mitomycin has been researched along with Leukemia L 1210 in 51 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A yellow crystalline product, named rebeccamycin, was isolated from the mycelium and was found to have activity against P388 leukemia, L1210 leukemia and B16 melanoma implanted in mice." | 3.67 | Production and biological activity of rebeccamycin, a novel antitumor agent. ( Bradner, WT; Bush, JA; Catino, JJ; Long, BH; Tomita, K, 1987) |
| " Pharmacokinetic analysis of each plasma concentration indicated that for each conjugate, the in vitro drug release reported previously was useful for the approximate estimation of the in vivo regeneration of MMC." | 1.29 | Pharmacokinetic characteristics and antitumor activity of the N-succinyl-chitosan-mitomycin C conjugate and the carboxymethyl-chitin-mitomycin C conjugate. ( Nagai, T; Onishi, H; Song, Y, 1993) |
| " A good dose-response increase in induced interstrand DNA cross-linking frequency was observed in cells treated with 2." | 1.28 | DNA breaks and repair in the mouse leukemia L1210 cells exposed to three different types of interstrand DNA cross-linkers. ( Hochi, S; Kawanishi, G; Kishi, T; Miyata, N; Yajima, N, 1990) |
| "Treatment of mitomycin C with pyrimidine nucleotides in acidic media produced derivatives of 2,7-diaminomitosene in which C-1 was covalently bound to the phosphate group of the nucleotides." | 1.27 | Nucleotide derivatives of 2,7-diaminomitosene. ( Dorr, RT; Iyengar, BS; Kowal, CD; Remers, WA, 1988) |
| "Augmentation of antitumor activity of Lactobacillus casei YIT 9018 (LC 9018), which strongly inhibits the growth of transplantable allogeneic and syngeneic mouse tumors, in combination with antitumor drugs was investigated." | 1.27 | [Augmentation of antitumor activity of Lactobacillus casei YIT 8018 (LC 9018) in combination with various antitumor drugs]. ( Kato, I; Matsuzaki, T; Mutai, M; Yokokura, T, 1984) |
| "Mitomycin C (MMC) has been evaluated in combination with several antitumor agents." | 1.27 | Mitomycin C combination therapy against murine tumor systems. Effectiveness with cyclophosphamide and methotrexate. ( Mabel, JA; Wodinsky, I, 1983) |
| "Nine lipophilic la-N-substituted prodrugs of mitomycin C were formulated in lipid dispersion dosage forms and their fundamental antitumor activities were evaluated." | 1.27 | Antitumor activity of lipophilic prodrugs of mitomycin C entrapped in liposome or O/W emulsion. ( Hashida, M; Kimura, T; Sasaki, H; Sezaki, H; Takakura, Y, 1984) |
| " There was a good correlation between ISCs and cytotoxicity in dose-response studies in each cell line." | 1.27 | Interactions of mitomycin C with mammalian DNA detected by alkaline elution. ( Alberts, DS; Bowden, GT; Dorr, RT; Liddil, JD, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (64.71) | 18.7374 |
| 1990's | 18 (35.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yoshimoto, M | 1 |
| Miyazawa, H | 1 |
| Nakao, H | 1 |
| Shinkai, K | 1 |
| Arakawa, M | 2 |
| Iyengar, BS | 3 |
| Dorr, RT | 4 |
| Remers, WA | 4 |
| Selassie, CD | 1 |
| Hansch, C | 1 |
| Khwaja, TA | 1 |
| Orlemans, EO | 1 |
| Verboom, W | 2 |
| Scheltinga, MW | 1 |
| Reinhoudt, DN | 2 |
| Lelieveld, P | 1 |
| Fiebig, HH | 1 |
| Winterhalter, BR | 1 |
| Double, JA | 1 |
| Bibby, MC | 1 |
| Sengupta, SK | 2 |
| Kogan, Y | 1 |
