents; Female; Half-Life; HeLa Cells; Humans; Leukemia P388; Male; Mice; Mi | 1993 |
Polymeric prodrugs of mitomycin C designed for tumour tropism and sustained activation.
Topics: Amino Acid Sequence; Animals; Antibiotics, Antineoplastic; Cell Survival; Colorectal Neoplasms; Dose | 1996 |
Characteristics of the antitumor activity of M-16 and M-18, major metabolites of a new mitomycin C derivative KW-2149, in mice.
Topics: Animals; Antineoplastic Agents; Biotransformation; Breast Neoplasms; Cell Survival; HeLa Cells; Huma | 1995 |
In vivo drug release and antitumor characteristics of water-soluble conjugates of mitomycin C with glycol-chitosan and N-succinyl-chitosan.
Topics: Animals; Antibiotics, Antineoplastic; Biopolymers; Body Weight; Chemical Phenomena; Chemistry, Physi | 1996 |
In vivo properties of the conjugates of mitomycin C with estradiol benzoate and estradiol: pharmacokinetics and antitumor characteristics against P388 leukemia and sarcoma 180.
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Estradiol; Female; Injections, Int | 1998 |
Antitumor activity and novel DNA-self-strand-breaking mechanism of CNDAC (1-(2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl) cytosine) and its N4-palmitoyl derivative (CS-682).
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Arabinonucleosides; Biotransformatio | 1999 |
[The radiosensitizer AK-2123 enhances sensitivity of MDR-tumors to Mitomycin C].
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug | 2000 |
Nitrotriazole AK-2123 enhances mitomycin C activity in mice bearing multidrug-resistant tumors.
Topics: Animals; Antibiotics, Antineoplastic; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Syn | 2001 |
Effect of buthionine sulfoximine and ethacrynic acid on cytotoxic activity of mitomycin C analogues BMY 25282 and BMY 25067.
Topics: Animals; Buthionine Sulfoximine; DNA, Neoplasm; Drug Resistance; Drug Screening Assays, Antitumor; E | 1992 |
Modulation of mitomycin C resistance by glutathione transferase inhibitor ethacrynic acid.
Topics: Animals; Biotransformation; Cell Survival; Drug Resistance, Microbial; Drug Synergism; Ethacrynic Ac | 1992 |
Potentiation of mitomycin C cytotoxicity by glutathione depletion in a multi-drug resistant mouse leukemia cell line.
Topics: Animals; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Glutathione; Leukemia P3 | 1992 |
[Synthesis and antitumor activities of conjugates of mitomycin C-polysaccharide from Tremella fuciformis].
Topics: Animals; Antineoplastic Agents; Drug Carriers; Leukemia P388; Leukocyte Count; Male; Mice; Mitomycin | 1992 |
Myeloprotective activity of deoxyspergualin: influence on splenic colony-forming cell injury and antitumor activity of mitomycin C in mice.
Topics: Adenocarcinoma; Animals; Blood Cells; Bone Marrow; Bone Marrow Cells; Colonic Neoplasms; Dose-Respon | 1992 |
[Cross-resistance of HO-221 and various antitumor agents in sublines of mouse leukemia].
Topics: Animals; Antineoplastic Agents; Benzamides; Cisplatin; Doxorubicin; Drug Resistance; Leukemia L1210; | 1991 |
[A pilot study of the combination of 5-FU and epirubicin for gastric cancer as an adjuvant chemotherapy].
Topics: Administration, Oral; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Epirubicin; Flu | 1991 |
[Experimental combination chemotherapy of YNK01, a novel analog of cytarabine, with other antitumor agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arabinonucleotides; | 1990 |
Antitumor activity of a derivative of mitomycin, 7-N-[2-[[2-(gamma-L-glutamylamino)ethyl]dithio]ethyl]mitomycin C (KW-2149), against murine and human tumors and a mitomycin C-resistant tumor in vitro and in vivo.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Weight; Colonic Neoplasms; Drug Screening Assay | 1990 |
New sugar mitomycin C analogues: preparation, murine P388 antitumor activity, and leukopenia induction.
Topics: Animals; Antineoplastic Agents; Leukemia P388; Leukopenia; Magnetic Resonance Spectroscopy; Mitomyci | 1990 |
Structure studies of mitomycins. III. Structure of M-83.
Topics: Animals; Antibiotics, Antineoplastic; Crystallization; Leukemia P388; Mitomycin; Mitomycins; Molecul | 1990 |
Antitumor activity and toxicity in animals of N-7[2-(4-nitrophenyldithio) ethyl] mitomycin C (BMY-25067).
Topics: Animals; Antineoplastic Agents; Female; Injections, Intraperitoneal; Injections, Intravenous; Leukem | 1990 |
Antitumor activity of a novel antitumor antibiotic, quinocarmycin citrate (KW2152).
Topics: Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Cell Line; Cisplatin; DNA; Dose-Response Rel | 1987 |
Metal complexes of mitomycins.
Topics: Animals; Chemical Phenomena; Chemistry; Chlorides; Copper; Leukemia P388; Magnetic Resonance Spectro | 1986 |
Azinomycins A and B, new antitumor antibiotics. III. Antitumor activity.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Azabicyclo Compounds; Carcinoma, Ehrlic | 1987 |
Enhanced anticancer efficacy by use of mitomycin C adsorbed on small activated carbon particles in mice.
Topics: Adsorption; Animals; Carbon; Leukemia P388; Leukemia, Experimental; Mice; Mitomycin; Mitomycins; Sol | 1987 |
Production and biological activity of rebeccamycin, a novel antitumor agent.
Topics: Actinomycetales; Adenocarcinoma; Aminoglycosides; Animals; Anti-Bacterial Agents; Antibiotics, Antin | 1987 |
Synthesis and antineoplastic activity of 1a-formyl and 1a-thioformyl derivatives of mitomycin C and 2-methylaziridine.
Topics: Animals; Aziridines; Azirines; Formates; Leukemia P388; Melanoma; Mice; Mitomycin; Mitomycins; Struc | 1987 |
A novel antitumor cyclic hexapeptide (RA-700) obtained from Rubiae radix.
Topics: Animals; Antineoplastic Agents, Phytogenic; Doxorubicin; Drug Evaluation, Preclinical; Female; Leuke | 1987 |
Liposomal sustained-release delivery systems for intravenous injection. III. Antitumor activity of lipophilic mitomycin C prodrug-bearing liposomes.
Topics: Animals; Delayed-Action Preparations; Female; Injections, Intravenous; Leukemia P388; Liposomes; Mic | 1988 |
[Effects of combination chemotherapy of MCNU with various anti-cancer agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Doxorubi | 1985 |