mitomycin has been researched along with Leukemia L5178 in 15 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Leukemia L5178: An experimental lymphocytic leukemia of mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mitomycin C was used as a positive control for all cell types." | 1.33 | SFTG international collaborative study on in vitro micronucleus test I. General conditions and overall conclusions of the study. ( Aardema, MJ; Lorenzon, G; Lorge, E; Marzin, D; Oliver, J; Thybaud, V; Wakata, A, 2006) |
| "Mutations at the tk locus of mouse-lymphoma L5178Y cells were induced by treatment with ethyl methanesulphonate (EMS), primarily a point mutagen and mitomycin C (MMC), a potent clastogen." | 1.29 | Molecular analysis of mutations at the tk locus of L5178Y mouse-lymphoma cells induced by ethyl methanesulphonate and mitomycin C. ( Davies, MJ; Phillips, BJ; Rumsby, PC, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (40.00) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Selassie, CD | 1 |
| Hansch, C | 1 |
| Khwaja, TA | 1 |
| Dias, CB | 1 |
| Pentecost, S | 1 |
| Kirchner, S | 1 |
| Zeller, A | 1 |
| Lü, X | 1 |
| Zhang, L | 1 |
| Wang, R | 1 |
| Shuai, PQ | 1 |
| Zhang, LS | 2 |
| Wang, YJ | 1 |
| Lorge, E | 1 |
| Thybaud, V | 1 |
| Aardema, MJ | 1 |
| Oliver, J | 1 |
| Wakata, A | 1 |
| Lorenzon, G | 1 |
| Marzin, D | 1 |
| Fellows, MD | 1 |
| O'Donovan, MR | 1 |
| Honma, M | 1 |
| Hayashi, M | 1 |
| Suzuki, T | 1 |
| Matsuoka, A | 1 |
| Sofuni, T | 1 |
| Davies, MJ | 1 |
| Phillips, BJ | 1 |
| Rumsby, PC | 1 |
| Kinsella, JE | 1 |
| Black, JM | 1 |
| Miyamae, Y | 1 |
| Zaizen, K | 1 |
| Ohara, K | 1 |
| Mine, Y | 1 |
| Sasaki, YF | 1 |
| Wehrmaker, A | 2 |
| Lehmann, V | 1 |
| Dröge, W | 2 |
| Begleiter, A | 1 |
| Robotham, E | 1 |
| Lacey, G | 1 |
| Leith, MK | 1 |
| Shiomi, T | 2 |
| Hieda-Shiomi, N | 2 |
| Hama-Inaba, H | 1 |
| Ito, A | 1 |
| Sato, K | 2 |
| Yoshizumi, T | 1 |
| Nakazawa, T | 1 |
| Eck, HP | 1 |
15 other studies available for mitomycin and Leukemia L5178
| Article | Year |
|---|---|
Comparative structure-activity relationships of antifolate triazines inhibiting murine tumor cells sensitive and resistant to methotrexate.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Chickens; Drug Resistance; Folic Acid Antagonists; | 1984 |
Comparison of different cytotoxicity measures for the in vitro micronucleus test (MNVit) in L5178Y tk(+/-) cells: Summary of 4 compounds (Mitomycin C, Cyclophosphamide, Colchicine and Diethylstilboestrol) with clastogenic and aneugenic mode of action.
Topics: Aneugens; Animals; Cell Count; Cell Line, Tumor; Cell Proliferation; Colchicine; Cyclophosphamide; D | 2010 |
[Application of in vitro micronucleus tests using L5178Y mouse lymphoma and WTK1 human lymphoblastoid cell lines to antimutagenicity assay].
Topics: Animals; Antimutagenic Agents; Ascorbic Acid; Chlorophyllides; Humans; Leukemia L5178; Lymphocytes; | 1999 |
[TK locus mutation assay: comparison of L5178Y and TK6 cell lines].
Topics: Animals; Cell Line, Tumor; Ethyl Methanesulfonate; Humans; Leukemia L5178; Lymphoma; Methyl Methanes | 2004 |
SFTG international collaborative study on in vitro micronucleus test I. General conditions and overall conclusions of the study.
Topics: Aneugens; Animals; Bleomycin; Cell Line; CHO Cells; Clofibrate; Colchicine; Cricetinae; Cytarabine; | 2006 |
Cytotoxicity in cultured mammalian cells is a function of the method used to estimate it.
Topics: 2,4-Dinitrophenol; 4-Nitroquinoline-1-oxide; Animals; Benzimidazoles; Carbamates; Cell Line, Tumor; | 2007 |
A comparative study of TK6 human lymphoblastoid and L5178Y mouse lymphoma cell lines in the in vitro micronucleus test.
Topics: Animals; B-Lymphocytes; Cell Line; Cell Survival; Demecolcine; Ethyl Methanesulfonate; Humans; Leuke | 1995 |
Molecular analysis of mutations at the tk locus of L5178Y mouse-lymphoma cells induced by ethyl methanesulphonate and mitomycin C.
Topics: Animals; Blotting, Northern; Blotting, Southern; DNA Mutational Analysis; Ethyl Methanesulfonate; Ge | 1993 |
Effects of polyunsaturated fatty acids on the efficacy of antineoplastic agents toward L5178Y lymphoma cells.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Survival; Dexamethasone; Fatty Acids, Unsaturate | 1993 |
Detection of DNA lesions induced by chemical mutagens by the single cell gel electrophoresis (Comet) assay. 1. Relationship between the onset of DNA damage and the characteristics of mutagens.
Topics: Animals; Bleomycin; Cross-Linking Reagents; DNA Damage; Electrophoresis; Leukemia L5178; Mercaptopur | 1997 |
Analysis of protective and cytotoxic immune responses in vivo against metabolically inactivated and untreated cells of a mutagenized tumor line (requirements for tumor immunogenicity).
Topics: Animals; Antigens, Neoplasm; Cell Line; Epitopes; Histocompatibility Antigens Class II; Immunity, Ce | 1986 |
Increased sensitivity of quinone resistant cells to mitomycin C.
Topics: Animals; Antineoplastic Agents; Benzoquinones; Cell Line; Cell Survival; Dicumarol; DNA Damage; Drug | 1989 |
Mutagen detection with a mouse line containing 3 distinct mutations conferring sensitivity.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Line; Cross-Linking Reagents; DNA Repair; Drug Resistance; L | 1987 |
Cell fusion-mediated improvement in transfection competence for repair-deficient mutant of mouse T cell line.
Topics: Animals; Cell Fusion; Cell Survival; DNA; DNA Repair; Leukemia L5178; Leukemia, Experimental; Mice; | 1988 |
Alanine inhibits cytotoxic responses: its production by different tumor cell lines explains differences in their immunogenicity.
Topics: Alanine; Animals; Cell Line; Cytotoxicity, Immunologic; Female; Immunosuppression Therapy; Lactates; | 1988 |