| Kelly, C | 1 |
| Szabo, J | 1 |
| Rosenbaum, DP | 1 |
| Sehgal, RK | 1 |
| Almassian, B | 1 |
| Blondin, J | 1 |
| Kowal, CD | 1 |
| Sami, SM | 1 |
| Bradner, WT | 6 |
| Schurig, JE | 3 |
| Hodges, JC | 1 |
| BROCKMAN, RW | 1 |
| ANDERSON, EP | 1 |
| EVANS, JS | 1 |
| BOSTWICK, L | 1 |
| MENGEL, GD | 1 |
| BACHMAN, S | 1 |
| PINDELL, MH | 1 |
| Sezaki, H | 6 |
| Hashida, M | 6 |
| Matsumoto, T | 1 |
| Taguchi, A | 1 |
| Okawa, Y | 1 |
| Mikami, T | 1 |
| Suzuki, K | 1 |
| Suzuki, S | 1 |
| Suzuki, M | 1 |
| Kato, A | 2 |
| Kojima, T | 2 |
| Muranishi, S | 3 |
| Tanigawa, N | 1 |
| Satomura, K | 1 |
| Hikasa, Y | 1 |
| Takakura, Y | 3 |
| Matsumoto, S | 4 |
| Sasaki, H | 2 |
| Matsuzaki, T | 1 |
| Kato, I | 1 |
| Yokokura, T | 2 |
| Mutai, M | 1 |
| Mabel, JA | 1 |
| Wodinsky, I | 1 |
| Cohen, MH | 1 |
| Matthews, MJ | 1 |
| Kimura, T | 1 |
| Ninomiya, K | 1 |
| Sekido, S | 1 |
| Araki, T | 1 |
| Ludwig, C | 1 |
| Ohno, R | 1 |
| Kodera, Y | 1 |
| Ogura, M | 1 |
| Yamada, H | 2 |
| Rose, WC | 2 |
| Schlein, A | 1 |
| Huftalen, JB | 1 |
| Kataoka, T | 2 |
| Oh-Hashi, F | 1 |
| Sakurai, Y | 1 |
| Kawalec, M | 1 |
| Jakóbisiak, M | 1 |
| Skórski, T | 1 |
| Kawiak, J | 1 |
| Usui, S | 1 |
| Murashima, K | 1 |
| Sakai, M | 1 |
| Kiho, T | 1 |
| Ukai, S | 1 |
| Kitamura, M | 1 |
| Arai, K | 1 |
| Iwasaki, Y | 1 |
| Krivobok, S | 1 |
| Seigle-Murandi, F | 1 |
| Steiman, R | 1 |
| Benoit-Guyod, JL | 1 |
| Bartoli, MH | 1 |
| Song, Y | 1 |
| Onishi, H | 1 |
| Nagai, T | 1 |
| Tamura, T | 1 |
| Fujita, T | 1 |
| Itoh, Y | 1 |
| Sugimoto, S | 1 |
| Murakami, M | 1 |
| Yamamoto, A | 1 |
| Seymour, LW | 1 |
| Soyez, H | 1 |
| De Marre, A | 1 |
| Shoaibi, MA | 1 |
| Schacht, EH | 1 |
| Katayama, H | 1 |
| Tagawa, N | 1 |
| Kawada, Y | 1 |
| Shiobara, K | 1 |
| Kaneko, K | 1 |
| Honda, Y | 1 |
| Kondo, N | 1 |
| Ikeda, Y | 1 |
| Kuin, A | 1 |
| Aalders, M | 1 |
| Lamfers, M | 1 |
| van Zuidam, DJ | 1 |
| Essers, M | 1 |
| Beijnen, JH | 1 |
| Smets, LA | 1 |
| Maliepaard, M | 1 |
| de Mol, NJ | 1 |
| Janssen, LH | 1 |
| van der Neut, W | 1 |
| Zhu, Z | 1 |
| Ryoyama, K | 1 |
| Ryoyama, C | 1 |
| Nakajima, T | 1 |
| Masuda, H | 1 |
| Okamoto, T | 1 |
| Watanabe, M | 1 |
| Yokoyama, K | 1 |
| Yamada, N | 1 |
| Fujimoto, S | 1 |
| Tsukagoshi, S | 1 |
| Taguchi, T | 1 |
| Furuta, T | 1 |
| Yajima, N | 1 |
| Hochi, S | 1 |
| Miyata, N | 1 |
| Kishi, T | 1 |
| Kawanishi, G | 1 |
| Uchida, T | 1 |
| Nagahata, T | 1 |
| Ekimoto, H | 1 |
| Takahashi, K | 1 |
| Florczyk, AP | 1 |
| Nakamura, T | 1 |
| Masuda, K | 1 |
| Oku, T | 1 |
| Manda, T | 1 |
| Mori, J | 1 |
| Shimomura, K | 1 |
| Yamamoto, T | 1 |
| Honjo, K | 1 |
| Murayama, T | 1 |
| Bush, JA | 1 |
| Long, BH | 1 |
| Catino, JJ | 1 |
| Tomita, K | 1 |
| Liddil, JD | 2 |
| Trent, JM | 1 |
| Dalton, WS | 1 |
| Hayashi, Y | 1 |
| Shigeoka, T | 1 |
| Machida, S | 1 |
| Ito, Y | 1 |
| Hoshino, A | 1 |
| Bowden, GT | 1 |
| Alberts, DS | 1 |
| Suga, S | 1 |
| Kimura, K | 1 |
| Iwase, H | 1 |
| Ina, K | 1 |
| Takada, N | 1 |
| Matsuoka, S | 1 |
| Matsuura, T | 1 |
| Yamada, K | 1 |
| Horiuchi, T | 1 |
| Hashizume, H | 1 |
2 reviews available for mitomycin and Leukemia L 1210
| Article | Year |
|---|---|
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tum | 1963 |
Macromolecule-drug conjugates in targeted cancer chemotherapy.
Topics: Animals; Antibiotics, Antineoplastic; Antibodies, Neoplasm; Antineoplastic Agents; Blood Proteins; C | 1984 |
2 trials available for mitomycin and Leukemia L 1210
| Article | Year |
|---|---|
Macromolecule-drug conjugates in targeted cancer chemotherapy.
Topics: Animals; Antibiotics, Antineoplastic; Antibodies, Neoplasm; Antineoplastic Agents; Blood Proteins; C | 1984 |
[Evaluation of intraperitoneal chemotherapy using CDDP combined with MMC in gastric carcinomatous peritonitis].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Fe | 1994 |
48 other studies available for mitomycin and Leukemia L 1210
| Article | Year |
|---|---|
Quantitative structure-activity relationships in 2,5-bis(1-aziridinyl)-p-benzoquinone derivatives against leukemia L-1210.
Topics: Animals; Antineoplastic Agents; Leukemia L1210; Mice; Models, Biological; Quinones; Solubility; Stru | 1979 |
Additional nucleotide derivatives of mitosenes. Synthesis and activity against parental and multidrug resistant L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Cell Line; Chemical Phenomena; Chemistry; Leukemia L1210; Mice; Mito | 1991 |
Structure-activity relationships of antineoplastic agents in multidrug resistance.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; | 1990 |
Synthesis, mechanism of action, and biological evaluation of mitosenes.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Female; Humans; Leukemia L1210; Mice; | 1989 |
New actinomycin D analogues as superior chemotherapeutic agents against primary and advanced colon tumors and colon xenografts in nude mice.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Dactinomycin; Humans; Leukemia L1210; Leukemia P3 | 1988 |
Enantiomers of 7-(2,3-epoxypropoxy)actinomycin D as dual-action DNA-acting antitumor agents.
Topics: Animals; Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry; Colonic Neoplasms; Dactinomycin | 1988 |
Nucleotide derivatives of 2,7-diaminomitosene.
Topics: Alkylation; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Leukemia L1210; Leukemia | 1988 |
Mitomycin C and porfiromycin analogues with substituted ethylamines at position 7.
Topics: Animals; Ethylamines; Female; Leukemia L1210; Leukemia P388; Leukopenia; Melanoma; Mice; Mitomycins; | 1983 |
Synthesis and antineoplastic activity of mitosene analogues of the mitomycins.
Topics: Animals; Antineoplastic Agents; Leukemia L1210; Leukemia P388; Mice; Mitomycins; Structure-Activity | 1981 |
SYNERGISM OF THE ANTINEOPLASTIC ACTIVITY OF CYTOSINE ARABINOSIDE BY PORFIROMYCIN.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Body Weight; Cytarabine; Cytosine; Leukemia; | 1964 |
STUDIES OF LEUKEMIA L1210 HOMOGRAFT IN SWISS HA-ICR MICE.
Topics: Allografts; Animals; Antineoplastic Agents; Leukemia L1210; Leukemia, Experimental; Mice; Mice, Inbr | 1964 |
Growth-inhibition of leukemia L-1210 ascites tumor by combination of carrageenan and mitomycin C in vivo.
Topics: Acid Phosphatase; alpha-Galactosidase; Animals; Carrageenan; Exudates and Transudates; Kinetics; Leu | 1984 |
Antitumor activity of mitomycin C-dextran conjugate against various murine tumors.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Dextrans; Female; Injections, Intravenous; | 1981 |
Regeneration characteristics of mitomycin C-dextran conjugate in relation to its activity.
Topics: Animals; Dextrans; Drug Stability; Escherichia coli; Leukemia L1210; Male; Mice; Mitomycin; Mitomyci | 1983 |
[Augmentation of antitumor activity of Lactobacillus casei YIT 8018 (LC 9018) in combination with various antitumor drugs].
Topics: Animals; Antineoplastic Agents; Bleomycin; Cyclophosphamide; Fluorouracil; Lacticaseibacillus casei; | 1984 |
Mitomycin C combination therapy against murine tumor systems. Effectiveness with cyclophosphamide and methotrexate.
Topics: Animals; Antibiotics, Antineoplastic; Cyclophosphamide; Doxorubicin; Drug Synergism; Drug Therapy, C | 1983 |
Chemotherapy-induced pulmonary toxicity in mice bearing L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Doxorubicin; Leukemia L1210; Lung Dise | 1983 |
Antitumor activity of lipophilic prodrugs of mitomycin C entrapped in liposome or O/W emulsion.
Topics: Animals; Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry, Physical; Emulsions; In Vitro T | 1984 |
[Effect of combination chemotherapy of nitrosourea MCNU with various anti-tumor agents].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbazilquinone; Cell Line; Cyclophosphamid | 1984 |
Drug resistance of hypoxic tumour cells in vitro.
Topics: Animals; Anthracenes; Cell Line; DNA, Single-Stranded; Drug Evaluation, Preclinical; Drug Resistance | 1984 |
Induction of transplantation resistance to murine L1210 leukemia cells in BCG-primed mice by immunization with tuberculin protein-coupled L1210 cells.
Topics: Animals; Immunization; Immunotherapy; Leukemia L1210; Leukemia P388; Male; Mice; Mice, Inbred DBA; M | 1984 |
Antitumor activity and toxicity in animals of RR-150 (7-cysteaminomitosane), a new mitomycin derivative.
Topics: Animals; Antibiotics, Antineoplastic; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Resistan | 1984 |
Immunogenicity and amplifier cell production by tumor vaccines enhanced by concanavalin A.
Topics: Animals; Antigens, Neoplasm; Cell Division; Concanavalin A; Immunity; In Vitro Techniques; Leukemia | 1982 |
Immunogenicity of cyclophosphamide-treated leukaemia cells.
Topics: Animals; Antibiotics, Antineoplastic; Cyclophosphamide; Immune Tolerance; Leukemia L1210; Mice; Mice | 1982 |
Preparation and antitumor activities of mitomycin C beta-(1-->6)-branched (1-->3)-beta-D-glucan conjugate.
Topics: Animals; Antibiotics, Antineoplastic; Chemotaxis, Leukocyte; Chromatography, Gel; Drug Carriers; Fem | 1994 |
Antitumoral activity of patulin and patulin-cysteine adducts.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cysteine; Female; Leukemia L1210; Leukemia P388; Mice; M | 1994 |
Pharmacokinetic characteristics and antitumor activity of the N-succinyl-chitosan-mitomycin C conjugate and the carboxymethyl-chitin-mitomycin C conjugate.
Topics: Animals; Antineoplastic Agents; Cell Division; Chitin; Chitosan; Chromatography, High Pressure Liqui | 1993 |
Synergistic anti-tumor effects of mitomycin C and bile salts against L1210 cells.
Topics: Animals; Antineoplastic Agents; Cell Membrane Permeability; Diphenylhexatriene; Drug Synergism; Fluo | 1995 |
Polymeric prodrugs of mitomycin C designed for tumour tropism and sustained activation.
Topics: Amino Acid Sequence; Animals; Antibiotics, Antineoplastic; Cell Survival; Colorectal Neoplasms; Dose | 1996 |
Heterocyclic analogues of quinone methide: preparation and cytotoxicity of 3-oxo-3H-pyrazolo[1,5-a]indole derivatives.
Topics: Animals; Drug Screening Assays, Antitumor; Indolequinones; Indoles; Leukemia L1210; Male; Mice; Mito | 1997 |
Potentiation of anti-cancer drug activity at low intratumoral pH induced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) and its analogue benzylguanidine (BG).
Topics: 3-Iodobenzylguanidine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Antineo | 1999 |
Role of lipophilicity in the in vitro antitumour activity of a series of new mitosene compounds.
Topics: Animals; Colonic Neoplasms; Drug Design; Drug Screening Assays, Antitumor; Leukemia L1210; Membrane | 1992 |
[Preparation of a monoclonal antibody (HI30)-mitomycin C conjugate utilizing dextran T-40 and its specific cytotoxicity against human leukemia cell line CEM].
Topics: Animals; Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; Dextrans; Humans; Immunoto | 1990 |
Cyclophosphamide modifies the induction kinetics but not cell types and cytotoxic mechanisms of antitumor cells elicited with OK-432 plus attenuated tumor cells.
Topics: Animals; Arachidonic Acid; Cell Cycle; Cell Division; Cyclophosphamide; Exudates and Transudates; Ki | 1991 |
[Cross-resistance of HO-221 and various antitumor agents in sublines of mouse leukemia].
Topics: Animals; Antineoplastic Agents; Benzamides; Cisplatin; Doxorubicin; Drug Resistance; Leukemia L1210; | 1991 |
[Combination therapy of CPT-11, a camptothecin derivative, with various antitumor drugs against L 1210 leukemia].
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptoth | 1991 |
DNA breaks and repair in the mouse leukemia L1210 cells exposed to three different types of interstrand DNA cross-linkers.
Topics: Animals; Anthracyclines; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Survival; DNA Dama | 1990 |
[Experimental combination chemotherapy of YNK01, a novel analog of cytarabine, with other antitumor agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arabinonucleotides; | 1990 |
Antitumor activity and toxicity in animals of N-7[2-(4-nitrophenyldithio) ethyl] mitomycin C (BMY-25067).
Topics: Animals; Antineoplastic Agents; Female; Injections, Intraperitoneal; Injections, Intravenous; Leukem | 1990 |
Effect of FK973, a new antitumor antibiotic, on the cell cycle of L1210 cells in vitro.
Topics: Animals; Antineoplastic Agents; Bromodeoxyuridine; Cell Division; Cytarabine; DNA, Neoplasm; Flow Cy | 1989 |
Mitomycin C-augmented production of I-A antigen-positive macrophages in tumor vaccine-primed mice.
Topics: Animals; Antigen-Presenting Cells; Dinoprostone; Histocompatibility Antigens Class II; Leukemia L121 | 1986 |
Production and biological activity of rebeccamycin, a novel antitumor agent.
Topics: Actinomycetales; Adenocarcinoma; Aminoglycosides; Animals; Anti-Bacterial Agents; Antibiotics, Antin | 1987 |
Mitomycin C resistant L1210 leukemia cells: association with pleiotropic drug resistance.
Topics: Animals; Cell Line; Chromosome Aberrations; Drug Resistance; Glycoproteins; Leukemia L1210; Membrane | 1987 |
Cellular interaction and in vitro antitumor activity of lipophilic mitomycin C prodrugs.
Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Ehrlich Tumor; Chemical Phenomena; Chemistry, Physi | 1987 |
Cellular interaction and in vitro antitumor effect of various mitomycin C prodrugs in mitomycin C-resistant L1210 leukemia cell lines.
Topics: Animals; Drug Resistance; Leukemia L1210; Mice; Mitomycin; Mitomycins; Pharmacology; Prodrugs; Tumor | 1987 |
[Effects of combination chemotherapy of MCNU with various anti-cancer agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Doxorubi | 1985 |
Interactions of mitomycin C with mammalian DNA detected by alkaline elution.
Topics: Alkylation; Animals; Cell Line; Cell Nucleus; Cell Survival; Cross-Linking Reagents; DNA, Neoplasm; | 1985 |
[UFT, UFTM, and UFTM-Dpc treatment of gastric cancer].
Topics: Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Humans; Leukemia L1210; Male; Mice; M | 1985 |